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Lithium polysulfide solvation and speciation in the aprotic lithium-sulfur batteries

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Particuology 2024年第6期89卷 238-245页

作者： Jinhao Zhang Qingshan Fu peng Li Ruibo linghu Xiaozhong Fan Haibin Lin Juncao Bian Songbai Han Gengzhi Sun Long Kong Frontiers Science Center for Flexible Electronics and Xi’an Institute of Flexible Electronics Northwestern Polytechnical UniversityXi’an710129China China Automotive Innovation Corporation Nanjing211100China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen518055China Institute of Advanced Materials Nanjing Tech UniversityNanjing211816China

Fingerprinting sulfur speciation in aprotic electrolytes is a key to understand fundamental chemistry and design well-performing lithium–sulfur(Li–S)*** polysulfide(LiPS)dissolution and deposition in ether-based electrolytes during redox reactions have been probed and established by spectroscopy and ***,detailed LiPS structure and solvation properties influenced by conventional and newly developed electrolytes remain elusive,which exert fundamental challenges and practical difficulties in decoupling battery performance from electrolyte *** perspective aims to provide timely information to uncover underlying mechanisms that rein in sulfur speciation by considering the charge density of LiPSs and the coordination strength of solvents/*** discussion starts with unlocking the baseline electrolyte formulation to investigate its role in LiPS formation and *** that,the term coordination strength is used instead of donor number and dielectric constant to describe interactions between solvents and LiPSs and to reveal LiPS structure *** work is expected to encourage the discovery of new electrolyte working mechanisms to develop energy-dense and power-intensive Li–S batteries.

关键词： Sulfur speciation Redox kinetics Coordination strength Solvation chemistry Lithium-sulfur batteries

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang linghu Tian Zhang Guang-Tao Zhang peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-Sheng Zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

Chinese national clinical practice guidelines on the prevention,diagnosis,and treatment of early gastric cancer

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Chinese Medical Journal 2024年第8期137卷 887-908页

作者： peng Li Ziyu Li Enqiang linghu Jiafu Ji Society of Digestive Endoscopy of the Chinese Medical Association Colorectal Surgery Group of the Chinese Medical Association Chinese Association of Gastroenterologists&Hepatologists National Clinical Research Center for Digestive Diseases Chinese Medical Journal Clinical Practice Guideline Collaborative Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing 100050China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Gastroenterology and Hepatology the First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China 不详

Background:Gastric cancer is one of the most common malignant tumors in the digestive system in *** comprehensive practice guidelines for early gastric cancer in China are currently ***,we created the Chinese national clinical practice guideline for the prevention,diagnosis,and treatment of early gastric ***:This clinical practice guideline(CPG)was developed in accordance with the World Health Organization’s recommended process and with the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)in assessing evidence *** used the Evidence to Decision framework to formulate clinical recommendations to minimize bias and increase transparency in the CPG development *** used the Reporting Items for practice Guidelines in HealThcare(RIGHT)statement and the Appraisal of Guidelines for Research and Evaluation II(AGREE II)as reporting and conduct guidelines to ensure completeness and transparency of the ***:This CPG contains 40 recommendations regarding the prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer based on available clinical studies and *** provide recommendations for the timing of Helicobacter pylori eradication,screening populations for early gastric cancer,indications for endoscopic resection and surgical gastrectomy,follow-up interval after treatment,and other ***:This CPG can lead to optimum care for patients and populations by providing up-to-date medical *** intend this CPG for widespread adoption to increase the standard of prevention,screening,diagnosis,treatment,and follow-up of early gastric cancer;thereby,contributing to improving national health care and patient quality of life.

关键词： Early gastric cancer Prevention Screening Diagnosis Treatment Follow-up

不同频率增幅-降幅加卸载条件下红砂岩动力参数及耗散能研究

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矿业研究与开发 2021年第2期41卷 81-86页

作者：朱明礼令狐朋唐胡丹邓浩河南理工大学能源科学与工程学院河南焦作市454003 河南理工大学土木工程学院河南焦作市454003

对饱和红砂岩在RMT-150b岩石力学试验机上进行了不同频率、不同动应力系数下的循环加卸载试验,探讨应力增幅阶段和降幅阶段内红砂岩的动弹性模量、阻尼比、阻尼系数、滞回环宽度等与加载频率和动应力系数的关系。结果表明,在应力增幅阶... 详细信息

对饱和红砂岩在RMT-150b岩石力学试验机上进行了不同频率、不同动应力系数下的循环加卸载试验,探讨应力增幅阶段和降幅阶段内红砂岩的动弹性模量、阻尼比、阻尼系数、滞回环宽度等与加载频率和动应力系数的关系。结果表明,在应力增幅阶段动弹性模量随着动应力系数的增加而呈现抛物线递增,在应力降幅阶段动弹性模量随着动应力系数的增加而呈现线性递增;阻尼比随着动应力系数增加呈现开口向上的抛物线递减,随频率呈现幂函数递增;而阻尼系数随动应力系数的增加呈现幂函数递减,随频率增加呈现开口向上的抛物线递增;动应力-动应变滞回环最大宽度随着动应力系数的增加,在应力增幅阶段呈现线性递增,而在应力降幅阶段呈现抛物线递增。滞回环最大宽度随着频率的增加呈现曲线开口向下的对数递增;滞回环最大宽度与幅值的乘积与滞回环面积存在线性函数规律;在相同频率、相同幅值条件下,应力增幅阶段的动弹性模量、阻尼比、阻尼系数、最大滞回环宽度等均大于应力降幅阶段。

关键词：红砂岩动弹性模量阻尼比阻尼系数滞回环宽度

短肽型肠内营养制剂治疗环状混合痔病人术后效果观察

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肠外与肠内营养 2016年第5期23卷 286-289页

作者：李昌秀彭南海令狐玉双秦建平李逊龚田田遵义医学院附属医院护理学院贵州遵义563003 南京军区南京总医院普通外科江苏南京210002 遵义医学院附属医院肛肠外科贵州遵义563003 遵义医学院附属医院营养科贵州遵义563003

目的:探讨短肽型肠内营养(EN)制剂对环状混合痔病人术后饮食控制和排便管理的应用效果。方法:将60例环状混合痔手术病人随机分为试验组和对照组,每组各30例。试验组病人术后当天至第5天给予短肽型EN制剂,对照组术后给予传统饮食。比较... 详细信息

目的:探讨短肽型肠内营养(EN)制剂对环状混合痔病人术后饮食控制和排便管理的应用效果。方法:将60例环状混合痔手术病人随机分为试验组和对照组,每组各30例。试验组病人术后当天至第5天给予短肽型EN制剂,对照组术后给予传统饮食。比较两组病人术后首次排便时间,手术后5 d内每天的排便次数,术后排便时肛门部疼痛评分,术后出血、尿潴留发生率和平均住院日。结果:与对照组比较,试验组病人术后首次排便时间明显延长(P0.05)。结论:环状混合痔术后病人应用短肽型EN制剂,能延长病人术后首次排便时间,减少排便次数,缓解肛门部疼痛程度,减少术后出血的发生率。

关键词：短肽型肠内营养制剂环状混合痔手术病人疼痛程度排便次数

Structures and catalytic performances of Me/SAPO-34(Me=Mn,Ni,Co)catalysts for low-tem perature SCR of NO_x by ammonia

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Journal of Environmental Sciences 2021年第6期33卷 137-149页

作者： Xuesong Liu Zhiming Sui Hongfeng Chen Yong Chen Haigang Liu peng Jiang Zhongyun Shen Wensheng linghu Xiaodong Wu College of Chemistry and Chemical Engineering Shaoxing UniversityShaoxing 312000China Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Zhejiang Hailiang Eco.Mater.Co. Ltd.Zhuji 311814China Shaoxing Testing Institute of Quality and Technical Supervision Shaoxing 312000China Chemical Design and Research Institute of Qinghai Province Xining 810008China

Me/SAPO-34(Me=Mn,Ni,Co)series of catalysts were prepared by a wetness impregnation method and investigated for the selective catalytic reduction of nitrogen oxides with ammonia(NH 3-SCR).Among them,Mn/SAPO-34 catalyst was found as the most promising candidate based on its superior low-temperature *** catalysts were characterized by X-ray diffraction(XRD),transmission electron microscopy images(TEM),nuclear magnetic resonance(NMR),X-ray photoelectron spectroscopy(XPS),temperature programmed reduction and desorption(TPR and TPD),and diffuse reflectance infrared Fourier transformed spectroscopy(DRIFTS)of NH_(3)/NO_(x)***/SAPO-34 is obviously different from Ni/SAPO-34 and Co/SAPO-34 in the active species state and *** MnO_(x)species which play an essential role in NO oxidation and NO_(2)adsorption,act as better active sites than nickel and cobalt mostly in the form of the aluminates and silicates.

关键词： SAPO-34 Transition metals Low-temperature activity Fast SCR Surface species

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毕节市国家重点保护野生植物资源研究

陕西林业科技 2024年第1期52卷 50-55页

作者：徐世朋令狐克念徐永服代丽李鹤毕节市七星关区白马山国有林场贵州毕节551700 贵州省林业科学研究院贵州贵阳550005 毕节市七星关区林业局贵州毕节551700

为了解毕节市国家重点保护野生植物物种组成、生活型组成、珍稀濒危等级、水平分布特征,加强毕节市国家重点保护野生植物资源的保护,本文通过大量文献调查对毕节市现存的国家重点保护野生植物资源进行统计与分析。结果表明:毕节市分布... 详细信息

为了解毕节市国家重点保护野生植物物种组成、生活型组成、珍稀濒危等级、水平分布特征,加强毕节市国家重点保护野生植物资源的保护,本文通过大量文献调查对毕节市现存的国家重点保护野生植物资源进行统计与分析。结果表明:毕节市分布的国家重点保护野生植物有71种,隶属31科42属,占全省国家重点保护野生植物的33.81%,其中被子植物57种,裸子植物5种,石松和蕨类植物5种,苔藓植物3种,真菌1种;生活型以草本或常绿物种居多;珍稀濒危等级评估方面,近危或近危以上物种有38种,占总种数的54.29%;分布不均匀,部分物种群聚明显。今后应进一步加强本地区资源调查和保护宣传力度,进一步落实珍稀濒危植物保护法律法规,加强狭域分布和极小种群的监测和保护力度。

关键词：国家重点保护野生植物现状保护建议毕节市

低渗透率储层核磁共振测井环境分析与T_(2)谱油层识别方法

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测井技术 2024年第3期48卷 370-379页

作者：曹志锋令狐松孟鑫白鹏孙正龙张凯中国石油集团测井有限公司新疆分公司新疆克拉玛依834000 中国石油新疆油田公司开发公司新疆克拉玛依834000 中国石油新疆油田公司勘探事业部新疆克拉玛依834000

准噶尔盆地玛湖凹陷发育低渗透率砾岩储层,不同地层的核磁共振T_(2)谱对这些储层流体的识别结果存在较大差异。基于地质、钻井、测井、试油等资料,开展了此类地层测井环境、核磁共振实验和测井响应特征机理的研究。结果表明:研究区钻井... 详细信息

准噶尔盆地玛湖凹陷发育低渗透率砾岩储层,不同地层的核磁共振T_(2)谱对这些储层流体的识别结果存在较大差异。基于地质、钻井、测井、试油等资料,开展了此类地层测井环境、核磁共振实验和测井响应特征机理的研究。结果表明:研究区钻井改善了近井筒储层孔隙结构,从近井筒到原状地层依次发育破碎带、微细裂缝带、原状地层;在负压钻井环境下发生油气侵出,油气侵出特性径向上可分为油气富集带(油环)、油气侵出带、原状地层,厘清了核磁共振测井响应特征机理;利用模块式地层动态测试仪(Modular Formation Dynamics Tester,MDT)验证了井壁油环的存在。基于岩心饱水、饱油及饱水离心的核磁共振T_(2)谱体积弛豫谱与地层原油的核磁共振T_(2)谱长弛豫时间峰一致,确定了核磁共振T_(2)谱100 ms识别油层和水层的标准。该方法在储层流体识别方面取得了显著效果,研究结果为利用核磁共振T_(2)谱识别复杂储层流体提供了借鉴。

关键词：低渗透率砾岩储层核磁共振测井油气侵出特性岩石物理实验流体识别准噶尔盆地玛湖凹陷

SGK3 overexpression correlates with a poor prognosis in endoscopically resected superficial esophageal squamous cell neoplasia:A long-term study

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World Journal of Gastroenterology 2023年第23期29卷 3658-3667页

作者： Ning Xu Long-Song Li Hui Li Li-Hua Zhang Nan Zhang peng-Ju Wang Ya-Xuan Cheng Jing-Yuan Xiang En-Qiang linghu Ning-Li Chai Senior Department of Gastroenterology The First Medical Center of PLA General HospitalBeijing 100853China Department of Gastroenterology Air Force Medical CenterBeijing 100142China Department of Pathology The Fourth Medical Center of PLA General HospitalBeijing 100142China

BACKGROUND The expression status of serum and glucocorticoid-induced protein kinase 3(SGK3)in superficial esophageal squamous cell neoplasia(ESCN)remains *** To evaluate the SGK3 overexpression rate in ESCN and its influence on the prognosis and outcomes of patients with endoscopic *** A total of 92 patients who had undergone endoscopic resection for ESCN with more than 8 years of follow-up were *** was used to evaluate SGK3 *** SGK3 was overexpressed in 55(59.8%)patients with ***3 overexpression showed a significant correlation with death(P=0.031).Overall survival and disease-free survival rates were higher in the normal SGK3 expression group than in the SGK3 overexpression group(P=0.013 and P=0.004,respectively).Cox regression analysis models demonstrated that SGK3 overexpression was an independent predictor of poor prognosis in ESCN patients(hazard ratio 4.729;95% confidence interval:1.042-21.458).CONCLUSION SGK3 overexpression was detected in the majority of patients with endoscopically resected ESCN and was significantly associated with shortened ***,it might be a new prognostic factor for ESCN.

关键词： Superficial esophageal squamous cell neoplasia Serum and glucocorticoid-induced protein kinase Endoscopic submucosal dissection Immunohistochemistry Overall survival