检索结果-南通市图书馆

Bacterial and cancerous cell membrane fused liposome coordinates with PD-L1 inhibitor for cancer immunotherapy

Nano Research 2024年第9期17卷 8389-8401页

作者： Xianjin Luo Chenglong Li Zhaofei Guo Hairui Wang penghui he Yuanhao Zhao Yi Lin Chunting he Yingying Hou Yongshun Zhang Guangsheng Du Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Pharmaceutical Biotechnology Department of PharmacyLMU MunichButenandt Strasse 5-13Munich 81377Germany Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Although tumor cell membranes with broad-spectrum antigens have been explored for cancer vaccines for decades,their relatively poor capacity to stimulate immune responses,especially cellular immune responses,has limited their ***,we presented a novel bacterial and cancerous cell membrane fusogenic liposome for co-delivering cell membrane-derived antigens and ***,a programmed death-ligand 1(PD-L1)inhibitor,JQ-1,was incorporated into the formulation to tackle the up-regulated PD-L1 expression of antigen-presenting cells(APCs)upon vaccination,thereby augmenting its anti-tumor *** fusogenic liposomes demonstrated significantly improved cellular uptake by APCs and effectively suppressed PD-L1 expression in bone marrow-derived dendritic cells(BMDCs)in *** subcutaneous vaccination,the nano-vaccines efficiently drained to the tumor-draining lymph nodes(TDLNs),and significantly inhibited PD-L1 expression of both dendritic cells(DCs)and macrophages within the TDLNs and *** a result,the liposomal vaccine induced robust innate and cellular immune responses and inhibited tumor growth in a colorectal carcinoma-burden mouse *** summary,the fabricated cell membrane-based fusogenic liposomes offer a safe,effective,and easily applicable strategy for tumor immunotherapy and hold potential for personalized cancer immunotherapy.

关键词： fusogenic liposome tumor cell membrane adjuvant programmed death-ligand 1(PD-L1)inhibitor tumor draining lymph nodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机器人右半结肠手术现状和展望

引用

结直肠肛门外科 2024年第3期30卷 253-258页

作者：李太原何鹏辉南昌大学第一附属医院普外科江西南昌330006

机器人右半结肠手术在国内外已广泛开展。相比腹腔镜手术的局限性,机器人的手术操作更加精准灵活,在进行复杂手术和腹腔内吻合时具有更大的优势。近年来,国内外多款机器人手术系统相继推出并开始应用于外科手术,为手术机器人行业带来了... 详细信息

机器人右半结肠手术在国内外已广泛开展。相比腹腔镜手术的局限性,机器人的手术操作更加精准灵活,在进行复杂手术和腹腔内吻合时具有更大的优势。近年来,国内外多款机器人手术系统相继推出并开始应用于外科手术,为手术机器人行业带来了新可能。本文就机器人右半结肠手术的发展、现状以及未来展望分别进行阐述。

关键词：结肠肿瘤右半结肠切除术机器人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS

引用

Acta Pharmaceutica Sinica B 2020年第10期10卷 1977-1988页

作者： Rong Guoy Yang Longy Zhengze Lu Miao Deng penghui he Man Li Qin he Key Laboratory of Drug Targeting and Drug Delivery Systems of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610064China

Chemotherapy agents have been widely used for cancer treatment,while the insolubility,instability and toxicity seriously restrict their ***,prodrug strategy was *** some prodrugs are still with poor solubility or stability,a synergy strategy is needed to enhance their ***(GEM)is a prescribed anticancer drug,however,the rapid clearance,growing resistance and serious side effects limit its clinical *** GEM with D-a-tocopherol succinate(TOS)is an effective solution,while the GEM-TOS(GT)is unstable in aqueous solution.D-a-Tocopherol polyethylene glycol succinate(TPGS)has been used to enhance the stability,but GT stabilized by TPGS(GTT)has limited effect on tumor *** metastases lead to high mortality in patients suffering from *** order to further achieve antimetastatic effect,an amphiphilic polymer(LT)was synthesized by connecting low-molecular-weight heparin(LMWH)with TOS,and eventually obtained desired selfdelivery micellar NPs(GLT)by co-assembly GT with *** GLT not only possessed excellent stability,but also inhibited the metastases by acting on different phases of the metastatic *** hydrophobic TOS inhibited the secretion of matrix metalloproteinase-9(MMP-9),the hydrophilic LMWH inhibited the interaction between tumor cells and *** a result,GLT reduced tumor cells entering the blood and implanting at the distant organs,leading to a much more excellent inhibitory effect on the lung metastasis than GEM and GTT.

关键词： Gemcitabine TOS LMWH Tumor metastasis MMP-9

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment

引用

Acta Pharmaceutica Sinica B 2022年第1期12卷 467-482页

作者： Rong Guo Miao Deng Xuan he Mengmeng Li Jiaxin Li penghui he Houqin Liu Man Li Zhirong Zhang Qin he Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Tumor metastasis is responsible for most mortality in cancer patients, and remains a challenge in clinical cancer treatment. Platelets can be recruited and activated by tumor cells, then adhere to circulating tumor cells(CTCs) and assist tumor cells extravasate in distant organs. Therefore, nanoparticles specially hitchhiking on activated platelets are considered to have excellent targeting ability for primary tumor, CTCs and metastasis in distant organs. However, the activated tumor-homing platelets will release transforming growth factor-β(TGF-β), which promotes tumor metastasis and forms immunosuppressive microenvironment. Therefore, a multitalent strategy is needed to balance the accurate tumor tracking and alleviate the immunosuppressive signals. In this study, a fucoidan-functionalized micelle(FD/DOX) was constructed, which could efficiently adhere to activated platelets through *** with the micelle without P-selectin targeting effect, FD/DOX had increased distribution in both tumor tissue and metastasis niche, and exhibited excellent anti-tumor and anti-metastasis efficacy on 4 T1 spontaneous metastasis model. In addition, due to the contribution of fucoidan, FD/DOXtreatment was confirmed to inhibit the expression of TGF-β, thereby stimulating anti-tumor immune response and reversing the immunosuppressive microenvironment. The fucoidan-functionalized activated platelets-hitchhiking micelle was promising for the metastatic cancer treatment.

关键词： Fucoidan Activated platelets P-selectin Platelets-hitchhiking Track tumor cells TGF-β Reverse immunosuppressive microenvironment Tumor metastasis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于倾向性评分匹配的机器人经自然腔道取标本手术与机器人辅助直肠癌根治术的短期疗效比较

引用

中华胃肠外科杂志 2024年第8期27卷 833-839页

作者：叶善平余宏鑫胡惠宇刘东宁吴灿邹睿祥何鹏辉李太原南昌大学第一附属医院普通外科南昌330006 南昌大学江西医学院第一临床医学院南昌330031

目的:比较机器人经自然腔道取标本手术(NOSES)与机器人辅助直肠癌根治术的短期疗效。方法:采用回顾性队列研究和倾向评分匹配(PSM)的研究方法,回顾性分析2018年6月至2024年3月于南昌大学第一附属医院行直肠癌根治术的547例患者的临床资... 详细信息

目的:比较机器人经自然腔道取标本手术(NOSES)与机器人辅助直肠癌根治术的短期疗效。方法:采用回顾性队列研究和倾向评分匹配(PSM)的研究方法,回顾性分析2018年6月至2024年3月于南昌大学第一附属医院行直肠癌根治术的547例患者的临床资料,其中机器人NOSES组157例,常规机器人组390例。采用PSM对直肠癌患者的术前一般资料[年龄、性别、体质指数、术前是否合并基础疾病、术前癌胚抗原异常(>6.5μg/L)、术前糖类蛋白199异常(>27 kU/L)、术前美国麻醉医师协会(ASA)分级、肿瘤长径、肿瘤距肛缘距离、TNM分期]进行1∶1匹配,卡钳值为0.05。PSM后,两组各纳入77例直肠癌患者,基线资料比较差异无统计学意义(均P>0.05)。主要比较机器人NOSES组与常规机器人组的手术情况、术后恢复情况、术后病理资料及术后并发症发生率。结果:与常规机器人组相比,机器人NOSES组术后首次排气时间更短[48(38,50)h比56(50,60)h,Z=-7.513,P0.05)。结论:机器人NOSES手术治疗直肠癌安全、可行,术后恢复更快。

关键词：直肠肿瘤机器人手术经自然腔道取标本手术短期疗效

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

引用

Acta Pharmaceutica Sinica B 2023年第5期13卷 2219-2233页

作者： Fuhua Wu Shuang Luo Yongshun Zhang Yangsen Ou Hairui Wang Zhaofei Guo Chunting he Shuting Bai penghui he Min Jiang Xiaoyan Chen Guangsheng Du Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines,the epidemic prevention and control are still ***,we employ a capsid and antigen structure engineering(CASE)strategy to manufacture an adenoassociated viral serotype 6-based vaccine(S663V-RBD),which expresses trimeric receptor binding domain(RBD)of spike protein fused with a biological adjuvant ***,the engineered S663V-RBD could rapidly induce a satisfactory RBD-specific IgG titer within 2 weeks and maintain the titer for more than 4 *** to the licensed BBIBP-CorV(Sinopharm,China),a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type,C.37(Lambda)and B.1.617.2(Delta).More interestingly,the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the *** its effectiveness,the CASE-based S663VRBD may provide a new solution for the current and next pandemic.

关键词： AAV vectors Capsid engineering Vaccine Antigen structure design SARS-CoV-2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrospinning-hot pressing technique for the fabrication of thermal and electrical storage membranes and its applications

引用

International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 1945-1964页

作者： Panpan Che Baoshan Xie penghui Cao Youfu Lv Daifei Liu Huali Zhu Xianwen Wu Zhangxing he Jian Chen Chuanchang Li Key Laboratory of Renewable Energy Electric-Technology of Hunan Province School of Energy and Power EngineeringChangsha University of Science and TechnologyChangsha 410114China State Key Laboratory of Disaster Prevention&Reduction for Power Grid Changsha University of Science and TechnologyChangsha 410114China School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China School of Chemical Engineering North China University of Science and TechnologyTangshan 063009China

The combination of electrospinning and hot pressing,namely the electrospinning-hot pressing technique(EHPT),is an efficient and convenient method for preparing nanofibrous composite materials with good energy storage *** emerging composite membrane prepared by EHPT,which exhibits the advantages of large surface area,controllable morphology,and compact structure,has attracted immense *** this paper,the conduction mechanism of composite membranes in thermal and electrical energy storage and the performance enhancement method based on the fabrication process of EHPT are systematically ***,the state-of-the-art applications of composite membranes in these two fields are *** particular,in the field of thermal energy storage,EHPT-prepared membranes have longitudinal and transverse nanofibers,which generate unique thermal conductivity pathways;also,these nanofibers offer enough space for the filling of functional ***,EHPT-prepared membranes are beneficial in thermal management systems,building energy conservation,and electrical energy storage,e.g.,improving the electrochemical properties of the separators as well as their mechanical and thermal *** application of electrospinning-hot pressing membranes on capacitors,lithium-ion batteries(LIBs),fuel cells,sodium-ion batteries(SIBs),and hydrogen bromine flow batteries(HBFBs)still requires *** the future,EHPT is expected to make the field more exciting through its own technological breakthroughs or be combined with other technologies to produce intelligent materials.

关键词： electrospinning-hot pressing technique thermal storage electrical storage composite membranes nanofiber

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predicting the evolution of electrochemical trepanning for inner blisks with a chamfer structure at blade tip

引用

CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 560-576页

作者： Jiao, Erhao Zhu, Dong Wang, penghui Zuo, Hang Chen, Liyong Nanjing Univ Aeronaut & Astronaut Coll Mech & Elect Engn Nanjing 210016 Peoples R China

Electrochemical trepanning (ECTr) is an effective electrochemical machining (ECM) technique that can be used to manufacture the integral components of aero-engine compressors. This study focused on the dynamic evolution of ECTr for production of inner blisks (bladed disks) with a special chamfer structure at blade tip. Due to the existence of chamfer, the ECTr process of inner blades is in a non-equilibrium state during the early stages, and the physical field changes in the machining gap are complex, making it difficult to predict the forming process. In this paper, a dynamic evolution model (DEM) of inner blade ECTr with a special chamfer at blade tip structure is proposed, and an ECTr multi-physical fields simulation study was carried out. The evolution of the chamfer at blade tip was analyzed and data related to chamfer were predicted based on the dependence of anode boundary properties with machining time and feed rate. In addition, the distributions of current density, electrolyte flow rate, bubble volume fraction, temperature rise, and electrolyte conductivity in the machining area at different times were obtained by combining them with the multi-physical fields simulation results. Subsequently, a series of ECTr experiments were conducted, in which, as the feed rate increased, the surface quality and machining accuracy of the inner blades were improved. Compared with the simulation results, the error in machining accuracy of the chamfer profile is controlled within +/- 2%, and the machining accuracy of the blade full profile was controlled within +/- 0.2 mm, indicating that the model proposed in this study was effective in predicting the evolution of inner blades ECTr with chamfer structures at blade tip. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chinese Society of Aeronautics and Astronautics This is an open access article under the CC BY-NC-ND license (http://***/ licenses/by-nc-nd/4.0/).

关键词： Chamfer structure Inner blisk Electrochemical trepanning (ECTr) Dynamic evolution model Forming prediction Multiphysics Machining quality MATERIAL REMOVAL PROCESS CONVEX STRUCTURE SIMULATION MANUFACTURE PART

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arc Grounding Fault Identification Using Integrated Characteristics in the Power Grid

引用

Energy Engineering 2024年第7期121卷 1883-1901页

作者： penghui Liu Yaning Zhang Yuxing Dai Yanzhou Sun School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo454003China Research and Development Center Guangdong Zhicheng Champion Group Co.Ltd.Dongguan523000China henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment Henan Polytechnic UniversityJiaozuo454003China

Arc grounding faults occur frequently in the power grid with small resistance grounding neutral *** existing arc fault identification technology only uses the fault line signal characteristics to set the identification index,which leads to detection failure when the arc zero-off characteristic is *** solve this problem,this paper presents an arc fault identification method by utilizing integrated signal characteristics of both the fault line and sound ***,the waveform characteristics of the fault line and sound lines under an arc grounding fault are *** that,the convex hull,gradient product,and correlation coefficient index are used as the basic characteristic parameters to establish fault identification ***,the logistic regression algorithm is employed to deal with the reference samples,establish the machine discrimination model,and realize the discrimination of fault ***,simulation test results and experimental results verify the accuracy of the proposed *** comparison analysis shows that the proposed method has higher recognition accuracy,especially when the arc dissipation power is smaller than 2×10^(3) W,the zero-off period is not *** conclusion,the proposed method expands the arc fault identification theory.

关键词： Arc fault convex hull algorithm correlation coefficient fault identification gradient logistic regression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Car-following strategy of intelligent connected vehicle using extended disturbance observer adjusted by reinforcement learning

引用

CAAI Transactions on Intelligence Technology 2024年第2期9卷 365-373页

作者： Ruidong Yan penghui Li Hongbo Gao Jin Huang Chengbo Wang School of Traffic and Transportation The Beijing Jiaotong UniversityBeijingChina Department of Automation School of Information Science and TechnologyUniversity of Science and Technology of ChinaHefeiChina School of Vehicle and Mobility The Tsinghua UniversityBeijingChina Liverpool Logistics Offshore and Marine Research Institute(LOOM)Liverpool John Moores UniversityLiverpoolUK

Disturbance observer-based control method has achieved good results in the carfollowing scenario of intelligent and connected vehicle(ICV).However,the gain of conventional extended disturbance observer(EDO)-based control method is usually set manually rather than adjusted adaptively according to real time traffic conditions,thus declining the car-following *** solve this problem,a car-following strategy of ICV using EDO adjusted by reinforcement learning is *** from the conventional method,the gain of proposed strategy can be adjusted by reinforcement learning to improve its estimation *** the“equivalent disturbance”can be compensated by EDO to a great extent,the disturbance rejection ability of the carfollowing method will be improved *** Lyapunov approach and numerical simulations are carried out to verify the effectiveness of the proposed method.

关键词： adaptive system autonomous vehicle intelligent control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：