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Quasi-Two-Dimensional Diffusion in Adherent Cells Revealed by Three-Dimensional Single Quantum Dot Tracking

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Chinese Physics Letters 2020年第7期37卷 130-136页

作者： Chao Jiang Bo Li Shuo-Xing Dou peng-ye Wang Hui Li Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China School of Systems Science Beijing Normal UniversityBeijing 100875China

Intracellular diffusion is critical for molecule translocation in cytoplasm and mediates many important cellular ***,the diffusion dynamics is affected by the heterogeneous *** studies on intracellular diffusion are mainly based on two-dimensional(2 D)measurements under the assumption that the three-dimensional(3 D)diffusion is ***,the real behaviors of 3 D diffusion of molecules in cytoplasm are still ***,we have built a 3 D single-particle tracking(SPT)microscopy and studied the 3 D diffusion of quantum dots(QDs)in adherent A549 ***,we found that the intracellular diffusion of QDs is quasi-2 D,with the axial motion being severely *** investigations demonstrated that disrupting the cytoskeleton component or endoplasmic reticulum(ER)does not alter the quasi-2 D diffusion pattern,although ER reduces the diffusion rates and slightly relieves the constraint in the axial *** preferred quasi-2 D diffusion is quite robust and attributed to the complex cytoarchitectures in the flat adherent *** the aid of 3 D SPT method,the quasi-2 D diffusion in cells was revealed,shedding new light on the physical nature of cytoplasm.

关键词： diffusion quasi Quantum

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具有全局对称性的强关联拓扑物态的规范场论

物理学报 2020年第7期69卷 218-245页

作者：叶鹏中山大学物理学院广州510275

在有对称性保护的条件下,拓扑能带绝缘体等自由费米子体系的拓扑不变量可以在能带结构计算中得到.但是,为了得到强关联拓扑物质态的拓扑不变量,我们需要全新的理论思路.最典型的例子就是分数量子霍尔效应:其低能有效物理一般可以用Chern... 详细信息

在有对称性保护的条件下,拓扑能带绝缘体等自由费米子体系的拓扑不变量可以在能带结构计算中得到.但是,为了得到强关联拓扑物质态的拓扑不变量,我们需要全新的理论思路.最典型的例子就是分数量子霍尔效应:其低能有效物理一般可以用Chern-Simons拓扑规范场论来计算得到;霍尔电导的量子化平台蕴含着十分丰富的强关联物理.本文将讨论存在于玻色和自旋模型中的三大类强关联拓扑物质态:本征拓扑序、对称保护拓扑态和对称富化拓扑态.第一类无需考虑对称性,后两者需要考虑对称性.理论上,规范场论是一种非常有效的研究方法.本文将简要回顾用规范场论来研究强关联拓扑物质态的一些研究进展.具体内容集中在"投影构造理论"、"低能有效理论"、"拓扑响应理论"三个方面.

关键词：强关联系统拓扑序对称保护拓扑态拓扑量子场论

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang peng ye Xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Photorefractive Image Amplification and Beam Fanning with Inclusion of Random Volume Scattering

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Chinese Physics Letters 1997年第12期14卷 908-911页

作者： XIE Ping WANG peng-ye DAI Jiari-hua ZHANG Hong-jun Laboratory of Optical Physics Institute of Physics&Center for Condensed Matter PhysicsChinese Acaderr1.v of SciencesBeijing 100080

Photorefractive effects,such as the image amplification and the beam fanning,can be described by a set of multivariable Langevin equations with inclusion of the random-phased volume scattering due to the inhomogeneities and/or defects in the *** image amplification by two-wave-coupling configuration was studied analytically in the undepleted-pump approximation and *** was found that the volume scattering can generate the beam fanning,as the surface scattering does.

关键词： scattering pump coupling

Process Analysis of Double Circuit Transmission Line Trip-out on the Same Tower Due to Lightning

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高压电器 2011年第9期47卷 31-36,43页

作者： DUAN Da-peng REN Zhi-gang WANG peng ye Kuan CHANG Xiao-qi LI Wei Beijing Electric Power Research Institute Beijing 100075 China

In recent years,several failures of double circuit transmission line on the same tower due to lightning were happened in Beijing power *** it can be reclosed successful,the lightning strike caused a grave threat to the power grid *** cause of the accident and the accident process were studied for the sake of further understanding of the impact of lightning on power *** an example,110 kV double circuit transmission line(Xilong-line) was *** first,the system topology was *** the analysis on relay protection actions and the fault recorder data,over voltage on the insulator strings was *** on the analysis and the calculation,accident cause and the process were presented ***,it comes to the conclusion that the lightning failure was caused by *** wave of the lightning over voltage would spread to the not grounded neutral point of the transformers,and make the neutral protective gap breakdown,then cause freewheeling with the frequency of 50 *** results of the relay protection,the double circuit transmission line all tripped ***,the causes of the accident were proposed that included terrain features,large corner towers,strong thunderstorm weather and poor grounded contact of the tower.

关键词： double circuit transmission lines on the same tower lightning trip-out at the same time fault recorder over-voltage calculation lightning protection

Intracellular transport dynamics revealed by single-particle tracking

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Biophysics Reports 2021年第5期7卷 413-427页

作者： Ming-Li Zhang Hui-Ying Ti peng-ye Wang Hui Li School of Systems Science Beijing Normal University Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Songshan Lake Materials Laboratory

Intracellular transport is the basis for the transfer of matter, energy, and information in cells and is critical to many cellular functions. Within the nonequilibrium environment of living cells, the transport behaviours are far from the traditional motion in liquid but are more complex and active. With the advantage of high spatial and temporal resolution, the single-particle tracking(SPT) method is widely utilized and has achieved great advances in revealing intracellular transport dynamics. This review describes intracellular transport from a physical perspective and classifies it into two modes: diffusive motion and directed motion. The biological functions and physical mechanisms for these two transport modes are introduced. Next, we review the principle of SPT and its advances in two aspects of intracellular transport. Finally, we discuss the prospect of near infrared SPT in exploring the in vivo intracellular transport dynamics.

关键词： Dynamics Intracellular transport Single-particle tracking (SPT) Diffusive motion Directed motion Near infrared SPT

Two-step emulsification for the fabrication of homogeneous PCL microspheres encapsulating geniposidic acid with antioxidant properties

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Particuology 2024年第11期94卷 305-313页

作者： Hongyu Wang peng ye Ran Song Guiru Chen Limei Zhang Huatai Zhu Yuting Ren Jiandu Lei Jing He Beijing Key Laboratory of Lignocellulosic Chemistry College of Material Science and TechnologyBeijing Forestry UniversityBeijing100083China

The mortality rate of neurological disorders is increasing globally,and natural antioxidant geniposidic acid(GPA)holds great potential in the treatment of neuronal oxidative ***,its inherent instability constrains its pragmatic ***,we introduced a drug delivery system capable of protecting unstable natural active compounds from *** the various methods for preparing drug-loaded microspheres,the emulsification-solvent evaporation technique is one of the most commonly employed due to its efficiency and ***,this method results in microspheres with heterogeneous particle *** address this limitation,we developed a two-step emulsification method involving stirring and *** the biocompatible,synthetic,biodegradable polymer polycaprolactone(PCL)as the drug delivery carrier,we prepared GPA-loaded PCL microspheres via the two-step emulsification *** results demonstrated that the microspheres possessed uniform particle size(polydispersity index=0.12),excellent drug loading capacity(∼4.86%),sustained drug release profiles(∼68.55%in 264 h),and biocompatibility(cell viability>85%).The in vitro tests showed that the microspheres exerted antioxidant effects by scavenging reactive oxygen species(ROS)induced by oxidative stress,thereby protecting neuronal cells from oxidative *** work presents a promising new approach for the treatment of neuronal oxidative damage.

关键词： Eucommia ulmoides Oliv. Polycaprolactone Geniposidic acid Two-step emulsification Neuronal oxidative damage Antioxidant

Preparation of waterborne polyurethane/β-cyclodextrin composite nanosponge by ion condensation method and its application in removing of dyes from wastewater

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Chinese Journal of Chemical Engineering 2023年第6期58卷 124-136页

作者： Shanghong Ma Haitao Zhang Jianbo Qu Xiuzhong Zhu Qingfei Hu Jianyong Wang peng ye Futao Sai Shiwei Chen State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China Institute of Material Science and Technology Qilu University of TechnologyShandong Academy of SciencesJinan 250353China

Currently,polymer nanosponges have received extensive ***,developing new synthetic techniques for novel nanosponges remains a ***,to date,composite nanosponge adsorbents based on waterborne polyurethane(WPU)andβ-cyclodextrin(β-CD)have not been ***,a novel green method,ion condensation method,was developed in this study for the preparation of polymer nanosponge adsorbents for efficient removal of dyes from *** on the principle of charge repulsion between nanoparticles to maintain emulsion stability,waterborne polyurethane/β-cyclodextrin composite nanosponges(WPU-x,y)were prepared by coagulating the emulsions synthesized from 2,2-dimethylolpropionic acid,polypropylene glycol and hexamethylene diisocyanate as raw materials in a mixture of hydrochloric acid and anhydrous *** structure and appearance of WPU-x,y were characterized by attenuated total reflectance Fourier transform infrared spectroscopy,thermal gravimetric analyzer,scanning electron microscope and mercury intrusion *** adsorption capacity of WPU-x,y was tested by parameters such as cross-linking degree,β-CD dosage,contact time,initial dye concentration and p H *** study found that WPU-4,4.62 had the best adsorption effect on methylene blue(MB),the maximum removal rate was 93.42%,and the maximum adsorption capacity was 136.03 mg·g^(-1).Moreover,the Sips isotherm and pseudo-second-order-model were suitable for MB ***,this study provides some perspectives for the fabrication of nanosponge adsorbents.

关键词： Ion condensation Composites Nanomaterials Waterborne polyurethane(WPU) β-Cyclodextrin(β-CD) Adsorption

Unsymmetrical Quantum Key Distribution Using Tripartite Entanglement

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Communications in Theoretical Physics 2007年第3期47卷 441-445页

作者： XIONG Jin ZHANG Zhe-Shen ZHOU Nan-Run peng Jin-ye ZENG Gui-Hua State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering Shanghai Jiao Tong University Shargghai 200240 China School of Information Science and Technology Northwest University Xi＇an 710069 China

An unsymmetrical quantum key distribution protocol is proposed, in which Greenherger-Horne-Zeilinger （GHZ） triplet states are used to obtain the secret key. Except the lost qubits due to the unperfectness of the physical devices, the unsymmetrical characteristic makes all transmitted qubits useful. This leads to：an excellent efficiency, which reaches 100% in an ideal case. The ＇security is studied from the aspect of information theory. By using the correlation of the GHZ tripartite entanglement state, eavesdropping can be easily checked out, which indicates that the presented protocol is more secure.

关键词： unsymmetrical quantum key distribution GHZ triplet states