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Journal of Genetics and Genomics 2022年第3期49卷 217-229页

作者： Wei Zhang Yan Li Sijie chen Cuizhen Zhang Lili chen Gang peng State Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai 200032China Department of Endocrinology Huashan HospitalFudan UniversityShanghai 200040China

The nuclear receptor DAX-1, encoded by the NR0B1 gene, is presented in the hypothalamic tissues in humans and other vertebrates. Human patients with NR0B1 mutations often have hypothalamic-pituitary defects, but the involvement of NR0B1 in hypothalamic development and function is not well understood. Here, we report the disruption of the nr0b1 gene in zebrafish causes abnormal expression of gonadotropins, a reduction in fertilization rate, and an increase in postfasting food intake, which are indicators of abnormal hypothalamic functions. We find that loss of nr0b1 increases the number of prodynorphin(pdyn)-expressing neurons but decreases the number of pro-opiomelanocortin(pomcb)-expressing neurons in the zebrafish hypothalamic arcuate region(ARC). Further examination reveals that the proliferation of progenitor cells is reduced in the hypothalamus of nr0b1 mutant embryos accompanying the decreased expression of genes in the Notch signaling pathway. Additionally, the inhibition of Notch signaling in wildtype embryos increases the number of pdyn neurons, mimicking the nr0b1 mutant phenotype. In contrast,ectopic activation of Notch signaling in nr0b1 mutant embryos decreases the number of pdyn *** together, our results suggest that nr0b1 regulates neural progenitor proliferation and maintenance to ensure normal hypothalamic neuron development.

关键词： nr0b1 DAX-1 Hypogonadism Feeding Arcuate nucleus Neural progenitor

Comparison of the mechanisms of microwave roasting and conventional roasting and of their effects on vanadium extraction from stone coal

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 476-482页

作者： Yi-zhong Yuan Yi-min Zhang Tao Liu Tie-jun chen College of Resources and Environmental Engineering Wuhan University of Science and Technology Hubei Provincial Engineering Technology Research Center of High efficient Cleaning Utilization for Shale Vanadium Resource

Experiments comparing microwave blank roasting and conventional blank roasting for typical vanadium-bearing stone coal from Hubei Province in central China, in which vanadium is present in muscovite, were conducted to investigate the effects of roasting tempera- ture, roasting time, H2SO4 concentration, and leaching time on vanadium extraction. The results show that the vanadium leaching efficiency is 84% when the sample is roasted at 800℃ for 30 min by microwave irradiation and the H2SO4 concentration, liquid/solid ratio, leaching temperature, and leaching time are set as 20vo1%, 1.5：1 mL.g-1, 95℃, and 8 h, respectively. However, the vanadium leaching efficiency achieved for the sample subjected to conventional roasting at 900℃ for 60 min is just 71% under the same leaching conditions. Scanning electron microscopy （SEM） analysis shows that the microwave roasted samples contain more cracks and that the particles are more porous compared to the conventionally roasted samples. According to the results of X-ray diffraction （XRD） and Fourier-transform infrared （FTIR） analyses, neither of these roasting methods could completely destroy the mica lattice structure under the experimental conditions; however, both methods deformed the muscovite structure and facilitated the leaching process. Comparing with conventional roasting, microwave roasting causes a greater deformation of the mineral structure at a lower temperature for a shorter roasting time.

关键词： vanadium metallurgy extraction stone coal microwave roasting leaching vanadium oxides

EFFECT OF TESTING ENVIRONMENT ON FRACTURING BEHAVIOR OF Fe_3Si BASED ALLOY

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Acta Metallurgica Sinica(English Letters) 2003年第2期16卷 104-109页

作者： J.H.peng G.L.chen National Key Laboratory for Nuclear Fuel&Materials China Nuclear Power InstituteChengdu 610041ChinaState Key Laboratory for Advanced Metal MaterialsUniversity of Science&Technology BeijingBeijing 100083China

The mechanical behavior of Fes Si based alloy with B2 structure was studied by tension and fracture toughness test in various testing media. The fracture strength σb of Fe3Si alloy decreased in the following order: oxygen, air and hydrogen respectively. The fracture toughness in different testing environment showed that KIC in oxygen is 11.5±0.3MPa·m1/2, and is 8.6±0.4MPa·ml/2 in distilled water. The reduction of fracture toughness is contributed to the environmental reaction of Si with water. Addition of Al element in Fe3Si is not beneficial to improve the intrinsic ductility of Fe-14Si-3Al alloy. The scattering phenomenon of fracture strength was found, and explained by fracture mechanics. It was found by means of SEM that the fracture mode changed from transgranular in oxygen to intergranular in hydrogen gas and distilled water.

关键词： Fe3Si intermetallic mechanical behavior environmental em- brittlement

Burial History and Petroleum Entrapment in the Yaoyingtai Region of the Changling Fault Depression, China

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Acta Geologica Sinica(English Edition) 2017年第6期91卷 2230-2242页

作者： YANG Guang LIU Changli FAN Jiarui chen peng College of Earth Sciences Jilin University Dalian Branch China Railway No.9 group Co.Ltd. D&P Technology Research Institute Petro China Liaohe Oilfield Company

This work aims to reconstruct the burial history of various kinds of sandstones penetrated by the well YS201 in the Yaoyingtai region of the Changling Fault Depression, southern Songliao Basin, China. Analyses of fluid inclusions in the reservoir rocks, combined with a review of the regional tectonic evolution, revealed the hydrocarbon accumulation stage and accumulation age of the Early Cretaceous Denglouku group and the first member of the Quantou group reservoir, which are the future exploration focus for deep gas reservoirs in this region. Acoustic time data and sedimentary rates calculated for sediments in the YS201 well yielded thicknesses for the Yingcheng, Nenjiang, and Mingshui groups of 506, 539.18, and 144.85 m, respectively, thereby revealing the burial history of the sediments in the well. Fluid inclusions of the Denglouku group reservoir and the first member of the Quantou group reservoir contain oil inclusions and hydro-carbonaceous salt water inclusions. The main peaks of the homogenization temperature and salinity of these saltwater inclusions in the first member of the Quantou group reservoir are generally 110-120℃ and 6wt%-8wt%, respectively, and for the Denglouku group are 130-140oc and 4wt%-6wt%. The data for both reservoirs show only one main peak, indicating that they both have experienced single-stage accumulation. Combining the homogenization temperature of the reservoir fluid inclusions with the burial and thermal history of the sediments in the YS201 well, we infer that the hydrocarbon gas in these two intervals accumulated at 79 Ma （middle Late Cretaceous）.

关键词： Songliao Basin Yaoyingtai region reservoir fluid inclusion denudation thickness,accumulation stage accumulation age

Dynamically measuring the holo-information of light fields in three-dimensional space using a periodic polarization-structured light

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Science China(Physics,Mechanics & Astronomy) 2021年第6期64卷 58-65页

作者： ShuXia Qi Sheng Liu Lei Han BingYan Wei peng Li JinZhan zhong XuYue Guo JianLin Zhao Key Laboratory of Light-field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnic UniversityXi'an 710129China

Spatially structured light field has attracted great attention due to its novel properties and application potential in numerous *** them,the most striking one is the polarization-structured light,known as the vector ***,using a periodic polarization-structured light,we propose a method to dynamically measure the holo-information of light fields,including the amplitude,phase,and polarization distributions,in three-dimensional(3D)*** measurement system is composed of a Mach-Zender interferometer involving a liquid crystal polarized grating in the reference arm,which is simple,stable,and easy to *** the single-shot measurement,this method supports observing the dynamic variation of object light *** accuracy,3D polarimetry,and dynamic observation of this method are validated by measuring a calibrated quarter-wave plate,a vector vortex beam,a Poincarébeam,and a stressed polymethyl methacrylate sample.

关键词： polarization structured light measurement holography

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苏州中南中心深基坑降水工程设计与施工

工程质量 2024年第3期42卷 87-90页

作者：陈川王帅亮宗秀金师朋钟世万周全江苏中南建筑产业集团有限责任公司江苏南通226100

苏州中南中心项目周边环境复杂且保护要求高、对基坑变形控制要求严格,属于典型的大面积超深软土基坑工程,地下不同深度埋藏有一道微承压含水层及三道承压含水层,塔楼基底已进入承压含水层,并在苏州地区首次大规模抽取第11层承压水,同... 详细信息

苏州中南中心项目周边环境复杂且保护要求高、对基坑变形控制要求严格,属于典型的大面积超深软土基坑工程,地下不同深度埋藏有一道微承压含水层及三道承压含水层,塔楼基底已进入承压含水层,并在苏州地区首次大规模抽取第11层承压水,同时砂质粉土层内存在夹层滞水,整体工程降水难度大。通过相似工程经验及基坑三维渗漏计算模拟分析优化降水设计方案、现场精细化降水实施、信息化监测监控等措施,尽量减小降水对周边环境的影响,确保基坑及周边环境的安全。

关键词：深基坑软土地基夹层水承压水

低鱼粉饲料中添加酶解鱼小肽对牛蛙蝌蚪生长、变态、肝脏代谢及抗氧化能力的影响

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动物营养学报 2024年第1期36卷 478-489页

作者：徐文杰朱波蔡明浪戴济鸿钟蕾邵闯胡毅陈开健湖南农业大学水产学院长沙410128

本试验旨在低鱼粉饲料中添加酶解鱼小肽,研究其对牛蛙蝌蚪生长、变态、肝脏代谢及抗氧化能力的影响。试验挑选4800尾初始体重为0.04 g左右的牛蛙蝌蚪,随机分成5组,每组3个重复,每个重复320尾牛蛙蝌蚪,分别饲喂5种不同的等氮等脂饲料,其... 详细信息

本试验旨在低鱼粉饲料中添加酶解鱼小肽,研究其对牛蛙蝌蚪生长、变态、肝脏代谢及抗氧化能力的影响。试验挑选4800尾初始体重为0.04 g左右的牛蛙蝌蚪,随机分成5组,每组3个重复,每个重复320尾牛蛙蝌蚪,分别饲喂5种不同的等氮等脂饲料,其中以15%鱼粉饲料(FM15组)为对照,另设置2个不同鱼粉水平饲料,鱼粉水平分别为10%、5%,并在每个鱼粉水平饲料中分别添加2.5%和5.0%酶解鱼小肽,分别记为F10E2.5、F10E5、F5E2.5、F5E5组,试验投喂持续65 d。结果显示:1)与FM15组相比,低鱼粉水平饲料中添加酶解鱼小肽均能提高蝌蚪的变态率和存活率,其中F10E5组牛蛙蝌蚪变态率显著提高(P<0.05)。2)与FM15组相比,除F5E2.5组外其余3组肠道脂肪酶活性均显著提高(P<0.05)。3)与FM15组相比,饲料中添加酶解鱼小肽均能显著提高肠道超氧化物歧化酶(SOD)活性(P<0.05),此外F10E5组肠道谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性及谷胱甘肽(GSH)含量显著提高(P<0.05)。4)与FM15组比,饲料中添加酶解鱼小肽均能显著提升肠道磺基转移酶(SULT)基因相对表达量(P<0.05),此外F10E5组肠道CAT、SOD及谷胱甘肽S-转移酶(GST)基因相对表达量显著提升(P<0.05)。5)除F5E5组外,饲料中添加酶解鱼小肽均能改善肝细胞空泡化。6)与FM15组相比,饲料中添加酶解鱼小肽均能显著提高肝脏谷草转氨酶与酸性磷酸酶活性(P<0.05),此外添加5.0%酶解鱼小肽后肝脏谷丙转氨酶活性均显著提高(P<0.05)。综上所述,饲料中添加10%鱼粉和5.0%酶解鱼小肽(F10E5)能够在不影响生长的情况下,提高牛蛙蝌蚪变态率、存活率及抗氧化能力。

关键词：酶解鱼小肽牛蛙蝌蚪生长变态抗氧化

CMIA法和ELISA法诊断HBV感染准确率的对比研究

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四川生理科学杂志 2024年第3期46卷 523-525页

作者：赵晨李萌戚润鹏河南中医药大学第五临床医学院河南郑州450000 郑州人民医院检验科河南郑州450000

目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法:回顾性选取我院2020年5月至2022年4月就诊的85例HBV感染患者,并采用CMIA法、ELISA法分析HBV感染的准确率、血清学标志物检测结果[乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)、乙肝e抗体(Hepatitis B e antibody,HBeAb)、乙肝e抗原(Hepatitis B e antigen,HBeAg)、乙肝核心抗体(Hepatitis B core antibody,HBcAb)浓度]、HBsAb、HBsAg回收率.结果:CMIA法诊断准确率,检测HBsAg、HBeAb、HBcAb阳性率高于ELISA法(P<0.05);两组平均回收率无统计学差异.结论:与ELISA法相比,CMIA法用于检测HBV感染患者血清学标志物具有较高准确度、回收率.

关键词： CMIA HBV 血清学标志物准确率

DEM-CFD simulation of modular PB-FHR core with two-grid method

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Nuclear Science and Techniques 2017年第7期28卷 115-126页

作者： Feng-Rui Liu Xing-Wei chen zhong Li Na-Xiu Wang Shanghai Institute of Applied Physics Chinese Academy of Sciences Jiadig Campus Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China

For designing and optimizing the reactor core of modular pebble-bed fluoride salt-cooled high-temperature reactor(PB-FHR),it is of importance to simulate the coupled fluid and particle flow due to strong coolantpebble *** fluid dynamics and discrete element method(DEM) coupling approach can be used to track particles individually while it requires a fluid cell being greater than the pebble ***,the large size of pebbles makes the fluid grid too coarse to capture the complicated flow *** solve this problem,a two-grid approach is proposed to calculate interphase momentum transfer between pebbles and coolant without the constraint on the shape and size of fluid *** solid velocity,fluid velocity,fluid pressure and void fraction are mapped between hexahedral coarse particle grid and tine fluid *** the total interphase force can be calculated independently to speed up *** evaluate suitability of this two-grid approach,the pressure drop and minimum fluidization velocity of a fluidized bed were predicted,and movements of the pebbles in complex flow field were studied experimentally and *** spouting fluid through a central inlet pipe of a scaled visible PB-FHR core facility was set up to provide the complex flow *** was chosen as Liquid to simulate the molten salt coolant,and polypropylene balls were used to simulate the pebble *** show that the pebble flow pattern captured from experiment agrees well with the simulation from two-grid approach,hence the applicability of the two-grid approach for the later PB-FHR core design.

关键词： CFD模拟网格方法计算流体动力学核心模块最小流化速度堆芯设计固体速度六面体网格

Effect of long-term continuous cropping of strawberry on soil bacterial community structure and diversity

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Journal of Integrative Agriculture 2018年第11期17卷 2570-2582页

作者： LI Wei-hua LIU Qi-zhi chen peng College of Plant Protection China Agricultural University

Long-term monoculture leads to continuous cropping （CC） problems, which complicate agricultural production, both locally and abroad. This study contrasted the different bacterial community compositions, physicochemical properties and enzyme activities of strawberry soil subjected to CC, CC rhizosphere （CCR）, non-CC （NCC） and non-CC rhizosphere （NCCR） treatments. The soil physicochemical properties and enzyme activities were significantly reduced after long-term CC. In addition, five variation trends were observed for the 11 major bacterial genera in the soil. Sphingomonas was the only stable group among all treatments. The proportions of Novosphingobium, Rhodoplanes, Povalibacter, Cellvibrio and Stenotrophobacterdecreased after CC. The relative abundances of Pelagibius, Thioprofundum and AIIokutzneria increased only in the CC treatment. Nitrospira were more abundant in rhizosphere soil than in non-rhizosphere soil. The relative abundance of Bacillus increased after CC. Redundancy analysis revealed that Bacillus, Pelagibius and AIIokutzneria had significant negative correlations with the soil physicochemical properties and enzyme activities. Therefore, these genera may be the key bacteria influenced by the physicochemical properties and enzyme activities altered by replanting. These results indicate that long-term CC of strawberry leads to less favourable rhizosphere soil conditions, which can be understood as a stress-induced response of the bacterial community diversity. Further research is needed to determine how the quality of soil is reduced by the shift in the diversity of the soil bacterial community.

关键词： rhizosphere soil high-throughput sequencing biogeochemical cycle bacterial diversity