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Catalytic recycling of plastics into value-added products

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Nano Research 2024年第11期17卷 9428-9445页

作者： Tianyu Wei pengcheng zhou Wenxian Liu Xijun Liu Tairong Kuang Functional Polymers and Advanced Materials (FPAM) Lab Zhejiang Key Laboratory of Plastic Modification and Processing Technology College of Materials Science and Engineering Zhejiang University of Technology Hangzhou 310014 China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Processing for Nonferrous Metals and Featured Materials MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materials School of Resources Environment and Materials Guangxi University Nanning 530004 China

The overuse and ineffective management of plastics have led to significant environmental pollution. Catalytic upcycling into value-added chemicals has emerged as a promising solution. This review provides a comprehensive overview of recent advances in catalytic upcycling, focusing on the cleavage of chemical bonds such as carbon-carbon (C-C), carbon-oxygen (C-O), and carbon-hydrogen (C-H) in plastics. It systematically discusses plastics conversion via electrocatalysis, thermal catalysis, and photocatalysis. Additionally, it explores the conversion of plastics into value-added chemicals and functional polymers. The review also addresses the challenges in this field and aims to offer insights for developing sustainable and effective plastics upcycling technologies.

关键词： plastics recycling catalysis chemical recycling value-added chemicals functional polymers

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3077-3096页

作者： pengcheng zhou Xuanlong Du Weilu Jia Kun Feng Yewei Zhang Department of General Surgery Affiliated Hospital of Nantong UniversityNantongChina School of Medicine Southeast UniversityNanjingChina Nanjing Medical University NanjingChina Hepatobiliary and Pancreatic Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeutic options for *** tumor microenvironment(TME)in pancreatic cancer,distinguished by fibrosis and the existence of cancer-associated fibroblasts(CAFs),exerts a pivotal influence on both tumor advancement and resistance to *** advancements in the field of engineered extracellular vesicles(EVs)offer novel avenues for targeted therapy in pancreatic *** study aimed to develop engineered EVs for the targeted reprogramming of CAFs and modulating the TME in pancreatic *** obtained from bone marrow mesenchymal stem cells(BMSCs)were loaded with miR-138-5p and the anti-fibrotic agent pirfenidone(PFD)and subjected to surface modification with integrinα5-targeting peptides(named IEVs-PFD/138)to reprogram CAFs and suppress their pro-tumorigenic ***α5-targeting peptide modification enhanced the CAF-targeting ability of ***-138-5p directly inhibited the formation of the FERMT2-TGFBR1 complex,inhibiting TGF-βsignaling pathway *** addition,miR-138-5p inhibited proline-mediated collagen synthesis by directly targeting the FERMT2-PYCR1 *** combination of miR-138-5p and PFD in EVs synergistically promoted CAF reprogramming and suppressed the pro-cancer effects of *** experiments using the orthotopic stroma-rich and patient-derived xenograft mouse models yielded promising *** particular,IEVs-PFD/138 effectively reprogrammed CAFs and remodeled TME,which resulted in decreased tumor pressure,enhanced gemcitabine perfusion,tumor hypoxia amelioration,and greater sensitivity of cancer cells to ***,the strategy developed in this study can improve chemotherapy *** IEVs-PFD/138 as a targeted therapeutic agent to modulate CAFs and the TME represents a promising therapeutic approach for pancreatic cancer.

关键词： inhibited targeted chemotherapy

A Framework for Personalized Adaptive User Interest Prediction Based on Topic Model and Forgetting Mechanism

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Wuhan University Journal of Natural Sciences 2018年第1期23卷 9-16页

作者： GUI Sisi LU Wei zhou pengcheng ZHENG Zhan School of Information Management Wuhan UniversityWuhan 430072 Hubei China School of Media and Communication Wuhan TextileUniversity Wuhan 430073 Hubei China

User interest is not static and changes dynamically. In the scenario of a search engine, this paper presents a personalized adaptive user interest prediction framework. It represents user interest as a topic distribution, captures every change of user interest in the history, and uses the changes to predict future individual user interest dynamically. More specifically, it first uses a personalized user interest representation model to infer user interest from queries in the user＇s history data using a topic model; then it presents a personalized user interest prediction model to capture the dynamic changes of user interest and to predict future user interest by leveraging the query submission time in the history data. Compared with the Interest Degree Multi-Stage Quantization Model, experiment results on an AOL Search Query Log query log show that our framework is more stable and effective in user interest prediction.

关键词： user interest user interest presentation user interestprediction topic model forgetting mechanism

An optimized method to differentiate mouse follicular helper T cells in vitro

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Cellular & Molecular Immunology 2020年第7期17卷 779-781页

作者： Xin Gao Hao Wang Zhian Chen pengcheng zhou Di Yu Department of Immunology and Infectious Disease John Curtin School of Medical ResearchThe Australian National UniversityCanberraACTAustralia China-Australia Centre for Personalized Immunology Shanghai Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Upon priming,naive CD4^(+) helper T(Th)cells differentiate into distinct subsets with specialized *** differentiation of Th subsets is driven not only by signals from the T cell receptor(TCR)and costimulatory receptors but is also critically dependent on the specific cytokine *** mimicking such conditions,robust methods have been developed for the in vitro differentiation of type 1 and type 2 Th(Th1 and Th2)cells,and more recently,IL-17-producing Th(Th17)cells and regulatory T(Treg)cells,1 which greatly support the research and applications of these Th *** helper T(Tfh)cells represent another Th subset that specializes in supporting the germinal center(GC)response and regulating the generation of memory B cells and long-lived plasma cells.2 However,current methods for in vitro Tfh differentiation are not *** in the best practice,only 20%of polarized cells showed the expression of CXCR5,the key Tfh functional marker.3 Here,we report an optimized in vitro differentiation method that generates 50–75%CXCR5+cells with enhanced B cell helper *** demonstrate that the priming of antigen-presenting cells(APCs)by lipopolysaccharide(LPS)and the increase of the APC:T cell ratio were key to efficiently generating Tfh cells in vitro.

关键词： Th2 specialized supporting

Oxymatrine reduces neuroinflammation in rat brain A signaling pathway

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Neural Regeneration Research 2012年第30期7卷 2333-2339页

作者： Jiahui Mao Yae Hu Ailing zhou Bing Zheng Yi Liu Yueming Du Jia Li Jinyang Lu pengcheng zhou Department of Pathophysiology Medical School of Nantong University Nantong 226001 Jiangsu Province China Department of Urology the First People's Hospital of Nantong Nantong 226001 Jiangsu Province China Undergraduate of Medical School of Nantong University Nantong 226001 Jiangsu Province China

Cerebral neuroinflammation models were established by injecting 10μg lipopolysaccharide into the hippocampus of male Sprague-Dawley rats. The rats were treated with an intraperitoneal injection of 120, 90, or 60 mg/kg oxymatrine daily for three days prior to the lipopolysaccharide injection. Twenty-four hours after model induction, the hippocampus was analyzed by real-time quantitative PCR, and the cerebral cortex was analyzed by enzyme-linked immunosorbent assay and western blot assay. The results of the enzyme-linked immunosorbent assay and the real-time quantitative PCR showed that the secretion and mRNA expression of the pro-inflammatory cytokines interleukin-113 and tumor necrosis factor-a were significantly decreased in the hippocampus and cerebral cortex of model rats treated with oxymatrine. Western blot assay and real-time quantitative PCR analysis indicated that toll-like receptor 4 mRNA and protein expression were significantly decreased in the groups receiving different doses of oxymatrine. Additionally, 120 and 90 mg/kg oxymatrine were shown to reduce protein levels of nuclear factor-KB p65 in the nucleus and of phosphorylated IKBa in the cytoplasm of brain cells, as detected by western blot assay. Experimental findings indicate that oxymatrine may inhibit neuroinflammation in rat brain via downregulating the expression of molecules in the toll-like receptor 4/nuclear factor-KB signaling Dathwav.

关键词： oxymatrine neuroinflammation toll-like receptor 4 nuclear factor-KB signaling pathway inflammatory factors lipopolysaccharide hippocampus cerebral cortex neural regeneration

Machine-learning-facilitated earthquake and anthropogenic source detections near the Weiyuan Shale Gas Blocks,Sichuan,China

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Earth and Planetary Physics 2021年第6期5卷 501-519页

作者： pengcheng zhou William L.Ellsworth HongFeng Yang Yen Joe Tan Gregory C.Beroza MinHan Sheng RiSheng Chu Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou 510301China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongSha TinHong Kong 999077China Department of Geophysics Stanford UniversityStanfordCA 94305USA State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China

Seismic hazard assessment and risk mitigation depend critically on rapid analysis and characterization of earthquake *** seismicity in shale gas blocks of the Sichuan Basin,China,has presented a serious challenge to monitoring and managing the seismicity *** this study,to detect events we apply a machine-learning-based phase picker(PhaseNet)to continuous seismic data collected between November 2015 and November 2016 from a temporary network covering the Weiyuan Shale Gas Blocks(SGB).Both P-and S-phases are picked and associated for *** refine the velocity model by using detected explosions and earthquakes and then relocate the detected events using our new velocity *** detections and absolute relocations provide the basis for building a high-precision earthquake *** primary catalog contains about 60 times as many earthquakes as those in the catalog of the Chinese Earthquake Network Center(CENC),which used only the sparsely distributed permanent *** also measure the local magnitude and achieve magnitude completeness of *** relocate clusters of events,showing sequential migration patterns overlapping with horizontal well branches around several well pads in the Wei202 and Wei204 *** results demonstrate the applicability of a machine-learning phase picker to a dense seismic *** algorithms can facilitate rapid characterization of earthquake sequences.

关键词： induced seismicity machine learning Weiyuan Shale Gas Block

Metallurgy at the Crossroads: New Analyses of Copper-based Objects at Tianshanbeilu, Eastern Xinjiang, China

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 594-602页

作者： LIU Cheng LIU Ruiliang zhou pengcheng LU Chun YANG Zengxin A.Mark POLLARD Peter HOMMEL MA Jian CUI Jianfeng Peter BRAY TONG Jianyi Jessica RAWSON School of Cultural Heritage Northwest UniversityXi’an 710069China Research Center of Material Science and Archaeology NPU Institute of Culture and HeritageNorthwestern Polytechnical UniversityXi’an 710072China School of Archaeology University of OxfordOxfordUK(OX13TG Xi’an Museum Xi’an 710068China Shandong University of Finance and Economics Library Jinan 250012China School of Electronic Engineering Xidian UniversityXi’an 710068China Department of Archaeology Classics and EgyptologyUniversity of LiverpoolLiverpoolUK(L77BD School of Archaeology and Museology Peking UniversityBeijing 100871China British Museum LondonUK(WC1B 3DG Department of Archaeology University of ReadingReadingUK(RG66AB

Tianshanbeilu is the largest Bronze Age site in eastern Xinjiang, China. Stretching across the entire second millennium BC, it performed a prominent role in connecting the Hexi corridor, Central China and the steppe. A further insight into the metallurgical tradition and the metal supply network is of vital importance to improve our understanding of its multi-connected nature. This paper offers a new set of chemical and isotopic data on the copper-based objects at Tianshanbeilu, including alloying elements, trace elements(impurities) and lead isotopes. Combining the concentrations of arsenic and antimony reveals that arsenic was introduced to copper partially due to the use of specific minerals tethrahedrite-tennantite. Lead isotopes demonstrate that multiple sources of copper were employed at Tianshanbeilu and a majority of them are characterized by common lead, which appears rather different from those of the Central Plains and the Hexi corridor, but highly consistent with local ores. Surprisingly, one object at Tianshanbeilu contains the well-known highly radiogenic lead. This object undoubtedly marks the westernmost boundary of the distribution of the highly radiogenic lead. We also anticipate that more lead isotopic analyses in NW China will further contribute to the study of the highly radiogenic lead in Central China.

关键词： highly radiogenic lead chemical and isotopic analysis metallurgy Tianshanbeilu

Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

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National Science Review 2024年第1期11卷 161-173页

作者： Feng Xue Fei Li Ke-ming Zhang Lufeng Ding Yang Wang Xingtao Zhao Fang Xu Danke Zhang Mingzhai Sun Pak-Ming Lau Qingyuan Zhu pengcheng zhou Guo-Qiang Bi Department of Precision Machinery and Precision Instruments University of Science and Technology of China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Interdisciplinary Center for Brain Information the Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Faculty of Life and Health Sciences Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China Institute of Semiconductors Chinese Academy of Sciences Department of Modern Life Sciences and Biotecnology Xiongan Institute of Innovation Xiongan New Area Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Suzhou Institute for Advanced Research University of Science and Technology of China Institute of Artiflcial Intelligence Hefei Comprehensive National Science Center

To investigate the circuit-level neural mechanisms of behavior, simultaneous imaging of neuronal activity in multiple cortical and subcortical regions is highly desired. Miniature head-mounted microscopes offer the capability of calcium imaging in freely behaving animals. However, implanting multiple microscopes on a mouse brain remains challenging due to space constraints and the cumbersome weight of the ***, we present TINIscope, a Tightly Integrated Neuronal Imaging microscope optimized for electronic and opto-mechanical design. With its compact and lightweight design of 0.43 g, TINIscope enables unprecedented simultaneous imaging of behavior-relevant activity in up to four brain regions in ***-of-concept experiments with TINIscope recorded over 1000 neurons in four hippocampal subregions and revealed concurrent activity patterns spanning across these regions. Moreover, we explored potential multi-modal experimental designs by integrating additional modules for optogenetics, electrical stimulation or local field potential recordings. Overall, TINIscope represents a timely and indispensable tool for studying the brain-wide interregional coordination that underlies unrestrained behaviors.

关键词： miniature microscope multiple sites calcium imaging multimodal integration hippocampus

The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss

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The farnesoid X receptor negatively regulates osteoclastogen...