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Metal ion metabolism and osteoporosis:possible implications for pharmaceutical biotechnology and tissue engineering

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Science China Life Sciences 2024年第8期 1763-1765页

作者： Huaqiang Tao Qiufei Wang Kai Chen pengfei zhu Ye Gu Dechun Geng Department of Orthopedics The First Affiliated Hospital of Soochow University Department of Orthopedics Changshu Hospital Affiliated to Soochow UniversityFirst People's Hospital of Changshu City Department of Orthopedics Hai'an People's Hospital

Osteoporosis(OP) is a systemic metabolic bone disease characterized by low bone mass,damage to bone microstructure and increased bone fragility.The imbalance of functional coupling between osteoblasts and osteoclasts ...

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Lateral photovoltaic effect in the Ni-SiO_(2)-Si structure with bias

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Optoelectronics Letters 2024年第5期20卷 257-264页

作者： LING Xiang zhu pengfei zhu Kun SONG Pei LI Xiong School of Mathematics Physics and StatisticsShanghai University of Engineering ScienceShanghai 201600China School of Electrical Engineering Liupanshui Normal UniversityLiupanshui 553004China School of Railway Telecommunication Hunan Technical College of Railway High-speedHengyang 421002China

We designed a clamping device to study lateral photovoltaic effect (LPE) in Ni-SiO_(2)-Si structure with bias due to the appropriate barrier height.The LPE has a prominent sensitivity and linearity with 532 nm wavelength laser.The transient response time is 450μs and the relaxation time is 2 250μs in the Ni-SiO_(2)-Si structure without bias.The LPE sensitivity has a significant improvement with bias.The transient response time is 6μs and the relaxion time is 47μs with-7 V bias,not only improving the LPE sensitivity,but also increasing the response speed with bias.The research shows that the Schottky barrier structure can improve the sensitivity and linearity of LPE with bias effectively,and thus it can be used in position sensitive sensors.

关键词： LPE structure effect

A review of low-carbon technologies and projects for the global cement industry

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Journal of Environmental Sciences 2024年第2期136卷 682-697页

作者： Yangyang Guo Lei Luo Tingting Liu Liwei Hao Yinming Li pengfei Liu Tingyu zhu CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringInnovation Academy for Green ManufactureChinese Academy of SciencesBeijing 100190China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China State Key Laboratory of Solid Waste Reuse for Building Materials Beijing Building Materials Academy of Sciences ResearchBeijing 100041China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341000China

Carbon dioxide(CO_(2))emissions from the cement industry account for 26%of the total industrial emissions,and the need to develop low-carbon techniques within the cement industry is extremely urgent.Low-carbon projects and technologies for the cement industry in different regions and countries have been thoroughly reviewed in this manuscript,and the low-carbon development concept for each county has been analyzed.For developing countries such as China and India,energy saving and efficiency enhancement are currently the key points,while for developed countries and regions such as Europe,more efforts have been focused on carbon capture,utilization,and storage(CCUS).Global CCUS projects have been previously conducted,and the majority of CCUS projects are currently performed in Europe where major projects such as the CEMCAP,CLEANKER,and IEILAC projects represent the latest research progress in cement production technologies and low-carbon technologies for the global cement industry.The development of low-carbon cement technologies has changed from focusing on the end point to instead focusing on the source and process through the exploration of hydrogen and solar energies,and more disruptive and original technologies are expected to be developed,particularly in the cement industry in China.

关键词： Cement industry CO_(2)emissions Low carbon development Projects Carbon capture utilization and storage

PbrARF4 contributes to calyx shedding of fruitlets in ‘Dangshan Suli’ pear by partly regulating the expression of abscission genes

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Horticultural Plant Journal 2024年第2期10卷 341-354页

作者： Guoling Guo pengfei Wei Tao Yu Haiyan Zhang Wei Heng Lun Liu Liwu zhu Bing Jia School of Horticulture Anhui Agricultural UniversityHefeiAnhui 230036China Huayuan Foreign Language School Zhejiang Normal UniversityJinhuaZhejiang 322100China Agricultural Experimental Center of Guiyang Guiyang Agriculture and Rural BureauGuiyangGuizhou 550018China

Fruitlet calyx shedding in pear plants is apparently regulated via numerous pathways that involve both environmental triggers and phytohormones cues such as auxin. In this study, we found at 10 days after full bloom (DAFB) higher levels of indoleacetic acid (IAA) and tryptophan (Trp) in calyx persistence fruitlet (CPF) than calyx shedding fruitlet (CSF) ofDanshan Suli’ pear (Pyrus bretschneideri Rhed.). Consisting with this, the activity of indolealdehyde oxidase (IAAIdO), which promotes IAA synthesis, was remarkably increased, and that of peroxidase(POD), which degrades IAA, dropped markedly in CPF but not in CSF. Further, qRT-PCR results revealed that most of 31 PbrARFs (encoding auxin response factors) in Pyrus bretschneideri were highly expressed in CPF, whereas PbrARF4, PbrARF24 and PbrARF26 were significantly downregulated in CPF vis-a-vis CSF. Phylogenetic analysis revealed that 6 PbrARFs clustered in the group III, where PbrARF4 showed the closest affinity with AtARF1 that promotes organ abscission, indicating a putative role of PbrARF4 in mediating the process of calyx shedding in pear. In fact, the ectopic overexpression of PbrARF4 in Solanum lycopersicum resulted in an earlier-formed and deeper abscission layer (AL) in the transgenic plants, whose calyxes were more prone to wilt at the mature red stage (MR) compared with the control plants (wild-type). More importantly, expression levels of the abscission genes SILS and Sl Cel2 in transgenic plants overexpressing PbrARF4 were significantly upregulated in comparation with the WT, whereas those of Sl BI and Sl TAPG2 were considerably inhibited. Further, PbrJOINTLESS and PbrIDA,the two genes related to calyx shedding in pear, were up-regulated more in CSF than CPF. The findings contribute to a better understanding of PbrARFs involved in fruitlet calyx shedding of pear, which could prove beneficial to improving the quality of pear fruit.

关键词： Pear Pyrus bretschneideri Rehd Calyx shedding IAA PbrARF4 Abscission genes

Machine learning solution for regional landslide susceptibility based on fault zone division strategy

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Journal of Mountain Science 2024年第5期21卷 1745-1760页

作者： WANG Yunhao WANG Luqi LIU Songlin SUN Weixin LIU pengfei zhu Lin YANG Wenyu GUO Tong School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing 400045China National Joint Engineering Research Center of Geohazards Prevention in the Reservoir Areas Chongqing UniversityChongqing 400045China Institute of Geological Environment Monitoring Chongqing 401147China Chongqing 205 Geological Team Chongqing 401121China

Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.

关键词： Landslide susceptibility mapping Fault division strategy Random forest GIS

Let the World Enjoy the Infinite Charm of Ice&Snow in China

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China & The World Cultural Exchange 2024年第2期 18-21页

作者： zhu pengfei 不详

Series of events of "Nihao!China"2024 China Ice&Snow Tourism Overseas Promotion Season will further enhance the visibility of China ice&snow tourism in the international market and tourists,drive the"hot economy"of culture and tourism with the"cold resources"of ice&snow,and play a positive role in and far-reaching impact on promoting the vigorous development of the market of winter inbound tourism.

关键词： visibility tourism Ice

Ingenious Design of Co Al-LDH p-n Heterojunction Based on CuI as Holes Receptor for Photocatalytic Hydrogen Evolution

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Chinese Journal of Structural Chemistry 2022年第6期41卷 79-85页

作者： Yue Cao Hongqian Gou pengfei zhu Zhiliang Jin School of Chemistry and Chemical Engineering Key Laboratory for Chemical Engineering and TechnologyState Ethnic Affairs CommissionNingxia Key Laboratory of Solar Chemical Conversion TechnologyNorth Minzu UniversityYinchuan 750021China School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021China

Reasonable design of heterojunction can greatly improve the photocatalytic hydrogen evolution activity of materials.Herein,p-n heterojunction of 2D/3D structure is constructed by the nanosheet of CoAl-LDH and rock-like CuI.The introduction of CuI can make CoAl-LDH disperse better,which brings more reaction sites for the hydrogen evolution reaction.Meanwhile,the 2D/3D structure is conducive to the construction of p-n heterojunction between the CoAl-LDH and CuI.The optical and electrochemical properties of the material indicate that the separation and transference of photon-generated carriers are promoted by the p-n heterojunction.The activity of composite catalyst(CI-10)reaches a maximum of 3.59 mmol g^(−1) h^(−1) which is 28.5 times higher than that of CuI.Furthermore,the influence of the amount of CuI and pH value on the hydrogen evolution reaction is explored.Based on the band structures of CoAl-LDH and CuI,the mechanism of photocatalytic reaction of CI-10 is proposed.The p-n heterojunction constructed with the CuI as hole receptor provides a new way to enhance the activity of photocatalytic H_(2) evolution.

关键词： CoAl-LDH CuI p-n heterojunction photocatalysis hydrogen production

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1241-1256页

作者： pengfei Xu Yue Xi Jong-Won Kim Junjie zhu Min Zhang Meishu Xu Songrong Ren Da Yang Xiaochao Ma Wen Xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Pharmacology&Chemical Biology University of PittsburghPittsburghPA 15261USA

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor PAPS.The involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been reported.Here,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon cancer.Gut epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)mice.Apc^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of Wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory axis.Chondroitin sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal tumorigenesis.In summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of Wnt/β-catenin signaling.Chondroitin sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

关键词： Colon cancer APC Wnt/b-catenin PAPSS2 Chondroitin sulfate Sulfation Bile acids FXR

Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment

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Cancer Biology & Medicine 2023年第1期20卷 44-55页

作者： pengfei zhu Hongrui Lu Mingxing Wang Ke Chen Zheling Chen Liu Yang Cancer Center Department of Medical OncologyZhejiang Provincial People's Hospital(Affiliated People's HospitalHangzhoul Medical College)Hangzhou 310014China Graduate School of Clinical Medicine Bengbu Medical CollegeBengbu 233000China Department of Gastroenterology&Pancreatic Surgery Zhejiang Provincial People's HospitalHangzhou 310014China

Mechanical forces in the tumor microenvironment(TME)are associated with tumor growth,proliferation,and drug resistance.Strong mechanical forces in tumors alter the metabolism and behavior of cancer cells,thus promoting tumor progression and metastasis.Mechanical signals are transformed into biochemical signals,which activate tumorigenic signaling pathways through mechanical transduction.Cancer immunotherapy has recently made exciting progress,ushering in a new era of“chemo-free”treatments.However,immunotherapy has not achieved satisfactory results in a variety of tumors,because of the complex tumor microenvironment.Herein,we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy.

关键词： Mechanical force microenvironment immunotherapy extracellular matrix cancer