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一种3-溴芴酮的合成工艺

化工技术与开发 2024年第10期53卷 11-13,22页

作者：韩蒙蒙马欣李瑞陈鹏丽李奎杨振强申奥河南省科学院化学研究所有限公司河南郑州450002 河南科化环境材料有限公司河南沁阳454550

3-溴芴酮是制备有机电致发光材料、太阳能电池材料等功能性材料的重要中间体。本文以2-氨基芴为起始原料,经溴代反应、重氮化反应和氧化反应合成了3-溴芴酮产物。针对氧化过程中溶剂及碱的种类对收率的影响进行了优化选择。较佳的反应... 详细信息

3-溴芴酮是制备有机电致发光材料、太阳能电池材料等功能性材料的重要中间体。本文以2-氨基芴为起始原料,经溴代反应、重氮化反应和氧化反应合成了3-溴芴酮产物。针对氧化过程中溶剂及碱的种类对收率的影响进行了优化选择。较佳的反应条件是:以四氢呋喃作为溶剂,氢氧化钾作为碱时,3-溴芴酮的收率较高,纯度达到99.9%,产品的质量好,生产成本较低,适合工业化生产。

关键词： 2-氨基芴 3-溴芴酮合成工艺

青少年双相抑郁患者冲动攻击行为神经代谢改变:一项质子磁共振波谱成像研究

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神经疾病与精神卫生 2024年第1期24卷 37-41页

作者：王丞基曲源沈小琴唐潇潇佟钙玉陈鹏莉邹韶红石河子大学医学院 832000 新疆维吾尔自治区人民医院临床心理科乌鲁木齐830000 新疆维吾尔自治区人民医院放射影像中心乌鲁木齐830000

目的基于质子磁共振波谱成像(1H-MRS)技术分析青少年双相抑郁(ABD)患者冲动攻击行为(IAB)与腹内侧前额叶(vmPFC)神经代谢的关系。方法回顾性选取2023年1—7月新疆维吾尔自治区人民医院临床心理科门诊及住院部收治的23例30 d内未经任何... 详细信息

目的基于质子磁共振波谱成像(1H-MRS)技术分析青少年双相抑郁(ABD)患者冲动攻击行为(IAB)与腹内侧前额叶(vmPFC)神经代谢的关系。方法回顾性选取2023年1—7月新疆维吾尔自治区人民医院临床心理科门诊及住院部收治的23例30 d内未经任何治疗的ABD患者为研究对象。将Barratt冲动量表(BIS-11)总分≥70分、外显攻击行为量表(MOAS)加权总分≥5分且体力攻击条目得分≥1分的患者纳入伴IAB组,将BIS-11总分0.05)。结论ABD伴IAB患者的NAA/Cr值下降,ABD患者的IAB可能与vmPFC神经元密度减少或存在神经元功能障碍有关。

关键词：青少年双相情感障碍抑郁发作冲动攻击行为磁共振波谱

Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy

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Chinese Journal of Natural Medicines 2024年第6期22卷 515-529页

作者： SU Lili GUO pengli GUO Xiangjuan HE Zhongmei ZHAO Yan ZONG Ying LI Jianming chen Weijia DU Rui College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118China Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer Changchun 130118China Key Laboratory of Animal Production and Product Quality and Security Ministry of EducationMinistry of National EducationChangchun 130118China

Depression ranks among the most common neuropsychiatric disorders *** studies examining the roles of inflammation and mitochondrial autophagy in the antidepressant efficacy of paeoniflorin(PF)are *** study aimed to elucidate PF’s antidepressant mechanism by promoting autophagy and inhibiting NLRP3 inflammasome activation using chronic unpredictable mild stimulation(CUMS)-induced C57BL/6 mouse models in vivo and corticosterone(CORT)-induced HT22 cell models in *** demonstrated that PF enhanced the viability of HT22 cells following CORT exposure,restored mitochondrial membrane poten-tial(MMP),reduced reactive oxygen species accumulation,increased LC3 fluorescence intensity,and suppressed inflammatory cy-tokine secretion and inflammation ***,PF ameliorated depressive behaviors induced by CUMS and improved damage in hippocampal *** also reduced the expression of NLRP3,ASC,Caspase-1,IL-1β,and the assembly of the NLRP3 ***,PF upregulated the expression of autophagy-related proteins in the hippocampus,facilitating the clearance of damaged mitochondria and enhancing *** role of autophagy in PF’s antidepressant effects was further confirmed through the use of the autophagy inhibitor 3-methyladenine(3-MA),which reduced the efficacy of *** conclusion,PF effectively improved depressive behaviors in CUMS-induced mice and reduced NLRP3-mediated inflammation both in vivo and in vitro,likely via the in-duction of autophagy.

关键词： Paeoniflorin Depression Autophagy NLRP3 inflammasome

Astronomical Knowledge Entity Extraction in Astrophysics Journal Articles via Large Language Models

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Research in Astronomy and Astrophysics 2024年第6期24卷 140-155页

作者： Wujun Shao Rui Zhang pengli Ji Dongwei Fan Yaohua Hu Xiaoran Yan chenzhou Cui Yihan Tao Linying Mi Lang chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China Research Institute of Artificial Intelligence Zhejiang LabHangzhou 311100China Guilin University Guangxi 541006China Xidian University Xi’an 710126China

Astronomical knowledge entities,such as celestial object identifiers,are crucial for literature retrieval and knowledge graph construction,and other research and applications in the field of *** methods of extracting knowledge entities from texts face numerous challenging obstacles that are difficult to ***,there is a pressing need for improved methods to efficiently extract *** study explores the potential of pre-trained Large Language Models(LLMs)to perform astronomical knowledge entity extraction(KEE)task from astrophysical journal articles using *** propose a prompting strategy called PromptKEE,which includes five prompt elements,and design eight combination prompts based on *** select four representative LLMs(Llama-2-70B,GPT-3.5,GPT-4,and Claude 2)and attempt to extract the most typical astronomical knowledge entities,celestial object identifiers and telescope names,from astronomical journal articles using these eight combination *** accommodate their token limitations,we construct two data sets:the full texts and paragraph collections of 30 *** the eight prompts,we test on full texts with GPT-4and Claude 2,on paragraph collections with all *** experimental results demonstrate that pre-trained LLMs show significant potential in performing KEE tasks,but their performance varies on the two data ***,we analyze some important factors that influence the performance of LLMs in entity extraction and provide insights for future KEE tasks in astrophysical articles using ***,compared to other methods of KEE,LLMs exhibit strong competitiveness in multiple aspects.

关键词： astronomical databases:miscellaneous virtual observatory tools methods:data analysis

Synthesis and characterization of 7,7-dimethyl-7H-benzo[c]flourene

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Synthesis and characterization of 7,7-dimethyl-7H-benzo[c]fl...

The synthesis and characterization of(7-bromo-9,9-dimethyl-9H-fluoren-2-yl)methanol

河南省化学会2016年学术年会

作者： Kui Li pengli chen Zhenqiang Yang Hui chen Ruina Yang Institute of Chemistry Henan Academy of Sciences

Fluorene compounds used in photoelectric materials has researched and involved organic photoelectric molecular devices, electronic photographic materials, solar battery materials, color liquid crystal materials and cutting-edge technology fields such as organic optical information recording materials, has showed a broad application prospect. 7,7-dimethyl-7H-benzo[c]flourene is a very promising blu-ray material *** nitrogen protection, the Grignard reagent was synthesized used 1-bromonaphthalen as the starting material and tetrahydrofuran as solvent. 7,7-dimethyl-7H-benzo[c]flourene was synthesized with coupling reaction of 2-Bromochlorobenzene and The Grignard reagent preparation, with Addition reaction with acetone, with Closed loop reaction. The yield was 75%, and the content was 98%.1H NMR(400 MHz, DMSO-d6), δ: 8.799-8.778(d, 1H), 8.421-8.401(d, 1H), 8.051-8.031(d, 1H),7.961-7.940(d, 1H), 7.787-7.766(d, 1H), 7.716-7.552(m, 3H), 7.478-7.361(m, 2H), 1.501(s, 6H).

关键词： 1-bromonaphthalen 7,7-dimethyl-7H-benzo[c]flourene

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The synthesis and characterization of(7-bromo-9,9-dimethyl-9...

河南省化学会2016年学术年会

作者： chen pengli Wang Chaojie Qu Fengbo Yang Zhenqiang Yang Ruina Institute of Chemistry Henan Academy of Sciences

Organic electroluminescent materials are one of the hotspot in the field of photoelectric information functional materials. Fluorene derivatives have attracted considerable attention in recent years as organic light-emitting materials with development prospect and practical value of blue light emitting materials.(7-bromo-9,9-dimethyl-9H-fluoren-2-yl) methanol is a very promising blue-ray material *** nitrogen atmosphere, 7-bromo-9,9-dimethyl-9H-fluorene-2-carbaldehyde was synthesized with THF as solvent and 2,7-dibromo-9,9-dimethylfluorene as starting material at-78 °C. n-Bu Li was slowly added drop wise. After stirring for 1 hr, DMF was added at-78 °C. The reaction solution was poured into HCl and extracted with ethyl acetate. Recrystallization by Me OH as yellow solid. Yield: 52%。1HNMR(400 MHz, DMSO-d6), δ/ppm: 10.053(s,1H), 8.105-8.085(d, J=7.96 Hz, 2H), 7.956-7.914(m,3H), 7.622-7.597(m, 1H), 1.501(s, 6H).(7-bromo-9,9-dimethyl-9H-fluoren-2-yl)methanol was synthesized with reduction of7-bromo-9,9-dimethyl-9H-fluorene-2-carbaldehyde by Na BH4. Recrystallization by Me OH as white solid. Yield: 90%.1HNMR(400 MHz, DMSO-d6), δ/ppm:7.796-7.741(m, 3H), 7.523-7.486(m, 2H), 7.315-7.293(m,1H), 5.256-5.227(t, J=5.80 Hz 1H), 4.572-4.558(d, J=5.60 Hz, 2H), 1.438(s, 1H).

关键词： 2,7-dibromo-9,9-dimethylfluorene 7-bromo-9,9-dimethyl-9H-fluorene-2-carbaldehyde (7-bromo-9,9-dimethyl-9H-fluoren-2-yl) methanol

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引入遗传因子的骨密度机器学习回归模型研究

中国骨质疏松杂志 2022年第10期28卷 1459-1464,1471页

作者：陈鹏丽孔祥勇林勇上海理工大学医疗器械与食品学院上海200093

目的构建遗传因素及临床风险因素相结合的骨密度机器学习回归模型,识别影响个体对骨质疏松易感性的最优特征组合。方法以最大互信息系数与序列浮动前向选择作为两阶段特征选择方法选择最优特征子集,基于随机森林建立骨密度回归模型。结... 详细信息

目的构建遗传因素及临床风险因素相结合的骨密度机器学习回归模型,识别影响个体对骨质疏松易感性的最优特征组合。方法以最大互信息系数与序列浮动前向选择作为两阶段特征选择方法选择最优特征子集,基于随机森林建立骨密度回归模型。结果在2263例白种人样本数据集进行十折交叉验证实验,结果表明当包含51个SNP位点,6个临床特征时,两阶段特征选择方法结合随机森林模型的均方根误差最低为0.093598 g/cm^(3),相较仅以临床危险因素作为特征时RMSE降低了5.36%;与选用其他特征选择方法及回归模型的比较实验证实了本文提出模型的良好稳定性。结论骨质疏松症致病因素分析方法能够发现隐藏的特征间相互作用,识别最优特征组合,从而更好地预测和诊断复杂疾病。

关键词：机器学习骨质疏松症骨密度最大互信息系数序列特征选择

苯扎贝特在超临界CO_2中溶解度的测定与关联

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中国医药工业杂志 2017年第9期48卷 1346-1350页

作者：陈琪陈鹏丽胡国勤河南省人民医院药学部河南郑州450003 郑州大学化工与能源学院河南郑州450001

固体药物在超临界二氧化碳(SC-CO_2)中溶解度的大小,对采用超临界技术制备药物超细微粒方法的选择上有重要意义。本试验采用动态法测定了苯扎贝特在纯SC-CO_2及含夹带剂(无水乙醇、丙酮、乙酸乙酯)的SC-CO_2中的溶解度。结果表明,在试... 详细信息

固体药物在超临界二氧化碳(SC-CO_2)中溶解度的大小,对采用超临界技术制备药物超细微粒方法的选择上有重要意义。本试验采用动态法测定了苯扎贝特在纯SC-CO_2及含夹带剂(无水乙醇、丙酮、乙酸乙酯)的SC-CO_2中的溶解度。结果表明,在试验温度(308.15~328.15 K)和压力(10~30 MPa)下,苯扎贝特在纯SC-CO_2中的溶解度随温度和压力的升高而增大。夹带剂的加入有利于提高苯扎贝特的溶解度,其中无水乙醇效果尤其显著。采用Chrastil模型对试验结果进行拟合,结果表明Chrastil模型有较好的效果,相对偏差绝对值的平均值(AARD)为12.44%。

关键词：苯扎贝特超临界二氧化碳溶解度夹带剂 Chrastil模型

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谈生物技术在水质检测与污水处理中的应用

环境与发展 2019年第9期31卷 81-82页

作者：陈朋利江苏环保产业技术研究院股份公司

随着我国经济的发展,水污染问题日益严重,水质检测与污水处理工艺的选择在解决水污染问题中尤为重要。本文着重介绍了生物技术在水质检测及污水处理中的应用,并在分析生物技术在水质检测与污水处理应用问题的基础上提出相应策略,期望为... 详细信息

随着我国经济的发展,水污染问题日益严重,水质检测与污水处理工艺的选择在解决水污染问题中尤为重要。本文着重介绍了生物技术在水质检测及污水处理中的应用,并在分析生物技术在水质检测与污水处理应用问题的基础上提出相应策略,期望为今后生物技术在水质检测与污水处理中的应用提供一些参考。

关键词：生物技术水质监测污水处理应用