The fluid resonance of a moonpool freely heaving in a beam sea is studied by an in-house constrained interpolation profile(CIP)***,the moonpool behaves as in the piston mode with a narrow *** numerical studies are car...
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The fluid resonance of a moonpool freely heaving in a beam sea is studied by an in-house constrained interpolation profile(CIP)***,the moonpool behaves as in the piston mode with a narrow *** numerical studies are carried out for a wide range of the incident waves,and a new secondary resonant region is identified in the low frequency region of the incident waves,besides the ordinary main resonant *** results demonstrate that the horizontal wave forces are significant in the secondary resonant region,although the resonant wave elevations are less remarkable than those of the main resonant *** is concluded that the fluid resonance of the low frequency is excited mainly by the heave motion of the *** studies of the moonpool draft and the gap width of the moonpool based on the fluid resonance are also performed.
In this paper,hierarchical ultra-thin core/shell Ni_(3)S_(2)@MoS_(2)nano-arrays with Mo atomic site grown on nickel foam(Ni_(3)S_(2)@MoS_(2)-NF)were designed and synthesized through the hydrothermal *** they are teste...
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In this paper,hierarchical ultra-thin core/shell Ni_(3)S_(2)@MoS_(2)nano-arrays with Mo atomic site grown on nickel foam(Ni_(3)S_(2)@MoS_(2)-NF)were designed and synthesized through the hydrothermal *** they are tested as photoelectric catalysis electrodes to anti-bacteria,the Ni_(3)S_(2)@MoS_(2)within core/shell structure exhibits about several times higher rate capability and outstanding cycling stability than traditional *** reacting with water and oxygen,large numbers of extracellular reactive oxygen species on the surface of Ni_(3)S_(2)@MoS_(2)are *** reactive oxygen species can penetrate bacterial cells,resulting in a rapid rise of intracellular reactive oxygen species in a short *** integrity of the bacterial cell membrane is also destroyed,which can be observed in both scanning and transmission *** synthetic primer was used to specifically label the gene fragment with antibiotic resistance,which was oxidized and eliminated after the photoelectron catalysis(PEC)reaction,proving that this material for PEC antibacterial can not only kill *** elimination of antibiotic-resistance gene fragments can also be achieved.
As a promising cathode material for aqueous zinc-ion batteries,1T-MoS_(2)has been extensively investigated because of its facile two-dimensional ion-diffusion channels and high electrical ***,the limited number of ava...
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As a promising cathode material for aqueous zinc-ion batteries,1T-MoS_(2)has been extensively investigated because of its facile two-dimensional ion-diffusion channels and high electrical ***,the limited number of available Zn storage sites,i.e.,limited capacity,hinders its application because the inserted Zn^(2+),which form strong electrostatic interactions with 1T-MoS_(2),preventing subsequent Zn^(2+)***,the approach of enlarging the interlayer distance to reduce electrostatic interactions has been commonly used to enhance the capacity and reduce Zn^(2+)migration ***,an enlarged interlayer spacing can weaken the van der Waals force between 1T-MoS_(2)monolayers,easily disrupting the structural ***,to address this issue,an effective strategy based on Fe doping is proposed for 1T-MoS_(2)(Fe-1T-MoS_(2)).The theoretical calculations reveal that Fe doping can simultaneously moderate the rate of decrease in the adsorption energy after gradually increasing the number of stored atoms,and enhance the electron delocalization on metal-O ***,the experiment results show that Fe doping can simultaneously activate more Zn storage sites,thus enhancing the capacity,and stabilize the structural stability for improved cycling ***,Fe-1T-MoS_(2)exhibits a larger capacity(189 mAh·g^(-1)at 0.1 A·g^(-1))and superior cycling stability(78%capacity retention after 400 cycles at 2 A·g^(-1))than pure 1T-MoS_(2).This work may open up a new avenue for constructing high-performance MoS_(2)-based cathodes.
Gradient nano-grained structure is frequently engineered into metallic materials,including Mg alloys,to achieve superior combination of strength and ***,the influence of this microstructural feature on aging precipita...
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Gradient nano-grained structure is frequently engineered into metallic materials,including Mg alloys,to achieve superior combination of strength and ***,the influence of this microstructural feature on aging precipitation behavior remains inadequately *** this study,the age-precipitation behavior of a gradient nano-grained Mg-Gd-Ag-Zr alloy prepared via ultrasonic severe surface rolling was *** result indicates that the aging precipitation behavior exhibits a depth-dependent variation within this *** the nano-grained surface layer,hierarchicalβnano-precipitates are predominant,while at greater depths,the precipitates consist ofβnanoparticles located at grain boundaries,along with intragranularβ′andγ″*** formation ofβnano-precipitates deviates from the conventional precipitation behavior observed in Mg-Gd-Ag alloys,and is attributed to the high density of defects induced by the surface nano-grained *** finding advances our understanding of the precipitation behavior in the alloys with heterogeneous microstructure.
The recent article by Jiang et al published in World Journal of Gastroenterology reports substantial bidirectional associations between gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone ...
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The recent article by Jiang et al published in World Journal of Gastroenterology reports substantial bidirectional associations between gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD),based on multicenter cross-sectional studies and a systematic review with *** the findings have the potential to significantly impact clinical and pre-ventive strategies,several methodological issues merit closer *** letter critiques key aspects of the study,including sample population hetero-geneity,potential confounding variables,and the reliance on cross-sectional data that may limit causal *** also discuss the generalizability of these results to broader populations given the study's focus on the Chinese *** addressing these concerns,we suggest a more nuanced interpretation of the associations between GSD,NAFLD,and KSD,advocating for longitudinal studies to validate these findings and enhance their applicability in global health contexts.
Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degrada...
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Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.
Cartilage tissues possess an extremely limited capacity for self-repair,and current clinical surgical approaches for treating articular cartilage defects can only provide short-term relief. Despite significantadvances...
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Cartilage tissues possess an extremely limited capacity for self-repair,and current clinical surgical approaches for treating articular cartilage defects can only provide short-term relief. Despite significantadvances in the field of cartilage tissue engineering, avoiding secondary damage caused by invasive surgical procedures remains achallenge. In this study, injectable cartilage microtissues were developed through 3D culture of rat bone marrow mesenchymal stemcells (BMSCs) within porous gelatin microcarriers (GMs) and induceddifferentiation. These microtissues were then injected for thepurpose of treating cartilage defects in vivo, via a minimally invasiveapproach. GMs were found to be noncytotoxic and favorable for cellattachment, proliferation and migration evaluated with BMSCs. Moreover, cartilage microtissues with a considerable number of cells andabundant extracellular matrix components were obtained from BMSC-laden GMs after induction differentiation culture for 28days. Notably,ATDC5 cells were complementally tested to verify that the GMs were conducive to cell attachment, proliferation, migration and chondrogenicdifferentiation. The microtissues obtained from BMSC-laden GMs were then injected into articular cartilage defect areas in rats and achievedsuperior performance in alleviating inflammation and repairing cartilage. These findings suggest that the use of injectable cartilagemicrotissues in this study may hold promise for enhancing the long-term outcomes of cartilage defect treatments while minimizing the risk ofsecondary damage associated with traditional surgical techniques.
Sunscreen agents derived from plants have been regarded as promising alternatives to artificial *** this work,carbon dots(CDs)were prepared from carrot juice via a continuous microflowbased approach,where the influenc...
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Sunscreen agents derived from plants have been regarded as promising alternatives to artificial *** this work,carbon dots(CDs)were prepared from carrot juice via a continuous microflowbased approach,where the influence of process parameters was studied and *** characterization revealed the CDs not only have small size,narrow size distribution,and good water solubility,but also have abundant functional groups as well as excellent UV absorption *** on these properties,the CDs were used as UV absorbers,suggesting they have strong long-term UV absorption ability over a broad pH *** UV-absorption properties of the CDs were confirmed by incorporating the CDs in polyvinyl alcohol(PVA)to get C-CDs@PVA films of different thickness,in which significantly enhanced UV absorption performance was ***,the sun protection performance is also related to the film ***,the practical application of the CDs was evaluated by adding them in a typical skin *** the addition of the CDs,the cream has drastically reduced UV transmittance in both UVA and UVB regions,and exhibits better UV absorption performance than commercial sunscreen *** CDs also demonstrated low cytotoxicity and high DPPH radical scavenging activity,making them promising as green sunscreen *** work is expected to provide a guidance for the development of green and effective natural sunscreen agents via microflowbased method.
The bridgmanite(Bgm)to silicate post-perovskite(PPv)phase transition is believed to be the main cause for the distinct seismic features observed in the D''layer,the lowermost region of the Earth’s ***,the transition ...
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The bridgmanite(Bgm)to silicate post-perovskite(PPv)phase transition is believed to be the main cause for the distinct seismic features observed in the D''layer,the lowermost region of the Earth’s ***,the transition depth and elasticity of the PPv phase have been highly debated,as the chemical complexity within the D''layer can largely affect the Bgm-PPv transition pressure and the associated velocity *** measurements of sound velocities for PPv with different chemical compositions under relevant lowermost-mantle conditions are essential but remain *** this study,we have reliably measured both compressional wave velocity(VP),shear wave velocity(V_(S)),and density,for two Fe-bearing PPv compositions[(Mg_(0.85)Fe_(0.15))SiO_(3)and(Mg0.75Fe0.25)SiO_(3)]at lowermost mantle pressures using Impulsive Stimulated Light Scattering(ISS),Brillouin Light Scattering(BLS),and X-ray Diffraction(XRD)in diamond anvil *** results indicate that the velocities of Fe-bearing PPv at 120 GPa can be described by the following relationships:V_(S)(km/s)=7.65-2.8XFe and VP(km/s)=14.11-3.8XFe,where XFe represents mole fraction of the Fe *** variations in the Fe content of PPv may provide one of the explanations for the seismic lateral variations observed at the Earth’s core mantle *** comparing our results with the high-pressure velocities of Bgm,our velocity model suggests significant discontinuities across the Bgm-PPv transition,characterized by a reduction in both VP and VΦ,and an increase in V_(S).These findings highlight the importance of considering the influence of chemical composition,particularly Fe content which could vary significantly at the D''region,on the seismic properties of the PPv *** observed velocity contrasts across the Bgm-PPv transition may contribute to the complex seismic signatures observed in the D''layer,underscoring the potential role of this phase transition in interpreting the seismic features of th
Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability an...
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Gold nanoparticles have recently been exploited as versatile nanocarriers in diagnostic and therapeutic drug delivery for cancer nanomedicine, owing to their biocompatibility, low biotoxicity, surface modifiability and plasma optical properties. A variety of gold nanoparticles have emerged for drug delivery, mainly including gold nanorods, gold nanocages, gold nanostars, gold solid nanospheres and hollow gold nanospheres (HGNs). Among these, HGNs have widely been studied for their higher photothermal conversion efficiency, wider spectral absorption range and stronger surface-enhanced Raman scattering compared with solid gold nanospheres. Therefore, nowadays, researchers prefer to use HGNs to other metal nanocarriers, which can not only play the role of controlled-release drugs but also act as photothermal agents for tumor therapy and diagnosis, due to their properties of surface modification. Combined with the Au–S bond on the surface of HGNs, the targeted preparation is loaded to achieve precise drug delivery. With the assistance of the photothermal characteristics of HGNs themselves, the efficacy of loaded drugs in HGNs is enhanced. In addition, HGNs also have vital values in the field of bioimaging, which serve as photothermal imaging agents and Raman scattering-guided preparations due to their surface-enhanced Raman scattering properties to assist researchers in achieving the purpose of tumor diagnosis. In this review, we summarize the synthesis methods of HGNs and the recent application of HGNs-based nanomaterials in the field of cancer diagnosis and therapy. In addition, the issues to be addressed were pointed out for a bright prospect of HGNs-based nanomaterials.
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