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Journal of Systems Engineering and Electronics 2010年第4期21卷 623-628页

作者： peng wu ming yang Control and Simulation Center Harbin Institute of Technology Harbin 150001 E R. China

Aimed at the guidance requirements of some missiles which attack targets with terminal impact angle at the terminal point,a new integrated guidance and control design scheme based on variable structure control approach for missile with terminal impact angle constraint is ***,a mathematical model of an integrated guidance and control model in pitch plane is established,and then nonlinear transformation is employed to transform the mathematical model into a standard form suitable for sliding mode control method design.A sufficient condition for the existence of linear sliding surface is given in terms of linear matrix inequalities（LMIs）,based on which the corresponding reaching motion controller is also *** verify the effectiveness of the proposed integrated design scheme,the numerical simulation of missile is *** simulation results demonstrate that the proposed guidance and control law can guide missile to hit the target with desired impact angle and desired flight attitude angle simultaneously.

关键词： guidance terminal impact angle sliding mode control integrated guidance and control linear matrix inequality(LMI).

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui peng peng wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen Zhang Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： Yuan-Jing Jiang Lu wu Xiao yang Yu Pu Bing-Jie Ning Na peng Xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan wu Zhiqin Ruan Yue‑peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Advances and Applications of Brain Organoids

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Neuroscience Bulletin 2023年第11期39卷 1703-1716页

作者： yang Li peng‑ming Zeng Jian wu Zhen‑Ge Luo School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

Understanding the fundamental processes of human brain development and diseases is of great importance for our ***,existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with *** the past years,an emerging model,the“brain organoid”integrated from human pluripotent stem cells,has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent,making it possible to better understand the complex structures and functions of the human *** this review,we summarize recent advances in brain organoid technologies and their applications in brain development and diseases,including neurodevelopmental,neurodegenerative,psychiatric diseases,and brain ***,we also discuss current limitations and the potential of brain organoids.

关键词： Human pluripotent stem cell Brain organoid Brain development Neurological disease

Theoretical Studies on the Thermo- electric Properties of Tin-based Clathrates:Cs_8M_4Sn_(42)(M=Zn,Cd,Hg) and Cs_8Sn_(44)□_2

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Chinese Journal of Structural Chemistry 2013年第12期32卷 1793-1804页

作者： WANG peng wu Li-ming State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences University of Chinese Academy of Sciences

The site occupancies and thermoelectric properties of tin-based clathrates Cs8M4Sn44□2 （M = Zn, Cd, Hg） and CssSn44□2 were studied by the first principle calculations. We had provided an efficient way to probe the relationship between the crystalline structure and power factor. Detailed analyses indicated the p states of Sn at 16i and 24k sites together with the p states of M substitute contributed significantly to the maximum power factor, yet Cs atoms nearly did not. The dangling bonds of vacancies in Cs8Snn44□2 are also discussed. The power factors of p- and n-type CssMaSn42 and Cs8Sn44□2 at optimal temperature and carder concentration are predicted. Our results suggest that Cs8ZnaSn44□2 is a promising candidate at the 5.25 ×10^19 cm-3 hole carrier concentration as a high temperature thermoelectric material that is competitive to the state-of-art Ge-based clathrate thermoelectric materials.

关键词： the first principle thermoelectric boltzmann theory,clathrate tin electronic structure

Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： Xing-yu Chen Lin Cheng Cheng-yang Hu Yu-peng Zhang Kai-ming wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

Insecticide resistance monitoring for the invasive populations of fall armyworm,Spodoptera frugiperda in China

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Journal of Integrative Agriculture 2021年第3期20卷 783-791页

作者： ZHANG Dan-dan XIAO Yu-tao XU peng-jun yang Xian-ming wu Qiu-Iin wu Kong-ming Sfafe Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China Agricultural Genomics institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101P.R.China

Fall armyworm has invaded China and colonized its populations in tropical and sub-tropical regions of South China since December *** spray has been widely used to control the pest,which shall lead to resistance *** this research,we collected five populations of the pest from Yunnan,Hainan,Tibet,and Fujian of China,and tested their susceptibilities to pyrethroid,organophosphorus,oxadiazine,diamide,antibiotics and other types of insecticides(14 insecticides totally)in the *** on the susceptible baseline published from the previous studies,the resistance ratio was 615-1068-fold to chlorpyrifos,60-388-fold to spinosad,26-317-fold to lambda-cyhalothrin,13-29-fold to malathion,9-33-fold to fenvalerate,8-20-fold to deltamethrin,3-8-fold to emamectin benzoate and 1-2-fold to chlorantraniliprole,*** median lethal concentration(LC_(50))of other six insecticides without the susceptible baselines was 148.27-220.96μgmL^(-1) for beta-cypermethrin,87.03-128.43μgmL^(-1) for chlorfenapyr,16.35-99.67μgmL^(-1) for indoxacarb,10.55-51.01μgmL^(-1) for phoxim,7.08-8.78μgmL^(-1) for M-EBI(the mixed insecticide of emamectin benzoate and indoxcarb)and 1.49-4.64μg mL^(-1) for *** study can be helpful for chemical control as well as for resistance monitoring and management of the pest in China.

关键词： Spodoptera frugiperda insecticides resistance monitoring China