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piRT-IFC:Physics-informed real-time impedance flow cytometry for the characterization of cellular intrinsic electrical properties

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Microsystems & Nanoengineering 2023年第3期9卷 347-356页

作者： Xiaofeng Luan pengbin liu Di Huang Haiping Zhao Yuang Li Sheng Sun Wenchang Zhang Lingqian Zhang Mingxiao Li Tian Zhi Yang Zhao Chengjun Huang Institute of Microelectronics of the Chinese Academy of Sciences BeijingChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijingChina Cerebrovascular Diseases Research Institute Xuanwu Hospital of Capital Medical UniversityBeijingChina

Real-time transformation was important for the practical implementation of impedance flow *** major obstacle was the time-consuming step of translating raw data to cellular intrinsic electrical properties(e.g.,specific membrane capacitance C_(sm) and cytoplasm conductivityσ_(cyto)).Although optimization strategies such as neural network-aided strategies were recently reported to provide an impressive boost to the translation process,simultaneously achieving high speed,accuracy,and generalization capability is still *** this end,we proposed a fast parallel physical fitting solver that could characterize single cells’C_(sm)andσ_(cyto)within 0.62 ms/cell without any data preacquisition or pretraining *** achieved the 27000-fold acceleration without loss of accuracy compared with the traditional *** on the solver,we implemented physics-informed real-time impedance flow cytometry(piRT-IFC),which was able to characterize up to 100,902 cells’C_(sm) andσ_(cyto)within 50 min in a real-time *** to the fully connected neural network(FCNN)predictor,the proposed real-time solver showed comparable processing speed but higher ***,we used a neutrophil degranulation cell model to represent tasks to test unfamiliar samples without data for *** being treated with cytochalasin B and N-Formyl-Met-Leu-Phe,HL-60 cells underwent dynamic degranulation processes,and we characterized cell’s C_(sm)andσ_(cyto)using *** to the results from our solver,accuracy loss was observed in the results predicted by the FCNN,revealing the advantages of high speed,accuracy,and generalizability of the proposed piRT-IFC.

关键词： impedance intrinsic flow

芬太尼复合甲磺酸罗哌卡因硬膜外麻醉对下腹部手术应激反应的影响

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维普期刊数据库

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西安交通大学学报（医学版） 2007年第6期28卷 693-695,699页

作者：刘鹏斌西安交通大学医学院第二附属医院麻醉科陕西西安710004

目的研究芬太尼复合甲磺酸罗哌卡因硬膜外麻醉对下腹部手术应激反应的影响。方法60例选择性下腹部手术患者,随机分为两组:甲磺酸罗哌卡因复合芬太尼组(研究组,n=32)和甲磺酸罗哌卡因组(对照组,n=28)。硬膜外穿刺部位均为L1-2间隙,每组... 详细信息

目的研究芬太尼复合甲磺酸罗哌卡因硬膜外麻醉对下腹部手术应激反应的影响。方法60例选择性下腹部手术患者,随机分为两组:甲磺酸罗哌卡因复合芬太尼组(研究组,n=32)和甲磺酸罗哌卡因组(对照组,n=28)。硬膜外穿刺部位均为L1-2间隙,每组硬膜外首剂量均为20 g/L利多卡因5 mL(试验量),随后加入8.94 g/L甲磺酸罗哌卡因12 mL,研究组复合芬太尼0.1 mg(2 mL),对照组复合生理盐水2 mL。记录术前、术中血压、心率变化,测定麻醉前、切皮后60 min、切皮后90 min的血清肾上腺素、去甲肾上腺素、皮质醇、胰岛素和血糖水平。结果切皮后60 min、切皮后90 min的血清肾上腺素、去甲肾上腺素、皮质醇水平均高于术前(P0.05),对照组血糖浓度在切皮后60 min和90 min与术前比较均明显增高(P<0.05)。结论芬太尼和甲磺酸罗哌卡因复合应用于连续硬膜外麻醉能够减轻下腹部手术时应激反应所导致的肾上腺素、去甲肾上腺素、皮质醇和血糖水平增高。

关键词：甲磺酸罗哌卡因芬太尼硬膜外阻滞应激反应下腹部手术

Cognitive function correlations with apolipoprotein Eε4 single nucleotide polymorphism in 1000 elderly patients following general anesthesia A randomized controlled study

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Neural Regeneration Research 2009年第4期4卷 316-320页

作者： Yingmin Cai Haitao Hu Rongliang Xue pengbin liu Gaifeng Feng Weijiang Dong Bin Yu Minggang Zhao Department of Anesthesia Second Affiliated Hospital Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Neuroanatomy Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Department of Forensic Medicine Medical College Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

BACKGROUND： Cognitive dysfunction occurs in elderly patients following general anesthesia, and this might be associated with genetics. Studies have shown that the ε4 allele gene is closely associated with senile dementia. OBJECTIVE： To compare and analyze the correlations between cognitive dysfunction and single nucleotide polymorphism of apolipoprotein E （ApoE） following inhalation or intravenous anesthesia. DESIGN, TIME AND SETTING： A randomized, controlled study was performed. The patients were recruited from the Department of Anesthesia, Second Affiliated Hospital, Medical College, Xi＇an Jiaotong University, China between May 2005 and December 2008. Genetic analyses were conducted at the Departments of Neuroanatomy and Forensic Medicine, Medical Corlege, Xi＇an Jiaotong University, China. PARTICIPANTS： A total of t 000 patients of ASA I-II grade, without genetic connection, were enrolled in this study, comprising 520 males and 480 females, aged （70.1± 4.6） years and weighing （57.3 ± 7.5） kg. No patients suffered from cognitive dysfunction. METHODS： The patients were equally and randomly divided into intravenous anesthesia and gas anesthesia groups. Total intravenous anesthesia and inhaled anesthesia were used. Genomic DNA from whole blood was extracted. The ApoE gene was amplified by PCR. Restriction fragment length polymorphism of ApoE gene was analyzed. Cognitive function was evaluated by Mini-Mental State Examination （MMSE）. Patients scoring 〈 25 points were diagnosed with cognitive dysfunction. MAIN OUTCOME MEASURES： Correlation of ApoE gene frequency and ApoE ε 4 allele to MMSE scores was measured. RESULTS： MMSE scores in patients from the gas anesthesia group significantly decreased 3 days after surgery, compared with the intravenous anesthesia group. The proportion of patients that scored 〈 25 points was significantly greater in the gas anesthesia group compared with the intravenous anesthesia group 3 days after surgery. Reduced MMSE scores closely correla

关键词： general anesthesia cognitive function apolipoprotein E polymorphism elderly

Propofol-controlled infusion technique in assessing the safe dosage for sedation during epidural anesthesia

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Neural Regeneration Research 2006年第6期1卷 537-540页

作者： Yingmin Cai pengbin liu Jinxin Song Rongliang Xue Department of Anesthesiology Second Affiliated Hospital Medical College of Xi＇an Jiao Tong University Xi＇an 710004 Shaanxi Province. China

BACKGROUND： Epidural anesthesia requires a convenient and accurate method to determine the plasma concentration of the given subsidiary drug. The target-controlled infusion （TCI） technique, controlling infusion pump by computer, has been used. Intravenous injection of propofol was given for the purpose of measuring plasma concentrations and to observe the effects of different target concentrations on the memory, consciousness, hemodynamics and blood gases of patients, in order to find a safe dosage for sedation in epidural anesthesia. OBJECTIVE： To observe the influence of different target concentrations on the memory, consciousness hemodynamics and blood gases of patients accepted epidural anesthesia. DESIGN ： A randomized and controlled study SETTING ： Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Xi＇an Jiao Tong University. PARTICIPANTS： The experiment was conducted in the Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Xi＇an Jiao Tong University from June 2005 to June 2006. Fifty patients underwent surgery for lower abdomen and lower limbs were selected, including 30 males and 20 females, 30-60 years old with an average of （46±6） years, weighing （65.8±8.5） kg, and American Society of Anesthesiology （ASA） grading of Ⅰ- Ⅱ. All the patients were informed and agreed with the items for detection.METHODS： All the patients were given diazepam （10 mg） and atropine （0.5 mg） intramuscularly 30 minutes before surgery, They were placed supinely and given oxygen inhalation, their blood pressure, heart rate and blood oxygen saturation were determined, then an epidural puncture was made in the left lateral decubitus position with hands crossed over knees. The patients were in a horizontal position and a radial artery puncture was done, after the epidural catheter was positioned into epidural space. Blood of radial artery was drawn to get a blood gas, a linked HP multi-functional monitor was used to m

关键词：二异丙酚/投药和剂量记忆麻醉硬膜外/方法随机对照试验血气分析成年人男(雄)性女(雌)性人类中年人

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350 MW超临界锅炉精细化燃烧调整试验

锅炉技术 2019年第4期50卷 46-48,69页

作者：傅旭峰刘鹏彬华电电力科学研究院有限公司

某电厂350 MW超临界机组锅炉进行了精细化燃烧调整试验,对锅炉调试过程中出现飞灰含碳量高问题进行相应调整试验,从煤质、一次粉管调平、煤粉细度和氧量四方面分析原因,得出影响本机组飞灰大渣含碳量高主要因素:每台磨煤机粉管出口风速... 详细信息

某电厂350 MW超临界机组锅炉进行了精细化燃烧调整试验,对锅炉调试过程中出现飞灰含碳量高问题进行相应调整试验,从煤质、一次粉管调平、煤粉细度和氧量四方面分析原因,得出影响本机组飞灰大渣含碳量高主要因素:每台磨煤机粉管出口风速未控制在±5%;磨煤机运行时分离器频率过小,导致煤粉过粗;运行氧量对飞灰大渣也有影响.最终将问题得到解决,建议在运行过程中将磨煤机的动态分离器频率在12 Hz^15 Hz左右;磨煤机出口煤粉管风速控制±5%;氧量的增高,飞灰和大渣可燃物含量逐渐下降,350MW负荷工况下将氧量控制4.74%.本次精细化调整试验对同类型锅炉运行指导有一定的参考意义.

关键词：超临界锅炉精细化试验

EGFR和Cyclin D1的联合表达预测胶质瘤的放疗敏感性

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西安交通大学学报（医学版） 2008年第6期29卷 689-691页

作者：崔刚张熙周乐屈建强刘鹏斌西安交通大学医学院第二附属医院神经外科陕西西安710004 西安交通大学医学院第一附属医院神经外科陕西西安710061 西安交通大学医学院第二附属医院麻醉科陕西西安710004

目的探讨表皮生长因子受体(EGFR)和Cyclin D1蛋白的表达与胶质瘤放疗敏感性的关系。方法采用免疫组织化学方法检测EGFR和Cyclin D1蛋白在53例不同放疗敏感性胶质瘤和10例正常脑组织中的表达。结果EGFR或Cyclin D1蛋白的表达与胶质瘤的... 详细信息

目的探讨表皮生长因子受体(EGFR)和Cyclin D1蛋白的表达与胶质瘤放疗敏感性的关系。方法采用免疫组织化学方法检测EGFR和Cyclin D1蛋白在53例不同放疗敏感性胶质瘤和10例正常脑组织中的表达。结果EGFR或Cyclin D1蛋白的表达与胶质瘤的放疗敏感性均无统计学意义(P>0.05)。EGFR和Cyclin D1蛋白的联合表达与胶质瘤的放疗敏感性具有统计学意义(P<0.05)。结论EGFR和Cyclin D1蛋白的联合表达可预测胶质瘤的放疗敏感性。

关键词： EGFR蛋白 Cyclin D1蛋白脑胶质瘤放疗敏感性

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基于吸收剂分区的同时脱硫脱硝反应特性研究

动力工程学报 2019年第12期39卷 994-998,1004页

作者：刘凤李昊天张彩端张晓光汪黎东刘鹏宾曾芳华北电力大学"区域能源系统优化"教育部重点实验室北京102206 华北电力大学环境科学与工程系河北保定071003 平顶山中电环保发电有限责任公司河南平顶山475000

在鼓泡反应装置中进行了MgO为吸收区吸收剂、NaClO2为氧化区吸收剂的脱硫脱硝实验,研究了NaClO2浓度、NaClO2溶液的pH、温度和烟气体积流量等参数对脱硫脱硝效率的影响,并在液相产物分析的基础上推测了反应历程。结果表明:在最佳条件下,... 详细信息

在鼓泡反应装置中进行了MgO为吸收区吸收剂、NaClO2为氧化区吸收剂的脱硫脱硝实验,研究了NaClO2浓度、NaClO2溶液的pH、温度和烟气体积流量等参数对脱硫脱硝效率的影响,并在液相产物分析的基础上推测了反应历程。结果表明:在最佳条件下,SO2和NO的脱除效率均达到100%,NOx的脱除效率可达65%。

关键词： MgO NaClO2 吸收剂分区脱硫脱硝

A Framework and QoS Based Web Services Discovery

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A Framework and QoS Based Web Services Discovery

IEEE BEIJING SECTION(跨国电气电子工程师学会北京分会)

作者： Yin Baocai,Yang Huirong,Fu pengbin,Gu Liheng,liu Mingli Beijing Municipal Key Laboratory of Multimedia and Intelligent Software Technology, College of Computer Science and Technology,Beijing University of Technology, Beijing,China

Current web services standards lack the support of formal semantic descriptions of a service’s nonfunctional characters,*** Quality Of *** a large number of functionally-equivalent services have been discovered,it is difficult for users to choose which one to be ***,QoS becomes a very critical factor in selecting among these candidates services to best meet users *** this paper,we design and build a general QoS ontology to support web services nonfunctional *** ontology can solve the interoperability of QoS *** also give a semantic web services discovery framework based on QoS *** framework supports the automatic discovery of web services and it can improve the efficiency for users to find the best services.

关键词： semantic web QoS ontology web services discovery

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浅谈公路桥涵工程施工质量控制

科技传播 2010年第21期2卷 113-113,119页

作者：郑慧敏刘鹏斌河南省路桥建设集团有限公司河南商丘476000 河南省亚坤路桥工程有限公司河南宝丰467400

本文对公路桥涵的各项施工进行了详细的分析,并提出了质量保证措施,以供有关人员参考。

关键词：公路桥涵施工质量控制