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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

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Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai yu peng wen Hu Yi Liu Hui Wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

Elastohydrodynamic Lubrication Interface Stiffness and Damping Considering Asperity Lateral Contact

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Acta Mechanica Solida Sinica 2024年第1期37卷 109-123页

作者： Zhiqiang Gao yu Zhang Xian Wei Yanfang Zhu Lixia peng Weiping Fu wen Wang School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Intelligent Manufacturing Panzhihua UniversityPanzhihua 617000China Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Light Chemical TechnologyYibin 644002China School of Mechanical Engineering Anyang Institute of TechnologyAnyang 455099China

Elastohydrodynamic lubrication(EHL)point contact occurs between two rough surfaces at the mesoscopic level,while the interaction of rough surfaces involves contact between asperities at the microscale *** most cases,the contact between asperities within an interface takes the form of lateral contact rather than peak *** devoid of contact asperities are filled with lubricating ***,conventional models often oversimplify lateral contact forms as interactions between asperities and a smooth,rigid *** simplifications fail to accurately represent the true contact conditions and can lead to inaccuracies in the analysis of EHL’s contact *** address this issue,we have developed a novel EHL interface model comprising two rough *** model allows us to explore the influence of asperity height,contact angle,and contact azimuth angle on EHL interface performance.

关键词： EHL interface Asperity lateral contact Contact stiffness Damping

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 498-507页

作者： Bojian Chen Tao Jiang Jing wen Guangdong Yang Tangxia yu Fengxiang Zhu peng Hu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China State key laboratory of vanadium and titanium resources comprehensive utilization Panzhihua 617000China

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be *** allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the *** referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux *** results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting *** comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was *** melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 *** permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently *** acid pellets played a role in withstanding load during the softening *** flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting *** slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single *** segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

关键词： high-chromium vanadium-titanium magnetite softening-melting properties all pellets integrated burden flux pellets

Strigolactones modulate cotton fiber elongation and secondary cell wall thickening

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Journal of Integrative Agriculture 2024年第6期23卷 1850-1863页

作者： yunze wen peng He Xiaohan Bai Huizhi Zhang yunfeng Zhang Jianing yu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China

Cotton is one of the most important economic crops in the world,and it is a major source of fiber in the textile ***(SLs)are a class of carotenoid-derived plant hormones involved in many processes of plant growth and development,although the functions of SL in fiber development remain largely ***,we found that the endogenous SLs were significantly higher in fibers at 20 days post-anthesis(DPA).Exogenous SLs significantly increased fiber length and cell wall ***,we cloned three key SL biosynthetic genes,namely GhD27,GhMAX3,and GhMAX4,which were highly expressed in fibers,and subcellular localization analyses revealed that GhD27,GhMAX3,and GhMAX4 were localized in the *** exogenous expression of GhD27,GhMAX3,and GhMAX4 complemented the physiological phenotypes of d27,max3,and max4 mutations in Arabidopsis,*** of GhD27,GhMAX3,and GhMAX4 in cotton resulted in increased numbers of axillary buds and leaves,reduced fiber length,and significantly reduced fiber *** findings revealed that SLs participate in plant growth,fiber elongation,and secondary cell wall formation in *** results provide new and effective genetic resources for improving cotton fiber yield and plant architecture.

关键词： strigolactones fiber elongation secondary cell wall thickening cotton

A thermodynamic model on predicting density of medium-Mn steels with experimental verification

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Journal of Iron and Steel Research(International) 2017年第11期24卷 1078-1084页

作者： Guo-hui Shen peng-yu wen Hal-wen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

A new model on predicting the density of hot-rolled multi-phased medium-Mn steel has been presen ted on the basis of thermodynamic calculations. This is an integrated model, which includes one for calculating the retained austenite （RA） fraction and the other for volume expansion during the aus tenite-to martensite transformation, because both of them are key parameters for calculating the den- sity of steel at ambient temperature. The existing empirical equations for calculating Mx temperature and lattice constants of both martensite and austenite have been all rcassessed by the XRD measure ments on the microstructures of seven hot-rolled medium-Mn steels. Finally, the densities ot seven steels were calculated merely from compositions and compared with the measured ones. The differ ence between them is no more than 1 %, suggesting that the presented model should be of good value in designing the low density steels.

关键词： Density Medium Mn steel Retained austenite fraction Volume expansion Transformation

Experimental demonstration of mode-matching and Sagnac effect in a millimeter-scale wedged resonator gyroscope

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Photonics Research 2022年第9期10卷 2115-2121页

作者： XUAN MAO HONG YANG DAN LONG MIN WANG peng-yu wen yuN-QI HU BO-YANG WANG GUI-QIN LI JIAN-CUN GAO GUI-LU LONG Department of Physics State Key Laboratory of Low-Dimensional Quantum PhysicsTsinghua UniversityBeijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China Frontier Science Center for Quantum Information Beijing 100084China Beijing National Research Center for Information Science and Technology Beijing 100084China School of Information Tsinghua UniversityBeijing 100084China

The highly efficient coupling of light from conventional optical components to optical mode volumes lies in the heart of chip-based micro-devices,which is determined by the mode-matching between propagation constants of fiber taper and the whispering-gallery-mode(WGM)of the *** gyroscopes,typically realized as fiber-optic gyroscopes and ring-laser gyroscopes,have been the mainstay in diverse applications such as positioning and inertial ***,the mode-matching is theoretically analyzed and experimentally *** observe the Sagnac effect in a millimeter-scale wedged resonator gyroscope,which has attracted considerable attention and has been rapidly promoted in recent *** demonstrate a bidirectional pump and probe scheme,which directly measures the frequency beat caused by the Sagnac *** establish the linear response between the detected beat frequency and the rotation *** clockwise and counterclockwise rotation can also be distinguished according to the value of the frequency *** experimental results verify the feasibility of developing the gyroscope in a WGM resonator system and pave the way for future development.

关键词： resonator millimeter pump

A Weighted Flow related to a Trudinger–Moser Functional on Closed Riemann Surface

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2244-2262页

作者： peng Xiu yu School of Mathematics Renmin University of ChinaBeijing 100872P.R.China

In this paper,with(Σ,g)being a closed Riemann surface,we analyze the possible concentration behavior of a heat flow related to the Trudinger–Moser *** obtain a long time existence for the *** along some sequence of times t_(k)→+∞,we can deduce the convergence of the flow in H2(Σ).Furthermore,the limit function is a critical point of the Trudinger–Moser functional under certain constraint.

关键词： Trudinger-Moser inequality global convergence heat flow

Effect of flash processing on recrystallization behavior and mechanical performance of cold-rolled IF steel

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1234-1243页

作者： peng-yu wen Jian-sheng Han Hai-wen Luo Xin-ping Mao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Department of Ferrous Metallurgy University of Science and Technology BeijingBeijing 100083China

Flash processing(FP)has attracted considerable attention due to its high efficiency,economic advantages,and the extraordinary opportunity if offers to improve the mechanical properties of *** this study,we investigated the influences of FP on the recrystallization(REX)behavior and mechanical performance of cold-rolled IF *** a thermomechanical simulator,we performed both single-stage FPs,at heating rates of 200℃/s and 500℃/s,and two-stage FP,with an initial preheating to 400℃ at a rate of 5℃/s and then to peak temperatures at a rate of 200℃/*** comparison to continuous annealing(CA),single-stage FP can effectively refine the recrystallized grain sizes and produce a similar or even sharperγ(ND(normal direction)//{111})texture *** particular,the heating rate of 500℃/s led to an increase in the yield strength of about 23.2%and a similar *** contrast,the two-stage FP resulted in a higher REX temperature as well as a certain grain refinement due to the stored strain energy,i.e.,the driving force of REX,which was largely consumed during ***,both stronger{110}and weakerγtexture components appeared in the two-stage FP and were believed to be responsible for the early necking and deterioration in ductility.

关键词： flash processing interstitial-free steel recrystallization mechanical properties texture

Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu Bing wen-yu Ma Ming-Hui Wu peng Gao Xiao Zhou Hai-Bin Luo Long Wang wen-Ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness