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scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling

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Asian Journal of Andrology 2024年第1期26卷 46-56页

作者： Shi-Wei Liu Jia-Qiang Luo Liang-Yu Zhao Ning-Jing Ou Chao-yang Yu-xiang Zhang Hao-Wei Bai Hong-Fang Sun Jian-Xiong Zhang Chen-Cheng Yao peng Li Ru-Hui Tian Zheng Li Zi-Jue Zhu Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining *** single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upregulated in *** scRNAseq analysis,we identified the spermatogonia upregulated gene origin recognition complex subunit 6(Orc6),which is involved in DNA replication and cell cycle regulation;its protein expression in the human and mouse testis was detected by western blot and *** explore the potential function of Orc6 in spermatogonia,the C18-4 cell line was transfected with control or Orc6 ***,5-ethynyl-2-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,flow cytometry,and western blot were used to evaluate its effects on proliferation and *** was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 *** RNA sequencing and bioinformatics analysis indicated that Orc6 was involved in the activation of wingless/integrated(Wnt)/β-catenin *** blot revealed that the expression ofβ-catenin protein and its phosphorylation(Ser675)were significantly decreased when silencing the expression of *** findings indicated that Orc6 was upregulated in spermatogonia,whereby it regulated proliferation and apoptosis by activating Wnt/β-catenin signaling.

关键词： cell proliferation ORCG scRNA-seq analysis spermatogonia Wnt/β-catenin signaling

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矩阵方程A^T X A=B的反对称正交反对称最小二乘解

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工程数学学报 2004年第F12期21卷 93-97页

作者：彭向阳张磊胡锡炎湖南大学数学与计量经济学院

通过广义奇异值分解定理.得到了矩阵方程ATXA=B的反对称正交反对称最小二乘解表达式,同时导出了相应解集中与已知矩阵最佳逼近的最小二乘解和矩阵方程的最小范数解。

关键词：最小二乘解矩阵方程广义奇异值分解最小范数解最佳逼近对称正交解表

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矩阵方程的正交对称与正交反对称最小二乘解

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工程数学学报 2006年第6期23卷 1048-1052页

作者：彭向阳胡锡炎张磊长沙学院信息与计算科学系湖南大学数学与计量经济学院

研究了正交对称矩阵与对称矩阵、正交反对称矩阵与反对称矩阵之间的关系,根据广义奇异值分解定理,获得了矩阵方程A^TXB=C的正交对称和正交反对称最小二乘解存在的充分必要条件,并导出了相应的通解表达式。

关键词：矩阵方程正交对称正交反对称最小二乘解

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Simultaneous achievement of large electrocaloric effect and ultrawide operating temperature range in BaTiO_(3)-based lead-free ceramic

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Journal of Advanced Ceramics 2024年第8期13卷 1234-1241页

作者： Zhaojie Wang Yingzhi Meng Silin Tang xiang Niu Hongfang Zhang Dingyuan Wang Yisong Bai Bialin peng Xue Chen Qingqing Ke Sheng-Guo Lu Laijun Liu Guangxi Key Lab of Optical and Electronic Functional Materials and Devices Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of ResourcesCollege of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China School of Microelectronics Science and Technology Sun Yat-sen UniversityZhuhai 519082China Guangdong Provincial Research Center on Smart Materials and Energy Conversion Devices School of Materials and EnergyGuangdong University of TechnologyGuangzhou 510006China School of Physical Science and Technology&Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China Suzhou University of Science and TechnologySuzhou 215009China Qingdao Haier Smart Technology R&D Co. Ltd.Qingdao 266100China School of Advanced Materials and Nanotechnology Xidian UniversityXi'an 710071China Guangxi Key Laboratory of Manufacturing System&Advanced Manufacturing Technology Guilin University of Electronic TechnologyGuilin 541004China

The electrocaloric effect(ECE),known for its environmentally friendly characteristics,holds significant promise for advancing next-generation solid-state refrigeration *** a large ECE along with a wide working temperature range near room temperature remains a key developmental *** this study,we successfully obtained a substantial ECE of 1.78 K and an extensive working temperature range of 103 K(AT>1.52 K)near room temperature in CaZrO_(3)-modified BaTiO_(3) lead-free ferroelectric ***,this achievement was verified using direct *** piezoresponse force microscopy(PFM)results suggest that the broad temperature range is attributed to the formation of ferroelectric microdomains and polar nanoregions(PNRs).Furthermore,X-ray photoelectron spectroscopy(XPS)and ultraviolet-visible(UV-Vis)spectroscopy reveal a decrease in the oxygen vacancy concentration and an increase in the bandgap for higher CaZrO_(3) doping *** changes synergistically enhance the maximum applied electric field,helping to achieve a high-performance EcE near room *** research presents a straightforward and effective approach for achieving high-performance ECEs in BaTiOg lead-free ceramics,offering promising prospects for application in next-generation solid-state refrigeration technologies.

关键词： BaTiO_(3) electrocaloric effect oxygen vacancy band-gap

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广东电网直流融冰装置安装调试及实冰演练

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高压电器 2010年第3期46卷 98-102,105页

作者：彭向阳周华敏杨楚明广东省电力科学研究院广东广州510600 广东电网公司广东广州510600

介绍了广东电网直流融冰装置及接入系统参数配置、建设情况,提出融冰装置现场调试项目,详细阐述融冰装置系统调试结果,特别对线路通流试验时交直流系统、水冷系统运行参数、融冰回路温升、各电压等级系统谐波水平进行分析。提出直流融... 详细信息

介绍了广东电网直流融冰装置及接入系统参数配置、建设情况,提出融冰装置现场调试项目,详细阐述融冰装置系统调试结果,特别对线路通流试验时交直流系统、水冷系统运行参数、融冰回路温升、各电压等级系统谐波水平进行分析。提出直流融冰装置调试发现的问题和改进建议,建议加装融冰滤波器以消除谐波危害,强调应加强融冰装置的运行维护和技术培训,以最大限度的发挥直流融冰装置作用。

关键词：直流融冰装置现场调试接入系统谐波

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Applicability of different indices for delineating the boundary of arid region: A case study in northwestern China

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Journal of Earth Science 2024年

作者： Xue peng xiang Li Yingyibing Shen Xuehua Che Shipei Dong Zhuolun Li Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Center for Glacier and Desert Research， Lanzhou University

Arid regions are vital components of Earth's land surface. Clarifying the area/boundary of arid region is crucial for comprehending area changes and potential mechanisms. However， the accuracy and applicability of arid region boundary delineated by different indices remain unclear. In this study， the annual precipitation （AP）， humidity index （H）， and aridity index （K） were calculated for delineating arid region of China using 106 meteorological stations during 1990–2019. The results suggest that AP and H can accurately delineate arid region， because they are consistent with the distribution of typical soil and vegetation in arid region， whereas K is not. Moreover， AP is the best index for delineating arid region in regions with limited meteorological data， especially in studying long-term patterns and mechanisms of area changes. The accuracy of delineating arid region using H is enhanced in regions with abundant meteorological data. Over the past 30 years， influenced by the increase of atmospheric moisture influx and precipitation， the area in arid region of northwestern China decreased by 70×103–90×103km2， resulting in the present area of approximately 1.55×106km2. This study provides appropriate indices for delineating arid region， contributing to improving our knowledge of regional responses difference to climate change.

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Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

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Food Science and Human Wellness 2024年第5期13卷 2917-2936页

作者： peng Ma Jie Xiao Biyu Hou Ping He Xinyu yang Yisa Wang Zijing Wang Tianshu Xu Xiuying yang Xuan Zhu Shasha xiang Song Li Guanhua Du Jian Ying Guifen Qiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening ResearchBeijing 100050China COFCO Nutrition and Health Research Institute Beijing 102209China Department of Pharmacy The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China Faculty of Biology Medicine and Health SciencesThe University of ManchesterManchester M139PLUnited Kingdom Changchun University of Chinese Medicine Changchun 130117China School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310018China China Tea Technology(Beijing)Co. Ltd.Beijing 102209China Beijing Key Laboratory of Nutrition Health and Food SafetyBeijing 102209China

Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a“disease”.Brown adipose tissue(BAT)thermogenesis and white adipose tissue(WAT)browning emerge as a potential strategy of anti-obesity by dissipating energy as ***,drugs based on adipose tissue thermogenesis have not been successfully approved *** current study,we found that black tea extract(BTE)obtained by patentauthorized manufacturing process prevented body weight gain as novel thermogenic activator with reduction of adiposity,improvement of adipose distribution,and glucose metabolism improvement in diet-induced obesity ***,anti-obesity effect of BTE depends on promoting BAT thermogenesis and WAT browning with upregulation of uncoupling protein 1(UCP1),especially visceral adipose tissue(VAT)with browning ***,utilizing in silico approach of network pharmacology and molecular docking,we identified carbonic anhydrase 2(CA2)in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B(AKT)signaling pathway linked CA2 and *** gut microbiota regulation may prompt the CA2-dependent thermogenesis *** findings demonstrated anti-obesity effect of BTE as thermogenic activator through CA2-mediated BAT thermogenesis and WAT browning via CA2-AKT-UCP1 signaling pathway,which could be developed as promising anti-obesity agent with good safety and efficacy.

关键词： Obesity Black tea Thermogenesis Browning Adipose tissue

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A rapid assessment of MWRI-RM/FY3G brightness temperature

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 42-46页

作者： Wenying He Xinran Xia Shengli Wu peng Zhang Hongbin Chen xiang'ao Xia Yuquan Zhou Miao Cai LAGEO Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina School of Hydrology and Water Resources Nanjing University of Information Science&TechnologyNanjingChina National Satellite Meteorological Centure Chinese Meteorological AdministrationBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina Key Laboratory of Cloud-Precipitation Physics and Weather Modification CMABeijingChina

2023年4月发射的FY-3G上搭载17个频率的测雨微波成像仪(MWRI-RM),其业务定标的微波亮温(Tb)数据于2023年10月23日公开发布.本文比对了发布10天的MWRI-RM与全球降水测量(GPM)卫星上的微波成像仪(GMI)相匹配的Tb数据,并借助辐射传输模式... 详细信息

2023年4月发射的FY-3G上搭载17个频率的测雨微波成像仪(MWRI-RM),其业务定标的微波亮温(Tb)数据于2023年10月23日公开发布.本文比对了发布10天的MWRI-RM与全球降水测量(GPM)卫星上的微波成像仪(GMI)相匹配的Tb数据,并借助辐射传输模式进行双差分(DD)交叉定标分析,旨在快速评估新一代MWRI-RM观测数据质量.观测比较表明,MWR1-RM与GMI测量的Tb一致性很好,大多通道的平均偏差(MBE)和均方根误差(RMSE)均小于1K.两种传感器由于观测角度略有不同在水面产生约0.5 K差异.DD分析也展示出MWRI-RM的大多数通道性能与GMI相当接近,尤其是首次启用的高频166 GHz和183 GHz.

关键词： FY3G MWRI-RM GMI 亮度温度双差分方法

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Clinical characteristics of peripapillary hyperreflective ovoid mass-like structures in myopic children

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1292-1299页

作者： Lu Zhang Zuo-Hui-Zi Yi Xuan Jiang Gong-peng Sun Fang Zhao Li Zhang Yi xiang Chang-Zheng Chen Department of Ophthalmology the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Eye Center Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

AIM:To describe the characteristics of peripapillary hyperreflective ovoid mass-like structure(PHOMS)in myopic children and to investigate factors associated with ***:This retrospective observational study included 101 eyes of 101 children(age≤17y)with *** included patients underwent comprehensive clinical *** nerve canal parameters,including disc diameter,optic nerve head(ONH)tilt angle,and border tissue angle were measured using serial enhanced-depth imaging spectral-domain optical coherence tomography(EDI-OCT).Based on the optic disc drusen consortium’s definition of PHOMS,eyes were classified as PHOMS group and non-PHOMS *** was categorized according to ***:Sixty-seven(66.3%)eyes were found with *** PHOMS could only be detected by optical coherence tomography(OCT).Medium PHOMS could be seen with blurred optic disc borders corresponding to *** most frequent location of PHOMS was at the nasosuperior(91%,61 of 67 eyes)to ONH *** axial length and spherical equivalent were more myopic in the PHOMS group than in the non-PHOMS group(both P<0.001).ONH tilt angle was also significantly greater in PHOMS group than in non-PHOMS group[8.90(7.16-10.54)vs 3.93(3.09-5.25),P<0.001].Border tissue angle was significantly smaller in PHOMS group than in non-PHOMS group[29.70(20.90-43.81)vs 45.62(35.18-60.45),P<0.001].In the multivariable analysis,spherical equivalent(OR=3.246,95%CI=1.209-8.718,P=0.019)and ONH tilt angle(OR=3.275,95%CI=1.422-7.542,P=0.005)were significantly correlated with *** was no disc diameter associated with *** the linear regression analysis,border tissue angle was negatively associated with PHOMS height(β=-2.227,P<0.001).CONCLUSION:PHOMS is associated with optic disc tilt and optic disc nasal shift in *** diameter is not a risk factor for *** changes in ONH caused by axial elongation facilitated an understanding of the mechanism of PHOMS.

关键词： peripapillary hyperreflective ovoid masslike structure myopia optic disc edema enhanced-depth imaging spectral-domain optical coherence tomography

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Modification of the CuO electronic structure for enhanced selective electrochemical CO_(2) reduction to ethylene

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Nano Research 2024年第8期17卷 7194-7202页

作者： Xin Wu Zhuang Tong Yunliang Liu Yaxi Li Yuanyuan Cheng Jingwen Yu peng Cao Chunqiang Zhuang Qiuzhong Shi Naiyun Liu xiang Liu Hongyu Liang Haitao Li Institute for Energy Research School of Energy and Power EngineeringJiangsu UniversityZhenjiang 212013China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China Institute of Medicine&Chemical Engineering Zhenjiang CollegeZhenjiang 212013China Institute of Advanced Manufacturing and Modern Equipment Technology School of Mechanical EngineeringJiangsu UniversityZhenjiang 212013China

Electrochemical carbon dioxide reduction reaction(CO_(2)RR)can produce value-added hydrocarbons from renewable electricity,providing a sustainable and promising approach to meet dual-carbon targets and alleviate the energy ***,it is still challenging to improve the selectivity and stability of the products,especially the C^(2+) *** we propose to modulate the electronic structure of copper oxide(CuO)through lattice strain construction by zinc(Zn)doping to improve the selectivity of the catalyst to *** performance and in situ characterization analyses show that the compressive strain generated within the CuO lattice and the electronic structure modulation by Zn doping enhances the adsorption of the key intermediate*CO,thereby increasing the intrinsic activity of CO_(2)RR and inhibiting the hydrogen precipitation *** the best catalysts had significantly improved ethylene selectivity of 60.5%and partial current density of 500 mA·cm^(–2),and the highest C^(2+) Faraday efficiency of 71.47%.This paper provides a simple idea to study the modulation of CO_(2)RR properties by heteroatom doped and lattice strain.

关键词： CO_(2) reduction heteroatom-doped lattice strain ethylene selectivity

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