检索结果-南通市图书馆

Fgl2对小鼠急性肾损伤中巨噬细胞极化的作用

在线全文

学校读者我要写书评

暂无评论

陆军军医大学学报 2024年第13期46卷 1467-1476页

作者：朱琳许桂莲谢攀彭侃夫陆军军医大学(第三军医大学)第一附属医院肾内科重庆400038 陆军军医大学(第三军医大学)基础医学院免疫学教研室重庆400038

目的探讨纤维蛋白原样蛋白2(fibrinogen-like protein2,Fgl2)对顺铂诱导的急性肾损伤(cisplatin-induced acute kidney injury,Cis-AKI)中巨噬细胞极化的作用。方法选取24只8~10周龄(体质量20~25 g)的雄性野生型(Fgl2^(+/+))小鼠和Fgl2基因敲除(Fgl2^(-/-))小鼠各12只。单次腹腔注射生理盐水(saline)或顺铂(cisplatin,Cis)处理3 d,按随机数字表法分成4组(n=6):Fgl2^(+/+)Saline组、Fgl2^(+/+)Cis组、Fgl2^(-/-)Saline组和Fgl2^(-/-)Cis组。3 d后,检测肾功能相关指标血肌酐(serum creatinine,Scr)、尿素氮(blood urea nitrogen,BUN)的水平,HE染色评估肾损伤程度;Western blot检测肾组织中Fgl2和肾损伤分子1(kidney injury molecule 1,Kim-1)的表达;RT-qPCR检测Fgl2、Kim-1、中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、IL-6、IL-12p40、IL-1β、诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、TNF-α的表达;免疫组化检测肾脏Fgl2和巨噬细胞(F4/80^(+))的表达;免疫荧光检测肾组织中巨噬细胞(F4/80^(+))和M1型巨噬细胞(F4/80^(+)CD86^(+))的表达;流式细胞术检测肾组织中巨噬细胞(F4/80^(+))及M1型巨噬细胞(F4/80^(+)MHCⅡ+)、M2型巨噬细胞(F4/80^(+)CD206^(+))的表达。结果与Fgl2^(+/+)Saline组比较,Fgl2^(+/+)Cis组小鼠肾功能显著下降(P<0.05),肾小管损伤病理评分显著升高(P<0.05),肾组织Fgl2表达显著上调(P<0.05);与Fgl2^(+/+)Cis组相比,Fgl2^(-/-)Cis组小鼠肾功能显著下降(P<0.05),肾损伤相关分子Kim-1、NGAL表达显著升高(P<0.05),肾小管损伤病理评分显著升高(P<0.05),巨噬细胞浸润显著增加(P<0.05),M1型巨噬细胞相关分子IL-6、IL-1β、TNF-α和iNOS表达显著上升(P<0.05),流式细胞术结果显示M1型巨噬细胞百分比显著升高(P<0.05),M2型巨噬细胞百分比无明显变化,且M1型占比显著高于M2型(P<0.05)。结论Fgl2基因敲除可通过促进巨噬细胞向M1型转化加重Cis-AKI。

关键词：顺铂急性肾损伤纤维蛋白原样蛋白2 巨噬细胞

中空碳双面修饰的隔膜在高性能锂硫电池中的应用

在线全文

学校读者我要写书评

暂无评论

无机化学学报 2024年第6期40卷 1218-1232页

作者：张渝赵芳芳潘聪王鹏魏良明嘉兴南湖学院新材料工程学院嘉兴314001 上海交通大学电子信息与电气工程学院微纳电子系上海200240 嘉兴大学数据科学学院嘉兴314001 嘉兴大学生物与化学工程学院嘉兴314001

为减少多硫化锂(LIPs)“穿梭效应”及锂枝晶对锂硫电池的影响,采用刮涂法制备中空碳材料修饰隔膜。接触角测试表明修饰隔膜对LIPs具有更强的吸引力,其对LIPs“穿梭”的有效抑制也可以通过渗透性实验进一步得到印证。在隔膜的正极对称电... 详细信息

为减少多硫化锂(LIPs)“穿梭效应”及锂枝晶对锂硫电池的影响,采用刮涂法制备中空碳材料修饰隔膜。接触角测试表明修饰隔膜对LIPs具有更强的吸引力,其对LIPs“穿梭”的有效抑制也可以通过渗透性实验进一步得到印证。在隔膜的正极对称电池测试中,电流响应显示中空碳材料的催化使LIPs快速转化为Li2S。通过隔膜的负极对称电池测试发现修饰隔膜呈现出更稳定的电压-时间曲线。为证明隔膜修饰对锂硫电池性能改进的效果,分别采用聚丙烯(PP)隔膜、单面改性和双面改性的PP隔膜组装成纽扣电池并进行电化学测试,其中电极材料的硫负载量为1.8~2.0 mg·cm^(-2)。GITT(恒电流间歇滴定法)测试和锂离子扩散系数计算表明,改性隔膜的离子传输更快且阻抗较小。通过分析第1、5、10、50及100次的充放电循环阻抗谱图发现,中空碳材料的多通道能够为锂离子的传输提供更多的通道,因此能够使锂离子具有更加稳定的扩散行为。在电流密度为0.2C时,由双面改性隔膜组装的锂硫电池在首次充放电时有1035 mAh·g^(-1)的可逆比容量,700圈后仍有500 mAh·g^(-1)的高比容量,并在高硫负载时表现出500 mAh·g^(-1)的可逆比容量。双面修饰隔膜赋予了锂硫电池优异的电化学性能,这是由于中空碳材料的修饰加速了LIPs的转化和吸附,有效缓解了LIPs的穿梭效应,且对锂枝晶有很好的抑制作用,提高了锂硫电池的安全性。

关键词：锂硫电池多孔碳多硫化物隔膜修饰

pan-genome analysis reveals a highly plastic genome and extensive secreted protein polymorphism in Puccinia striformis ***

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第5期51卷 574-577页

作者： Jierong Wang Yuxi peng Yiwen Xu Zhiru Li Gangming Zhan Zhensheng Kang Jing Zhao College of Plant Protection Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYanglingShaanxi 712100China College of Life Science Northwest A&F UniversityYanglingShaanxi 712100China

The obligate biotrophic basidiomycete fungus Puccinia striformis ***(Pst)is the causative agent of wheat stripe(yellow)rust,a disease that results in severe damage to global wheat production(Chen and Kang,2017).This pathogen has a mixed reproductive mode encompassing both asexual and sexual *** asexual stage is accomplished by reinfecting wheat with urediniospores,while the sexual cycle involves five different spore types and two phylogenetically unrelated plant hosts wheat,which is the primary host,and barberry,which is the alternate host(Zhao et al.,2016).This extremely complex lifecycle facilitates large genetic variation among Pst populations,which is conducive to the emergence of new virulent races that can overcome wheat resistance genes,resulting in epidemics(Chen and Kang,2017).Secreted effector proteins,the key virulence factors in fungal pathogens,can not only suppress plant immune systems but also trigger host immune responses following recognition by plant receptors(Toruno et al.,2016).

关键词： Puccinia overcome wheat

Structure,ferroelectric,and enhanced fatigue properties of sol–gel-processed new Bi-based perovskite thin films of Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第5期33卷 608-615页

作者：宋伟宾席国强潘昭刘锦叶旭斌刘哲宏王潇单鹏飞张林兴鲁年鹏樊龙龙秦晓梅龙有文 Department of Physics Shanghai Normal UniversityShanghai 200234China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Advanced Materials Technology University of Science and Technology BeijingBeijing 100083China Songshan Lake Materials Laboratory Dongguan 523808China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Bi-based perovskite ferroelectric thin films have wide applications in electronic devices due to their excellent ferroelectric *** Bi-based perovskite thin films Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)(BCT–PT) are deposited on Pt(111)/Ti/SiO_(2)/Si substrates in the present study by the traditional sol–gel *** structures and related ferroelectric and fatigue characteristics are studied *** BCT–PT thin films exhibit good crystallization within the phase-pure perovskite structure,besides,they have a predominant(100) orientation together with a dense and homogeneous *** remnant polarization(2P_(r)) values at 30 μC/cm^(2) and 16 μC/cm^(2) are observed in 0.1BCT–0.9PT and 0.2BCT–0.8PT thin films,*** intriguingly,although the polarization values are not so high,0.2BCT–0.8PT thin films show outstanding polarization fatigue properties,with a high switchable polarization of 93.6% of the starting values after 10^(8) cycles,indicating promising applications in ferroelectric memories.

关键词： ferroelectric thin films perovskite PbTiO_(3)-BiMeO_(3)

在线全文

学校读者我要写书评

暂无评论

神经辐射场加速算法综述

图学学报 2024年第1期45卷 1-13页

作者：王稚儒常远鲁鹏潘成伟北京航空航天大学人工智能研究院北京100191 中国电信股份有限公司研究院北京102209 北京邮电大学人工智能学院北京100876

近年来,神经辐射场(NeRF)已成为计算机图形学和计算机视觉领域中一个重要的研究方向,因其高逼真的视觉合成效果,在真实感渲染、虚拟现实、人体建模、城市地图等领域得到了广泛的应用。NeRF利用神经网络从输入图片集中学习三维场景的隐... 详细信息

近年来,神经辐射场(NeRF)已成为计算机图形学和计算机视觉领域中一个重要的研究方向,因其高逼真的视觉合成效果,在真实感渲染、虚拟现实、人体建模、城市地图等领域得到了广泛的应用。NeRF利用神经网络从输入图片集中学习三维场景的隐式表征,并合成高逼真的新视角图像。然而原始NeRF模型的训练和推理速度都很慢,难以在真实环境下部署与应用。针对NeRF的加速问题,研究者们从场景建模方法、光线采样策略等方面展开对NeRF进行提速的研究。该类工作大致可分为以下研究方向:烘焙模型、与离散表示方法结合、提高采样效率、利用哈希编码降低MLP网络复杂度、引入场景泛化性、引入深度监督信息和分解方法。通过介绍NeRF模型提出的背景,对上述思路的代表方法的优势与特点进行了讨论和分析,最后总结了NeRF相关工作在加速方面所取得的进展和对于未来的展望。

关键词：神经辐射场视点合成神经渲染 NeRF加速深度学习

在线全文

学校读者我要写书评

暂无评论

阿拉尔耕地沙土与65Mn摩擦行为的研究

表面技术 2024年第7期53卷 85-95页

作者：姚强韩晓蕊郭展宏潘鹏张有强塔里木大学机械电气化工程学院新疆阿拉尔843300 新疆维吾尔自治区普通高等学校现代农业工程重点实验室新疆阿拉尔843300

目的探究阿拉尔耕地沙土与65Mn的摩擦学行为,为高速犁结构设计、优化和材料选择提供理论基础。方法采用摩擦磨损试验机,选择土壤含水率、平均粒径、载荷、转速和摩擦时间等5个参数进行单因素多水平试验,研究沙土对65Mn的摩擦行为,并对... 详细信息

目的探究阿拉尔耕地沙土与65Mn的摩擦学行为,为高速犁结构设计、优化和材料选择提供理论基础。方法采用摩擦磨损试验机,选择土壤含水率、平均粒径、载荷、转速和摩擦时间等5个参数进行单因素多水平试验,研究沙土对65Mn的摩擦行为,并对各因素水平下金属磨损形貌进行分析。结果随着含水率的增加,土壤黏附力和润滑水膜的厚度增大,摩擦因数减小,磨损量呈二阶抛物线规律;随着平均粒径的增加,微观接触面积减小,摩擦因数、磨损量与粒径呈负相关;随着载荷的增加,磨料挤压嵌入金属表面,使得微观切削量增加,摩擦因数呈小幅上升趋势,磨损量呈大幅上升趋势;随着转速的增加,摩擦因数、磨损量变化较缓和;随着摩擦时间的增加,因热量的累积,摩擦因数和磨损量呈上升趋势,土壤与金属的摩擦逐渐演变为土壤之间的摩擦。分析磨损形貌发现,65Mn金属磨损表面始终伴随着磨料磨损造成的犁沟、疲劳和剥落,还发现了腐蚀磨损造成的裂纹,表面金属材料被腐蚀成金属盐结晶体,2种形式的磨损交互影响,加剧了65Mn的磨损。结论方差分析表明,与土壤含水率、载荷、转速相比,平均粒径和摩擦时间对沙土与65Mn的摩擦因数的影响较大,平均粒径对65Mn的磨损的影响最大。

关键词：沙土 65Mn 摩擦因数磨料磨损单因素方差分析

Non-invasive estimation of pulmonary hypertension and clinical deterioration risk in pediatric congenital heart disease:Development and validation of predictive tools

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第11期137卷 1384-1386页

作者： Ting Wang Dansha Zhou Yuqin Chen Suhua Kuang Yue Xing Qijian Yi Zhengxia pan Weibin Xu Jiao Rao Yunqi Liu Guoliang Lu Ziying Lin xiang Li Yi Xie Yulong Wu peng An Xiaoxiao Deng Jiayue He Jiayi Xie Chenxi Li Gang Geng Daiyin Tian Enmei Liu Jingsi Huang Zhou Fu Jian Wang Department of Respiratory Chongqing Higher Institution Engineering Research Center of Children’s Medical Big Data Intelligent ApplicationNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China State Key Laboratory of Respiratory Diseases National Center for Respiratory MedicineGuangdong Key Laboratory of Vascular DiseasesNational Clinical Research Center for Respiratory DiseasesGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiac Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Cardiovascular Medicine Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Thoracic and Cardiac Surgery Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Cardiac Center of Guangdong Women and Children Hospital Guangzhou GuangzhouGuangdong 511400China Department of Guangzhou Laboratory Guangzhou International Bio IslandGuangzhouGuangdong 510005China

To the Editor:Owing to the heterogeneity of congenital heart disease-associated pulmonary hypertension(CHDPH)disease and the development of the pulmonary vascular system in pediatric patients,the management of CHD-PH in children is signicantly different from that in adults.[1]Early identication and intervention of CHD-PH are of great signicance for disease management in children with CHD,and non-invasive,accurate clinical tools are urgently needed to predict PH risk in children with ***,the applicability of the current risk-scoring system to pediatric CHD-PH remains ***,there are presently no user-friendly,non-invasive online tools available for predicting CHD-PH,and there is a scarcity of related studies in Asian *** study aimed to develop and validate the prediction tools for estimating the risk of pulmonary hypertension and clinical deterioration in children with congenital heart disease.

关键词： pediatric congenital hypertension

Modeling the performance of perovskite solar cells with inserting porous insulating alumina nanoplates

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第3期33卷 668-671页

作者：潘赵耀杨金彭沈小双 College of Physical Science and Technology Yangzhou UniversityYangzhou 225009China

peng et al.[Science 379683(2023)]reported an effective method to improve the performance of perovskite solar cells by using thicker porous insulator contact(PIC)-alumina *** method overcomes the trade-off between the open-circuit voltage and the fill factor through two mechanisms:reduced surface recombination velocity and increased bulk recombination lifetime due to better perovskite *** arguments of drift-diffusion simulations,we find that an increase in mobility and carrier recombination lifetime in bulk are the key factors for minimizing the resistance-effect from thicker PICs and achieving a maximum power conversion efficiency(PCE)at approximately 25%reduced contact ***,the partially replacement of perovskite films with thicker PICs would result in a reduction in short-current density,but the relative low refractive index of the PICs imbedded into the high refractive index perovskite creates light trapping structures that compensate for this loss.

关键词： perovskite solar cells nanostructure crystalline mobility

基于WRF模拟的中国西北河谷城市夏季的大气边界层特征

在线全文

学校读者我要写书评

暂无评论

兰州大学学报（自然科学版） 2024年第5期60卷 569-576,585页

作者：王鹏波刘永乐魏永鹏潘峰兰州大学大气科学学院半干旱气候变化教育部重点实验室兰州730000

为提高河谷地形气象场的模拟效果,利用第5代再分析资料(ERA5)和全球再分析资料(FNL)作为初始场,以天水市为研究对象,驱动中尺度天气预报模式比较对西北河谷城市边界层模拟的适用性,分析西北河谷城市夏季的大气边界层特征.结果表明, ERA... 详细信息

为提高河谷地形气象场的模拟效果,利用第5代再分析资料(ERA5)和全球再分析资料(FNL)作为初始场,以天水市为研究对象,驱动中尺度天气预报模式比较对西北河谷城市边界层模拟的适用性,分析西北河谷城市夏季的大气边界层特征.结果表明, ERA5模拟的天水市主城区近地面温度、近地面风速、风向以及相对湿度与观测值的相关性更好,尤其是近地面风速和风向,分别比FNL模拟的结果提升25.4%和70.0%.天水市主城区的气象场空间分布呈明显的城市热岛效应和山谷风环流,相对开阔的麦积区城市热岛效应更强;白天发生的降水会弱化谷风环流和热岛效应,河谷内及周边风速均较小.天水市主城区夏季近地面温度与风速呈正相关,与相对湿度呈负相关,大气边界层高度呈现明显的日变化,大气层结稳定.

关键词：第5代再分析资料河谷城市大气边界层中尺度天气预报模式