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CCS Chemistry 2024年第10期6卷 2452-2464页

作者： Youbin peng Guanlin Li Chongyu Han Yicong Luo xiaohong Huo Wanbin Zhang Shanghai Key Laboratory of Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240

Transition-metal-catalyzed asymmetric benzylic substitution of racemic benzyl esters is an efficient and straightforward route towards the construction of benzylic stereocenters but remains a challenge,due to the difficulty encountered in the suppression ofβ–H elimination and asymmetric ***,we successfully developed a highly diastereo-and enantioselective benzylic substitution of racemic 1-(aryl)alkyl esters with aldimine esters enabled by pd/Cu dual *** array of enantioenrichedα-benzyl substitutedα-amino acids containing vicinal stereocenters were prepared with high levels of diastereo-and enantioselectivities(up to>20:1 dr and>99%ee)and the practicability of the products was further illustrated via their diverse *** dynamic kinetic asymmetric transformation process of the racemic benzyl esters was investigated experimentally and by computational studies.

关键词： amino acids asymmetric catalysis benzylic substitution bimetallic catalysis stereodivergent synthesis

Biochar regulates biogeochemical cycling of iron and chromium in a soil-rice system by stimulating Geobacter and Clostridium

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pedosphere 2024年第5期34卷 929-940页

作者： Min XU Yang LIN Jing MA Lulu LONG Chao CHEN Gang YANG Chun SONG Jun WU xiaohong ZHANG peng GAO College of Environmental science Sichuan Agricultural University Soil Water and Ecosystem Sciences Department University of Florida College of Water Conservancy and Hydropower Engineering Sichuan Agricultural University Department of Environmental and Occupational Health University of Pittsburgh School of Public Health

In soil-rice systems,microbial reduction of iron （Fe） has been recognized as a crucial biogeochemical process that regulates Fe and chromium （Cr）translocation;however,the underlying processes are *** investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%（weight/weight） to a paddy soil spiked with 300 mg kg-1Cr under two phosphorus （p） levels (0 or 90 mg kg-1) in a pot *** key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were *** inhibited root Cr uptake by 36%,owing to the promoted iron plaque （Ip） formation on the rice root *** analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter （r=0.81–0.94,pridium （r=0.83–0.95,pr and Clostridium played essential roles in Fe *** analysis showed that labile carbon and pore water p concentrations were the key determinants influencing Fe-reducing bacterial abundances,accounting for 42%and 32%of the variation in community composition,***,biochar increased Fe and p concentrations in root cell walls,which retained more ***,Cr stress in rice under biochar treatment was relieved through increasing Ip formation and altering subcellular *** mechanistic insights had important implications for reducing Cr uptake by rice.

关键词： chromium translocation iron plaque iron reduction maize straw biochar microbial reduction paddy soil phosphorus fertilization subcellular distribution

A weak allele of TGW5 enables greater seed propagation and efficient size-based seed sorting for hybrid rice production

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plant Communications 2024年第4期5卷 137-140页

作者： Jiezheng Ying Yaobing Qin Fengyong Zhang Liu Duan peng Cheng Man Yin Yifeng Wang xiaohong Tong Jie Huang Zhiyong Li Xianjun Song Jian Zhang State Key Lab of rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China Key Laboratory of plant Molecular physiology Institute of Botanythe Chinese Academy of SciencesBeijing 100093China These authors contributed equally to this article

Dear Editors,Heterosis utilization is an effective way to improve crop *** rice typically out-yield inbred rice varieties by 10%and show better stress resistance,and they have been widely adopted in Asian countries since the 1980s(Cheng et al.,2007).To produce rice F1 hybrid seeds(HSDs),male sterile lines(MSLs)are grown side by side with restorer lines(rLs)in order to receive the rL *** seed production system faces challenges in maintaining the seed purity of the HSDs owing to the physical proximity of MSL and rL plants in the ***,MSLs and rLs are planted in alternate rows to enable physical separation of seeds during harvesting.

关键词： planted sterile enable

Integration of HiBiT into enteroviruses:A universal tool for advancing enterovirus virology research

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Virologica Sinica 2024年第3期39卷 422-433页

作者： rui Yu xiaohong Li peng Zhang Minghao Xu Jitong Zhao Jingjing Yan Chenli Qiu Jiayi Shu Shuo Zhang Miaomiao Kang Xiaoyan Zhang Jianqing Xu Shuye Zhang school of Medicine Shanghai UniversityShanghai200444China Clinical Center for Biotherapy Zhongshan HospitalFudan UniversityShanghai200433China Guangzhou Institutes of Biomedicine and Health The Chinese Academy of SciencesGuangzhou510530China Institutes of Biomedical sciences Fudan UniversityShanghai200032China Shanghai Geriatric Medical Center Shanghai201104China Clinical Center for Biotherapy Zhongshan Hospital/Zhongshan Hospital(Xiamen)Fudan University361015China Shanghai public Health Clinical Center Fudan UniversityShanghai201508China

The utilization of enteroviruses engineered with reporter genes serves as a valuable tool for advancing our understanding of enterovirus biology and its applications,enabling the development of effective therapeutic and preventive *** this study,our initial attempts to introduce a NanoLuc luciferase(NLuc)reporter gene into recombinant enteroviruses were unsuccessful in rescuing viable *** hypothesized that the size of the inserted tag might be a determining factor in the rescue of the ***,we inserted the 11-amino-acid HiBiT tag into the genomes of enterovirus A71(EV-A71),coxsackievirus A10(CVA10),coxsackievirus A7(CVA7),coxsackievirus A16(CVA16),namely EV-A71-HiBiT,CVA16-HiBiT,CVA10-HiBiT,CVA7-HiBiT,and observed that the HiBiT-tagged viruses exhibited remarkably high rescue ***,the HiBiT-tagged enteroviruses displayed comparable characteristics to the wild-type viruses.A direct comparison between CVA16-NLuc and CVA16-HiBiT recombinant viruses revealed that the tiny HiBiT insertion had minimal impact on virus infectivity and replication ***,these HiBiT-tagged enteroviruses demonstrated high genetic stability in different cell lines over multiple *** addition,the HiBiT-tagged viruses were successfully tested in antiviral drug assays,and the sensitivity of the viruses to drugs was not affected by the HiBiT ***,our findings provide definitive evidence that the integration of HiBiT into enteroviruses presents a universal,convenient,and invaluable method for advancing research in the realm of enterovirus ***,HiBiT-tagged enteroviruses exhibit great potential for diverse applications,including the development of antivirals and the elucidation of viral infection mechanisms.

关键词： Enterovirus Infectious clones reporter genes Luciferase Drug screening

Al-driven analysis establishes the single base substitution signatures as personalized prognostic predictors for five-year survival of gastric cancer

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Genes & Diseases 2024年第4期11卷 73-76页

作者： Zhenzhang Li Lingqing Xu Wen Luo Shaoan Zhangg Chunyu Hou xiaohong Xu ,Xubei peng E.Shiju Janak L.pathak Shizhen Zhang Jiawei Liu Linhai Li Yang Li school of Biomedical Engineering The Sixth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China College of Mathematics and Systems science Guangdong Polytechnic Normal UniversityGuangzhouGuangdong 510665China The Second Affiliated Hospital Guangzhou Medical UniversityGuangzhouGuangdong 510260China Center for Learning sciences and Technologies The Chinese University of Hong KongShatinNew Territories 999077China Affiliated Stomatology Hospital of Guangzhou Medical university Guangzhou Medical UniversityGuangzhouGuangdong 510182China International school of photonics Cochin University of Science and TechnologyKochiKerala 682022India

Al-driven genetic engineering,as a burgeoning diagnostic tool,can offer predictive information on the five-year survival rate(FYSr)in the setup of a prognostic therapeutic *** approach provides the individuality and accuracy of prognosis for FYSr of gastric cancer(GC).Unlike traditional neoplasm staging criteria,our technique ensures accuracy and individuality without relying on statistical data and empirical study.

关键词： cancer gastric prognosis

农户数字素养对化学农药减量使用的影响及其机制研究

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中国软科学 2024年第2期 64-73页

作者：张鹏李小红吴雨西南财经大学经济学院四川成都611130 西南财经大学经济与管理研究院四川成都611130 南京农业大学金融学院江苏南京210095 西南财经大学《经济学家》编辑部四川成都610074

推进农药减量化是全方位夯实粮食安全根基,加快农业绿色发展的必然要求。本文立足于我国农业绿色转型和数字经济快速发展的实践背景,探讨分析了农户数字素养对其化学农药减量使用的影响。本文基于中国家庭金融调查数据,构建了农户数字... 详细信息

推进农药减量化是全方位夯实粮食安全根基,加快农业绿色发展的必然要求。本文立足于我国农业绿色转型和数字经济快速发展的实践背景,探讨分析了农户数字素养对其化学农药减量使用的影响。本文基于中国家庭金融调查数据,构建了农户数字素养指数,发现农户数字素养提升会显著促使其农药使用减量。从农药使用的三个重要环节施药者、施药机械选择和施药技术出发,探索了这种影响的内在机制,发现了数字素养提升可以帮助农户树立绿色生产理念、选择高效施药机械、学习科学施药技术。异质性分析表明,数字素养对小规模种植户、未转入耕地的农户、所在村没有农业职业经理人的农户的农药使用减量边际效应更显著。本文的边际贡献在于,提供了数字技术介入对农户生产决策行为的影响效果,揭示了农户数字素养对农药使用决策的重要性。在推进农业农村现代化和大力实施乡村振兴战略的背景下,本文的研究结论为促进绿色农业发展和保障粮食安全提供了微观基础和有益启示。

关键词：农药减量数字素养绿色农业粮食安全

A survey on membership inference attacks and defenses in machine learning

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Journal of Information and Intelligence 2024年第5期2卷 404-454页

作者： Jun Niu peng Liu Xiaoyan Zhu Kuo Shen Yuecong Wang Haotian Chi Yulong Shen xiaohong Jiang Jianfeng Ma Yuqing Zhang school of Computer science and technology Xidian UniversityXi'an 710071China Information sciences and technology Pennsylvania State UniversityPA 16802United States school of Telecommunications Engineering Xidian UniversityXian 710071China school of Hangzhou Institute of technology Xidian UniversityHangzhou 311231China school of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China school of Systems Information science Future University of HakodateHakodate 041-8655Japan school of Computer&Control Engineering University of Chinese Academy of SciencesBeijing 101408China school of Cyber Engineering Xidian UniversityXian 710071China

Membership inference(MI)attacks mainly aim to infer whether a data record was used to train a target model or *** to the serious privacy risks,MI attacks have been attracting a tremendous amount of attention in the research *** existing work conducted-to our best knowledge the first dedicated survey study in this specific area:The survey provides a comprehensive review of the literature during the period of 2017~2021(e.g.,over 100 papers).However,due to the tremendous amount of progress(i.e.,176 papers)made in this area since 2021,the survey conducted by the one existing work has unfortunately already become very limited in the following two aspects:(1)Although the entire literature from 2017~2021 covers 18 ways to categorize(all the proposed)MI attacks,the literature during the period of 2017~2021,which was reviewed in the one existing work,only covered 5 ways to categorize MI *** 13 ways missing,the survey conducted by the one existing work only covers 27%of the landscape(in terms of how to categorize MI attacks)if a retrospective view is taken.(2)Since the literature during the period of 2017~2021 only covers 27%of the landscape(in terms of how to categorize),the number of new insights(i.e.,why an MI attack could succeed)behind all the proposed MI attacks has been significantly increasing since year *** a result,although none of the previous work has made the insights as a main focus of their studies,we found that the various insights leveraged in the literature can be broken down into 10 *** making the insights as a main focus,a survey study could fail to help researchers gain adequate intellectual depth in this area of *** this work,we conduct a systematic study to address these *** particular,in order to address the first limitation,we make the 13 newly emerged ways to categorize MI attacks as a main focus on the *** order to address the second limitation,we provide-to our best knowledge-the first r

关键词： Machine learning privacy and security Membershipinferenceattacks Defensivetechniques

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辜鸿铭《论语》译本“杂合”特征解读

沈阳大学学报 2011年第5期23卷 61-64页

作者：边立红吴鹏长沙理工大学外国语学院

以后殖民主义理论中的'杂合'概念解读辜鸿铭的《论语》译本,指出辜鸿铭的译本体现了一种杂合特征,展示了他在特定历史语境中抵制西方文化中心主义,构建中国文化与西方文化间平等对话的良苦用心。

关键词：辜鸿铭《论语》译本杂合特征

Deep Broad Learning for Emotion Classification in Textual Conversations

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Tsinghua science and technology 2024年第2期29卷 481-491页

作者： Sancheng peng rong Zeng Hongzhan Liu Lihong Cao Guojun Wang Jianguo Xie Center for Linguistics and Applied Linguistics and Laboratory of Language Engineering and ComputingGuangdong University of Foreign StudiesGuangzhou 510006China Guangdong provincial Key Laboratory of Nanophotonic Functional Materials and Devices South China Normal UniversityGuangzhou 510006China school of Computer science and Cyber Engineering Guangzhou UniversityGuangzhou 510006China Modern Education technology Center Guangdong University of Foreign StudiesGuangzhou 510006China

Emotion classification in textual conversations focuses on classifying the emotion of each utterance from textual *** is becoming one of the most important tasks for natural language processing in recent ***,it is a challenging task for machines to conduct emotion classification in textual conversations because emotions rely heavily on textual *** address the challenge,we propose a method to classify emotion in textual conversations,by integrating the advantages of deep learning and broad learning,namely *** aims to provide a more effective solution to capture local contextual information(i.e.,utterance-level)in an utterance,as well as global contextual information(i.e.,speaker-level)in a conversation,based on Convolutional Neural Network(CNN),Bidirectional Long Short-Term Memory(Bi-LSTM),and broad *** experiments have been conducted on three public textual conversation datasets,which show that the context in both utterance-level and speaker-level is consistently beneficial to the performance of emotion *** addition,the results show that our proposed method outperforms the baseline methods on most of the testing datasets in weighted-average F1.

关键词： emotion classification textual conversation Convolutional Neural Network(CNN) Bidirectional Long Short-Term Memory(Bi-LSTM) broad learning