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Detecting bulk and edge exceptional points in non-Hermitian systems through generalized Petermann factors

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Frontiers of physics 2024年第2期19卷 169-177页

作者： Yue-Yu Zou Yao Zhou Li-Mei Chen peng ye School of Physics State Key Laboratory of Optoelectronic Materials and Technologiesand Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSun Yat-sen UniversityGuangzhou 510275China

Non-orthogonality in non-Hermitian quantum systems gives rise to tremendous exotic quantum phenomena,which can be fundamentally traced back to *** this paper,we introduce an interesting quantity(denoted asη)as a new variant of the Petermann factor to directly and efficiently measure non-unitarity and the associated non-Hermitian *** tuning the model parameters of underlying non-Hermitian systems,we find that the discontinuity of bothηand its first-order derivative(denoted as■η)pronouncedly captures rich physics that is fundamentally caused by *** concretely,in the 1D non-Hermitian topological systems,two mutually orthogonal edge states that are respectively localized on two boundaries become non-orthogonal in the vicinity of discontinuity ofηas a function of the model parameter,which is dubbed"edge state transition".Through theoretical analysis,we identify that the appearance of edge state transition indicates the existence of exceptional points(EPs)in topological edge *** the discontinuity of■η,we investigate a two-level non-Hermitian model and establish a connection between the points of discontinuity of■ηand EPs of bulk *** studying this connection in more general lattice models,we find that some models have discontinuity of■η,implying the existence of EPs in bulk states.

关键词： non-Hermitian Su−Schrieffer−Heeger(SSH)model exceptional point

LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： Xian-Hui Ning Bing Han ye peng Shao-Wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

Synthesis of waterborne polyurethane-humic acid cross-linked biomass porous materials for the adsorption of methylene blue

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Chinese Journal of Chemical Engineering 2024年第3期67卷 27-38页

作者： Shanghong Ma Jianbo Qu Haitao Zhang Xiubin Cui peng ye Qingfei Hu Mingzhen Chao State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan 250353China Faculty of Light Industry Qilu University of TechnologyShandong Academy of SciencesJinan 250353China

A series of adsorbent materials(WPU-HAx-y)with a three-dimensional porous structure,green sustainability,and excellent performance were prepared and evaluated for the removal of methylene blue using nontoxic and environmentally friendly waterborne polyurethane as the matrix material and humic acid,a biomass material,as the functional *** newly synthesized adsorbents were characterized by infrared spectroscopy,scanning electron microscopy,specific surface area,and *** effects of contact time(0-8 h),starting concentration(10-100 mg·L^(-1)),pH(3-11),solution temperature(30-60℃),and coexisting ions(Ca2+,Na+,K+,Mg2+)on the performance were ***-first-order,pseudo-second-order,elovich,and intra-particle diffusion models were used to analyze the adsorption kinetics;the Langmuir,Freundlich,Temkin,and Dubin-Radushkovich adsorption isotherms were evaluated;and the adsorption behavior of the adsorbent materials was found to be more appropriate for the pseudo-second-order model for chemical pollutant removal than the Langmuir model,which depends on monolayer ***-HA2-3 stood out with a maximum adsorption capacity of 813.0081 mg·g^(-1) fitted to the pseudo-second-order and 309.2832 mg·g^(-1) fitted to the Langmuir model,showing superior adsorption performance and regenerability.

关键词： Porous media Bioenergy Sustainability Waste water

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang peng ye Xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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Chinese Medical Journal 2024年第7期137卷 846-858页

作者： peng ye Yunfei Deng Yue Gu pengfei Liu Jie Luo Jiangqin Pu Jingyu Chen Yu Huang Nanping Wang Yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

Chlorantraniliprole exposure aggravates high-fat diet-induced metabolic disorders in mice by regulating gut microbiota and its metabolites

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Food Science and Human Wellness 2024年

作者： Ting Gu Jie Lin Jiani Yang William Mumby Quancai Sun ye peng Faculty of Medicine， Macau University of Science and Technology School of Food and Biological Engineering， Jiangsu University Department of Health， Nutrition， and Food Sciences， Florida State University

Food contaminants， particularly insecticides， are important factors contributing to obesity and other adverse effects. As the most widely used diamide insecticide worldwide， chlorantraniliprole (CP) is ubiquitous in food and the environment. However， the influence of CP on obesity and the gut microbiota remains unknown. In this study， we administered CP/carboxymethyl cellulose sodium to C57BL/6J mice with a high-fat diet (HFD) via gavage for 13 weeks. The CP exposure induced significant increases in body weight gain， fat mass， serum total cholesterol (TC)， and low-density lipoprotein cholesterol (LDL-C). Moreover， CP aggravated the imbalance in the gut microbiota by increasing the relative abundance of obesity-associated bacteria and reducing the relative abundance of beneficial bacteria. Based on untargeted metabolomics analysis， CP was found to be involved in the regulation of pathways including ‘alanine， aspartate and glutamate metabolism’ and ‘arginine and proline metabolism’. Notably， CP exposure primarily induced alterations in microbial metabolites within these pathways， such as L-(+)-aspartic acid and L-glutamic acid. Additionally， individual metabolites， such as the lipid mediator (oleoyl ethanolamide)， also demonstrated alterations upon CP exposure. Furthermore， Spearman correlation analysis revealed several noteworthy associations between microbial alterations， metabolite changes， and phenotypes. The results of the study demonstrate a connection between microbiota， metabolites， and the effects of CP exposure on HFD-induced obesity， elucidating the critical role of the gut microbiota and its metabolites in the toxic effects of CP.

关键词：

数字示波器中FPGA间高速信号传输同步方法

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电子科技大学学报 2024年第2期53卷 219-226页

作者：高媛赵禹王厚军叶芃军委装备发展部北京100034 电子科技大学(深圳)高等研究院深圳518110

数据采集系统是数字示波器(DSO)的核心组成单元,随着示波器带宽采样率的逐步提升,单片模数转换器(ADC)+现场可编辑门控阵列(FPGA)的架构难以满足超高速以及多通道的应用场景,因此,高端示波器中数据采集系统普遍采用“主从”FPGA控制架... 详细信息

数据采集系统是数字示波器(DSO)的核心组成单元,随着示波器带宽采样率的逐步提升,单片模数转换器(ADC)+现场可编辑门控阵列(FPGA)的架构难以满足超高速以及多通道的应用场景,因此,高端示波器中数据采集系统普遍采用“主从”FPGA控制架构。在该架构下,多个FPGA之间信号的同步传输是实现采集系统的同步和精确采集的重要前提。针对多FPGA板卡之间的信号同步传输问题,提出了一种FPGA之间高速信号同步传输的方法,借助FPGA的IODELAY单元,通过测试数据训练找到最稳定的同步传输区间,实现多FPGA之间的同步传输。在自研的数字示波器上的实验表明,该方法能够有效实现FPGA之间高速信号的同步传输。

关键词：超高速数据采集系统现场可编辑门控阵列传输同步数字存储示波器

阅读需求变迁视角下中国出版业现代化的数据表现、关键点与趋势展望

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出版发行研究 2024年第7期 24-34页

作者：吴赟叶芃浙江大学传媒与国际文化学院新闻与传播学系浙江大学传播研究所浙江大学传媒与文化产业研究中心浙江大学传媒与国际文化学院

现代化是对现存政治、经济、文化等社会因素进行超越的过程。讨论出版业现代化的变迁、表现、趋势和关键,有必要聚焦社会阅读需求这一形成和促进现代化的力量。文章首先从社会阅读需求变迁的视角切入,考察中国特色社会主义进入新时代以... 详细信息

现代化是对现存政治、经济、文化等社会因素进行超越的过程。讨论出版业现代化的变迁、表现、趋势和关键,有必要聚焦社会阅读需求这一形成和促进现代化的力量。文章首先从社会阅读需求变迁的视角切入,考察中国特色社会主义进入新时代以来阅读需求的变迁趋势,以及出版业在技术、规模、制度、理念层面所发生变化的表现与特征,进而在此基础上分析出版业现代化的关键点;随后考察出版借由促进社会公平、塑造个性需求、形成社会共识等层面的功能,推动社会现代化进程的现代性意义与作用,并结合中国式现代化的特征和阶段性的新形势,对出版业的未来发展进行前瞻。

关键词：出版业现代化现代性阅读需求互动机制

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基于混合知识分解的增强残差网络

模式识别与人工智能 2024年第4期37卷 328-338页

作者：唐圣汲叶鹏林炜豪陈涛复旦大学信息科学与工程学院上海200433

当前如刺激性训练、组知识训练等方法收集残差网络中浅层网络的组知识进行自蒸馏,可提升网络性能,然而上述方法获取的组知识面临知识更新较慢、难以与数据混合技术结合等问题.为了解决此问题,文中提出基于混合知识分解的增强残差网络,... 详细信息

当前如刺激性训练、组知识训练等方法收集残差网络中浅层网络的组知识进行自蒸馏,可提升网络性能,然而上述方法获取的组知识面临知识更新较慢、难以与数据混合技术结合等问题.为了解决此问题,文中提出基于混合知识分解的增强残差网络,通过最小化分解误差,将混合知识分解建模为二次规划问题,从而能从混合知识中获取高质量的组知识.为了提升知识的鲁棒性与多样性,结合多种数据混合技术,构建复合数据混合技术.不同于效率较低的高精度优化算法,采用简单高效的线性知识分解方法,将先前的组知识作为知识基,并将混合知识分解到知识基上,利用增强后的组知识蒸馏采样的子网.在多个主流的残差模型及图像分类数据集上的实验验证文中网络的有效性.

关键词：深度学习神经网络知识蒸馏网络增强残差网络