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Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

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Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： Qian-zhuo Liu Hui Han Xin-ru Fang Lu-yao Wang Dan Zhao Miao-zhu Yin Nian Zhang peng-yu Jiang zhi-hui Ji Li-min Wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress

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A Comparative Study of the Power-law Relationship between the Pulse width and Energy of Precursor and Main Burst

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Research in Astronomy and Astrophysics 2024年第3期24卷 144-168页

作者： Hui-Ying Deng Zhao-Yang peng Jia-Ming Chen Dan zhu College of Physics and Electronic Information Yunnan Normal UniversityKunming 650500China

In gamma-ray burst prompt emission,there is still no consistent conclusion if the precursor and main burst share the same *** this paper,we try to study this issue based on the relationship between pulse width and energy of the precursor and main *** systematically search the light curve data observed by Swift/BAT and Fermi/GBM,and find 13 long bursts with well-structured precursors and main *** fitting the precursor light curve of each different energy channel with the Norris function,we find that there is not only a power-law relationship between precursor width and energy,but also a power-law relationship between the ratio of the rising width to the decaying width and *** comparing the relationship between the precursors and the main burst pulses,we find that the distribution of the precursors and the relationship between the power-law indices are roughly the same as those of the main *** addition,it is found that the precursor width distribution as well as the upper limit of the pulse width ratio does not exceed 1 and both are asymmetric,which are also consistent with the main *** indicate that the precursor and the main burst are indistinguishable,and the precursor and the main burst may have the same physical origin.

关键词： methods data analysis-(stars) gamma-ray burst general-shock waves

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Dynamic coupling of ferrihydrite transformation and associated arsenic desorption/redistribution mediated by sulfate-reducing bacteria

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Journal of Environmental Sciences 2024年第1期135卷 39-50页

作者： Wenjing Zhou Huiyan zhu Shiwen Hu Bowei Zhang Kun Gao zhi Dang Chongxuan Liu State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationSouth China University of TechnologyGuangzhou 510006China

Sulfate-reducing bacteria play an important role in the geochemistry of iron(oxyhydr)oxide and arsenic(As)in natural environments;however,the associated reaction processes are yet to be fully *** this study,batch experiments coupled with geochemical,spectroscopic,microscopic,and thermodynamic analyses were conducted to investigate the dynamic coupling of ferrihydrite transformation and the associated As desorption/redistribution mediated by Desulfovibrio vulgaris(***).The results indicated that *** could induce ferrihydrite transformation via S^(2-)-driven and direct reduction *** the absence of SO_(4)^(2-),*** directly reduced ferrihydrite,and As desorption and re-sorption occurred simultaneously during the partial transformation of ferrihydrite to *** increase in SO_(4)^(2-)loading promoted the S^(2-)-driven reduction of ferrihydrite and accelerated the subsequent mineralogical *** the low and medium SO_(4)^(2-)treatments,ferrihydrite was completely transformed to a mixture of magnetite and mackinawite,which increased the fraction of As in the residual phase and stabilized *** the high SO_(4)^(2-)treatment,although the replacement of ferrihydrite by only mackinawite also increased the fraction of As in the residual phase,22.1%of the total As was released into the solution due to the poor adsorption affinity of As to mackinawite and the conversion of As^(5+)to As^(3+).The mechanisms of ferrihydrite reduction,mineralogy transformation,and As mobilization and redistribution mediated by sulfate-reducing bacteria are closely related to the surrounding SO_(4)^(2-)*** results advance our understanding of the biogeochemical behavior of Fe,S,and As,and are helpful for the risk assessment and remediation of As contamination.

关键词： Sulfate-reducing bacteria Arsenic Ferrihydrite Transformation Redistribution

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Digital CEOs in Digital Enterprises:Automating,Augmenting,and Parallel in Metaverse/CPSS/TAOs

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 820-823页

作者： Juanjuan Li Rui Qin Sangtian Guan Xiao Xue peng zhu Fei-Yue Wang with State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China the College of Intelligence and Computing Tianjin UniversityTianjin 300072China School of Economics and Management Nanjing University of Science and TechnologyNanjing 210094China the State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China

BIG models or foundation models are rapidly emerging as a key force in advancing intelligent societies[1]–[3]Their significance stems not only from their exceptional ability to process complex data and simulate advan... 详细信息

关键词： exceptional Auto advancing

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Genomic variation,environmental adaptation,and feralization in ramie,an ancient fiber crop

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Plant Communications 2024年第8期5卷 189-207页

作者： Zeng-Yuan Wu Mark A.Chapman Jie Liu Richard I.Milne Ying Zhao Ya-Huang Luo Guang-Fu zhu Marc W.Cadotte Ming-Bao Luan peng-Zhen Fan Alex K.Monro zhi-peng Li Richard T.Corlett De-zhu Li Germplasm Bank of Wild Species&Yunnan Key Laboratory of Crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China School of Biological Sciences University of SouthamptonSouthampton SO171BJUK CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93JHUK Department of Biological Sciences University of Toronto-ScarboroughTorontoOntarioCanada Institute of Bast Fiber Crops Chinese Academy of Agricultural SciencesChangshaHunan 410205China Royal Botanic Gardens Kew RichmondSurrey TW93AEUK Center for Integrative Conservation and Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunYunnan 666303China

Feralization is an important evolutionary process,but the mechanisms behind it remain poorly ***,we use the ancient fiber crop ramie(Boehmeria nivea(L.)Gaudich.)as a model to investigate genomic changes associated with both domestication and *** first produced a chromosome-scale de novo genome assembly of feral ramie and investigated structural variations between feral and domesticated ramie ***,we gathered 915 accessions from 23 countries,comprising cultivars,major landraces,feral populations,and the wild *** on whole-genome resequencing of these accessions,we constructed the most comprehensive ramie genomic variation map to ***,demographic,and admixture signal detection analyses indicated that feral ramie is of exoferal or exo-endo origin,i.e.,descended from hybridization between domesticated ramie and the wild progenitor or ancient *** ramie has higher genetic diversity than wild or domesticated ramie,and genomic regions affected by natural selection during feralization differ from those under selection during *** analyses showed that feral and domesticated ramie have similar ecological niches that differ substantially from the niche of the wild progenitor,and three environmental variables are associated with habitat-specific adaptation in feral *** findings advance our understanding of feralization,providing a scientific basis for the excavation of new crop germplasm resources and offering novel insights into the evolution of feralization in nature.

关键词： ramie fiber offering

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Chemical Scissors Tailored Nano‑Tellurium with High‑Entropy Morphology for Efficient Foam‑Hydrogel‑Based Solar Photothermal Evaporators

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Nano-Micro Letters 2024年第3期16卷 149-168页

作者： Chenyang Xing Zihao Li Ziao Wang Shaohui Zhang Zhongjian Xie Xi zhu Zhengchun peng State Key Laboratory of Radio FrequencyHeterogeneous Integration Shenzhen UniversityShenzhen 518060People’s Republic of China Center for Stretchable Electronics and NanoSensors College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhen 518172People’s Republic of China Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038GuangdongPeople’s Republic of China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060People’s Republic of China

The development of tellurium(Te)-based semiconductor nanomaterials for efficient light-to-heat conversion may offer an effective means of harvesting sunlight to address global energy ***,the nanosized Te(nano-Te)materials reported to date suffer from a series of drawbacks,including limited light absorption and a lack of surface ***,we report the preparation of nano-Te by electrochemical exfoliation using an electrolyzable room-temperature ionic ***,cations,and their corresponding electrolytic products acting as chemical scissors can precisely intercalate and functionalize bulk *** resulting nano-Te has high morphological entropy,rich surface functional groups,and broad light *** also constructed foam hydrogels based on poly(vinyl alcohol)/nano-Te,which achieved an evaporation rate and energy efficiency of 4.11 kg m^(−2)h^(−1)and 128%,respectively,under 1 sun ***,the evaporation rate was maintained in the range 2.5-3.0 kg m^(−2)h^(−1)outdoors under 0.5-1.0 sun,providing highly efficient evaporation under low light conditions.

关键词： Tellurium High entropy Electrochemical modification Solar absorption Evaporation rate

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Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-peng Song Lu-Ping Zhou Jing-Yu Tang zhi-Hao Zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

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Elastohydrodynamic Lubrication Interface Stiffness and Damping Considering Asperity Lateral Contact

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Acta Mechanica Solida Sinica 2024年第1期37卷 109-123页

作者： zhiqiang Gao Yu Zhang Xian Wei Yanfang zhu Lixia peng Weiping Fu Wen Wang School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Intelligent Manufacturing Panzhihua UniversityPanzhihua 617000China Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Light Chemical TechnologyYibin 644002China School of Mechanical Engineering Anyang Institute of TechnologyAnyang 455099China

Elastohydrodynamic lubrication(EHL)point contact occurs between two rough surfaces at the mesoscopic level,while the interaction of rough surfaces involves contact between asperities at the microscale *** most cases,the contact between asperities within an interface takes the form of lateral contact rather than peak *** devoid of contact asperities are filled with lubricating ***,conventional models often oversimplify lateral contact forms as interactions between asperities and a smooth,rigid *** simplifications fail to accurately represent the true contact conditions and can lead to inaccuracies in the analysis of EHL’s contact *** address this issue,we have developed a novel EHL interface model comprising two rough *** model allows us to explore the influence of asperity height,contact angle,and contact azimuth angle on EHL interface performance.

关键词： EHL interface Asperity lateral contact Contact stiffness Damping

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Colorectal cancer screening:The value of early detection and modern challenges

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World Journal of Gastroenterology 2024年第20期30卷 2726-2730页

作者： Jian Li zhi-peng Li Wen-Jie Ruan Wei Wang Department of Interventional Oncology Municipal Hospital Affiliated to Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina

The screening of colorectal cancer(CRC)is pivotal for both the prevention and treatment of this disease,significantly improving early-stage tumor detection *** advancement not only boosts survival rates and quality of life for patients but also reduces the costs associated with ***,the adoption of CRC screening methods faces numerous challenges,including the technical limitations of both noninvasive and invasive methods in terms of sensitivity and ***,socioeconomic factors such as regional disparities,economic conditions,and varying levels of awareness affect screening *** coronavirus disease 2019 pandemic further intensified these challenges,leading to reduced screening participation and increased waiting ***,the growing prevalence of early-onset CRC necessitates innovative screening *** response,research into new methodologies,including artificial intelligence-based systems,aims to improve the precision and accessibility of *** measures by governments and health organizations to enhance CRC screening efforts are underway,including increased advocacy,improved service delivery,and international *** role of technological innovation and global health collaboration in advancing CRC screening is *** such as artificial intelligence and gene sequencing are set to revolutionize CRC screening,making a significant impact on the fight against this *** the rise in early-onset CRC,it is crucial for screening strategies to continually evolve,ensuring their effectiveness and applicability.

关键词： Colorectal cancer Early detection Economic implications Noninvasive tests Quality of life Survival rates Therapeutic modalities Technical challenges

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Preliminary discussion on the ignition mechanism of exploding foil initiators igniting boron potassium nitrate

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Defence Technology（防务技术） 2024年第2期32卷 222-231页

作者： Haotian Jian Guoqiang Zheng Lejian Chen Zheng Ning Guofu Yin peng zhu Ruiqi Shen School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Micro-Nano Energetic Devices Key Laboratory of MIIT Nanjing University of Science and TechnologyNanjing 210094China Anhui Province Key Laboratory of Microsystem the 43rd Research Institute of CETCHefei 230088China Science and Technology on Applied Physical and Chemistry Laboratory Shanxi Applied Physics and Chemistry Research Institute Xi'an 710061China

Exploding foil initiator(EFI)is a kind of advanced device for initiating explosives,but its function is unstable when it comes to directly igniting *** solve the problem,this research aims to reveal the ignition mechanism of EFIs directly igniting *** oscilloscope,a photon Doppler velocimetry,and a plasma spectrum measurement system were employed to obtain information of electric characteristics,impact pressure,and plasma *** results of the electric characteristics and the impact pressure were inconsistent with ignition *** only thing that the ignition success tests had in common was that their plasma all had a relatively long period of high-temperature duration(HTD).It eventually concludes that the ignition mechanism in this research is the microconvection heat transfer rather than the shock initiation,which differs from that of exploding foil initiators detonating ***,the methods for evaluating the ignition success of semiconductor bridge initiators are not entirely applicable to the tests mentioned in this *** HTD is the critical parameter for judging the ignition success,and it is influenced by two factors:the late time discharge and the energy of the electric *** longer time of the late time discharge and the more energy of the electric explosion,the easier it is to expand the HTD,which improves the probability of the ignition success.

关键词： Exploding foil initiator PDV Plasma spectrum Ignition mechanism Boron potassium nitrate

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