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Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer

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Nano Research 2015年第3期8卷 751-764页

作者： Guangbao Yang Hua Gong Xiaoxin Qian pengli Tan Zhiwei li Teng liu Jingjing liu Youyong li Zhuang liu Institute of Functional Nano and Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Suzhou Jiangsu 215123 China

Mesoporous silica nanoparticles （MSNs） have attracted tremendous attention in recent years as drug delivery carriers due to their large surface areas, tunable sizes, facile modification and considerable biocompatibility. In this work, we fabricate an interesting type of MSNs which are intrinsically doped with photosensitizing molecules, chlorin e6 （Ce6）. By increasing the amount of Ce6 doped inside the silica matrix, it is found that the morphology of MSNs changes from spheres to rod-like shapes. The obtained Ce6-doped mesoporous silica nanorods （CMSNRs） are not only able to produce singlet oxygen for photodynamic therapy, but can also serve as a drug delivery platform with high drug loading capacity by utilizing their mesoporous structure. Compared to spherical nano- particles, it is found that CMSNRs with a larger aspect ratio show much faster uptake by cancer cells. With doxorubicin （DOX） employed as a model drug, the combined photodynamic and chemotherapy is carried out, achieving synergistic anti-tumor effects both in vitro and in vivo. Our study presents a new design of an MSN-based drug delivery platform, which intrinsically is fluorescent and able to serve as a photodynamic agent, promising for future imaging-guided combination therapy of cancer.

关键词： mesoporous silicananorods chlorin e6 photodynamic therapy drug delivery combination therapy

Plant buffering against the high-light stress- induced accumulation of CsGA2ox8 transcripts via alter native splici ng to fi n ely tune gibberelli n levels and maintain hypocotyl elongation

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Horticulture Research 2021年第1期8卷 171-180页

作者： Bin liu Shuo Zhao pengli li Yilu Yin Qingliang Niu Jinqiang Yan Danfeng Huang School of Agriculture and Biology Shanghai Jiao Tong UniversityKey Lab oratory of Urban Agricult ure(South)Ministry of AgricultureDongchuan RoadShanghai 200240China Department of Plant Genomics Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UBBellaterra 08193Spain Vegetable Research Institute Guangdong Academy of Agricultural SciencesGuan gzhou 510640China Guangdong Key Lab oratory for New Technology Research of Vegetables Guangzhou 510640China

In plants,alternative splicing(AS)is markedly induced in response to environmental stresses,but it is unclear why plants generate multiple transcripts under stress *** this study,RNA-seq was performed to identify AS events in cucumber seedlings grown under different light *** identi fi ed a novel transcript of the gibberellin(GA)-deactivating enzyme Gibberellin 2-beta-dioxygenase 8(CsGA2ox8).Compared with canonical CsGA2ox8.1,the CsGA2ox8.2 isoform presented intron retention between the second and third *** analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive ***,expression analysis demonstrated that both transcripts were upregulated by increased light intensity,but the expression level of CsGA2ox8.1 increased slowly when the light intensity was>400μmol-m-2-s-1 PPFD(photosynthetic photon fl ux density),while the CsGA2ox8.2 transcript levels increased rapidly when the light intensity was>200 pmol-m-2-s-1 *** fi ndings provide evidence that plants might fi nely tune their GA levels by buffering against the normal transcripts of CsGA2ox8 through AS.

关键词： stress light Plant

Preparation, Characterization and Pharmacokinetics of Fluorescence Labeled Propylene Glycol Alginate Sodium Sulfate

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Journal of Ocean University of China 2014年第4期13卷 683-690页

作者： li pengli li Chunxia XUE Yiting ZHANG Yang liU Hongbing ZHAO Xia YU Guangli GUAN Huashi Key Laboratory of Marine Drugs of Ministry of Education Provincial Key Laboratory of Glycoscience and Glycotechnology of Shandong School of Medicine and Pharmacy Ocean University of China

A rapid and sensitive fluorescence labeling method was developed and validated for the microanalysis of a sulfated polysaccharide drug,namely propylene glycol alginate sodium sulfate(PSS), in rat plasma. Fluorescein isothiocyanate(FITC) was selected to label PSS, and 1, 6-diaminohexane was used to link PSS and FITC in order to prepare FITC-labeled PSS(F-PSS) through a reductive amination reaction. F-PSS was identified by UV-Vis, FT-IR and 1H-NMR spectrum. The cell stability and cytotoxicity of F-PSS were tested in Madin-Darby canine kidney(MDCK) cells. The results indicated that the labeling efficiency of F-PSS was 0.522% ± 0.0248% and the absolute bioavailability was 8.39%. F-PSS was stable in MDCK cells without obvious cytotoxicity. The method was sensitive and reliable; it showed a good linearity, precision, recovery and stability. The FITC labeling method can be applied to investigating the absorption and metabolism of PSS and other polysaccharides in biological samples.

关键词： propylene glycol alginate sodium sulfate fluorescence labeling fluorescein isothiocyanate pharmacokinetics

Self-cleaning of superhydrophobic nanostructured surfaces at low humidity enhanced by vertical electric field

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Nano Research 2022年第5期15卷 4732-4738页

作者： Yijie liu Yujun Guo Xueqin Zhang Guoqiang Gao Chaoqun Shi Guizao Huang pengli li Qi Kang Xingyi Huang Guangning Wu College of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingState Key laboratory of Metal Matrix CompositesShanghai Jiaotong UniversityShanghai 200240China

Self-cleaning is the key factor that makes superhydrophobic nanostructured materials have wide *** self-cleaning effect,however,strongly depends on formations and movement of water droplets on superhydrophobic nanostructured surfaces,which is greatly restricted at low humidity(lified numerical model describing pollution movements is *** results are consistent with experimental *** proposed method realizes the self-cleaning of superhydrophobic nanostructured surfaces above dew point curve for the first time,which extends applications of superhydrophobic nanostructured materials in low humidity,and is expected to solve self-cleaning problems of outdoor objects in low humidity areas(<5.0 g·kg^(-1)).

关键词： self-cleaning electric field low humidity electro-aggregation superhydrophobic nanostructured surface

Universal precursors dispersed in Vaseline-octadecene gel for nanocrystal synthesis

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Nano Research 2022年第5期15卷 4724-4731页

A great variety of high-quality inorganic nanocrystals are synthesized solely in hydrocarbon solvents in both academic and industrial settings on a daily basis,which is largely complicated by lack of simple precursors containing inorganic element(s)yet soluble in the reaction solvents at ambient ***,we introduce a new strategy for preparing the precursors,namely inorganic(or element-containing organic)molecules dispersed in hydrocarbon(Vaseline-octadecene)*** strategy not only greatly expands spectra of potential precursors and their concentration range,but also simplifies synthetic system,enables automated large-scale synthesis,and minimizes environmental concerns.

关键词： nanocrystals synthesis precursors gel

Hierarchically porous composite fabrics with ultrahigh metal–organic framework loading for zero-energy-consumption heat dissipation

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Science Bulletin 2022年第19期67卷 1991-2000页

作者： Xiangyu liu pengli li Jie Chen Pingkai Jiang Yiu-Wing Mai Xingyi Huang Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingDepartment of Polymer Science and EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Centre for Advanced Materials Technology School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia

The long-term safe operation of high-power equipment and integrated electronic devices requires efficient thermal management,which in turn increases the energy consumption ***,the sustainable development of our society needs advanced thermal management with low,even zero,energy *** water from the atmosphere,followed by moisture desorption to dissipate heat,is an efficient and feasible approach for zero-energy-consumption thermal ***,current methods are limited by the low absorbance of water,low water vapor transmission rate(WVTR)and low stability,thus resulting in low thermal management *** this study,we report an innovative electrospinning method to process hierarchically porous metal–organic framework(MOF)composite fabrics with high-efficiency and zero-energy-consumption thermal *** composite fabrics are highly loaded with MOF(75 wt%)and their WVTR value can be up to 3138 g m^(-2) d^(-1).The composite fabrics also exhibit stable microstructure and *** a conventional environment(30℃,60%relative humidity),the composite fabrics adsorb water vapor for regeneration within 1.5 h to a saturated value Wsat of 0.614 g g^(-1),and a corresponding equivalent enthalpy of 1705.6 J g^(-1).In the thermal management tests,the composite fabrics show a strong cooling capability and significantly improve the performance of thermoelectric devices,portable storage devices and wireless *** results suggest that hierarchically porous MOF composite fabrics are highly promising for thermal management of intermittent-operation electronic devices.

关键词： Metal-organic framework Hierarchically porous materials Adsorption-based cooling Electrospinning

支架置入后择期手术与急诊手术治疗急性右半结肠恶性梗阻临床疗效比较

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实用医学杂志 2022年第1期38卷 79-84页

作者：李鹏莉石定河南中医药大学郑州450046 中国科学院大学宁波华美医院浙江宁波315000

目的本研究旨在比较支架置入术后择期手术与急诊手术治疗急性右半结肠恶性梗阻的临床价值和远期预后。方法选取2010年1月至2018年5月在中国科学院大学宁波华美医院因急性右半结肠恶性梗阻行支架置入后择期手术的25例患者作为病例组(支架... 详细信息

目的本研究旨在比较支架置入术后择期手术与急诊手术治疗急性右半结肠恶性梗阻的临床价值和远期预后。方法选取2010年1月至2018年5月在中国科学院大学宁波华美医院因急性右半结肠恶性梗阻行支架置入后择期手术的25例患者作为病例组(支架组)。以年龄、性别、肿瘤大小和位置以及TNM分期5个协变量作为患者的基线特征。采用1∶2最邻近匹配法匹配该院同时期因急性右半结肠恶性梗阻行急诊手术的230例患者,以均衡两组患者的协变量。经倾向评分匹配后,急诊手术组纳入50例患者。结果支架置入术治疗急性右半结肠恶性梗阻的技术成功率和临床成功率分别为100%和96.0%。支架组接受腹腔镜手术的比例明显高于急诊手术组,平均手术时间明显低于急诊手术组,差异具有统计学意义(P0.05)。结论支架置入术治疗急性右半结肠恶性梗阻具有一定的安全性和可行性。支架置入术作为外科手术的桥梁,可增加急性右半结肠恶性梗阻患者接受微创手术的机会,缩短手术时间,降低患者并发症发生率、缩短住院时间,可作为治疗急性右半结肠梗阻的一项选择。

关键词：支架右侧结肠癌急性肠梗阻择期手术急诊手术

2019CIGRE成都国际研讨会配电技术报道

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电网技术 2020年第7期44卷 2642-2648页

作者：苏剑尚宇炜马钊李鹏丽王辉中国电力科学研究院有限公司北京市海淀区100192 华北电力大学控制与计算机工程学院北京市昌平区102206

首先介绍了2019 CIGRE成都国际研讨会概况;然后报道了配电网规划和运行,分布式灵活性资源,微电网、光伏和电池储能,直流配电,综合能源系统规划和运行等技术领域或专题的新进展;最后,对主动配电系统规划与运行、交直流混合配电,以及综合... 详细信息

首先介绍了2019 CIGRE成都国际研讨会概况;然后报道了配电网规划和运行,分布式灵活性资源,微电网、光伏和电池储能,直流配电,综合能源系统规划和运行等技术领域或专题的新进展;最后,对主动配电系统规划与运行、交直流混合配电,以及综合能源系统等技术的发展趋势和相关前沿问题进行了展望。

关键词：配电网分布式能源规划和运行微网直流配电综合能源系统

基于GNU Radio的雷达信号处理系统设计实现

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电光与控制 2021年第5期28卷 75-78,102页

作者：李鹏利李兴成空军工程大学西安710051

针对现有雷达仿真系统的单线程运行模式在处理较大数据量或多任务执行时会造成CPU负担加重、导致系统运行速度缓慢与数据丢失,进而影响仿真测试的实效性等问题,提出了基于GNU Radio软件平台利用其多线程技术与模块化思想,同时设计并使... 详细信息

针对现有雷达仿真系统的单线程运行模式在处理较大数据量或多任务执行时会造成CPU负担加重、导致系统运行速度缓慢与数据丢失,进而影响仿真测试的实效性等问题,提出了基于GNU Radio软件平台利用其多线程技术与模块化思想,同时设计并使用传输内存地址的方法来搭建雷达信号系统,提升计算机的资源利用率。多线程模式下的系统运行不仅能够对大量数据进行处理,而且能提升其处理数据的速度,同时兼具美观性与操作性。最后的测试数据表明了雷达信号处理系统的有效性,达到了预期的设计目标,满足了实际应用需求。

关键词：雷达信号处理 GNU Radio软件平台多线程模块化传输内存地址