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梅毒患者血清中白介素-17和白介素-22表达水平及临床意义

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临床医药实践 2024年第8期33卷 589-591页

作者：李鹏花赵树强山西省汾阳医院山西汾阳032200

目的:探讨梅毒患者治疗前后以及健康者血清中白介素-17(IL-17)和白介素-22(IL-22)表达水平及临床意义。方法:采用流式细胞仪检测技术,分别检测梅毒患者(梅毒组)、经治疗的梅毒患者(治疗组)和健康者(健康组)IL-17和IL-22的表达水平。结果... 详细信息

目的:探讨梅毒患者治疗前后以及健康者血清中白介素-17(IL-17)和白介素-22(IL-22)表达水平及临床意义。方法:采用流式细胞仪检测技术,分别检测梅毒患者(梅毒组)、经治疗的梅毒患者(治疗组)和健康者(健康组)IL-17和IL-22的表达水平。结果:健康组IL-22的表达水平低于梅毒组(P0.05)。受试者工作特征曲线(ROC)结果显示IL-22预测梅毒发生的曲线下面积(AUC)为0.848(P<0.05),具有较高的诊断价值,而IL-17的AUC值没有统计学意义。结论:IL-17和IL-22是梅毒免疫机制中重要的细胞因子,IL-22对梅毒的诊断具有重要的临床价值。

关键词：梅毒梅毒螺旋体白细胞介素-17 白细胞介素-22 细胞因子

Integrated Distribution Management System:Architecture,Functions,and Application in China

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 245-258页

作者： Wenchuan Wu penghua li Bin Wang Yingshang liu Tao Xu Hongwei Du Yan He the State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China the Electric Power Control Center of China Southern Power Grid Corporation GuangzhouChina the National Electric Power Control Center of State Grid Corporation of China BeijingChina NARI Technology Co. Ltd.NanjingChina Beijing Guoke Hengtong Technology Co. Ltd.BeijingChina

As massive distributed energy resources(DERs)are integrated into distribution networks(DNs)and the distribution automation facilities are widely deployed,the DNs are evolving to active distribution networks(ADNs).This paper introduces the architecture and main function modules of an integrated distribution management system(IDMS)and its applica-tions in *** system consists of three subsystems,including the real-time operation and control system(OCS),outage management system(OMS),and operator training simulator(OTS).The OCS has a hierarchical architecture with three levels,including the local controller for DER clusters,the optimization of DNs incorporated with multi-clusters,and the coordina-tion operation of integrated transmission&distribution(T&D)*** OMS is developed based on the geographical information system(GIS)and coordinated with *** in the OTS,both the ADN and its host transmission network(TN)are simulated to make the simulation results more *** main functions of the three subsystems and their interaction data flows are described and some typical application scenarios are also presented.

关键词： Active distribution network(ADN) integrated distribution management system(IDMS) operation and control system(OCS) outage management system(OMS) operator training simulator(OTS) geographical information system(GIS).

Experimental and Numerical Investigations of Shock-Wave Boundary Layer Interactions in a Highly Loaded Transonic Compressor Cascade

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Journal of Thermal Science 2024年第1期33卷 158-171页

作者： MENG Fanjie li Kunhang GUO penghua GAN Jiuliang li Jingyin School of Energy and Power Engineering Xi'an Jiaotong UniversityXi'an 710049China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China

Experimental and numerical investigations were conducted to investigate the variations of shock-wave boundary layer interaction(SBli) phenomena in a highly loaded transonic compressor cascade with Mach *** schlieren technique was used to observe the shock structure in the cascade and the pressure tap method to measure the pressure distribution on the blade *** unsteady pressure distribution on blade surface was measured with the fast-response pressure-sensitive paint(PSP) technique to obtain the unsteady pressure distribution on the whole blade surface and to capture the shock oscillation characteristics caused by *** addition,the Reynolds Averaged Navier Stokes simulations were used to compute the three-dimensional steady flow field in the transonic *** was found that the shock wave patterns and behaviors are affected evidently with the increase in incoming Mach number at the design flow angle,especially with the presence of the separation bubble caused by *** time-averaged pressure distribution on the blade surface measured by PSP technique showed a symmetric pressure filed at Mach numbers of 0.85,while the pressure field on the blade surface was an asymmetric one at Mach numbers of 0.90 and *** oscillation of the shock wave was closely with the flow separation bubble on the blade surface and could transverse over nearly one interval of the pressure *** oscillation of the shock wave may smear the pressure jump phenomenon measured by the pressure taps.

关键词： transonic flow transonic compressor cascade shock-wave boundary-layer interaction shock oscillation

Multi-Objective Multi-Variable Large-Size Fan Aerodynamic Optimization by Using Multi-Model Ensemble Optimization Algorithm

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Journal of Thermal Science 2024年第3期33卷 914-930页

作者： XIONG Jin GUO penghua li Jingyin School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

The constrained multi-objective multi-variable optimization of fans usually needs a great deal of computational fluid dynamics(CFD)calculations and is *** this study,a new multi-model ensemble optimization algorithm is proposed to tackle such an expensive optimization *** multi-variable and multi-objective optimization are conducted with a new flexible multi-objective infill *** addition,the search direction is determined by the multi-model ensemble assisted evolutionary algorithm and the feature extraction by the principal component analysis is used to reduce the dimension of optimization ***,the proposed algorithm and other two optimization algorithms which prevail in fan optimizations were compared by using test *** the same number of objective function evaluations,the proposed algorithm shows a fast convergency rate on finding the optimal objective function ***,this algorithm was used to optimize the rotor and stator blades of a large axial fan,with the efficiencies as the objectives at three flow rates,the high,the design and the low flow ***-two variables were included in the optimization *** results show that compared with the prototype fan,the total pressure efficiencies of the optimized fan at the high,the design and the low flow rate were increased by 3.35%,3.07%and 2.89%,respectively,after CFD simulations for 500 fan candidates with the constraint for the design *** optimization results validate the effectiveness and feasibility of the proposed algorithm.

关键词： multi-objective optimization surrogate-assisted evolutionary algorithm axial fan computational fluid dynamics aerodynamic optimization

In silico Discovery of Novel FXa Inhibitors by Pharmacophore Modeling and Molecular Docking

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Natural Products and Bioprospecting 2017年第3期7卷 249-256页

作者： Yinglan Pu Hui liu Yeheng Zhou Jiale Peng Yaping li penghua li Yingying li Xingyong liu li Zhang School of Chemical Engineering Sichuan University of Science&EngineeringZigongChina

Coagulation Factor Xa(FXa)is the crucial enzyme at the convergent point of the intrinsic and extrinsic coagulation *** inhibition of FXa is an effective approach against thrombotic *** the present study,a specific strategy is reported to discover 10 novel FXa inhibitors based on ligand-based(pharmacophore)virtual screening and molecular docking analysis from a dataset of specs(containing 220000 molecules).The binding modes analysis provide insights into the contribution of particular structural moieties of the compounds towards their activity against FXa,and 10 novel structural compounds were discovered as potent candidate *** work could be helpful in further design and development of FXa inhibitors.

关键词： FXa Thrombotic diseases Pharmacophore Docking

A study on the tourism practitioners' perception of tourism impact:a case study of Hainan,China

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Ecological Economy 2009年第2期5卷 168-176页

作者： Xie Genzong Chen Yongsheng Qiu penghua li Pengshan College of Geography and Tourism Hainan Normal University Haikou 571158 P R China

This study examines the urban population of tourism practitioners' perceptions of economic, environmental, and social impacts on cultural, convention, and sport tourism may have in Haikou and Sanya, Hainan, China. The study uses a modif ied Urban Tourism Impact (UTI) to examine economic, environmental, and social perceived impacts. Analysis of the data includes testing three models of structural relationships between tourism impacts and support for development in each of the tourism market sub-divisions through a confirmatory factor analysis. The results of this study show that the positive economic impacts consistently exert influence on predicting support for tourism development in all three models. However, the social impacts play a greater explanatory role with all three market segment, the negative environmental impacts play a role in determining support for sport tourism only. Differences have been found with those with a higher education level in predicting support for cultural tourism, but not convention or sport tourism.

关键词： Community, perceptions Tourism impact, Urban tourism impact

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基于广域响应的电力系统暂态失步判据综述

电网技术 2022年第7期46卷 2677-2689页

作者：朱存浩马世英郑超李鹏华陈长胜中国电力科学研究院有限公司北京市海淀区100192

广域测量技术为暂态稳定判别方法的应用提供了契机。结合电力系统暂态稳定评估的基本原理,概述了基于相量角度差、暂态能量函数、扩展等面积准则、响应轨迹特征和人工智能等5种类型的广域暂态失步判据的研究现状,探讨了各种判据在发展... 详细信息

广域测量技术为暂态稳定判别方法的应用提供了契机。结合电力系统暂态稳定评估的基本原理,概述了基于相量角度差、暂态能量函数、扩展等面积准则、响应轨迹特征和人工智能等5种类型的广域暂态失步判据的研究现状,探讨了各种判据在发展应用中需解决的问题。从准确性、预测性、稳定裕度定量化、适应性4个方面,对比了以上各种类型广域暂态失步判据的特点,并分析展望了各类判据的重点研究与突破方向,为相关研究的进一步开展提供有益借鉴。

关键词：暂态失步判据广域响应信息能量函数扩展等面积准则响应轨迹特性

部分可观测条件下的配电网数据驱动最优潮流模型

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中国电力 2023年第12期56卷 51-57页

作者：李鹏华宋卓然吴文传清华大学北京100091 国网辽宁省电力有限公司辽宁沈阳110006

电力系统最优潮流计算是典型的非线性非凸问题,线性化潮流模型主要用于将原始最优潮流问题转化为凸优化问题。配电网覆盖范围广,设备众多,模型参数维护困难,已有的基于数据驱动的线性化潮流模型多基于完备的系统量测数据,而实际中考虑... 详细信息

电力系统最优潮流计算是典型的非线性非凸问题,线性化潮流模型主要用于将原始最优潮流问题转化为凸优化问题。配电网覆盖范围广,设备众多,模型参数维护困难,已有的基于数据驱动的线性化潮流模型多基于完备的系统量测数据,而实际中考虑经济性安装的测量单元,无法覆盖所有设备,系统量测通常是部分可观测的。为解决量测的部分可观测性问题,提出一种数据驱动线性潮流模型,并基于此构建基于数据驱动的线性化最优潮流模型,该模型对量测中的不良数据具有鲁棒性。通过对不同部分可观测场景的测试,验证了所提模型的有效性。

关键词：数据驱动线性化最优潮流部分可观测

Ortho-(1-phenylvinyl)benzyl glycosides: Ether-type glycosyl donors for the efficient synthesis of both O-glycosides and nucleosides

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Green Synthesis and Catalysis 2020年第2期1卷 160-166页

作者： penghua li Haiqing He lili Xu Yingying Huang Zixi Chen Yunqin Zhang Rui Yang Guozhi Xiao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyUniversity of Chinese Academy of SciencesChinese Academy of SciencesKunming 650201China School of Chemical Science and Technology Yunnan UniversityKunming 650091China

Both O-glycosides and nucleosides are essential biomolecules with important roles in a variety of biological *** synthesis of both O-glycosides and nucleosides is a scalable and reliable method to develop new therapeutic agents and decipher their ***,the efficient synthesis of both O-glycosides and nucleosides remains one of long-standing challenges in chemical *** particular,ether-type glycosyl donors are rarely developed to achieve the efficient synthesis of both O-glycosides and nucleosides due to the stronger conditions required for breaking of the glycosidic C–O *** we report that ortho-(1-phenylvinyl)benzyl glycosides are new ether-type donors for efficient synthesis of both O-glycosides and nucleosides under mild reaction *** glycosylation method enables glycosylation with both alcoholic acceptors and nucleobases with a variety of reactive ***,the latent-active synthesis of glycans and the efficient synthesis of nucleosides antibiotics have also been successfully demonstrated in the current glycosylation protocol,thereby representing an important step toward streamlining the chemical synthesis of both O-glycosides and nucleosides.

关键词： Glycosylation O-Glycosides Nucleosides ortho-(1-Phenylvinyl)benzyl Glycosides