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An integrative analysis of miRNA and mRNA expression in the brains of Alzheimer's disease transgenic mice after real-world PM_(2.5)exposure

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Journal of Environmental Sciences 2022年第12期34卷 25-40页

作者： Pengfei Fu Yufei Zhao Chuan Dong Zongwei Cai Ruijin Li Ken Kin Lam Yung Department of Biology Hong Kong Baptist UniversityHong Kong SARChina Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityHong Kong SARChina Institute of Environmental Science Shanxi UniversityTaiyuan 237016China State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist UniversityHong Kong SARChina

Fine particulate matter(PM_(2.5))is associated with increased risks of Alzheimer's disease(AD),yet the toxicological mechanisms of PM_(2.5)promoting AD remain unclear.In this study,wildtype and APP/PS1 transgenic mice(AD mice)were exposed to either filtered air(FA)or PM_(2.5)for eight weeks with a real-world exposure system in Taiyuan,China(mean PM_(2.5)concentration in the cage was 61μg/m~3).We found that PM_(2.5)exposure could remarkably aggravate AD mice's ethological and brain ultrastructural damage,along with the elevation of the pro-inflammatory cytokines(IL-6 and TNF-α),Aβ-42 and ACh E levels and the decline of Ch AT levels in the brains.Based on high-throughput sequencing results,some differentially expressed(DE)m RNAs and DE mi RNAs in the brains of AD mice after PM_(2.5)exposure were screened.Using RT-q PCR,seven DE mi RNAs(mmu-mi R-193b-5p,122b-5p,466h-3p,10b-5p,1895,384–5p,and 6412)and six genes(Pcdhgb8,Unc13b,Robo3,Prph,Pter,and Tbata)were evidenced the and verified.Two mi RNA-target gene pairs(mi R-125b-Pcdhgb8 pair and mi R-466h-3p-IL-17Rα/TGF-βR2/Aβ-42/ACh E pairs)were demonstrated that they were more related to PM_(2.5)-induced brain injury.Results of Gene Ontology(GO)pathways and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways predicted that synaptic and postsynaptic regulation,axon guidance,Wnt,MAPK,and m TOR pathways might be the possible regulatory mechanisms associated with pathological response.These revealed that PM_(2.5)-elevated pro-inflammatory cytokine levels and PM_(2.5)-altered neurotransmitter levels in AD mice could be the important causes of brain damage and proposed the promising mi RNA and m RNA biomarkers and potential mi RNA-m RNA interaction networks of PM_(2.5)-promoted AD.

关键词： Fine particulate matter mRNAs miRNAs Brain Alzheimer’s disease APP/PS1 transgenic mice

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Material exploration via designing spatial arrangement of octahedral units: a case study of lead halide perovskites

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Frontiers of Optoelectronics 2021年第2期14卷 252-259页

作者： Pengfei Fu Sanlue HU Jiang TANG Zewen XIAO Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Physics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Halide perovskites have attracted tremendous attention as semiconducting materials for various optoelectronic applications.The functional metal-halide octahedral units and their spatial arrangements play a key role in the optoelectronic properties of these materials.At present,most of the efforts for material exploration focus on substituting the constituent elements of functional octahedral units,whereas designing the spatial arrangement of the functional units has received relatively little consideration.In this work,via a global structure search based on density functional theory(DFT),we discovered a metastable three-dimensional honeycomb-like perovskite structure with the functional octahedral units arranged through mixed edge-and comer-sharing.We experimentally confirmed that the honeycomb-like perovskite structure can be stabilized by divalent molecular cations with suitable size and shape,such as 2,2’-bisimidazole(BIM).DFT calculations and experimental characterizations revealed that the honeycomb-like perovskite with the formula of BIMPb2l6,synthesized through a solution process,exhibits high electronic dimensionality,a direct allowed bandgap of 2.1 eV,small effective masses for both electrons and holes,and high optical absorption coefficients,which indicates a significant potential for optoelectronic applications.The employed combination of DFT and experimental study provides an exemplary approach to explore prospective optoelectronic semiconductors via spatially arranging functional units.

关键词： lead halide perovskite electronic dimensionality functional octahedral units optoelectronic properties photodetector

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NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry

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Science China(Life Sciences) 2022年第2期65卷 341-361页

作者： Guoli Li Bingqian Su Pengfei Fu Yilin Bai Guangxu Ding Dahua Li Jiang Wang Guoyu Yang Beibei Chu College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046China Key Laboratory of Animal Biochemistry and Nutrition Ministry of Agriculture and Rural Affairs of the People’s Republic of ChinaZhengzhou 450046China International Joint Research Center of National Animal Immunology Henan Agricultural UniversityZhengzhou 450046China College of Veterinary Medicine Northwest A&F UniversityYangling 712100China

Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread.Therefore,the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial.Using a library of compounds targeting host lipid metabolic factors and testing them for their ability to block pseudorabies virus(PRV)and vesicular stomatitis virus(VSV)infection,we found that U18666A,a specific inhibitor of Niemann-Pick C1(NPC1),is highly potent in suppressing the entry of diverse viruses including pseudotyped severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).NPC1 deficiency markedly attenuates viral growth by decreasing cholesterol abundance in the plasma mem-brane,thereby inhibiting the dynamics of clathrin-coated pits(CCPs),which are indispensable for clathrin-mediated endocytosis.Significantly,exogenous cholesterol can complement the dynamics of CCPs,leading to efficient viral entry and infectivity.Administration of U18666A improves the survival and pathology of PRV-and influenza A virus-infected mice.Thus,our studies demonstrate a unique mechanism by which NPC1 inhibition achieves broad antiviral activity,indicating a potential new therapeutic strategy against SARS-CoV-2,as well as other emerging viruses.

关键词： broad-spectrum antiviral NPC inhibition CCP dynamics viral entry

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VenomAttack: automated and adaptive activity hijacking in Android

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Frontiers of Computer Science 2023年第1期17卷 187-204页

作者： Pu SUN Sen CHEN Lingling FAN pengfei GAO fu SONG Min YANG School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China College of Intelligence and Computing Tianjin UniversityTianjin 300350China College of Cyber Science Nankai UniversityTianjin 300350China School of Computer Science Fudan UniversityShanghai 200438China

Activity hijacking is one of the most powerful attacks in Android. Though promising, all the prior activity hijacking attacks suffer from some limitations and have limited attack capabilities. They no longer pose security threats in recent Android due to the presence of effective defense mechanisms. In this work, we propose the first automated and adaptive activity hijacking attack, named VenomAttack, enabling a spectrum of customized attacks (e.g., phishing, spoofing, and DoS) on a large scale in recent Android, even the state-of-the-art defense mechanisms are deployed. Specifically, we propose to use hotpatch techniques to identify vulnerable devices and update attack payload without re-installation and re-distribution, hence bypassing offline detection. We present a newly-discovered flaw in Android and a bug in derivatives of Android, each of which allows us to check if a target app is running in the background or not, by which we can determine the right attack timing via a designed transparent activity. We also propose an automated fake activity generation approach, allowing large-scale attacks. Requiring only the common permission INTERNET, we can hijack activities at the right timing without destroying the GUI integrity of the foreground app. We conduct proof-of-concept attacks, showing that VenomAttack poses severe security risks on recent Android versions. The user study demonstrates the effectiveness of VenomAttack in real-world scenarios, achieving a high success rate (95%) without users’ awareness. That would call more attention to the stakeholders like Google.

关键词： Android activity hijacking Android security mobile security

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Sampled-data Observer Design for a Class of Stochastic Nonlinear Systems Based on the Approximate Discrete-time Models

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 507-511页

作者： Xinxin fu Yu Kang pengfei Li Department of Automation University of Science and Technology of China State Key Laboratory of Fire Science Department of AutomationInstitute of Advanced TechnologyUniversity of Science and Technology of China Key Laboratory of Technology in GeoSpatial Information Processing and Application System Chinese Academy of Sciences IEEE

In this paper,we studied the approximate sampleddata observer design for a class of stochastic nonlinear systems.Euler-Maruyama approximation was investigated in this paper because it is the basis of other higher precision numerical methods,and it preserves important structures of the nonlinear systems.Also,the form of Euler-Maruyama model is simple and easy to be calculated.The results provide a reference for sampled-data observer design method for such stochastic nonlinear systems,and may be useful to many practical control applications,such as tracking control in mechanical systems.And the effectiveness of the approach is demonstrated by a simulation example.

关键词： Approximation model exponentially bounded sampled-data observer stochastic nonlinear

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Soil bacterial and fungal communities resilience to long-term nitrogen addition in subtropical forests in China

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Journal of Forestry Research 2024年第2期35卷 95-108页

作者： Xinlei fu Yunze Dai Jun Cui pengfei Deng Wei Fan Xiaoniu Xu School of Forestry and Landscape Architecture Anhui Agricultural UniversityHefei 230036AnhuiPeople’s Republic of China Suzhou Polytechnic Institute of Agriculture Suzhou 215008JiangsuPeople’s Republic of China College of Life and Environment Sciences Huangshan UniversityHuangshan 245041AnhuiPeople’s Republic of China

Atmospheric nitrogen(N)deposition is predicted to increase,especially in the subtropics.However,the responses of soil microorganisms to long-term N addition at the molecular level in N-rich subtropical forests have not been clarified.A long-term nutrient addition experiment was conducted in a subtropical evergreen old-growth forest in China.The four treatments were:control,low N(50 kg N ha^(-1)a^(-1)),high N(100 kg N ha^(-1)a^(-1)),and combined N and phosphorus(P)(100 kg N ha^(-1)a^(-1)+50 kg P ha^(-1)a^(-1)).Metagenomic sequencing characterized diversity and composition of soil microbial communities and used to construct bacterial/fungal co-occurrence networks.Nutrient-treated soils were more acidic and had higher levels of dissolved organic carbon than controls.There were no significant differences in microbial diversity and community composition across treatments.The addition of nutrients increased the abundance of copiotrophic bacteria and potentially beneficial microorganisms(e.g.,Gemmatimonadetes,Chaetomium,and Aureobasidium).Low N addition increased microbiome network connectivity.Three rare fungi were identified as module hubs under nutrient addition,indicating that low abundance fungi were more sensitive to increased nutrients.The results indicate that the overall composition of microbial communities was stable but not static to long-term N addition.Our findings provide new insights that can aid predictions of the response of soil microbial communities to long-term N addition.

关键词： Long-term nitrogen addition Old-growth subtropical forest Metagenomics Beneficial microorganisms Co-occurrence network

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Formability enhancement in hot spinning of titanium alloy thin-walled tube via prediction and control of ductile fracture

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Chinese Journal of Aeronautics 2022年第2期35卷 320-331页

作者： pengfei GAO Chao YU Mingwang fu Lu XING Mei ZHAN Jing GUO State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of High-Performance Precision Forming Technology and EquipmentSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HornKowloonHong Kong 999077China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China

The damage and fracture in hot spinning of titanium alloy is a very complex process under the combined effects of microstructure evolution and stress state.In this study,their dependences on processing parameters were investigated by an integrated FE model considering microstructure and damage evolution,and revealing the effects of microstructure and stress states on damage evolution.The results show that the inner surface of workpiece with the largest voids volume fraction is the place with the greatest potential of fracture.This is mainly attributed to the superposition effects of positive stress triaxiality and the smallest dynamic recrystallization(DRX)fraction andβphase fraction at the inner surface.The damage degree is decreased gradually with the increase of initial spinning temperature and roller fillet radius.Meanwhile,it is first decreased and then increased with the increases of spinning pass and roller feed rate,which can be explained based on the variations ofβphase fraction,DRX fraction,stress state and tensile plastic strain with processing parameters.In addition,the dominant influencing mechanisms were identified and discussed.Finally,the thickness reduction without defect in the hot spinning of TA15 alloy tube is greatly increased by proposing an optimal processing scheme.

关键词： Control of ductile fracture Dynamic recrystallization Forming limit Hot spinning Titanium alloy tube

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Regulating dissolution chemistry of nitrates in carbonate electrolyte for high-stable lithium metal batteries

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Journal of Energy Chemistry 2022年第10期31卷 422-428,I0011页

作者： Yazhen Zhu Xiang Li Yubing Si Xiuqing Zhang pengfei Sang Yongzhu fu College of Chemistry Zhengzhou UniversityZhengzhou 450001HenanChina

Lithium metal batteries(LMBs)have received increasing attention due to the high energy density.However,the practical application of LMBs is limited due to the incompatibility of ester electrolytes.Transition metal(TM)nitrates have been reported as effective additives in ester electrolyte to improve the stability of lithium anode.Unfortunately,the nitrates are restricted to use due to their poor solubility.We find that the nitrates containing crystal water have high solubility in ester electrolytes.Considering that most TM nitrates contain crystal water and the crystal water can be used as a perfect solubilizer of nitrates,thus,the method is of universality and facile without introducing any solubilizing agent.Herein,In(NO_(3))_(3.6)H_(2)O is chosen as one typical case with increased solubility up to 0.2 M compared with In(NO_(3))_(3)which hardly dissolves in ester electrolyte.The additive promotes the rapid and stable formation of the solid electrolyte interface(SEI),which effectively inhibits the lithium dendrites formation.Moreover,the induced cathode electrolyte interface(CEI)maintains the structural stability of Li Ni_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811).As a result,the electrochemical performance of Li|NCM811 cell is obviously improved.Our study provides a new idea for dissolving nitrates in ester electrolytes and discloses the synergistic function of TM-ions.

关键词： Nitrates additive Solubilizer Crystal water Stable SEI and CEI Lithium metal battery

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Increased EZH2 Levels in Anterior Cingulate Cortex Microglia Aggravate Neuropathic Pain by Inhibiting Autophagy Following Brachial Plexus Avulsion in Rats

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Neuroscience Bulletin 2020年第7期36卷 793-805页

作者： Xiang-Lei Meng Pengfei Fu Lin Wang Xun Yang Guanghui Hong Xin Zhao Jie Lao Department of Hand Surgery Huashan HospitalFudan UniversityShanghai 200040China Key Laboratory of Hand Reconstruction Ministry of HealthShanghai 200032China Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai 200032China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China

After brachial plexus avulsion(BPA),microglia induce inflammation,initiating and maintaining neuropathic pain.EZH2(enhancer of zeste homolog 2) has been implicated in inflammation and neuropathic pain,but the mechanisms by which it regulates neuropathic pain remain unclear.Here,we found that EZH2 levels were markedly upregulated during BPA-induced neuropathic pain in vivo and in vitro,stimulating pro-inflammatory cytokines(IL-1β,TNF-α,and IL-6) secretion in vivo.In rats with BPAinduced neuropathic pain,mechanical and cold hypersensitivities were induced by EZH2 upregulation and inhibited by EZH2 downregulation in the anterior cingulate cortex.Microglial autophagy was also significantly inhibited,with EZH2 inhibition activating autophagy and reducing neuroinflammation in vivo.However,this effect was impaired by inhibiting autophagy with 3-methyladenine,suggesting that the MTOR signaling pathway is a functional target of EZH2.These data suggest that EZH2 regulates neuroinflammation and neuropathic pain via a novel MTOR-mediated autophagy signaling pathway,providing a promising approach for managing neuropathic pain.

关键词： EZH2 Neuropathic pain Autophagy Brachial plexus avulsion Neuroinflammation

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Perovskite nanocrystals:synthesis,properties and applications

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Science Bulletin 2017年第5期62卷 369-380页

作者： Pengfei Fu Qingsong Shan Yuequn Shang Jizhong Song Haibo Zeng Zhijun Ning Jinkang Gong Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Institute of Optoelectronics & Nanomaterials Jiangsu Key Laboratory of Advanced Micro & Nano Materials and TechnologyCollege of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Halide perovskites have emerged as superstar materials for optoelectronic devices. Besides the fever of research in solar cells, these materials show great promise on light emitting diodes(LEDs), photodetectors and lasers as well. Rapid advances in bulk perovskite materials aroused universal interest for the development of perovskite nanocrystals, inspired by the great progress of classic colloidal semiconductor quantum dots. Perovskite nanocrystals have been synthesized based on solution process and exhibited high luminescence quantum yield, sharp emission peak, and emission color tunability. Significant progresses have been made about the application of perovskite nanocrystals for LED and lasers in recent years. In this paper, we will comprehensively introduce the synthesis strategies, physical and chemical characteristics, as well as their applications in optoelectronic devices.

关键词： Halide perovskite Nanocrystals Light emitting diode Laser

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