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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai Yu peng Wen Hu Yi liu hui Wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

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Three New Classes of Subsystem Codes

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 38-44页

作者： LI hui liu Xiusheng HU peng School of Mathematics and Physics Hubei Polytechnic UniversityHuangshi 435003HubeiChina College of Arts and Science Hubei Normal UniversityHuangshi 435003HubeiChina

In this paper,we construct three classes of Clifford subsystem maximum distance separable(MDS)codes based on Reed-Solomon codes and extended generalized Reed-Solomon codes over finite fields Fq for specific code ***,o... 详细信息

关键词： Clifford subsystem codes Reed-Solomon codes generator matrices

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On the Specificity of Nanozymes: A Perspective

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Chinese Journal of Chemistry 2024年第13期42卷 1515-1522页

作者： Gen Wei Shuje liu Yung-Kang peng hui Wei Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjingJiangsu 21023China Department of Chemistry.City University of Hong Kong Hong Kong 999077Hong Kong SARChina State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjingJiangsu 210023China NMPA Key Laboratory for Biomedical Optics HangzhouZhejiang 310018China

We have compiled eight promising strategies for enhancing the specificity and selectivity of nanozymes,as depicted in the comprehensive summary *** exhibit intricate and sophisticated structures,including substrate channels and active sites,which can inform the design of *** of these structural features and the application of facet engineering/doping techniques can significantly enhance the catalytic specificity of ***,the use of Molecularly Imprinted Polymers(MiPs)to coat nanozymes represents an effective approach to impart substrate ***,several straightforward stopgap strategies have been devised to improve nanozyme specificity for analytical applications,such as the integration of biorecognition elements and nanozyme sensor arrays through surface modification.

关键词： Nanozymes Enzymes Catalytic activity Specificity Perspective

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HIV Infection and Associated Factors Among Out-of-School MSM Aged 16–24 Years—6 Cities and Tianjin Municipality,China,2022–2023

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China CDC weekly 2024年第3期6卷 45-50页

作者： hui liu Qiyu Zhu Lei Zhang Yujing liu peng Xu Mengjie Han National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Association of STD and AIDS Prevention and Control BeijingChina Beijing Chaoyang Kangzhong Health and Education Center BeijingChina

What is already known about this topic?Approximately 80%of newly diagnosed human immunodeficiency virus(HIV)cases among individuals aged 15–24 years in China are attributed to out-ofschool *** is added by this report?This study presents findings on HIV prevalence and comprehensive insights into HIV service utilization,risky behaviors,and prevention knowledge among young out-of-school men who have sex with men(MSM)aged 16–24 years in *** population exhibits a disproportionately high burden of HIV,with only 51.6%of HIV cases previously *** are the implications for public health practice?HIV services should be expanded to include these key *** interventions are needed to remove barriers to regular HIV services faced by young key populations.

关键词： prevention remove expanded

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RuO_(2)/CoMO_(2)O_(x )Catalyst with Low Ruthenium Loading for Long-Term Acidic Oxygen Evolution

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Transactions of Tianjin University 2024年第5期30卷 395-405页

作者： Yingying Wang hui Pan Zhikun liu peng Kang School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

We must urgently synthesize highly efficient and stable oxygen-evolution reaction(OER) catalysts for acidic media. Herein, we constructed a series of Ti mesh(TM)-supported RuO_(2)/CoMo_(y)O_(x )catalysts(RuO_(2)/CoMo_(y)O_(x)/TM) with heterogeneous structures. By optimizing the ratio of Co to Mo, RuO_(2)/CoMO_(2)O_(x)/TM with low Ru loading(0.079 mg/cm^(2)) achieves remarkable OER performance( η = 243 mV at 10 mA/cm^(2)) and high stability(300 h @ 10 mA/cm^(2)) in 0.5 mol/L H_(2)SO_(4) electrolyte. The activity of RuO_(2)/CoMo_yO_x/TM can be maintained for 50 h at 100 mA/cm^(2), and a water electrolyzer with RuO_(2)/CoMO_(2)O_(x)/TM as anode can operate for 40 h at 100 mA/cm~2, suggesting the remarkable OER durability of RuO_(2)/CoMo__(y)O__(x)/TM in acidic electrolyte. Owing to the heterogeneous interface between CoMO_(2)O_(x) and RuO_(2), the electronic structure of Ru atoms was optimized and electron-rich Ru was formed. With modulated electronic properties, the dissociation energy of H_(2)O is weakened, and the OER barrier is lowered. This study provides the design of low-cost noble metal catalysts with long-term stability in an acidic environment.

关键词： Oxygen-evolution reaction Ru-based catalyst Acidic media Heterostructure Long-term electrolysis Low precious metal

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Total ionizing dose effect modeling method for CMOS digital-integrated circuit

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Nuclear Science and Techniques 2024年第2期35卷 32-46页

作者： Bo Liang Jin-hui liu Xiao-peng Zhang Gang liu Wen-Dan Tan Xin-Dan Zhang School of Computer Science and Technology Xidian UniversityXi’an 710071China

Simulating the total ionizing dose(TID)of an electrical system using transistor-level models can be difficult and expensive,particularly for digital-integrated circuits(ICs).In this study,a method for modeling TID effects in complementary metaloxide semiconductor(CMOS)digital ICs based on the input/output buffer information specification(IBIS)was *** digital IC was first divided into three parts based on its internal structure:the input buffer,output buffer,and functional *** of these three parts was separately *** the IBIS model,the transistor V-I characteristic curves of the buffers were processed,and the physical parameters were extracted and modeled using *** the functional area,logic functions were modeled in VHDL according to the data sheet.A golden digital IC model was developed by combining the input buffer,output buffer,and functional area ***,the golden ratio was reconstructed based on TID experimental data,enabling the assessment of TID effects on the threshold voltage,carrier mobility,and time series of the digital *** experiments were conducted using a CMOS non-inverting multiplexer,NC7SZ157,and the results were compared with the simulation results,which showed that the relative errors were less than 2%at each dose *** confirms the practicality and accuracy of the proposed modeling *** TID effect model for digital ICs developed using this modeling technique includes both the logical function of the IC and changes in electrical properties and functional degradation impacted by TID,which has potential applications in the design of radiation-hardening tolerance in digital ICs.

关键词： CMOS digital-integrated circuit Total ionizing dose IBIS model Behavior-physical hybrid model Physical parameters

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Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： peng-hui Li hui Zhou Wen-Juan Wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance

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Multi-Level Parallel Network for Brain Tumor Segmentation

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 741-757页

作者： Juhong Tie hui peng School of Software Engineering Chengdu University of Information TechnologyChengdu610225China

Accurate automatic segmentation of gliomas in various sub-regions,including peritumoral edema,necrotic core,and enhancing and non-enhancing tumor core from 3D multimodal MRI images,is challenging because of its highly heterogeneous appearance and *** convolution neural networks(CNNs)have recently improved glioma segmentation ***,extensive down-sampling such as pooling or stridden convolution in CNNs significantly decreases the initial image resolution,resulting in the loss of accurate spatial and object parts information,especially information on the small sub-region tumors,affecting segmentation ***,this paper proposes a novel multi-level parallel network comprising three different level parallel subnetworks to fully use low-level,mid-level,and high-level information and improve the performance of brain tumor *** also introduce the Combo loss function to address input class imbalance and false positives and negatives imbalance in deep *** proposed method is trained and validated on the BraTS 2020 training and validation *** the validation dataset,ourmethod achieved a mean Dice score of 0.907,0.830,and 0.787 for the whole tumor,tumor core,and enhancing tumor core,*** with state-of-the-art methods,the multi-level parallel network has achieved competitive results on the validation dataset.

关键词： Convolution neural network brain tumor segmentation parallel network

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Ten key issues for ecological restoration of territorial space

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National Science Review 2024年第7期11卷 75-79页

作者： Jian peng Dongmei Xu Zihan Xu hui Tang Hong Jiang Jianquan Dong Yanxu liu Technology Innovation Center for Integrated Ecosystem Restoration and Sustainable Utilization Ministry of Natural Resources College of Urban and Environmental Sciences Peking University School of Soil and Water Conservation Beijing Forestry University Key Laboratory for Environmental and Urban Sciences School of Urban Planning and DesignShenzhen Graduate School Peking University School of Landscape Architecture Beijing Forestry University State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical Science Beijing Normal University

Ecological restoration is an effective measure to protect biodiversity, sustain ecosystem services and enhance socialecological resilience. It is defined as the process of assisting the recovery of an ecosystem that h... 详细信息

关键词： PRIORITY AREAS

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Ethical concerns in aging research:perspectives of global frontline researchers

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Science China(Life Sciences) 2024年第10期67卷 2149-2156页

作者： Yaojin peng Lulu Ding Zhenyu Xiao Moshi Song Jianwei Lv Guang-hui liu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Stem Cell and Reproductive BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Aging Biomarker Consortium(ABC) Beijing 100101China School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Life Sciences Xiamen UniversityXiamen 361102China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China

This study investigated the ethical landscape of aging research amid the increasing global focus on extending the human lifespan and health *** global survey of 180 researchers across 38 jurisdictions revealed divergent perceptions of aging,a consensus regarding the feasibility of delaying aging,and multiple perspectives regarding lifespan *** present findings underscore a paradigm shift toward inclusive and ethically sound research,emphasizing the need for an approach that strikes a balance between basic and clinical *** addition,this study highlighted key ethical concerns in aging research,including the effects of misleading advertising,potential inequality in access to aging interventions,and risks pertaining to the extrapolation of research findings from lower-model organisms to *** insights presented in this paper call for an integrated approach for overcoming the complex ethical and societal challenges in aging research to ensure responsible and equitable advancements in this burgeoning field.

关键词： aging ethical landscape ethics surveys and questionnaires

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