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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma

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Chinese Journal of Polymer Science 2022年第9期40卷 1120-1128页

作者： Mei-yu Jiang Jia-Sheng Wu Wei-Min Liu Hao-Hui ren Xin Wang peng-Fei Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials and Cityu-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer ***-targeted sonodynamic therapy(SDT)can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven ***,we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting,which constituted a nano sonosensitizer(T-cRGD NPs)for fluorescence imaging-guided sonodynamic therapy.A comparable sonosensitizer(T-PEG NPs)without the targeting unit was also prepared for illustration of therapeutic *** to the role of peptide targeting,T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in *** imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.

关键词： Sonodynamic therapy Glioma Cyclic peptide Target enrichment Deep penetration

A Review of FPGA-Based Custom Computing Architecture for Convolutional Neural Network Inference

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Chinese Journal of Electronics 2021年第1期30卷 1-17页

作者： peng Xiyuan yu Jinxiang YAO Bowen LIU Liansheng peng yu School of Electronics and Information Engineering Harbin Institute of Technology

Convolutional neural network(CNN)has been widely adopted in many tasks. Its inference process is usually applied on edge devices where the computing resources and power consumption are *** present, the performance of general processors cannot meet the requirement for CNN models with high computation complexity and large number of parameters. Field-programmable gate array(FPGA)-based custom computing architecture is a promising solution to further enhance the CNN inference *** software/hardware co-design can effectively reduce the computing overhead, and improve the inference performance while ensuring accuracy. In this paper, the mainstream methods of CNN structure design, hardwareoriented model compression and FPGA-based custom architecture design are summarized, and the improvement of CNN inference performance is demonstrated through an example. Challenges and possible research directions in the future are concluded to foster research efforts in this domain.

关键词： inference mechanisms computing resources hardware-oriented model compression CNN structure design computing overhead convolutional neural nets electronic engineering computing field-programmable gate array-based custom computing architecture computation complexity FPGA-based custom computing architecture design computational complexity convolutional neural network inference CNN inference performance power consumption field programmable gate arrays

Flare Forecast Model Based on DS-SMOTE and SVM with Optimized Regular Term

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Research in Astronomy and Astrophysics 2023年第6期23卷 38-46页

作者： Jie Wan Jun-Feng Fu ren-Qing Wen Ke Han Meng-Yao yu peng E School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China Laboratory for Space Environment and Physical Sciences Harbin Institute of TechnologyHarbin 150001China School of Computer and Information Engineering Harbin University of CommerceHarbin 150028China

The research of flare forecast based on the machine learning algorithm is an important content of space *** order to improve the reliability of the data-driven model and weaken the impact of imbalanced data set on its forecast performance,we proposes a resampling method suitable for flare forecasting and a Particle Swarm Optimization(PSO)-based Support Vector Machine(SVM)regular term optimization *** the problem of intra-class imbalance and inter-class imbalance in flare samples,we adopt the density clustering method combined with the Synthetic Minority Over-sampling Technique(SMOTE)oversampling method,and performs the interpolation operation based on Euclidean distance on the basis of analyzing the clustering space in the minority *** the same time,for the problem that the objective function used for strong classification in SVM cannot adapt to the sample noise,In this research,on the basis of adding regularization parameters,the PSO algorithm is used to optimize the hyperparameters,which can maximize the performance of the ***,through a comprehensive comparison test,it is proved that the method designed can be well applied to the flare forecast problem,and the effectiveness of the method is proved.

关键词： Sun:flares Sun:magnetic fields Sun:X-rays gamma-rays (Sun:)sunspots

Recent Advances of Bismuth Oxychloride Photocatalytic Material: Property, Preparation, and Performance Enhancement

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Journal of Electronic Science and Technology 2020年第2期18卷 119-137页

作者： Wen-Wen Liu ren-Fu peng College of Physical Science and Engineering Yichun UniversityYichun 336000

Due to its unique layered structure, bismuth oxychloride(BiOCl) has potential applications as a photocatalytic material in clean energy utilization and environmental purification. In recent years, researchers have carried out a lot of studies and made important progress for the preparation and performance enhancement of *** this review, the charge separation property of BiOCl was analyzed based on the crystal structure and electronic structure. Subsequently, the common preparation method of BiOCl was expounded, and the growth mechanism of BiOCl was introduced. Furthermore, the strategies for modulating the photocatalytic performance of BiOCl via doping, vacancy creation, internal electric field tuning, co-catalysts modification, composites construction, and using sensitizers were summarized. Finally, in view of the current research status of the BiOCl photocatalytic material, some problems still need to be addressed including exploring the method of controlled synthesis of BiOCl exposed other high energy surfaces, developing advanced characterization methods to clarify the detailed transfer path of the photogenerated charge, and expanding the photocatalytic application range of BiOCl.

关键词： structure. summarized vacancy

A Weighted Flow related to a Trudinger–Moser Functional on Closed Riemann Surface

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2244-2262页

作者： peng Xiu yu School of Mathematics Renmin University of ChinaBeijing 100872P.R.China

In this paper,with(Σ,g)being a closed Riemann surface,we analyze the possible concentration behavior of a heat flow related to the Trudinger–Moser *** obtain a long time existence for the *** along some sequence of times t_(k)→+∞,we can deduce the convergence of the flow in H2(Σ).Furthermore,the limit function is a critical point of the Trudinger–Moser functional under certain constraint.

关键词： Trudinger-Moser inequality global convergence heat flow

Prediction of vertical PM2.5 concentrations alongside an elevated expressway by using the neural network hybrid model and generalized additive model

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Frontiers of Earth Science 2017年第2期11卷 347-360页

作者： Ya GAO Zhanyong WANG Qing-Chang LU Chao LIU Zhong-ren peng yue yu Center for ITS and UAV Applications Research State Key Laboratory of Ocean Engineering School of Naval Architecture Ocean and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Urban and Regional Planning University of Florida FL 32611-5706 USA Department of Electrical and Systems Engineering University of Pennsylvania PA 19104-6314 USA

A study on vertical variation of PM2.5 concentrations was carried out in this paper. Field measurements were conducted at eight different floor heights outside a building alongside a typical elevated expressway in downtown Shanghai, China. Results show that PM2.5 concentration decreases significantly with the increase of height from the 3rd to 7th floor or the 8th to 15th floor, and increases suddenly from the 7th to 8th floor which is the same height as the elevated expressway. A non-parametric test indicates that the data of PM2.5 concentration is statistically different under the 7th floor and above the 8th floor at the 5% significance level. To investigate the relationships between PM2.5 concentration and influencing factors, the Pearson correlation analysis was performed and the results indicate that both traffic and meteorological factors have crucial impacts on the variation of PM2.5 concentration, but there is a rather large variation in correlation coefficients under the 7th floor and above the 8th floor. Furthermore, the back propagation neural network based on principal component analysis （PCA-BPNN）, as well as generalized additive model （GAM）, was applied to predict the vertical PM2.5 concentration and examined with the field measurement dataset. Experimental results indicated that both models can obtain accurate predictions, while PCA-BPNN model provides more reliable and accurate predictions as it can reduce the complexity and eliminate data co-linearity. These findings reveal the vertical distribution of PM2.5 concentration and the potential of the proposed model to be applicable to predict the vertical trends of air pollution in similar situations.

关键词： vertical variations principal component ana-lysis back propagation neural network generalized additivemodel urban elevated expressway

Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2013年第15期19卷 2412-2418页

作者： peng ren Zhen-Tao yu Li Xiu Mei Wang Hua-Min Liu Department of Esophageal Cancer Tianjin Medical University Cancer Institute and Hospital and Key Laboratory of Cancer Prevention and Therapy

AIM: To assess the prognostic value of serum human relaxin 2 (H2 RLN) level in patients with esophageal squamous cell carcinoma (ESCC). METHODS: From October 1998 to September 2009, 146 patients with histopathologically confirmed ESCC were enrolled in this study. One hundred patients underwent en bloc esophagectomy, and 46 patients with unresectable tumors underwent palliative surgery. Five of the 146 patients died of surgical complications. Serum levels of H2 RLN were measured by enzyme linked immunosorbent assay. The relationship between serum H2 RLN level and each of the clinicopathological parameters was analyzed using the χ2 test. Patients were classified into two groups according to their H2 RLN level (rence between groups A and B in each clinicopathological category was determined by the Student's t test (two-tailed) or analysis of variance. Survival curves were plotted using the Kaplan-Meier method. The statistical difference in survival between the different groups was compared using the log-rank test. Survival correlation with the prognostic factors was further investigated by multivariate analysis using the Cox proportional hazards model with backward stepwise likelihood ratio. RESULTS: ESCC patients tended to have significantly higher serum H2 RLN concentrations (0.48 ± 0.17 ng/ mL, n=141) compared with the healthy control group (0.342 ± 0.12 ng/mL, n=112). There was a significant difference between patients with lymph node involvement (0.74 ± 0.15 ng/mL, n=90), distant metastasis (0.90 ± 0.19 ng/mL, n=32) and those without lymph node involvement (0.45 ± 0.12 ng/mL, n=51), and distant metastasis (0.43 ± 0.14 ng/mL, n=109), respectively (P < 0.01). Patients with high H2 RLN levels (≥ 0.462 ng/mL) had a poorer prognosis than patients with low serum H2 RLN levels (< 0.462 ng/mL; P=0.0056). The H2 RLN level was also correl

关键词： Esophageal squamous cell carcinoma Re- laxin Tumor markers Metastasis

Two-step method for creating a gastric tube during laparoscopic-thoracoscopic Ivor-Lewis esophagectomy

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World Journal of Gastroenterology 2017年第45期23卷 8035-8043页

作者： yu liu ji-jia li peng zu hong-xu liu zhan-wu yu yi ren Department of Thoracic Surgery Cancer Hospital of China Medical University/Liaoning Cancer Hospital and Institute

AIM To introduce a two-step method for creating a gastric tube during laparoscopic-thoracoscopic Ivor-Lewis esophagectomy and assess its clinical *** One hundred and twenty-two patients with middle or lower esophageal cancer who underwent laparoscopicthoracoscopic Ivor-Lewis esophagectomy at Liaoning Cancer Hospital and Institute from March 2014 to March 2016 were included in this study,and divided into two groups based on the procedure used for creating a gastric tube. One group used a two-step method for creating a gastric tube,and the other group used the conventional method. The two groups were compared regarding the operating time,surgical complications,and number of stapler cartridges *** The mean operating time was significantly shorter in the two-step method group than in the conventional method group [238(179-293) min vs 272(189-347) min,P rence in the rate of complications [14(21.9%) vs 13(22.4%),P= 0.55] or mean number of stapler cartridges used [5(4-6) vs 5.2(5-6),P = 0.007] between the two *** The two-step method for creating a gastric tube during laparoscopic-thoracoscopic Ivor-Lewis esophagectomy has the advantages of simple operation,minimal damage to the tubular stomach,and reduced use of stapler cartridges.

关键词： Minimally invasive srugery Gastric tube Ivor-Lewis esophagectomy