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Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei NG Xiaoping zhang Jianwu CHEN Yongqiang SHI Fuchang ZUO Wenxi peng Weichun FU Liansheng LI pengwei LUO Chi-Long TANG Guozheng zhang Zhiwu MEI Li WANG Cunhui LI Jiaming OU Yanyan Xu State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao999078China Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control EngineeringBeijing100190China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of PhysicsLanzhou730000China China National Space Administration(CNSA) Macao Center for Space Exploration and ScienceMacao999078China

The Solar X-ray Detector(SXD)on-board the Macao Science Satellite-1B(MSS-1B)was successfully launched via the Chinese Long March-2C rocket on 21 May 2023,and commenced operations in early June of the same *** MSS-1B/Soft X-ray Detection Units(SXDUs)employ two silicon drift detectors(SDDs),providing a wide range of energy spectra spanning from 0.7 to 24 ***,the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 ***,we perform thorough calibrations of the MSS-1B/SXDUs,employing a combination of ground experiments and *** addition,quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES),provides compelling evidence of their ***,the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs,unlocking their potential for facilitating the study of dynamic evolution of solar ***,the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays,thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B(MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

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DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis

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Science China(Life Sciences) 2025年第2期68卷 467-483页

作者： Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang pengcheng Shu Chen zhang Xiaozhong peng State KeyLaboratoryofCommon Mechanism Research for Major Diseases Departmentof Biochemistry&Molecular BiologyMedicalPrimate Research CenterNeuroscienceCenterInstituteof Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China Key Laboratoryof Biomechanics and Mechanobiology(Beihang University) Ministryof EducationBeijing AdvancedInnovation Center for Biomedical EngineeringSchoolof Engineering MedicineBeihang UniversityBeijing 100191China Chinese Institute for Brain Research Beijing 102206China

D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological ***-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ***,it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological *** the present research,we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis,which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic ***,DTD1 played a considerable role in regulating dendritic morphology and synaptic *** a consequence,DTD1 affected neurobiological events,including the synaptic strength of the CA3-to-CA1 circuit,dendritic spine density of hippocampal pyramidal neurons,and behavioral performance of mice in the Morris water *** findings highlight the important role of DTD1 in synaptic transmission,neuronal morphology,and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.

关键词： D-aminoacyl-tRNA deacylase 1 D-serine D-aspartate synaptic transmission neuronal morphology spatial learning and memory

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Interface engineering of Pt/CeO2-{100} catalysts for enhancing catalytic activity in auto-exhaust carbon particles oxidation

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Chinese Chemical Letters 2025年第2期36卷 195-200页

作者： peng zhang Yitao Yang Tian Qin Xueqiu Wu Yuechang Wei Jing Xiong Xi Liu Yu Wang Zhen Zhao Jinqing Jiao Liwei Chen State Key Laboratory of Heavy Oil Processing Key Laboratory of Optical Detection Technology for Oil and GasCollege of ScienceChina University of Petroleum School of Chemistry and Chemical In-situ Center for Physical SciencesFrontiers Science Center for Transformative MoleculesShanghai Jiao Tong University School of Chemistry and Chemical Engineering Ningxia University School of Environmental Science and Engineering Yancheng Institute of Technology State Key Laboratory of Chemical Safety SINOPEC Research Institute of Safety Engineering Co.Ltd.

Herein,we fabricate an embedding structure at the interface between Pt nanoparticles （NPs） and CeO2-{100}nanocubes with surface defect sites （CeO2-SDS） through quenching and gas bubbling-assisted membrane reduction *** in-situ substitution of Pt NPs for atomic-layer Ce lattice significantly increases the amount of reactive oxygen species from 133.68μmol/g to 199.44μmol/*** a result,the distinctive geometric structure of Pt/CeO2-SDS catalyst substantially improves the catalytic activity and stability for soot oxidation compared with the catalyst with no quenching process,i.e.,its T50and TOF values are 332°C and 2.915 h-1,*** with the results of experimental investigations and density functional theory calculations,it is unveiled that the unique embedding structure of Pt/CeO2-SDS catalyst can facilitate significantly electron transfer from Pt to the CeO2-{100}support,and induce the formation of interfacial[Ce-Ox-Pt2]bond chains,which plays a crucial role in enhancing the key step of soot oxidation through the dual activation of surface lattice oxygen and molecular *** a fundamental revelation of the interfacial electronic transmission and corresponding modification strategy contributes a novel opportunity to develop high-efficient and stable noble metal catalysts at the atomic level.

关键词： Catalytic oxidation Defective ceria Nanocube Pt NPs Soot particles

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting zhang Xiao-Jun Liu Xue-Bin peng Xiao-Rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Insights into microscopic oil occurrence characteristics in shales from the Paleogene Funing Formation in Subei Basin, China

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Petroleum Science 2025年第1期22卷 55-75页

作者： Jun-Jie Wang peng-Fei zhang Shuang-Fang Lu Zi-Zhi Lin Wen-Biao Li Jun-Jian zhang Wei-Zheng Gao Neng-Wu Zhou Guo-Hui Chen Ya-Jie Yin Han Wu Sanya Offshore Oil & Gas Research Institute of Northeast Petroleum University College of Earth Science and Engineering Shandong University of Science and Technology Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development Ministry of Education Northeast Petroleum University School of Geoscience China University of Petroleum (East China)

The microscopic occurrence characteristics primarily constrain the enrichment and mobility of shale *** study collected the lacustrine shales from the Palaeogene Funing Formation in the Gaoyou Sag, Subei Basin. Conventional and multistage Rock-Eval, scanning electron microscopy, and nuclear magnetic resonance(NMR) T1-T2were performed to analyze the contents and occurrence characteristics of shale oil. Low-temperature nitrogen adsorption-desorption(LTNA/D) experiments were conducted on the shales before and after extraction. The relationships between shale oil occurrence with organic matter and pore structures were then discussed. Predominantly, the shale oil in the Funing Formation is found within fractures, with secondary occurrences in interparticle pores linked to brittle minerals and sizeable intraparticle pores associated with clay minerals. The selected shales can be categorized into two types based on the nitrogen isotherms. Type A shales are characterized by high contents of felsic and calcareous minerals but low clay minerals, with larger TOC and shale oil values. Conversely, Type B shales are marked by abundant clay minerals but diminished TOC and shale oil contents. The lower BET specific surface area(SSA), larger average pore diameter, and simpler pore surfaces and pore structures lead to the Type A shales being more conducive to shale oil enrichment and mobility. Shale oil content is predominantly governed by the abundance of organic matter, while an overabundance of organic matter typically equates to a reduced ratio of free oil and diminished fluidity. The BET SSA, volumes of pores less than 25 and 100 nm at extracted state all correlate negatively with total and adsorbed oil contents but display no correlation with free oil, while they have positive relationships with capillary-bound ***, pore water is mainly saturated in micropores(<25 nm) and minipores(25-100 nm), as well as adsorbed oil, while free oil, i.e., bound and movable

关键词： Occurrence characteristic Shale oil content Pore structure Low-temperature nitrogen adsorption-desorption Gaoyou Sag

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PPS-SLAM: Dynamic Visual SLAM with a Precise Pruning Strategy

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Computers, Materials & Continua 2025年第2期82卷 2849-2868页

作者： Jiansheng peng Wei Qian Hongyu zhang College of Automation Guangxi University of Science and TechnologyLiuzhou545000China Department of Artificial Intelligence and Manufacturing Hechi UniversityHechi546300China Key Laboratory of AI and Information Processing Education Department of Guangxi Zhuang Autonomous RegionHechi546300China Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology School of Chemistry and BioengineeringHechi UniversityHechi546300China

Dynamic visual SLAM (Simultaneous Localization and Mapping) is an important research area, but existing methods struggle to balance real-time performance and accuracy in removing dynamic feature points, especially when semantic information is missing. This paper presents a novel dynamic SLAM system that uses optical flow tracking and epipolar geometry to identify dynamic feature points and applies a regional dynamic probability method to improve removal accuracy. We developed two innovative algorithms for precise pruning of dynamic regions: first, using optical flow and epipolar geometry to identify and prune dynamic areas while preserving static regions on stationary dynamic objects to optimize tracking performance;second, propagating dynamic probabilities across frames to mitigate the impact of semantic information loss in some frames. Experiments show that our system significantly reduces trajectory and pose errors in dynamic scenes, achieving dynamic feature point removal accuracy close to that of semantic segmentation methods, while maintaining high real-time performance. Our system performs exceptionally well in highly dynamic environments, especially where complex dynamic objects are present, demonstrating its advantage in handling dynamic scenarios. The experiments also show that while traditional methods may fail in tracking when semantic information is lost, our approach effectively reduces the misidentification of dynamic regions caused by such loss, thus improving system robustness and accuracy.

关键词： Visual SLAM dynamic SLAM YOLOv8

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Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao Yue Yiman zhang Lulu Li Zhong-Zhen Yu peng Min Hao-Bin zhang State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

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Non-specific/specific SERS spectra concatenation for precise bacteria classifications with few samples using a residual neural network

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Chinese Chemical Letters 2025年第1期36卷 484-490页

作者： Feihu Wu Gengwen Chen Kaitao Lai Shiqing zhang Yingchao Liu Ruijian Luo Xiaocong Wang Pinzhi Cao Yi Ye Jiarong Lian Junle Qu Zhigang Yang Xiaojun peng Shenzhen Key Laboratory of Photonics and Biophotonics&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China Hematology Reagent R&D department Mindray Bio-medical Electronics Co.LTD.Shenzhen 518107China State Key Laboratory of Fine Chemicals College of Material Science and EngineeringShenzhen UniversityShenzhen 518060China

Deep learning neural network incorporating surface enhancement Raman scattering technique(SERS)is becoming as a powerful tool for the precise classifications and diagnosis of bacterial ***,the large amount of sample requirement and time-consuming sample collection severely hinder its *** herein propose a spectral concatenation strategy for residual neural network using nonspecific and specific SERS spectra for the training data augmentation,which is accessible to acquiring larger training dataset with same number of SERS spectra or same size of training dataset with fewer SERS spectra,compared with pure non-specific SERS *** this strategy,the training loss exhibit rapid convergence,and an average accuracy up to 100%in bacteria classifications was achieved with50 SERS spectra for each kind of bacterium;even reduced to 20 SERS spectra per kind of bacterium,classification accuracy is still>95%,demonstrating marked advantage over the results without spectra *** method can markedly improve the classification accuracy under fewer samples and reduce the data collection workload,and can evidently enhance the performance when used in different machine learning models with high generalization ***,this strategy is beneficial for rapid and accurate bacteria classifications with residual neural network.

关键词： SERS Deep learning Resnet Bacteria classification Spectra concatenation

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Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases

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Neural Regeneration Research 2025年第12期20卷 3349-3369页

作者： Yichen peng Li Zhou Yaju Jin Danli Wu Na Chen Chengcai zhang Hongpeng Liu Chunlan Li Rong Ning Xichen Yang Qiuyue Mao Jiaxin Liu pengyue zhang Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment Key Laboratory of Acupuncture and Massage for Treatment of EncephalopathyCollege of AcupunctureTuina and RehabilitationYunnan University of Chinese MedicineKunmingYunnan ProvinceChina School of Medicine Kunming University of Science and TechnologyKunmingYunnan ProvinceChina

The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic ***-associated endoplasmic reticulum membranes serve as physical contact channels between the endoplasmic reticulum membrane and the mitochondrial outer membrane,formed by various proteins and protein *** microstructural domain mediates several specialized functions,including calcium(Ca^(2+))signaling,autophagy,mitochondrial morphology,oxidative stress response,and ***,the dysregulation of Ca^(2+)signaling mediated by mitochondria-associated endoplasmic reticulum membranes is a critical factor in the pathogenesis of neurological *** proteins or protein complexes within these membranes directly or indirectly regulate the distance between the endoplasmic reticulum and mitochondria,as well as the transduction of Ca^(2+)***,Ca^(2+)signaling mediated by mitochondria-associated endoplasmic reticulum membranes influences other mitochondria-associated endoplasmic reticulum membraneassociated *** functions can vary significantly across different neurological diseases—such as ischemic stroke,traumatic brain injury,Alzheimer's disease,Parkinson's disease,amyotrophic lateral sclerosis,and Huntington's disease—and their respective stages of *** modulation of these disease-related pathways and functional proteins can enhance neurological function and promote the regeneration and repair of damaged ***,mitochondria-associated endoplasmic reticulum membranes-mediated Ca^(2+)signaling plays a pivotal role in the pathological progression of neurological diseases and represents a significant potential therapeutic *** review focuses on the effects of protein complexes in mitochondria-associated endoplasmic reticulum membranes and the distinct roles of mitochondria-associated endoplasmic reticulum membranes-mediated Ca^(2+)sign

关键词： Alzheimer’s disease amyotrophic lateral sclerosis Ca^(2+)signaling conduction Huntington’s disease ischemic stroke mammals mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury

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