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Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder

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Acta Pharmaceutica Sinica B 2021年第3期11卷 599-608页

作者： Pei Wang Fang Wang Lan Ni pengfei wu Jianguo Chen Department of Pharmacology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Neurological Diseases(HUST) Ministry of Education of ChinaWuhan 430030China The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province Wuhan 430030China Laboratory of Neuropsychiatric Diseases the Institute of Brain ResearchHuazhong University of Science and TechnologyWuhan 430030China

Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity via altering functions of key proteins, such as N-methyl-D-aspartate receptor(NMDAR). Age-related cognitive disorders includes Alzheimer’s disease(AD), vascular dementia(VD), and age-associated memory impairment(AAMI). Based on the critical role of NMDAR-dependent long-term potentiation(LTP) in memory, the increase of reactive oxygen species in cognitive disorders, and the sensitivity of NMDAR to the redox status, converging lines have suggested the redox-altered NMDAR-dependent plasticity might underlie the synaptic dysfunctions associated with cognitive disorders. In this review, we summarize the involvement of redox-altered plasticity in cognitive disorders by presenting the available evidence. According to reports from our laboratory and other groups, this "redox-altered plasticity" is Hydrogen sulfidemore similar to functional changes rather than organic injuries, and strategies targeting redox-altered plasticity using pharmacological agents might reverse synaptic dysfunctions and memory abnormalities in the early stage of cognitive disorders. Targeting redox modifications for NMDARs may serve as a novel therapeutic strategy for memory deficits.

关键词： Reactive oxygen species N-Methyl-D-aspartate receptor Oxidative stress Synaptic plasticity Long-term potentiation Cognitive disorder Learning and memory Hydrogen sulfide

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Lightning-fast and privacy-preserving outsourced computation in the cloud

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Cybersecurity 2018年第1期1卷 48-68页

作者： Ximeng Liu Robert HDeng pengfei wu Yang Yang College of Mathematics and Computer Science Fuzhou UniversityFuzhouChina School of Information Systems Singapore Management UniversitySingaporeSingapore School of Software and Microelectronics Peking UniversityBeijingChina

In this paper,we propose a framework for lightning-fast privacy-preserving outsourced computation framework in the cloud,which we refer to as *** LightCom,a user can securely achieve the outsource data storage and fast,secure data processing in a single cloud server different from the existing multi-server outsourced computation ***,we first present a general secure computation framework for LightCom under the cloud server equipped with multiple Trusted Processing Units(TPUs),which face the side-channel *** the LightCom,we design two specified fast processing toolkits,which allow the user to achieve the commonly-used secure integer computation and secure floating-point computation against the side-channel information leakage of TPUs,***,our LightCom can also guarantee access pattern protection during the data processing and achieve private user information retrieve after the *** prove that the proposed LightCom can successfully achieve the goal of single cloud outsourced data processing to avoid the extra computation server and trusted computation server,and demonstrate the utility and the efficiency of LightCom using simulations.

关键词： Privacy-preserving Secure outsourced computation Homomorphic encryption Secret sharing technique Against side-channel attack

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Spatial and Temporal Distributions of Soil Organic Matter in the Mixed Plantations of Alder and Cypress in the Hilly Areas of Central Sichuan Basin

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wuhan University Journal of Natural Sciences 2006年第4期11卷 1021-1027页

作者： wu pengfei ZHU BO YANG Yuanli WANG Xiaoguo Institute of Mountain Hazards and Environment Chinese Academy ofSciences Chengdu 610041 Sichuan China Graduate University of Chinese Academy of Sciences Beijing 100049China College of Environmental Engineering Sichuan Agricultural UniversityYa＇an 625014 Sichuan China

The investigation was conducted on the spatial and temporal distributions of soil organic mater （SOM） in the mixed plantations of alder （Aluns crernastogyne） and cypress （Cupressus funebris ）（MPAC）, which distributed in the hilly areas of central Sichuan Basin （HACSB）. The results show that：（1） the spatial distribution of SOM among different sites at the same age are not significant before 15-year-old, but significant at 20-year-old, and not significant again after 25-year-old; （2） the SOM contents in 0-15 cm and 15-30 cm layers increase sharply from 10- to 15-year-old, and decline gradually from 15- to 30- year-old; the SOM contents of the 30-year-old PCP were 80. 38% and 78.42% higher than that of the 10-year-old, but 29.16% and 53.37% lower than that of 15-year-old in the 0-15 cm and 15-30 cm layers, respectively. The decrease of SOM contents would lead to the degradation of soil fertility and the decline of forest productivity.

关键词： hilly areas of central Sichuan mixed plantations of alder and cypress soil organic matter spatial distributions temporal dynamics

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Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution

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Chinese Chemical Letters 2023年第2期34卷 259-262页

作者： Peisi Xie Jinghui Zhang pengfei wu Yongjiang wu Yanjun Hong Jianing Wang Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China

Previous studies demonstrated that three-dimensional(3D) multicellular tumor spheroids(MCTS) could more closely mimic solid tumors than two-dimensional(2D) cancer cells in terms of the spatial structure, extracellular matrix-cell interaction, and gene expression pattern. However, no study has been reported on the differences in lipid metabolism and distribution among 2D cancer cells, MCTS, and solid tumors. Here, we used Hep G2 liver cancer cell lines to establish these three cancer models. The variations of lipid profiles and spatial distribution among them were explored by using mass spectrometry-based lipidomics and matrix-assisted laser desorption/ionization mass spectrometry imaging(MSI). The results revealed that MCTS, relative to 2D cells, had more shared lipid species with solid tumors. Furthermore,MCTS contained more comparable characteristics than 2D cells to solid tumors with respect to the relative abundance of most lipid classes and mass spectra patterns. MSI data showed that 46 of 71 lipids had similar spatial distribution between solid tumors and MCTS, while lipids in 2D cells had no specific spatial distribution. Interestingly, most of detected lipid species in sphingolipids and glycerolipids preferred locating in the necrotic region to the proliferative region of solid tumors and MCTS. Taken together, our study provides the evidence of lipid metabolism and distribution demonstrating that MCTS are a more suitable in vitro model to mimic solid tumors, which may offer insights into tumor metabolism and microenvironment.

关键词： Lipid metabolism Lipid distribution Two-dimensional cells Three-dimensional cell spheroids Solid tumors

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Modulation of long-term potentiation in the hippocampus by pharmacological approach:A novel strategy for the development of cognitive enhancers

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Chinese Science Bulletin 2010年第30期55卷 3374-3382页

作者： YANG YuanJian wu pengfei WANG Fang CHEN Jian Guo Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Key Laboratory of Neurological Diseases (HUST) Ministry of Education of China Wuhan 430030 China Institutes of Biomedicine and Drug Discovery Huazhong University of Science and Technology Wuhan 430030 China

Learning and memory not only provide the foundations of cognition, but are also closely related to sensory and motor function. Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are accompanied by deficits in synaptic function and cognition to varying degrees. The discovery of long-term potentiation (LTP) of hippocampal synaptic transmission, which has been recognized as a classical model of learning and memory at the cellular level, has spurred substantial progress in the development of cognitive enhancers in the past 20 years. Following intensive investigations into LTP, a variety of compounds and biologically active substances have been found to modulate hippocampal LTP via numerous molecular mechanisms including regulating presynaptic neurotransmitter release, postsynaptic N-methyl D-aspartate (NMDA) receptor activity, postsynaptic signal transduction and gene transcription. This review focuses on the progress of investigations into the overarching mechanisms of LTP, the drugs modulating LTP and prospects for the development of new drugs for treating cognitive impairments in the future.

关键词：药物治疗海马生物活性物质阿尔茨海默氏病突触传递电位调制分子机制

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Mesoporous amorphous FeOOH-encapsulated BiO_(2–x) photocatalyst with harnessing broad spectrum toward activation of persulfate for tetracycline degradation

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Chinese Journal of Chemical Engineering 2024年第7期71卷 235-248页

作者： pengfei wu Zhaolong Liu Li wu Yingkun Zhang Bing Wang Zhanghao Cheng Wenquan Cui Xiangyang Lv Qingling Liu Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China Hebei Pollution Control Technology Innovation Center of Steel and Coking Industry Department of Environmental and Chemical EngineeringHebei College of Industry and TechnologyShijiazhuang 050091China Hebei Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China Hebei Academy of Product Quality Supervision&Inspection Shijiazhuang 050227China

With the growing concern about the water environment,the advanced oxidation process of persulfate activation assisted by photocatalysis has attracted considerable attention to decompose dissolved organic *** this work,to overcome the drawbacks of the photocatalytic activity reduction caused by the photo-corrosion of non-stoichiometric BiO_(2–x),a novel material with amorphous FeOOH in situ grown on layered BiO_(2–x) to form a core-shell structure similar to popcorn chicken-like morphology was produced in two simple and environmentally beneficial *** a series of degradation activity tests of hybrid materials under different conditions,the as-prepared materials exhibited remarkable degradation activity and stability toward tetracycline in the FeOOH@BiO_(2–x)/Vis/PS system due to the synergism of photocatalysis and persulfate *** results of XRD,SEM,TEM,XPS,FTIR,and BET show that the loading of FeOOH increases the specific surface area and active sites appreciably;the heterogeneous structure formed by FeOOH and BiO_(2–x) is more favorable to the effective separation of photogenerated *** optimal degradation conditions were at a catalyst addition of 0.7 g·L^(–1),a persulfate concentration of 1.0 g·L^(–1),and an initial pH of 4.5,at which the degradation rate could reach 94.7%after 90 *** influence of typical inorganic anions on degradation was also *** studies and radical quenching experiments revealed that·OH,SO_(4)^(-)·,and·O_(2)^(-)were the principal active species generated during the degradation of *** results of the 1,10-phenanthroline approach proved that the effect of dissolved iron ions on the tetracycline degradation was limited,and the interfacial reaction that occurs on the active sites on the material's surface was a critical *** work provides a novel method for producing efficient broad-spectrum Bismuth-based composite photocatalysts and photocatalytic-activated persulfate synerg

关键词： Amorphous FeOOH BiO_(2–x) Activated persulfate Photocatalytic Tetracycline degradation

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Tailoring Ni based catalysts by indium for the dehydrogenative coupling of ethanol into ethyl acetate

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Green Energy & Environment 2024年第8期9卷 1321-1331页

作者： Ming Yin Jifeng Pang Jin Guo Xianquan Li Yujia Zhao pengfei wu Mingyuan Zheng CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023LiaoningChina University of Chinese Academy of Sciences Beijing100049China School of Materials Science and Engineering Dalian Jiaotong UniversityDalianLiaoning116028China

Exploring stable and robust catalysts to replace the current toxic CuCr based catalysts for dehydrogenative coupling of ethanol to ethyl acetate is a challenging but promising ***,novel NiIn based catalysts were developed by tailoring Ni catalysts with Indium(In)for this *** the optimal Ni0.1Zn0.7Al0.3InOx catalyst,the ethyl acetate selectivity reached 90.1%at 46.2%ethanol conversion under the conditions of 548 K and a weight hourly space velocity of 1.9 h^(-1)in the 370 h time on ***,the ethyl acetate productivity surpassed 1.1 g_(ethyl acetate)g_(catalyst)^(-1)h^(-1),,one of the best performance in current *** to catalyst characterizations and conditional experiments,the active sites for dehydrogenative coupling of ethanol to ethyl acetate were proved to be Ni4In *** presence of In tailored the chemical properties of Ni,and subsequently inhibited the C-C cracking and/or condensation reactions during ethanol *** Ni4In alloy sites,ethanol was dehydrogenated into acetaldehyde,and then transformed into acetyl species with the removal of H ***,the coupling between acetyl species and surface-abundant ethoxyde species into ethyl acetate was achieved,affording a high ethyl acetate selectivity and catalyst stability.

关键词： Dehydrogenative coupling Ethanol Ethyl acetate Nickel and indium alloys

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Designing Zinc Deposition Substrate with Fully Preferred Orientation to Elude the Interfacial Inhomogeneous Dendrite Growth

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Research 2023年第1期2022卷 31-39页

作者： Chunlin Xie Zefang Yang Qi Zhang Huimin Ji Yihu Li Tingqing wu Wenbin Li pengfei wu Haiyan Wang Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

The development of zinc-ion batteries with high energy density remains a great challenge due to the uncontrollable dendrite growth on their zinc metal *** anodes plated on the substrate have attracted increasing attention to alleviate these dendrite ***,we first point out that both the random crystal orientation and the low metal affinity of the substrate are important factors of zinc dendrite ***,the(1 O 1)fully preferred tin interface layer with high zinc affinity was fabricated by chemical tin plating on(1 O o)oriented *** tin decorated copper substrate can realize high reversible zinc plating/stripping behavior,and full cell using this zinc plated substrate can be operated for more than 1000 cycles with high capacity retention(85.3%)and low electrochemical *** proposed strategy can be also applied to lithium metal batteries,which demonstrates that the substrate orientation regulation and metal affinity design are the promising approaches to achieve dendrite-free metal anode and overcome the challenges of highly reactive metal anodes.

关键词： copper Zinc stripping

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Mixed Cations Enabled Combined Bulk and Interfacial Passivation for Efficient and Stable Perovskite Solar Cells

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Nano-Micro Letters 2023年第8期15卷 116-127页

作者： pengfei wu Shirong Wang Jin Hyuck Heo Hongli Liu Xihan Chen Xianggao Li Fei Zhang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072People’s Republic of China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072People’s Republic of China Department of Chemical and Biological Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 17104Republic of Korea SUSTech Energy Institute for Carbon Neutrality Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055People’s Republic of China

Here,we report a mixed GAI and MAI(MGM)treatment method by forming a 2D alternating-cation-interlayer(ACI)phase(n=2)perovskite layer on the 3D perovskite,modulating the bulk and interfacial defects in the perovskite films simultaneously,leading to the suppressed nonradiative recombination,longer lifetime,higher mobility,and reduced trap ***,the devices’performance is enhanced to 24.5%and 18.7%for 0.12 and 64 cm^(2),*** addition,the MGM treatment can be applied to a wide range of perovskite compositions,including MA-,FA-,MAFA-,and CsFAMA-based lead halide perovskites,making it a general method for preparing efficient perovskite solar *** encapsulation,the treated devices show improved stabilities.

关键词： Alternating-cation-interlayer Bulk defects Interfacial passivation Perovskite solar cells

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Pomegranate-type Si/C anode with SiC taped,well-dispersed tiny Si particles for lithium-ion batteries

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Journal of Advanced Ceramics 2021年第5期10卷 1129-1139页

作者： pengfei wu Benyang SHI Huibin TU Changqing GUO Anhua LIU Guan YAN Zhaoju YU Key Laboratory of High-Performance Ceramic Fibers of Ministry of Education College of MaterialsXiamen UniversityXiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

Severe volume expansion and inherently poor lithium ion transmission are two major problems of silicon *** address these issues,we proposed a pomegranate-type Si/C composite anode with highly dispersed tiny silicon particles as the core assisted by small amount of *** exploiting the high heat from magnesiothermic reduction,SiC can assist the good dispersion of silicon and provide good interface compatibility and chemical *** silicon anchored to the carbon shell provides multipoint contact mode,that together with the carbon shell frame,significantly promoting the transfer of dual ***,the pomegranate-type microcluster structure also improves the tap density of the electrode,reduces the direct contact area between active material and electrolyte,and enhances the electrochemical performance.

关键词： Si/C anode anchored Si SiC tape magnesiothermic reduction pomegranate like

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