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Animal models of Alzheimer's disease:Current strategies and new directions

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Zoological Research 2024年第6期45卷 1385-1407页

作者： qing Wang Bai-Ting Zhu peng Lei Department of Neurology and State Key Laboratory of biotherapy National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China

Animal models constructed using pathogenic factors have significantly advanced drug development for Alzheimer's disease(AD).These predominantly transgenic models,mainly in mice,replicate pathological phenotypes through gene mutations associated with familial AD cases,thus serving as vital tools for assessing drug efficacy and for performing mechanistic ***,the speciesspecific differences and complex,heterogeneous nature of AD etiology pose considerable challenges for the translatability of these animal models,limiting their utility in drug *** review offers a comprehensive analysis of widely employed rodent(mice and rats)and non-rodent models(Danio rerio(zebrafish),Drosophila melanogaster,and Caenorhabditis elegans),detailing their phenotypic features and specific research *** review also examines the limitations inherent in these models and introduces various strategies for expanding AD modeling across diverse species,emphasizing recent advancement in non-human primates(NHPs)as valuable ***,potential insights from the integration of innovative technologies in AD research are discussed,while providing valuable perspectives on the future development of AD animal models.

关键词： Alzheimer’s disease Animal models Aβ Tau Non-human primates

Soliton Solutions for Nonisospectral AKNS Equation by Hirota＇s Method

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Communications in Theoretical Physics 2006年第3期45卷 398-400页

作者： bi Jin-Bo SUN Ye-peng CHEN Deng-Yuan Department of Mathematics Shanghai University Shanghai 200444 China

bilinear form of the nonisospectral AKNS equation is given. The N-soliton solutions are obtained through Hirota＇s method.

关键词： nonisospectral AKNS equation soliton solutions Hirota's method

Integrating Inventory Monitoring and Capacity Changes in Dynamic Supply Chains With bi-Directional Cascading Propagation Effects

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IEEE/CAA Journal of Automatica Sinica 2024年第12期11卷 2515-2518页

作者： En-Zhi Cao Chen peng qing-Kui Li the School of Mechatronic Engineering and Automation Shanghai University IEEE the School of Automation Beijing Information Science and Technology University

Dear Editor,This letter focuses on the integration of inventory monitoring and capacity changes in dynamic supply chains(SCs) with the bullwhip effect(BE) and the ripple effect(RE). First, a new inventory monitoring model with stochastic switched topologies is proposed for SCs, potentially showing merits in incorporating the BE and the RE,and allowing control-theoretic approaches to identify their interrelations. Then, sufficient conditions on the existence of inventory controllers are derived such that the monitoring system is stabilizable with mitigation of the BE in the presence of the RE.

关键词： Monitoring Fluctuations Control theory Switches Topology Raw materials Markov processes

An improved mathematical model to simulate mold filling process in high pressure die casting using CLSVOF method and CSF model

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China Foundry 2015年第3期12卷 180-188页

作者： Cheng bi Zhi-peng Guo Shou-mei Xiong School of Materials Science and Engineering Tsinghua University

A 3D mathematical model was proposed to simulate the mold filling process in high-pressure die casting(HPDC) to improve accuracy considering the surface tension. Piecewise liner interface calculation(PLIC) and volume of fluid(VOF) methods were used to construct the pattern of the liquid interface. A coupled levelset and VOF method(CLSVOF) was proposed to capture the interface pattern and obtain its normal vector. A continuum surface force(CSF) model was used to consider the surface tension. Two water analogy experiments were carried out using the proposed model. Simulation and experimental results were analyzed and compared; and the effects of surface tension were also discussed. The simulation results agreed well with the experiments and the simulation accuracy was an improvement on interface geometries, liquid flows, and gas entrapments.

关键词： mold filling HPDC CLSVOF CSF surface tension force

From frequency domain to time domain:performance analysis on cyclic prefixed multi-user single-carrier transmission

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Science China(Information Sciences) 2016年第8期59卷 144-152页

作者： Wei peng qing F.ZHOU An HUANG Shaodan MA School of Electronics Information and Communications Huazhong University of Science and Technology School of Computer and Information Hefei University of Technology Faculty of Science and Technology University of Macau

This paper analyzes the performance of cyclic prefixed single-carrier transmission under multiuser interference(MUI). For multi-user receivers using single carrier frequency domain adaptive antenna array,we derive the signal to interference plus noise ratio by analyzing the time domain estimated signal after the transformation from frequency domain to time domain. By assuming the MUI follows the Gaussian distribution,we can derive the analytical expression for the bit error rate(BER) performance. The analytical result is verified by the numerical results generated by Monte Carlo method. It is concluded from the analytical results that if the number of receive antennas goes to infinity as assumed in massive multiple input multiple output(MIMO)system, the BER performance will be determined by two ratios: signal to noise ratio as well as the Nr to U ratio, where Nr is the number of receive antennas and U is the number of users.

关键词： single-carrier transmission multi-user interference frequency domain processing MIMO SCFDAAA

Comparison between controlled landfill reactor and conditioned landfill bioreactor

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Journal of Environmental Sciences 2004年第5期16卷 874-880页

作者： LUOFeng CHENWan-zhi SONGFu-zhong LIXiao-peng ZHANGGuo-qing CollegeofResourceandEnvironmentalScience ChongqingUniversityChongqing400044China ChongqingEnvironmentalProtectionBureau Chongqing400010China ChongqingConstructionCommittee Chongqing400010China

bioreactor landfills allow a more active landfill management that recognizes the biological, chemical and physical processes involved in a landfill environment. The laboratory-scale simulators of landfill reactors treating municipal solid wastes were studied, the effect of solid waste size, leachate recirculation, nutrient balance, pH value, moisture content and temperature on the rate of municipal solid waste(MSW) biodegradation were determined, and it indicated the optimum pH value, moisture content and temperature decomposing MSW. The results of waste biodegradation were compared with that of the leachate-recirculated landfill simulator and conservative sanitary landfill simulator. In the control experiment the antitheses of a decreasing trend of the organic load, measured as biological oxygen demand and chemical oxygen demand, was shown. An obvious enhancement of effective disposal from conservative sanitary landfill(CSL) simulator, to the leachate-recirculated landfill(LRL) simulator and to the conditioned bioreactor landfill(CBL) simulator would be noted, through displaying the compared results of solid waste settlement, heavy metal concentration in leachate, methane production rate, biogas composition, BOD and COD as well as their ratio.

关键词： landfill bioreactor methanogenesis methane production municipal solid waste leachate recirculation biodegradation of solid waste specific methanogenic activity(SMA)

Macular Perfusion Changes and Ganglion Cell Complex Loss in Patients with Silicone Oil-related Visual Loss

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biomedical and Environmental Sciences 2020年第3期33卷 151-157页

作者： MA Ya ZHU Xiao qing peng Xiao Yan Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective The aim of this study was to investigate macular perfusion changes and ganglion cell complex(GCC)loss in patients with unexplained visual loss following vitrectomy and silicone oil(SO)tamponade,and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT).Methods This retrospective study included seven eyes(seven patients)with unexpected visual loss after vitrectomy and SO *** was used to evaluate the alterations in retinal vessel density(VD)in the superficial capillary plexus(SCP),deep capillary plexus(DCP),and radial peripapillary capillary plexus(RPCP).OCT was used to measure the thickness of GCC and retinal nerve fiber layer(RNFL).Medical records of patients were *** Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls(all sections P<0.05).No difference was found in GCC thickness,but FLV(focal loss volume)and GLV(global loss volume)were significantly higher in the affected eyes(both P<0.001).SCP VD was inversely correlated with FLV and *** Silicone oil-related severe visual loss was associated with superficial retinal microvasculature damage and ganglion cell apoptosis.

关键词： Silicone oil Visual loss Optical coherence tomography angiography Ganglion cell complex

Effect of water droplet in solvent sublation

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Chinese Chemical Letters 2008年第5期19卷 623-626页

作者： peng Yu bi Hui Ru Dong Nan Nan Wang College of Science Beijing University of Chemical Technology Beijing 100029 China

Aqueous phase layer around bubble and water droplet are two additional processes in solvent sublation. In the dynamic process of mass transfer, they are always neglected, but they are very important in the investigation of thermodynamic equilibrium. In this paper, the effect of water droplet in solvent sublation was discussed in detail, and the previous mathematical model of solvent subaltion was improved. Matlab 6.5 was used to simulate the process of water droplets, and the comparison between the previous hypothesis and the improvement in this paper showed the superiority, especially in the investigation of thermodynamic equilibrium. Moreover, the separation and concentration of the complex compound dithizone-Co（Ⅱ） from aqueous phase to n-octanol by solvent sublation also proved the improved mathematical model was reasonable.

关键词： Solvent sublation Water droplet Mathematical model

The Low-Rank Approximation of Fourth-Order Partial-Symmetric and Conjugate Partial-Symmetric Tensor

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Journal of the Operations Research Society of China 2023年第4期11卷 735-758页

作者： Amina Sabir peng-Fei Huang qing-Zhi Yang School of Mathematics and Statistics Kashi UniversityKashi844008XinjiangChina School of Mathematical Sciences and LPMC Nankai UniversityTianjin300071China

We present an orthogonal matrix outer product decomposition for the fourth-order conjugate partial-symmetric(CPS)tensor and show that the greedy successive rank-one approximation(SROA)algorithm can recover this decomposition *** on this matrix decomposition,the CP rank of CPS tensor can be bounded by the matrix rank,which can be applied to low-rank tensor ***,we give the rank-one equivalence property for the CPS tensor based on the SVD of matrix,which can be applied to the rank-one approximation for CPS tensors.

关键词： Conjugate partial-symmetric tensor Approximation algorithm Rank-one equivalence property Convex relaxation