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Nano Research 2023年第3期16卷 4188-4196页

作者： Tiankai Chen Jiali Li pengfei cai Qiaofeng Yao Zekun Ren Yixin Zhu Saif Khan Jianping Xie Xiaonan Wang Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Singapore Singapore-MIT Alliance for Research and Technology(SMART) 1 CREATE WaySingapore 138602Singapore Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Rapid and accurate chemical composition identification is critically important in *** it can be achieved with optical absorption spectrometry by comparing the experimental spectra with the reference data when the chemical compositions are simple,such application is limited in more complicated scenarios especially in nano-scale *** is due to the difficulties in identifying optical absorption peaks(i.e.,from“featureless”spectra)arose from the *** this work,using the ultraviolet-visible(UV-Vis)absorption spectra of metal nanoclusters(NCs)as a demonstration,we develop a machine-learningbased method to unravel the compositions of metal NCs behind the“featureless”*** implementing a one-dimensional convolutional neural network,good matches between prediction results and experimental results and low mean absolute error values are achieved on these optical absorption spectra that human cannot *** work opens a door for the identification of nanomaterials at molecular precision from their optical properties,paving the way to rapid and high-throughput characterizations.

关键词： gold nanoclusters composition identification optical absorption machine learning convolutional neural network

Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer

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Protein & Cell 2022年第11期13卷 825-841页

作者： Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping cai pengfei cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang Anhui Key Laboratory of Hepatopancreatobiliary Surgery Department of General SurgeryAnhui Provincial HospitalThe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Hefei National Laboratory for Physical Sciences at Microscale The Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Shenzhen People’s Hospital Second Clinical Medical College of Jinan UniversityFirst Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518000China Department of Pathology School of MedicineAnhui Medical UniversityHefei 230032China School of Medicine and Institutes for Life Sciences South China University of TechnologyGuangzhou 510006China

Metformin is currently a strong candidate anti-tumor agent in multiple ***,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor *** thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin ***,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in ***,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin *** DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer ***,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 *** study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients.

关键词： CRISPR screen DOCK1 hepatocellular carcinoma metformin small GTPase

On the development of modular polyurethane-based bioelastomers for rapid hemostasis and wound healing

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Regenerative Biomaterials 2023年第1期10卷 640-654页

作者： Wanxin Guo Binan Zhao Muhammad Shafiq Xiao Yu Yihong Shen Jie Cui Yujie Chen pengfei cai Zhengchao Yuan Mohamed EL-Newehy Hany EL-Hamshary Yosry Morsi Binbin Sun Jianfeng Pan Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai 201620P.R.China Department of Orthopedics Shanghai Tongji HospitalSchool of MedicineTongji UniversityPutuoShanghai 200065China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819-0395Japan Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityJinganShanghai 200072China

Massive hemorrhage may be detrimental to the patients,which necessitates the advent of new materials with high hemostatic efficiency and good *** objective of this research was to screen for the effect of the different types of bio-elastomers as hemostatic dressings.3D loose nanofiber sponges were prepared;PU-TA/Gel showed promising ***(PU)was synthesized and electrospun to afford porous sponges,which were crosslinked with glutaraldehyde(GA).FTIR and 1H-NMR evidenced the successful synthesis of *** prepared PU-TA/Gel sponge had the highest porosity and water absorption ***,PU-TA/Gel sponges exhibited cytocompatibility,negligible hemolysis and the shortest clotting ***-TA/Gel sponge rapidly induced stable blood clots with shorter hemostasis time and less bleeding volume in a liver injury model in ***,PU-TA/Gel sponges also induced good skin regeneration in a full-thickness excisional defect model as revealed by the histological *** results showed that the PU-TA/Gel-based sponges may offer an alternative platform for hemostasis and wound healing.

关键词： polyurethane electrospinning hemostasis material wound healing tissue regeneration regenerative medicine

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觉巴山高海拔特长公路隧道施工通风优化研究

现代隧道技术 2021年第S1期58卷 156-161页

作者：蔡鹏飞中铁十一局集团第二工程有限公司十堰442000

对觉巴山隧道现阶段压入式施工通风效果进行现场实测,根据实测数据分析得出隧道内温度、湿度较高,粉尘浓度严重超标,风管破损严重,通风效果差,压入式通风难以满足高海拔特长隧道施工环境要求。根据觉巴山隧道正洞和导洞施工进度安排,进... 详细信息

对觉巴山隧道现阶段压入式施工通风效果进行现场实测,根据实测数据分析得出隧道内温度、湿度较高,粉尘浓度严重超标,风管破损严重,通风效果差,压入式通风难以满足高海拔特长隧道施工环境要求。根据觉巴山隧道正洞和导洞施工进度安排,进行巷道式施工通风设计,设计布置2组2×75 kW轴流风机,增设1组15 kW射流风机,较现阶段减少1组2×135 kW轴流风机,通风距离减为1 km,有效地减少了通风风阻,在保证通风效果的同时减少了通风成本。

关键词：特长公路隧道高海拔正导洞巷道式通风现场实测通风效果

Review of the 5·7 Nanjing^(192)Ir source radiological accident

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Radiation Medicine and Protection 2022年第4期3卷 190-195页

作者： Yuanyuan Zhou Ningle Yu Jin Wang Wei Chen pengfei cai Department of Radiation Protection Jiangsu Provincial Center for Disease Control and PreventionNanjing 210005China Department of Public Health Jiangsu Cancer HospitalNanjing 210005China

This paper gives a detailed description of a radiological accident of ^(192)Ir source occurring on May 7,2014 in Nanjing,China(the 5⋅7 accident),encompassing a combination of accident overview,emergency response,investigation process and results,dose estimation,medical treatment,experience and lessons *** investigation showed that the accident was mainly caused by insufficient attention to the radiation safety,non-compliance with licensing conditions and employment of untrained temporary radiographer without equipped with alarm ***,no area radiation survey meter was used to verify whether the source would have retracted to radiography camera after every *** therefore is the important means to strengthen the management of radioactive source safety and put the strict management measures in place,implement the requirements for personnel qualification management,strengthen regulatory inspection and actively poster safety culture,which are necessary to avoid *** paper aims to provide experience and reference for the emergency response and countermeasure of radiological accidents involving industrial radioactive sources.

关键词： ^(192)Ir radioactive source Radiological accident Radiation safety Radiation injury

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基于特征交互和聚类的行为识别方法

计算机辅助设计与图形学学报 2023年第6期35卷 903-914页

作者：李凯歌蔡鹏飞周忠北京航空航天大学虚拟现实技术与系统国家重点实验室北京100191

针对现有行为识别方法缺乏对时空特征关系建模的问题,提出一种基于特征交互和聚类的行为识别方法.首先设计一种混合多尺度特征提取网络提取连续帧的时间和空间特征;然后基于Non-local操作设计一种特征交互模块实现时空特征的交互;最后... 详细信息

针对现有行为识别方法缺乏对时空特征关系建模的问题,提出一种基于特征交互和聚类的行为识别方法.首先设计一种混合多尺度特征提取网络提取连续帧的时间和空间特征;然后基于Non-local操作设计一种特征交互模块实现时空特征的交互;最后基于三元组损失函数设计一种难样本选择策略来训练识别网络,实现时空特征的聚类,提高特征的鲁棒性和判别性.实验结果表明,与基线方法TSN相比,所提方法的准确度在UCF101数据集上提高了23.25个百分点,达到94.82%;在HMDB51数据集上提高了20.27个百分点,达到44.03%.

关键词：行为识别时空特征关系特征交互特征聚类

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穿浪双体船纵向减摇策略麻雀搜索优化

哈尔滨工程大学学报 2024年第7期45卷 1367-1375页

作者：梁利华蔡鹏飞程权成哈尔滨工程大学智能科学与工程学院黑龙江哈尔滨150001

为了改善穿浪双体船恶劣工况下的纵向稳定性,本文基于T型水翼及尾板设计了综合姿态控制系统。同时,对该系统相关控制参数的优化策略进行研究,以更好地实现减摇目标。采用了线性二次调节器和混合麻雀算法相结合的策略来设计控制器,将一... 详细信息

为了改善穿浪双体船恶劣工况下的纵向稳定性,本文基于T型水翼及尾板设计了综合姿态控制系统。同时,对该系统相关控制参数的优化策略进行研究,以更好地实现减摇目标。采用了线性二次调节器和混合麻雀算法相结合的策略来设计控制器,将一种新型群智能算法(麻雀算法)及其改进算法应用于线性二次调节控制器权重矩阵寻优。通过两者对比,不仅验证了所设计姿态控制系统的有效性,也验证了该智能算法改进策略的高效性。结果表明:基于混合麻雀算法的控制器具有很好的自适应能力,且寻优过程收敛速度快,精度高,对工程实践具有一定的参考价值。

关键词：穿浪双体船纵向运动线性二次调节智能算法 T型水翼尾板混合麻雀搜索算法减摇

Flexible Copper‑Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti‑inflammatory Effects

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Advanced Fiber Materials 2024年第1期6卷 278-296页

作者： Jie Cui Yuchen cai Xiao Yu Yihong Shen Tianyi Zhou Binbin Sun pengfei cai Zhengchao Yuan Muhammad Shafiq Mohamed EL‑Newehy Hany EL‑Hamshary Xingping Zhou Yao Fu Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011People’s Republic of China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011People’s Republic of China Innovation Center of NanoMedicine Kawasaki Institute of Industrial Promotion3‑25‑14 Tono‑machiKawasaki‑kuKanagawa 210‑0821Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia

The conjunctiva is crucial in safeguarding the eye from harm or infection,thereby ensuring the preservation of the *** repair of infected conjunctival damage is *** objective of this study is to develop copper-doped flexible silica nanofibers(SiO_(2)@Cu NFs)with multifunctional antibacterial and anti-inflammatory *** continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive *** membranes also exhibit biocompatibility and promote cell growth,angiogenesis,and inflammation *** vivo evaluations further reveal the therapeutic efficacy of SiO_(2)@Cu NFs to promote the structural and the functional recoveries of the *** together,SiO_(2)@Cu NFs may hold significant promise for the fabrication of alterna-tive ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines.

关键词： Conjunctival reconstruction Inorganic nanofiber Bacterial infection Angiogenesis Anti-inflammation

Optimisation of the DNA dipstick as a rapid extraction method for Schistosoma japonicum in infected mice samples and spiked human clinical samples

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Infectious Diseases of Poverty 2023年第4期12卷 108-108页

作者： Oyime P.Aula Donald P.McManus Malcolm K.Jones Hong You pengfei cai Catherine A.Gordon Molecular Parasitology Laboratory QIMR Berghofer Medical Research Institute Brisbane Australia School of Public Health Faculty of Medicine The University of Queensland Brisbane Australia School of Veterinary Science The University of Queensland Brisbane Australia Faculty of Medicine The University of Queensland Brisbane Australia

BackgroundSchistosomiasis remains a public health issue and the need for accurate and affordable diagnostics is crucial in the elimination of the disease. While molecular diagnostics are highly effective, they are expensive, with the main costs been associated with DNA extraction. The DNA dipstick is a rapid, affordable and simple purification method that allows DNA to be extracted from diagnostic samples within 30 s. We aimed to optimise the DNA dipstick method for samples from mice and egg-spiked human ***, blood and faeces were collected from mice exposed to Schistosoma japonicum infection at weekly intervals from Day 0 to Day 42. Urine and faecal samples were also collected from volunteer, uninfected humans and spiked with S. japonicum eggs. All samples were subject to several optimisation procedures and DNA extracted with the DNA dipstick. Amplification of the target DNA was carried out using LAMP and visualised using agarose gel electrophoresis and *** DNA dipstick successfully identified S. japonicum from infected mice and human clinical samples spiked with cracked eggs or genomic DNA from S. japonicum. Amplification was observed from week 4 post infection in infected mice. For human samples, amplification was observed in sieved faecal samples, filtered urine samples heated at 95 ℃ for 30 min, and sera samples heated at 95℃ for 30 *** DNA dipstick combined with LAMP has huge potential in providing cost-effective, simple and accurate detection of schistosomiasis infection in endemic regions. This will allow for rapid treatment, tracking outbreaks—such as occur after typhoons, leading to better health outcomes and contributing to control and eventual elimination of schistosomiasis.

关键词： Schistosomiasis Schistosoma japonicum DNA dipstick Loop-mediated isothermal amplification assay Flocculation

Performance of the point-of-care circulating cathodic antigen test in the diagnosis of schistosomiasis japonica in a human cohort from Northern Samar, the Philippines

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Infectious Diseases of Poverty 2021年第5期10卷 40-51页

作者： pengfei cai Yi Mu Kosala G.Weerakoon Remigio M.Olveda Allen G.Ross Donald P.McManus Molecular Parasitology Laboratory Infectious Diseases ProgramQIMR Berghofer Medical Research InstituteBrisbaneAustralia Department of Health Research Institute for Tropical MedicineManilaPhilippines icddr bDhakaBangladesh Present Address:Department of Parasitology Faculty of Medicine and Allied SciencesRajarata University of Sri LankaSaliyapuraSri Lanka

Background:Zoonotic schistosomiasis,caused by Schistosoma japonicum,remains a major public health problem in the *** study aimed to evaluate the commercially available rapid diagnostic point-of-care circulating cathodic antigen(POC-CCA)test in detecting individuals infected with *** in a human cohort from an endemic area for schistosomiasis japonica in the ***:Clinical samples were collectedin 18 barangays endemic for *** infection in Laoang and Palapag municipalities,Northern Samar,the Philippines,in *** presence of CCA in flter-concentrated urine samples(n=412)was evaluated using the commercial kits and the results were converted to images,which were further analyzed by ImageJ software to calculate R *** diagnostic performance of the immunochromatographic POCCCA test was compared using the Kato-Katz(KK)procedure,in-house enzyme-linked immunosorbent assays(ELISAs)and droplet digital(dd)PCR assays as ***:The POC-CCA test was able to detect ***-infected individuals in the cohort with an eggs per gram of faeces(EPG)more than or equal to 10 with sensitivity/specifcity values of 63.3%/93.3%.However,the assay showed an inability to diagnose schistosomiasis japonica infections in all cohort KK-positive individuals,of which the majority had an extremely low egg burden(EPG:1–9).The prevalence of *** infection in the total cohort determined by the POC-CCA test was 12.4%,only half of that determined by the KK method(26.2%).When compared with the ELISAs and ddPCR assays as a reference,the POC-CCA assay was further shown to be a test with low ***,the assay exhibited signifcant positive correlations with egg burden determined by the KK technique and the target gene copy number index values determined by the ddPCR assays within the entire ***:By using in silico image analysis,the POC-CCA cassette test could be converted to a quantitative assay to avoid reader

关键词： Schistosomiasis Schistosoma japonicum Kato-Katz POC-CCA ELISA Droplet digital PCR