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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng zhen Zhang Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao Yue Yiman Zhang Lulu Li Zhong-zhen Yu peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfa.es,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

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Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-fa. Chen Li Liu fa.g-zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-fa.g Zhang Cong-Cong Liu Xiang Chen Jie peng Yun-fa.Wang Zhi-Lin Wang Bin Chen De-Le Liu Yun Liu zheng-zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

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Imprints of ultralight axions on the gravitational wave and pulsar timing measurement

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 23-29页

作者： Ning Xie fa.peng Huang MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

The axion or axion-like particle motivated from a natural solution of strong CP problem or string theory is a promising dark matter *** study the new observational effects of ultralight axion-like particles by the space-borne gravitational wave detector and the radio *** the neutron star-black hole binary as an example,we demonstrate that the gravitational waveform could be obviously modified by the slow depletion of the axion cloud around the black hole formed through the superradiance *** compare these new effects on the binary with the well-studied effects from dynamical friction with dark matter and dipole radiation in model-independent ***,we discuss the constraints from LIGO/Virgo and study the detectability of the ultralight axion particles at LISA and TianQin.

关键词： gravitational wave axion dark matter

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Assessing the influence of the minimum measured diameter on forest spatial patterns and nearest neighborhood relationships

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Journal of Mountain Science 2019年第10期16卷 2308-2319页

作者： LI Yuan-fa.YANG Hai-peng WANG Hong-xiang YE Shao-ming LIU Wen-zhen Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Xiaolongshan Research Institute of Forestry of Gansu Province Gansu Provincial Key Laboratory of Secondary Forest CultivationTianshui 530004China

Forest structure analysis is important for understanding the properties and development of a forest community,and its outcomes can be influenced by how trees are measured in sampled *** there is a general consensus on the height at which tree diameter should be measured[1.3 m:diameter at breast height(DBH)],the minimum measureddiameter(MMD)often varies in different *** this study,we assumed that the outcomes of forest structure analysis can be influenced by MMD and,to this end,we applied g(r)function and stand spatial structural parameters(SSSPs)to investigate how different MMDs affect forest spatial structure analysis in two pine-oak mixed forests(30 and 57 years old)in southwest China and one old-growth oak forest(>120years old)from northwest *** results showed that 1)MMD was closely related to the distribution patterns of forest *** distribution patterns at each observational scale(r=0-20 m)tended tobecome random as the MMD *** older the community,the earlier this random distribution pattern appeared.2)As the MMD increased,neighboring trees became more regularly distributed around a reference *** most cases,however,nearest neighbors of a reference tree were randomly distributed.3)Tree species mingling decreased with increasing diameter,but it decreased slowly in older forests.4)No correlations can be found between individual tree size differentiation and *** recommend that comparisons of spatial structures between communities would be more effective if using a unified MMD criterion.

关键词： Distribution patterns Minimum measured diameter Mixed forest Nearest neighbor analysis Species mingling Uniform angle index

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CBMO Estimates for Multilinear Hardy Operators

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1245-1254页

作者： Shah zhen LU fa.You ZHAO School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

The purpose of this paper is to study the multilinear Hardy operators in higher dimensional cases and establish the CBMO estimates for multilinear Hardy operators on some function spaces, such as the Lebesgue spaces, ... 详细信息

关键词： multilinear Hardy operator central BMO space Herz space Morrey-Herz space

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Novel high-performance element in the electromagnetic finite-element method——node-edge element

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Journal of Systems Engineering and Electronics 2008年第5期19卷 878-881页

作者： Sheng Xinqing peng zhen Center for Electromagnetic Simulation School of Information Science and Technology Beijing Inst. of Technology Beijing 100081 P. R. China

It is known in the computational electromagnetics （CEM） that the node element has a relative wellconditioned matrix, but suffers from the spurious solution problem; whereas the edge element has no spurious solutions, but usually produces an ill-conditioned matrix. Particularly, when the mesh is over dense, the iterative solution of the matrix equation from edge element converges very slowly. Based on the node element and edge element, a node-edge element is presented, which has no spurious solutions and better-conditioned matrix. Numerical experiments demonstrate that the proposed node-edge element is more efficient than now-widely used edge element.

关键词： node-edge element node element edge element matrix condition number.

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Spectroscopic properties of Er^(3+)-doped fluoroindate glasses

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Journal of Rare Earths 2022年第7期40卷 1037-1042页

作者： zhen Liu Jiangbo She Bo peng State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision MechanicsChinese Academy of Sciences(CAS)Xi'an 710119China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The optical and thermal properties of a new class of fluoroindate glass with different erbium contents were investigated via Raman,transmission,and fluorescence spectroscopies,fluorescence decay curve analysis,and differential scanning *** strength parameters of the samples were calculated using the Judd-Ofelt *** mid-infrared luminescence properties of erbium-doped fluoroindate glasses were studied,and a strong emission at 2.7μm was *** with the traditional ZBLAN glass,this glass has excellent emission properties,especially a longer fluorescence lifetime(7.09 ms)and larger emission cross-section(6.95×10^(-21) cm^(2))at 2.7μ*** results indicate that fluoroindate glass is an attractive host for mid-infrared lasers and as a gain medium for optical amplifier applications.

关键词： Optical materials Spectroscopic properties Luminescence Fluoroindate glasses Rare earths

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Ferromagnetic and ferroelectric two-dimensional materials for memory application

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Nano Research 2021年第6期14卷 1802-1813页

作者： zhen Liu Longjiang Deng Bo peng National Engineering Research Center of Electromagnetic Radiation Control Materials School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu611731China Key Laboratory of Multi-spectral Absorbing Materials and Structures of Ministry of Education University of Electronic Science and Technology of ChinaChengdu611731China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu611731China

The discoveries of ferromagnetic and ferroelectric two-dimensional(2D)materials have dramatically inspired intense interests due to their potential in the field of spintronic and nonvolatile *** review focuses on the latest 2D ferromagnetic and ferroelectric materials that have been most recently studied,including insulating ferromagnetic,metallic ferromagnetic,antiferromagnetic and ferroelectric 2D *** fundamental properties that lead to the long-range magnetic orders of 2D materials are *** low Curie temperature(Tc)and instability in 2D systems limits their use in practical applications,and several strategies to address this constraint are proposed,such as gating and composition stoichiometry.A van der Waals(vdW)heterostructure comprising 2D ferromagnetic and ferroelectric materials will open a door to exploring exotic physical phenomena and achieve multifunctional or nonvolatile devices.

关键词： two-dimensional(2D)materials ferromagnetic ferroelectric heterostructure nonvolatile memory

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Scheme for Generation of Maximally Entangled States via Entanglement Swapping

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Communications in Theoretical Physics 2006年第3X期46卷 553-555页

作者： WU zhen-zhen fa.G Mao-fa.JIANG Chun-Lei College of Physics and Information Science Hunan Normal University Changsha 410081 China

Based on two atoms and two cavities initially in two pairs of atom-photon nonmaximally entangled states, we propose a relatively simple scheme to create maximally entangled photon-photon and atom-photon states via entanglement swapping using techniques of cavity QED inspired by the scheme proposed in [Phys. Rev. A 71 （2005） 044302] and [Phys. Rev. A 71 （2005） 034312]. Our scheme does not involve the measurement in Bell basis, we only require detecting the states of atoms.

关键词： quantum entanglement entanglement swapping cavity QED

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