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中国营养学会第十五届全国营养科学大会

作者： Tong peng yiran Guo Baoming He 四川省医学科学院·四川省人民医院北京航空航天大学

In this case study, we report a 24-year-old male who initially presented with 14 days of fever, cephalalgia and paroxysmal limb convulsions, unconscious on admission. The patient was diagnosed with klebsiella pneumoniae pulmonary infection, mNGS ruled out viral encephalitis, suspected autoimmune encephalitis, ultra-refractory epileptic state, hypoproteinemia, and gut microbiota disorder. We evaluated the effects of ketogenic diet intervention on epileptic seizures and gut microbiota dysbiosis in this patient after 40 days of hospitalization and 6 months after discharge. Methods This patient s health and neurological status were regularly monitored by a neurologist during the diet intervention, which consisted of a modified liquid ketogenic diet(60% fat, 30% protein, 5% fiber, and 5% net carbohydrate by weight, comprised of vegetables, meats, eggs, nuts, and vegetable oils, administered by nasogastric tube). The patient was discharged from the hospital and given a 6-month ketogenic diet(60% fat, 30% protein, 5% fiber, and 5% net carbohydrate by weight, comprised of vegetables, meats, eggs, nuts, seeds, and oils) intervention under the supervision of a registered dietitian(RD). A return visit was scheduled by the neurologist after six months for MRI and EEG and a special evoked test. Feces were collected at admission in hospital(0 d), discharge from hospital(40 d), 3 months after discharge from hospital(130 d), and 6 months at return visit(220 d), and shortchain fatty acids(SCFAs) were analyzed by GC-MS and gut microbiota structure was analyzed using 16 S rDNA high-throughput sequencing. Results The patient was discharged from the hospital with the recovery of consciousness, occasional twitching, and normalization of blood protein levels, but the gut microbiota was disturbed, showing loss of microbiota diversity(α-diversity) and dysbiosis of microbiota structure(β-diversity). Moreover, slight trace SCFAs(

关键词： Ketogenic diet,Gut microbiota SCFAs,Metagenomics

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政策工具视角下我国突发公共卫生事件应急管理政策文本量化分析

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中国公共卫生管理 2024年第4期40卷 480-486页

作者：高一冉王燕萍王鹏于甜魏敏王可欣孟楠诸葛瑞倩吴群红哈尔滨医科大学卫生管理学院黑龙江哈尔滨150081 哈尔滨医科大学公共卫生学院

目的剖析我国突发公共卫生事件应急管理相关政策文本,揭示防控治理的内在逻辑,探讨政策工具的特点与不足,为未来政策调整与优化提供有效参考。方法基于内容分析法,建立“政策工具-应急管理生命周期”二维分析框架,对我国367份突发公共... 详细信息

目的剖析我国突发公共卫生事件应急管理相关政策文本,揭示防控治理的内在逻辑,探讨政策工具的特点与不足,为未来政策调整与优化提供有效参考。方法基于内容分析法,建立“政策工具-应急管理生命周期”二维分析框架,对我国367份突发公共卫生事件应急管理政策文本进行量化分析。结果政策工具比重失衡:能力建设型、权威型、激励型政策工具使用较多,分别占32.5%、29.11%、21.19%;象征与劝诫型、系统变革型政策工具使用相对较少,仅占8.67%、8.53%。应急管理各阶段覆盖不均:反应阶段政策工具使用频率最高,占41.38%;恢复、预防阶段使用次之,分别占30.03%、20.96%;准备阶段政策工具使用最少,仅占7.63%。结论建议增加象征与劝诫型、系统变革型工具的使用,重视预防、准备阶段,调整内部结构,确保政策工具与应急管理阶段相协调,实现政策工具的多元化和均衡化,提升政策执行效果。

关键词：突发公共卫生事件卫生政策政策工具量化分析

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Preparation of cationic polyacrylamide microsphere emulsion and its performance for permeability reduction

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Petroleum Science 2014年第3期11卷 408-416页

作者： Guo Aijun Geng yiran Zhao Lili Li Jun Liu Dong Li peng State Key Laboratory of Heavy Oil Processing and College of Chemical Engineering China University of Petroleum (East China) Technical Department of Ethylene Complex Petrochina Dushanzi Petrochemical Company

In this paper, cationic polyacrylamide microspheres （CPAM） were synthesized using acrylamide （AM） and methacryloyloxyethyl trimethyl ammonium chloride （TMAEMC） as monomers, ammonium sulfate as dispersant, poly（acryloyloxyethyl trimethyl ammonium chloride）（PAETAC） as dispersion stabilizer, and ammonium persulfate as initiator. The synthetic method was dispersion polymerization. The effects of monomer ratio （AM/TMAEMC）, dispersant concentration, and dispersion stabilizer dosage on dispersion polymerization were systematically studied to determine the optimal preparation conditions. The structure and viscosity of the synthesized polymer were characterized by FTIR and capillary viscometry, respectively, and the particle sizes and distribution of the polymer microspheres were characterized by microscopy and dynamic light scattering, respectively. Finally, flow tests were conducted to measure the permeability reduction performance of the microspheres at various concentrations in sand packs with different permeability. Results show that CPAM emulsion of a solids content of 1 wt% has excellent performance in low-to-medium permeability formations （〈 1,000 mD）, and the efficiency may reach above 90%.

关键词： Dispersion polymerization cationic polyacrylamide microspheres profile modification,permeability reduction

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正畸中釉质脱矿的控制与治疗研究进展

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口腔医学 2020年第9期40卷 855-859页

作者：买尔旦江·肉孜胡首杉曾福磊周丹彭怡然四川大学华西口腔医学院口腔疾病研究国家重点实验室四川成都610041 遵义医科大学附属口腔医院牙体牙髓病科贵州遵义563100 四川大学华西口腔医院儿童口腔科口腔疾病研究国家重点实验室四川成都610041

釉质白色损害即釉质脱矿白斑是固定正畸治疗过程中常见的并发症,发病率在50%~80%之间。早期龋损严重影响牙齿的健康与美观。因此临床上对正畸脱矿白斑的防治提倡早预防、早发现、早治疗。目前,针对正畸脱矿白斑的防治包括清除菌斑、抗... 详细信息

釉质白色损害即釉质脱矿白斑是固定正畸治疗过程中常见的并发症,发病率在50%~80%之间。早期龋损严重影响牙齿的健康与美观。因此临床上对正畸脱矿白斑的防治提倡早预防、早发现、早治疗。目前,针对正畸脱矿白斑的防治包括清除菌斑、抗菌性粘接剂的使用、局部应用防龋药物、渗透树脂治疗等。研究表明,联合应用多种措施可达到更好的控制菌斑、终止脱矿、促进釉质再矿化的效果。本文将对正畸脱矿白斑的预防、治疗等方面的新进展作一综述,为正畸临床工作提供参考。

关键词：正畸治疗釉质脱矿渗透树脂牙菌斑

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Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3751-3767页

作者： Weijian Liu Wei Chen Mao Xie Chao Chen Zengwu Shao yiran Zhang Haiyue Zhao Qingcheng Song Hongzhi Hu Xin Xing Xianyi Cai Xiangtian Deng Xinyan Li peng Wang Guohui Liu Liming Xiong Xiao Lv Yingze Zhang Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityShijiazhuang 050051China School of Medicine Nankai UniversityTianjin 300071China NHC Key Laboratory of Intelligent Orthopeadic Equipment Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Animal Center of Hebei Ex&In vivo Biotechnology Shijiazhuang 050051China Department of Physiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Traumatic brain injury(TBI)accelerates fracture healing,but the underlying mechanism remains largely *** evidence indicates that the central nervous system(CNS)plays a pivotal role in regulating immune system and skeletal ***,the impact of CNS injury on hematopoiesis commitment was ***,we found that the dramatically elevated sympathetic tone accompanied with TBI-accelerated fracture healing;chemical sympathectomy blocks TBIinduced fracture ***-induced hypersensitivity of adrenergic signaling promotes the proliferation of bone marrow hematopoietic stem cells(HSCs)and swiftly skews HSCs toward anti-inflammation myeloid cells within 14 days,which favor fracture *** ofβ3-orβ2-adrenergic receptor(AR)eliminate TBI-mediated anti-inflammation macrophage expansion and TBIaccelerated fracture *** sequencing of bone marrow cells revealed that Adrb2 and Adrb3 maintain proliferation and commitment of immune ***,flow cytometry confirmed that deletion ofβ2-AR inhibits M2 polarization of macrophages at 7th day and 14th day;and TBI-induced HSCs proliferation was impaired inβ3-AR knockout ***,β3-andβ2-AR agonists synergistically promote infiltration of M2 macrophages in callus and accelerate bone healing ***,we conclude that TBI accelerates bone formation during early stage of fracture healing process by shaping the anti-inflammation environment in the bone *** results implicate that the adrenergic signals could serve as potential targets for fracture management.

关键词： healing inflammation Traumatic

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Nonalcoholic steatohepatitis critically rewires the ischemia/ reperfusion-induced dysregulation of cardiolipins and sphingolipids in mice

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 3-19,I0001,I0002页

作者： Sheng Yu Kai Wang Qingping Li yiran Wei Yiyi Li Qifan Zhang pengxiang Huang Hanbiao Liang Hang Sun Hongxian peng Xixin Huang Cuiting Liu Jie Zhou Jianping Qian Chuanjiang Li Division of Hepatobiliopancreatic Surgery Department of General SurgeryNanfang HospitalSouthern Medical UniversityGuangzhouChina The First Clinical College Southern Medical UniversityGuangzhouChina Department of Radiation Oncology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Central Laboratory Southern Medical UniversityGuangzhouChina

Background:Lipid dysregulation plays a fundamental role in nonalcoholic steatohepatitis(NASH),which is an emerging critical risk factor that aggravates hepatic ischemia/reperfusion(I/R)***,the specific lipids that mediate the aggressive I/R injury in NASH livers have not yet been ***:The mouse model of hepatic I/R injury on NASH was established on C56B/6J mice by first feeding the mice with a Western-style diet to induce NASH,then the NASH mice were subjected to surgical procedures to induce hepatic I/R *** lipidomics were performed to determine hepatic lipids in NASH livers with I/R injury through ultra-high performance liquid chromatography coupled with mass *** pathology associated with the dysregulated lipids was ***:Lipidomics analyses identified cardiolipins(CL)and sphingolipids(SL),including ceramides(CER),glycosphingolipids,sphingosines,and sphingomyelins,as the most relevant lipid classes that characterized the lipid dysregulation in NASH livers with I/R *** were increased in normal livers with I/R injury,and the I/R-induced increase of CER was further augmented in NASH *** pathway analysis revealed that the enzymes involved in the synthesis and degradation of CER were highly upregulated in NASH livers with I/R injury,including serine palmitoyltransferase 3(Sptlc3),ceramide synthase 2(Cers2),neutral sphingomyelinase 2(Smpd3),and glucosylceramidase beta 2(Gba2)that produced CER,and alkaline ceramidase 2(Acer2),alkaline ceramidase 3(Acer3),sphingosine kinase 1(Sphk1),sphingosine-1-phosphate lyase(Sgpl1),and sphingosine-1-phosphate phosphatase 1(Sgpp1)that catalyzed the degradation of *** were not affected by I/R challenge in normal livers,but CL was dramatically reduced in NASH livers with I/R ***,metabolic pathway analyses revealed that the enzymes catalyzing the generation of CL were downregulated in NASH-I/R injury,including cardiolipin synthase(Crls1)a

关键词： Nonalcoholic steatohepatitis(NASH) ischemia/reperfusion injury lipidomics lipid metabolism

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姜泉症-证结合论治活动期银屑病关节炎经验

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吉林中医药 2024年第1期44卷 1-4页

作者：常甜姜泉彭秋伟王一燃徐浩东张富渊夏聪敏李达管津智陈芊莼中国中医科学院广安门医院北京100053 北京中医药大学北京100029

活动期银屑病关节炎以皮损及关节炎为主要临床表现。姜泉认为血热内盛,泛溢肌肤,湿热胶结,痹阻关节是活动期银屑病反复发作缠绵难愈的根本原因,可根据皮损、关节炎之轻重采用症-证结合辨治。皮损为甚者,当先治之,以热入营血为核心,易裹... 详细信息

活动期银屑病关节炎以皮损及关节炎为主要临床表现。姜泉认为血热内盛,泛溢肌肤,湿热胶结,痹阻关节是活动期银屑病反复发作缠绵难愈的根本原因,可根据皮损、关节炎之轻重采用症-证结合辨治。皮损为甚者,当先治之,以热入营血为核心,易裹挟湿热,故于犀角地黄汤凉血之中合苦参、蛇莓之类清热燥湿。关节肿痛者,以湿热痹阻为核心,掺挟血热,方用二妙散加土茯苓、萆薢清利湿热,配合牡丹皮、赤芍之类清血中伏热,可使血凉而湿热俱清,守方缓缓图之,病乃渐愈。

关键词：银屑病关节炎症-证结合名医经验姜泉

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SiC/AZ91D镁基复合材料单轴压缩过程中裂纹萌生扩展机制

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复合材料学报 2023年第7期40卷 4282-4293页

作者：梁超群尧军平李怡然肖鹏南昌航空大学航空制造工程学院南昌330000

利用有限元分析软件Abaqus在有限元模型颗粒界面引入内聚力单元,研究了不同形状和不同体积分数SiC颗粒的SiC/AZ91D镁基复合材料在单轴压缩情况下裂纹萌生扩展机制。内聚力单元的引入避免了线弹性力学需要在试件中预制裂纹和裂纹尖端存... 详细信息

利用有限元分析软件Abaqus在有限元模型颗粒界面引入内聚力单元,研究了不同形状和不同体积分数SiC颗粒的SiC/AZ91D镁基复合材料在单轴压缩情况下裂纹萌生扩展机制。内聚力单元的引入避免了线弹性力学需要在试件中预制裂纹和裂纹尖端存在奇异性的弊端,提供了一种解决裂纹扩展问题的新手段。结果表明:圆形、原始形状和正方形颗粒SiC/AZ91D镁基复合材料抗压强度分别为474.853 MPa、435.783 MPa和397.211 MPa;其裂纹萌芽和断裂时间分别为施载后第15.6μs、第14.4μs、第12.6μs和第22.2μs、第20.4μs、第18μs;圆形颗粒复合材料裂纹扩展机制是基体损伤萌生的裂纹扩张导致材料断裂,而正方形和原始形状颗粒复合材料裂纹扩展机制是颗粒与基体交界处萌生裂纹,主裂纹和次生裂纹相互贯通,致使材料断裂;体积分数10vol%、15vol%和20vol%原始形状颗粒的SiC/AZ91D镁基复合材料裂纹萌芽和断裂时间分别在施载后第15.6μs、第14.4μs、第11.4μs和第22.2μs、第20.4μs和第18μs;颗粒体积分数的增加会加速SiC/AZ91D镁基复合材料的裂纹扩展过程。

关键词： SiC/AZ91D 有限元分析内聚力模型单轴压缩裂纹扩展

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The China Alzheimer Report 2022

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General Psychiatry 2022年第1期35卷 1-19页

作者： Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu pengfei Wang Yikang Zhu yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina School of Public Health Fudan UniversityShanghaiChina NHC Key Laboratory of Health Technology Assessment Fudan UniversityShanghaiChina Department of Geriatrics Huashan HospitalFudan UniversityShanghaiChina National Survey Research Center Renmin University of ChinaBeijingChina

China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and ***‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with *** report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health *** specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and *** addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.

关键词： Alzheimer mortality prevention

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Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer

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Cancer Biology & Medicine 2021年第3期18卷 849-859页

作者： Nanlin Hu yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu peng Yuan Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Nanjing Geneseeq Technology Inc. Nanjing 210032China Cancer Hospital of Huanxing Chaoyang District Beijing Beijing 100021China

Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking *** study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast ***:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were *** was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity ***,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment *** primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and ***:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)*** median follow-up time was 10.5 *** ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 *** changes in the detectable ct DNA variant allele frequency were consistent with the tumor *** most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast *** dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response.

关键词： Anlotinib angiogenesis HER2-negative breast cancer ct DNA

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