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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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硒及硒纳米颗粒生物学机制与口腔常见疾病的关系

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中国组织工程研究 2025年第22期29卷 4813-4822页

作者：彭璐瑶顾瑜遵义医科大学珠海校区广东省珠海市519041 贵州省高等学校口腔疾病研究特色重点实验室贵州省遵义市563000

背景:硒作为人体所需的微量非金属元素具有抗炎、抗氧化、抗菌、免疫调节和抗肿瘤等生物活性,已经在生物医学领域得到广泛应用。目的:总结硒及其纳米颗粒在抗炎、抗氧化、抗菌、免疫调节和抗肿瘤方面的功能和作用机制,以及在口腔医学领... 详细信息

背景:硒作为人体所需的微量非金属元素具有抗炎、抗氧化、抗菌、免疫调节和抗肿瘤等生物活性,已经在生物医学领域得到广泛应用。目的:总结硒及其纳米颗粒在抗炎、抗氧化、抗菌、免疫调节和抗肿瘤方面的功能和作用机制,以及在口腔医学领域的研究进展。方法:以“selenium,selenium nanoparticles,oral neoplasms,caries,dental pupal disease,periapical disease,dental implant”为英文检索词,以“硒,硒纳米颗粒,口腔癌,龋病,牙髓病,根尖周病,口腔种植”为中文检索词,分别在PubMed、中国知网、万方数据库进行文献检索,检索文献时限为2000年1月至2024年2月。经过对文献的深入分析和仔细阅读,最后选择74篇文献进行全面综述。结果与结论:(1)硒的生物学特性主要是通过合成硒蛋白,以抗氧化机制为核心,调节各种细胞因子和介导与之相关的信号通路,进而产生抗菌、免疫调节、抗肿瘤等作用;(2)硒除了在口腔癌、龋病、牙髓根尖周病等方面可用于早期诊断、治疗和预后判断外,更多的是可作为新型口腔材料在口腔领域应用,例如:用于开发新型牙科封闭剂或根管系统消毒剂,又或在优化口腔种植材料性能等方面有所应用;(3)生物安全性是影响硒在生物医药领域应用的最重要因素之一,选择合适的剂量和形式才能使其发挥出良好作用。硒在口腔材料学方面展现出了巨大的应用潜力和广阔的发展空间。

关键词：硒硒纳米颗粒口腔癌龋病牙髓根尖周病口腔种植

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe Sun, Xin yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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Clinical research progress in Traditional Chinese Medicine in treating wound healing after anal fistula surgery

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Journal of Traditional Chinese Medicine 2023年第5期43卷 1047-1054页

作者： MEI Pingping FENG Wenzhe SHI peng ZHANG Wenxiu zhuang yu the First Clinical Medical College Department Shaanxi University of Chinese MedicineXianyang 712046China Department of anorectal Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000China

In the study of the mechanism of wound healing after anal fistula surgery,how to scientifically and efficiently promote wound healing is of great *** present,modern medical treatment of wounds after anal fistula surgery mostly focuses on physical therapy intervention,new wound dressing and packing,and external application of growth ***,these therapies have many problems,and there is still no consensus on their clinical *** Chinese Medicine(TCM)has several methods to promote wound healing,such as oral administration,rubbing,and fumigation,which have a long history and obvious efficacy,but research in this area is relatively scattered and lacks classification and ***,this paper analyzes and summarizes the existing research on TCM for promotion of wound healing after anal fistula surgery,carries out targeted analyses according to different clinical syndromes and treatment methods,and analyzes the defects in current research and anticipates future research trends in order to provide theoretical support for the advantages of TCM in promoting wound healing after anal fistula surgery.

关键词： rectal fistula wound healing medicine Chinese traditional research report review

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Towards reliable assessment of hydrogen oxidation electrocatalysts for anion-exchange membrane fuel cells

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Nano Research 2023年第8期16卷 10787-10795页

作者： Fei-yue Gao Ye-Hua Wang yu Yang Jie Liao Jing-Wen DuanMu Xiao-Long Zhang zhuang-zhuang Niu peng-peng Yang Min-Rui Gao Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Recent advancement of proton exchange membrane fuel cells has led to commercial sales of fuel-cell cars but market barrier exists because this technology heavily relies on platinum *** the permission of adopting platinum-group-metal-free catalysts,anion-exchange membrane fuel cell has received notable ***,the sluggish kinetics of anodic hydrogen oxidation reaction(HOR)largely limit the cell *** many high-performance HOR catalysts have been reported,there are analytical uncertainties in the literature concerning the assessment of the catalyst *** we determine the origin of false HOR currents in the recorded polarization curves and propose a rigorous approach to eliminate *** unveil experimentally the uncertainties of obtaining exchange current densities(j0)using Tafel plot from Bulter–Volmer equation and recommend employing the micro-polarization region *** bulky catalysts that cannot establish a well-defined diffusion layer,we suggest applying external stirring bar to offer certain level of enforced convection and using j0 to compare the activity.

关键词： platinum group metal-free catalysts anion-exchange membrane fuel cell hydrogen oxidation reaction kinetic analysis

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Planning and Real-time Pricing of EV Charging Stations Considering Social Welfare and Profitability Balance

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1289-1301页

作者： Suyang Zhou yuxuan zhuang Zhi Wu Wei Gu peng yu Jinqiao Du Xiner Luo the School of Electrical Engineering Southeast UniversityNanjingChina the Jiangsu Key Laboratory of Smart Grid Technology and Equipment NanjingChina Shenzhen Power Supply Bureau Co. Ltd.ShenzhenChina

This paper presents a planning and real-time pricing approach for EV charging stations(CSs).The approach takes the form of a bi-level model to fully consider the interest of both the government and EV charging station operators in the planning *** the perspective of maximizing social welfare,the government acts as the decision-maker of the upper level that optimizes the charging price matrix,and uses it as a transfer variable to indirectly influence the decisions of the lower level *** each operator at the lower level determines their scale according to the goal of maximizing their own revenue,and feeds the scale matrix back to the upper level.A Logit model is applied to predict the drivers’preference when selecting a ***,an improved particle swarm optimization(PSO)with the utilization of a penalty function is introduced to solve the nonlinear nonconvex bi-level *** paper applies the proposed Bi-level planning model to a singlecenter small/medium-sized city with three scenarios to evaluate its performance,including the equipment utilization rate,payback period,traffic attraction ability,*** result verifies that the model performs very well in typical CS distribution scenarios with a reasonable station payback period(average 6.5 years),and relatively high equipment utilization rate,44.32%.

关键词： Bi-level model EV charging station planning particle swarm optimization real-time pricing drivers’preference model logit model

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Tracking Control for a Cushion Robot Based on Fuzzy Path Planning With Safe Angular Velocity

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 610-619页

作者： Ping Sun zhuang yu School of Information Science and Engineering Shenyang University of TechnologyShenyang 110870China

This study proposes a new nonlinear tracking control method with safe angular velocity constraints for a cushion robot. A fuzzy path planning algorithm is investigated and a realtime desired motion path of obstacle avoidance is obtained. The angular velocity is constrained by the controller, so the planned path guarantees the safety of users. According to Lyapunov theory, the controller is designed to maintain stability in terms of solutions of linear matrix inequalities and the controller's performance with safe angular velocity constraints is *** simulation and experiment results confirm the effectiveness of the proposed method and verify that the angular velocity of the cushion robot provided safe motion with obstacle avoidance.

关键词： Cushion robot path planning safe angular velocity tracking control

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Effects of Zr/Ti molar ratio in SO_4^(2-)/ZrO_(2-)TiO_2 calcined at different temperatures on its surface properties and glucose reactivity in near-critical methanol

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Journal of Natural Gas Chemistry 2012年第2期21卷 138-147页

作者： Lincai peng Junping zhuang Lu Lin State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640GuangdongChina School of Energy Research Xiamen UniversityXiamen 361005FujianChina

Effects of Zr/Ti molar ratio in SO42-/ZrO2-TiO2 solid acid catalyst calcined at different temperatures on its surface properties and catalytic activity were thoroughly investigated in this paper. The physicochemical characteristics of prepared samples were determined by N2 adsorptiondesorption, XRD, NH3-TPD and XPS techniques, respectively. It was found that the crystallization temperature of the samples increased after the combination of ZrO2 and TiO2; and phase transformations from the anatase to the rutile of TiO2 species and the tetragonal to the monoclinic of ZrO2 species were effectively suppressed at higher temperature. The sample with a Zr/Ti molar ratio of 3/1 calcined at 450℃ showed the highest surface area and the most acid sites among all the tested samples. The acid site densities of samples were relatively closed to each other if they were calcined at the same temperature, however, decreased with the calcination temperature. The result indicates that the sulfur content in samples is a crucial factor to control the acid site density. Calcining the sample at 650℃ and higher temperatures resulted in a significant desorption of sulfate ion on the samples. The synthesized samples were evaluated as a potential catalyst for glucose conversion under the near-critical methanol conditions （200℃/4 MPa）. The results suggested that the relatively weaker acid sites of the catalyst were more favorable for the accumulation of methyl glucosides, while the moderate acid sites were responsible for the formation of methyl levulinate. The catalytic activity for methyl levulinate production almost increases linearly with the catalyst acid site density. The catalyst deactivation is due to the loss of sulfate ion and the two catalysts with Zr/Ti molar ratios of 3/1 and 1/3 could effectively alleviate the deactivation caused by sulfate solution in the reaction medium and can be reused after calcination with the reuse rate of over 90% in terms of the methyl levulinate selectivi

关键词： SO42-/ZrO2-TiO2 surface properties catalysis glucose reactivity methyl levulinate

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Selection of a DNA barcode for Nectriaceae from fungal whole-genomes

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Science China(Life Sciences) 2012年第1期55卷 80-88页

作者： ZENG ZhaoQing ZHAO peng LUO Jing zhuang WenYing yu ZhiHe State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China College of Life Sciences Yangtze UniversityJingzhou 434025China

A DNA barcode is a short segment of sequence that is able to distinguish species. A barcode must ideally contain enough variation to distinguish every individual species and be easily obtained. Fungi of Nectriaceae are economically important and show high species diversity. To establish a standard DNA barcode for this group of fungi, the genomes of Neurospora crassa and 30 other filamentous fungi were compared. The expect value was treated as a criterion to recognize homologous sequences. Four candidate markers, Hsp90, AAC, CDC48, and EF3, were tested for their feasibility as barcodes in the identification of 34 well-established species belonging to 13 genera of Nectriaceae. Two hundred and fifteen sequences were analyzed. Intraand inter-specific variations and the success rate of PCR amplification and sequencing were considered as important criteria for estimation of the candidate markers. Ultimately, the partial EF3 gene met the requirements for a good DNA barcode: No overlap was found between the intra-and inter-specific pairwise distances. The smallest inter-specific distance of EF3 gene was 3.19%, while the largest intra-specific distance was 1.79%. In addition, there was a high success rate in PCR and sequencing for this gene (96.3%). CDC48 showed sufficiently high sequence variation among species, but the PCR and sequencing success rate was 84% using a single pair of primers. Although the Hsp90 and AAC genes had higher PCR and sequencing success rates (96.3% and 97.5%, respectively), overlapping occurred between the intraand inter-specific variations, which could lead to misidentification. Therefore, we propose the EF3 gene as a possible DNA barcode for the nectriaceous fungi.

关键词： barcoding gap expect value fungal genomes homologous sequence PCR and sequencing success rate sequence variation

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Modeling and Analysis of A Rotary Direct Drive Servovalve

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Chinese Journal of Mechanical Engineering 2014年第5期27卷 1064-1074页

作者： yu Jue zhuang Jian yu Dehong School of Mechanical Engineering Xi'an Jiaotong University

Direct drive servovalves are mostly restricted to low flow rate and low bandwidth applications due to the considerable flow *** studies mainly focus on enhancing the driving force,which in turn is limited to the development of the magnetic *** at reducing the flow forces,a novel rotary direct drive servovalve（RDDV）is introduced in this *** RDDV servovalve is designed in a rotating structure and its axially symmetric spool rotates within a certain angle range in the valve *** servovalve orifices are formed by the matching between the square wave shaped land on the spool and the rectangular ports on the *** order to study the RDDV servovalve performance,flow rate model and mechanical model are established,wherein flow rates and flow induced torques at different spool rotation angles or spool radiuses are *** model analysis shows that the driving torque can be alleviated due to the proposed valve *** fluid dynamics（CFD）analysis using ANSYS/FLUENT is applied to evaluate and validate the theoretical *** addition,experiments on the flow rate and the mechanical characteristic of the RDDV servovalve are carried *** simulation and experimental results conform to the results of the theoretical model analysis,which proves that this novel and innovative structure for direct drive servovalves can reduce the flow force on the spool and improve valve frequency response *** research proposes a novel rotary direct drive servovalve,which can reduce the flow forces effectively.

关键词： direct drive servovalve computational fluid dynamics(CFD) flow rate flow induced torque

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