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Recent advances in recurrent hepatocellular carcinoma therapy

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World Journal of Hepatology 2023年第4期15卷 460-476页

作者： Yu-Xue Gao Qi-Qi Ning peng-xiang yang Yuan-Yue Guan peng-xiang Liu Meng-Lu Liu Lu-Xin Qiao xiang-Hua Guo Tong-Wang yang De-Xi Chen Beijing Institute of Hepatology Beijing You An HospitalCapital Medical UniversityBeijing 100069China Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer Beijing 100069China Academician Workstation Changsha Medical UniversityChangsha 410219Hunan ProvinceChina Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations Changsha Medical UniversityChangsha 410219Hunan ProvinceChina

Hepatocellular carcinoma(HCC)is the most prevalent form of primary liver cancer,accounting for 75%-85%of *** treatments are given to cure early-stage HCC,up to 50%-70%of individuals may experience a relapse of the illness in the liver after 5 *** on the fundamental treatment modalities for recurrent HCC is moving significantly *** precise selection of individuals for therapy strategies with established survival advantages is crucial to ensuring better *** strategies aim to minimize substantial morbidity,support good life quality,and enhance survival for patients with recurrent *** individuals with recurring HCC after curative treatment,no approved therapeutic regimen is currently available.A recent study presented novel approaches,like immunotherapy and antiviral medication,to improve the prognosis of patients with recurring HCC with the apparent lack of data to guide the clinical *** data supporting several neoadjuvant and adjuvant therapies for patients with recurring HCC are outlined in this *** also discuss the potential for future clinical and translational investigations.

关键词： Recurrent hepatocellular carcinoma Liver transplantation Therapy Immunotherapy Neoadjuvant and adjuvant therapy

Co-aromatization of methane and hexane over Pt encapsulated in ZSM-5 zeolite and the electronic effect of K promoters

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Science China Chemistry 2024年第3期67卷 1017-1027页

作者： Bei Liu Fan Wang Xiaomeng Dou pengfei Li Hongwei xiang Yong yang peng He State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China Department of Chemistry Tsinghua UniversityBeijing 100084China National Energy R&D Center for Coal to Liquid Fuels Synfuels China Technology Co.Ltd.Beijing 101407China University of Chinese Academy of Sciences Beijing 101408China Leibniz-Institut für Katalyse e.V.an der Universitat Rostock Rostock 18059Germany

The co-aromatization of methane with higher hydrocarbons represents a promising route to valorize methane, an abundant but underexploited carbon resource. In this study, we elucidate a novel approach to enhance the catalytic co-aromatization of hexane and methane by confining Pt within zeolite catalysts and modulating its electron density. Our findings show that encapsulating Pt within MFI structure is pivotal for activating the feedstock and fostering the formation of aromatic products. Interaction between K atoms and the silanol nest forms siloxy groups which are critical for the stabilization of Pt species. Tuning the K content in PtSn@MFI catalysts adeptly alters the electronic configuration of Pt clusters. This modification is corroborated by infrared and X-ray photoelectron spectroscopy analysis, and density functional theory calculations. Remarkably, the catalyst with 0.8 wt% K exhibits an optimal Pt electron density, driving its superior efficacy in the co-aromatization reaction, converting 0.78 mol of methane for each mole of hexane processed. By employing ~(13)C isotopic labeling and solid-state NMR studies, we demonstrate the participation of methane in the adsorbed species inside the zeolite channel and its incorporation to the benzyl site of the substitute group and phenyl rings in aromatic compounds, underscoring the importance of Pt encapsulation.

关键词： Pt encapsulation MFI zeolite methane activation co-aromatization ^(13)C solid-state NMR

Construction of daily precipitation series and the observational characteristics of extreme precipitation in Tianjin,China during 1888-2022

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Advances in Climate Change Research 2024年第1期15卷 52-61页

作者： peng SI Qing-xiang LI Xiao-yang CHEN Min WANG Chuan-Jun LUO Tianjin Meteorological Information Center Tianjin Meteorological BureauTianjin 300074China Research Centerfor Ecology and Environment of Central Asia Chinese Academy of SciencesWulumuqi 830011China School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 528478China Key Laboratory of Tropical Amosphere-Ocean System Ministry of EducationZhuhai 528478China Shaoguan Meteorological Service Shaoguan 512028China

Given the difficulties in rescuing and ensuring the quality of long-term climate data,current studies on century-scale climate change are usually limited to annual and monthly data,resulting in the poor detection of extreme climate events and their changes before *** this study,we reconstructed a daily precipitation series for Tianjin from 15 September 1887 to 31 December 2022 on the basis of the most comprehensive daily precipitation records collected from the Tianjin Meteorological Archive,China,and in reference to the precipitation analysis results based on the datasets developed by the Climatic Research Unit Time-Series version 4.06,Global Precipitation Climatology Centre and University of Delaware along with the application of various homogenisation methods for climate *** approach provides a complete and reliable century-long daily precipitation series for the study of regional or local extreme weather and climate *** reconstructed daily dataset reveals that the annual precipitation amount and R95 intensity in Tianjin during 1888-2022 lack significant trends and have values of 0.74±6.99 and-1.84±3.22 mm per decade,*** the annual and seasonal scales,the precipitation amount and R95 intensity,particularly those in autumn,have increased since the latter half of the 20th century relative to those in ***,the increase in precipitation amount and R95 intensity is relatively limited compared with that in atmospheric water vapour content due to surface warming,indicating the highly sensitive response of extreme precipitation events to *** addition,the estimates for the return periods of 5,10,20,50 and 100 years covering 1888-2022,1888-1950 and 1951-2022 depict that the intensity of heavy rain and above magnitude was highest in 1888-1950 and decreased in 1951-2022.

关键词： Over a century-long timescale Daily precipitation series Extreme precipitation Return period

Progress and prospects of pH-neutral aqueous organic redox flow batteries:Electrolytes and membranes

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Journal of Energy Chemistry 2024年第9期96卷 89-109页

作者： Kang peng Gonggen Tang Chao Zhang Xian yang Peipei Zuo Zhanfeng xiang Zhong Yao Zhengjin yang Tongwen Xu Key Laboratory of Precision and Intelligent Chemistry Department of Applied ChemistrySchool of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026AnhuiChina Suqian Time Energy Storage Technology Co. Ltd.Suqian 223800JiangsuChina

Aqueous organic redox flow batteries(AORFBs),which exploit the reversible electrochemical reactions of water-soluble organic electrolytes to store electricity,have emerged as an efficient electrochemical energy storage technology for the grid-scale integration of renewable ***-neutral AORFBs that feature high safety,low corrosivity,and environmental benignity are particularly promising,and their battery performance is significantly impacted by redox-active molecules and ion-exchange membranes(IEMs).Here,representative anolytes and catholytes engineered for use in pH-neutral AORFBs are outlined and summarized,as well as their side reactions that cause irreversible battery capacity *** addition,the recent achievements of IEMs for pH-neutral AORFBs are discussed,with a focus on the construction and tuning of ion transport ***,the critical challenges and potential research opportunities for developing practically relevant pH-neutral AORFBs are presented.

关键词： Aqueous organic redox flow battery pH-Neutral Anolyte Catholyte Membrane

Multistage Microstructured Ionic Skin for Real-Time Vital Signs Monitoring and Human-Machine Interaction

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Energy & Environmental Materials 2024年第6期7卷 218-229页

作者： Xueke Wang Jinyu Zi Yi Chen Qiang Wu Zhimin xiang Yongqiang Tu peng yang Yanfen Wan National Center for International Research on Photoelectric and Energy Materials Yunnan Key Laboratory for Micro/Nano Materials&TechnologyYunnan Key Laboratory of Electromagnetic Materials and DevicesSchool of Materials and EnergyYunnan UniversityKunming 650091China

Skin-like electronics research aiming to mimic even surpass human-like specific tactile cognition by operating perception-to-cognition-to-feedback of stimulus to build intelligent cognition systems for certain imperceptible or inappreciable signals was so ***,we constructed an all-in-one tri-modal pressure sensing wearable device to address the issue of power supply by integrating multistage microstructured ionic skin(MM i-skin)and thermoelectric self-power staffs,which exhibits high sensitivity *** MM i-skin with multi-stage“interlocked”configurations achieved precise recognition of subtle signals,where the sensitivity reached up to 3.95 kPa^(−1),as well as response time of 46 ms,cyclic stability(over 1500 cycles),a wide detection range of 0–200 ***,we developed the thermoelectricity nanogenerator,piezoelectricity nanogenerator,and piezocapacitive sensing as an integrated tri-modal pressure sensing,denoted as P-iskin,T-iskin,and C-iskin,*** multifunctional ionic skin enables real-time monitoring of weak body signals,rehab guidance,and robotic motion recognition,demonstrating potential for Internet of things(IoT)applications involving the artificial intelligence-motivated sapiential healthcare Internet(SHI)and widely distributed human-machine interaction(HMI).

关键词： bio-template method integrated device ionic skin skin-like microstructure tri-modal pressure sensing

New γ-Ray Sources Identified in All-sky Surveys Based on Fermipy's Advanced Algorithm

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Research in Astronomy and Astrophysics 2024年第10期24卷 81-91页

作者： Yunchuan xiang peng Feng Xiaofei Lan School of Physics and Astronomy China West Normal UniversityNanchong 637009China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China

We employ an efficient method for identifying γ-ray sources across the entire sky,leveraging advanced algorithms from Fermipy,and cleverly utilizing the Galactic diffuse background emission model to partition the entire sky into72 regions,thereby greatly enhancing the efficiency of discovering new sources throughout the sky through multithreaded parallel *** confirming the reliability of the new method,we applied it for the first time to analyze data from the Fermi Large Area Telescope(Fermi-LAT)encompassing approximately 15.41 yr of all-sky *** this analysis,we successfully identified 1379 new sources with significance levels exceeding 4σ,of which 497 sources exhibited higher significance levels exceeding 5σ.Subsequently,we performed a systematic analysis of the spatial extension,spectra,and light variation characteristics of these newly identified *** identified 21 extended sources and 23 sources exhibiting spectral curvature above 10 ***,we identified 44 variable sources above 1 GeV.

关键词： gamma-rays:diffuse background methods:data analysis catalogs gamma-rays:general

Microstructural evolution and deformation behavior of friction stir welded twin-induced plasticity steel

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Journal of Materials Science & Technology 2024年第2期169卷 68-81页

作者： Ke Qiao Kuaishe Wang Jia Wang Zhengyang Hao Yating xiang peng Han Jun Cai Qi yang Wen Wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyXi’an 710055China Shanghai Research Institute of Materials Shanghai 200437China

The weldability of twin-induced plasticity(TWIP)steel with ultra-high strength via friction stir welding(FSW)technique was investigated,and microstructural evolution and deformation behavior of whole and micro-zones of FSW TWIP joint were studied for the first *** results showed that the content of recrystallized grains in the stir zone(SZ)increased from 10.5%of basal material(BM)to 14.2%,and that of heat affected zone(HAZ)increased to 78.6%.The percentage of annealing twins decreased from 26.8%in BM to 11%in SZ,while increased to 35%in *** with the BM,the ultimate tensile strength and yield strength of the FSW joint increased to 1036 and 550 MPa,respectively,reaching 106.7%and 110.9%of BM,*** elongation of the entire joint was 50.5%,which was lower than that of BM due to the nonuniform deformation during the tensile *** engineering strain was mainly concentrated in BM and SZ and transferred to each other during the tensile test,while the engineering strain in HAZ was always the ***,the tensile fracture occurred in the *** order of ultimate tensile strength of micro-zones in the FSW joint was as follows:HAZ>BM≈*** order of yield strength was as follows:HAZ>BM>SZ.

关键词： Twin-induced plasticity steel Friction stir welding Microstructure Mechanical property Deformation behavior

Feature-Grounded Single-Stage Text-to-Image Generation

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Tsinghua Science and Technology 2024年第2期29卷 469-480页

作者： Yuan Zhou peng Wang Lei xiang Haofeng Zhang School of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing 210044China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Recently,Generative Adversarial Networks(GANs)have become the mainstream text-to-image(T2I)***,a standard normal distribution noise of inputs cannot provide sufficient information to synthesize an image that approaches the ground-truth image ***,the multistage generation strategy results in complex T2I ***,this study proposes a novel feature-grounded single-stage T2I model,which considers the“real”distribution learned from training images as one input and introduces a worst-case-optimized similarity measure into the loss function to enhance the model's generation *** results on two benchmark datasets demonstrate the competitive performance of the proposed model in terms of the Frechet inception distance and inception score compared to those of some classical and state-of-the-art models,showing the improved similarities among the generated image,text,and ground truth.

关键词： text-to-image(T2I) feature-grounded single-stage generation Generative Adversarial Network(GAN)

Single-cell sequencing technology in diabetic wound healing:New insights into the progenitors-based repair strategies

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World Journal of Stem Cells 2024年第5期16卷 462-466页

作者： Zhen xiang Rui-peng Cai yang Xiao Yong-Can Huang Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Breast and Thyroid Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

Diabetes mellitus(DM),an increasingly prevalent chronic metabolic disease,is characterised by prolonged hyperglycaemia,which leads to long-term health *** much effort has been put into understanding the pathogenesis of diabetic wounds,the underlying mechanisms remain *** advent of single-cell RNA sequencing(scRNAseq)has revolutionised biological research by enabling the identification of novel cell types,the discovery of cellular markers,the analysis of gene expression patterns and the prediction of develop-mental *** powerful tool allows for an in-depth exploration of pathogenesis at the cellular and molecular *** this editorial,we focus on progenitor-based repair strategies for diabetic wound healing as revealed by scRNAseq and highlight the biological behaviour of various healing-related cells and the alteration of signalling pathways in the process of diabetic wound *** could not only deepen our understanding of the complex biology of diabetic wounds but also identify and validate new targets for inter-vention,offering hope for improved patient outcomes in the management of this challenging complication of DM.

关键词： Single-cell sequencing Diabetic wound healing Cell subpopulations Heterogeneity Pathogenesis Progenitor cells