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Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities

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Military Medical Research 2024年第4期11卷 469-478页

作者： Fu-lin Wang Wan-Zhou Wang fei-fei Zhang Su-Yuan peng Huai-Yu Wang Rui Chen Jin-Wei Wang peng-fei li Yang Wang Ming-Hui Zhao Chao Yang Lu-Xia Zhang Institute of Medical Technology Peking University Health Science CenterBeijing 100191China National Institute of Health Data Science at Peking University Beijing 100191China Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China Advanced Institute of Information Technology Peking UniversityHangzhou 311215China National Climate Center China Meteorological AdministrationBeijing 100081China Peking-Tsinghua Center for life Sciences Beijing 100034China

Background:Climate change profoundly shapes the population health at the global ***,there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease(CKD).Methods:In the present study,we studied the association of heat exposure with hospitalizations for cause-specific CKD using a national inpatient database in China during the study period of hot season from 2015 to *** time-series regression models and random-effects Meta-analysis were developed to estimate the city-specific and national averaged associations at a 7 lag-day span,***:A total of 768,129 hospitalizations for CKD was recorded during the study *** results showed that higher temperature was associated with elevated risk of hospitalizations for CKD,especially in sub-tropical *** a 1℃ increase in daily mean temperature,the cumulative relative risks(RR)over lag 0-7 d were 1.008[95% confidence interval(CI)1.003-1.012]for *** attributable fraction of CKD hospitalizations due to high temperatures was 5.50%.Stronger associations were observed among younger patients and those with obstructive *** study also found that exposure to heatwaves was associated with added risk of hospitalizations for CKD compared to non-heatwave days(RR=1.116,95%CI 1.069-1.166)above the effect of daily mean ***:Short-term heat exposure may increase the risk of hospitalization for *** findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures.

关键词： Chronic kidney disease Hospitalization Climate change Temperature Time-series study

A comparison of the effect of alendronate and You-Gui-Wan on osteoporosis in female rats with kidney-yang deficiency

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Traditional Medicine Research 2024年第6期9卷 31-41页

作者： Mei-Mei Wu Xing-peng He Wan-Ting Wu Wen-Jie Lu Yan-Yang Mai Kun-Cai Xu Yao-Feng Zhi Hai-Xin Mo Jia-Di He Xin Zhang peng-fei li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-Wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an EliSA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-Wan alendronate

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电化学脱卤氘化研究进展

电化学（中英文） 2024年第5期30卷 1-10页

作者：李鹏飞寇广生亓丽萍仇友爱南开大学化学院元素有机化学国家重点实验室天津300071

近年来,含有氘原子的化合物在包括材料和生物医药在内的各个领域中的重要性日益增加,被广泛应用于化学和生物学的机制研究中,将氘原子引入有机化合物已经成为药物分子发展的重要方向之一。同时,在非生物活性物质的活体内氚标记的化合物... 详细信息

近年来,含有氘原子的化合物在包括材料和生物医药在内的各个领域中的重要性日益增加,被广泛应用于化学和生物学的机制研究中,将氘原子引入有机化合物已经成为药物分子发展的重要方向之一。同时,在非生物活性物质的活体内氚标记的化合物也发挥了重要作用。自美国食品药品监督管理局(FDA)批准的第一种用于临床治疗的氘化药物问世以来,氘标记的化合物就迅速成为人们关注的焦点,各种有机化合物的氘化方法被广泛开发。其中,卤化物的还原氘化具有高选择性的优势,但是大部分反应策略受到氘源和催化模式的限制。有机电合成作为一种相对绿色的催化模式以及其对氧化还原反应的广泛适应性,电化学卤化物的还原氘化成为替代传统卤-氘原子交换的重要方法之一,它避免了传统方法中过渡金属催化剂、金属试剂及昂贵氘代试剂的使用。近年来卤化物的电化学脱卤氘化得到很快的的发展,电化学脱卤氘化通常仅需要重水作为最廉价易得的氘源就能高效得到高氘代掺入率的产物,这为氘代化合物的合成与发展提供了重要的支撑。本文根据卤化物的类型,综述了电化学条件下芳基卤化物和烷基卤化物还原氘化的最新进展以及其反应机制,有望为未来更为广泛的氘代方法研究以及氘代化合物的研究提供一定的基础.

关键词：电化学氘化卤化物氘水脱卤反应

Numerical research on adverse effect of muzzle flow formed by muzzle brake considering secondary combustion

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Defence Technology（防务技术） 2021年第4期17卷 1178-1189页

作者： peng-fei li Xiao-bing Zhang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing210094PR China

The simulation of the artillery interior and intermediate ballistics problem is performed to investigate the influence of a gas dynamics device,muzzle brake,on the muzzle hazard phenomena,such as flash and blast *** correlation of the chemical reactions with the characteristics of the muzzle flow field is analyzed by the simulation for a further understanding of the secondary combustion phenomenon of the muzzle *** novel structure of muzzle flow caused by the muzzle brake is presented by the simultaneous solution of the interior ballistics model and multi-species Navier-Stokes equations in order to analyze the influence of the muzzle brake structure on the chemical *** secondary combustion of the muzzle flow due to the oxygen-supplement chemical reactions is obtained by the chemical reaction kinetic *** interaction of the blast waves released from the muzzle brake is illustrated in detail and the mechanism of the formation of muzzle flash is *** research provides a reference for the studies on the suppression of the muzzle flash.

关键词： Muzzle flow Muzzle brake Secondary combustion Chemical reaction

Analytical solutions to ground settlement induced by ground loss and construction loadings during curved shield tunneling

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第4期22卷 296-313页

作者： Shao-hua li Ming-ju ZHANG peng-fei li Key Laboratory of Urban Security and Disaster Engineering of the Ministry of Education Beijing University of TechnologyBeijing 100124China China Railway 15th Bureau Group Co. Ltd.Shanghai 200070China

This paper focuses on the ground settlement induced by the construction of a curved shield *** loss and construction loadings are the two factors causing ground settlement,and two corresponding analytical models were ***,the ground settlement due to ground loss was analyzed based on 3D image ***"integrative gap at shield tail"(IGST)and overcutting gap of a curved tunnel were ***,the ground settlement due to construction loadings was analyzed by modifying Mindlin's *** additional thrust,frictional force,and grouting pressure were ***,a case study and a parameter analysis were ***,the obtained solutions were compared with a classical analytical solution,numerical simulations,and monitored *** proposed model could effectively predict the ground settlement in-duced during curved shield tunneling.

关键词： Curved tunnel Image theory Mindlin's solution Ground loss Ground settlement

Breathers and solitons for the coupled nonlinear Schrodinger system in three-spine α-helical protein

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Chinese Physics B 2021年第10期30卷 231-238页

作者： Xiao-Min Wang peng-fei li Department of Physics Taiyuan Normal UniversityJinzhong 030619China Institute of Computational and Applied Physics Taiyuan Normal UniversityJinzhong 030619China

We mainly investigate the variable-coefficient 3-coupled nonlinear Schrodinger(NLS)system,which describes soli- ton dynamics in the three-spineα-helical protein with inhomogeneous *** variable-coefficient NLS equation is transformed into the constant coefficient NLS equation by similarity transformation *** Hirota method is used to solve the constant coefficient NLS equation,and then we get the one-and two-breather solutions of the variable-coefficient NLS *** results show that,in the background of plane waves and periodic waves,the breather can be transformed into some forms of combined soliton *** influence of different parameters on the soliton solution and the collision between two solitons are discussed by some graphs in *** results are helpful to study the soliton dynamics inα-helical protein.

关键词： breather soliton nonlinear Schrodinger system a-helical protein

Synthesis and structures of triptycene-derived Tr?ger's base molecular clips

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Chinese Chemical Letters 2015年第7期26卷 839-842页

作者： peng-fei li Ying Han Chuan-Feng Chen Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences

A series of triptycene-derived Tr6ger＇s bases with molecular clip shaped structures have been conveniently and efficiently synthesized by one-pot condensation of corresponding amino-substituted triptycenes with paraformaldehyde in the presence of trifluoroacetic acid, and their structures have been characterized by NMR, MALDI-TOF MS spectra, elemental analyses and single-crystal X-ray diffraction. ~ 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

关键词： Triptycene Troger's base Molecular clip Synthesis

Squamous cell carcinoma of the nail bed: A case report

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World Journal of Clinical Cases 2019年第21期7卷 3590-3594页

作者： peng-fei li Ning Zhu Hui Lu Department of Plastic and Aesthetic Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Ophthalmology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Orthopedics The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Squamous cell carcinoma(SCC)of the nail bed is a poorly reported malignant subungual *** it presents with nonspecific symptoms and signs,it is frequently misdiagnosed by dermatologists or surgeons.A delay in diagnosis and/or wrong treatment might increase the possibility of disease ***,new perspectives are needed to assist dermatologists and surgeons with diagnosing and treating *** rare case presented with a 2-year delay in the diagnosis of SCC teaches a valuable *** SUMMARY A 62-year-old female presented with a non-healing subungual growth in the nail bed of the right middle finger for 2 *** lesion was first medicated with iodine by the patient herself without any *** months later,a dermatologist diagnosed the lesion as paronychia and treated it with nail avulsions repeatedly with no obvious alleviation.A lesionectomy confirmed the lesion was *** extended excision of the tumor with amputation of the distal interphalangeal joint was subsequently performed.A biopsy of sentinel lymph nodes was *** to the result of preoperative positron emission tomography-computed tomography scanning,sweeping of axillary lymph nodes was considered dispensable and was *** the 2-year follow-up,the patient showed a quick recovery and no sign of *** Our successful diagnosis and treatment of the case highlights the need for additional attention to long-standing non-healing lesions of the nail bed and the necessity for discreet evaluation and customization of surgical interventions.

关键词： Squamous cell carcinoma Nail bed lesion Customized treatment Malignant subungual tumor Case report

Crystal structure and phase transition of 2-methoxyanilinium perchlorate-18-crown-6

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Chinese Chemical Letters 2014年第5期25卷 723-726页

作者： Wei-Qiang liao Qin-Qin Zhou peng-fei li Yi Zhang Ordered Matter Science Research Center College of Chemistry and Chemical EngineeringSoutheast University

A new phase transition compound,2-methoxyanilinium perchlorate-18-crown-6（1） {（oCH3OC6H4NH3）＋（18-crown-6） ClO4 },has been synthesized and separated as *** scanning calorimetry（DSC） measurements show a pair of sharp peaks at 225 K（heating） and 210 K（cooling）,indicating the phase transition is *** anomalies observed at 225 K（heating）and 210 K（cooling） further confirm the phase *** crystal structures determined at 298 K and123 K are both triclinic in P *** most distinct difference between room-temperature and lowtemperature structures is the order–disorder transition of the host 18-crown-6 molecule,which is the driving force of the phase transition.

关键词： Phase transition Dielectric Crystal structure Host molecule