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新辅助内分泌治疗高危前列腺癌的早期疗效及相关危险因素分析

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重庆医科大学学报 2024年第6期49卷 745-749页

作者：彭朗吴小候重庆医科大学附属第一医院泌尿外科重庆400016

目的:对高危前列腺癌患者行新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的早期疗效进行研究,并分析相关风险因素。方法:在这项研究中,时间范围为2020年1月至2023年1月,共有151例高危前列腺癌患者纳入研究,患者均接受了根治性... 详细信息

目的:对高危前列腺癌患者行新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的早期疗效进行研究,并分析相关风险因素。方法:在这项研究中,时间范围为2020年1月至2023年1月,共有151例高危前列腺癌患者纳入研究,患者均接受了根治性前列腺切除术(radical prostatectomy,RP)。其中,70例患者被分入了新辅助内分泌治疗(NHT组),为实现最大程度的雄激素阻断效果,术前应用促黄体生成激素释放激素类似物(luteinizing hormone-releasing hormone analogue,LHRH-A)并且加用一种非甾体类抗雄激素药物。比较NHT组治疗前后前列腺及前列腺特异性抗原(prostate specific antigen,PSA)的变化情况;81例患者直接接受前列腺癌根治性切除术,作为对照组。研究对比2组围术期指标包括手术时间长短、出血量多少、引流管留置时间长短、住院时长;同时比较2组术后病理结果包括切缘阳性率是否有差异以及Gleason评分下降情况。同时分析影响2组影响切缘阳性率的相关危险因素。结果:新辅助内分泌治疗后NHT组前列腺特异性抗原及体积明显低于治疗前,且治疗时间越长,PSA值水平降低程度越大(P0.05)。2组中PSA值水平是影响切缘阳性率的危险因素。结论:通过新辅助内分泌治疗,可以降低高危前列腺癌患者的PSA值水平和前列腺体积,从而使其更适合接受手术治疗,甚至使一些无法手术的患者有可能进行根治性手术。这种治疗可以减少切缘阳性率,并使Gleason评分降低。PSA值水平是影响切缘阳性的危险因素。

关键词：高危前列腺癌新辅助内分泌治疗前列腺癌根治术早期疗效危险因素

银行业数字化转型重点问题研究——数字时代下的客户体验演变与转型路径

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西南金融 2024年第5期 62-72页

作者：彭浪吕进吴彪中国工商银行绵阳分行四川绵阳621000

“加快数字化发展、建设数字中国”战略是推动商业银行数字化转型的重要机遇,本文首先分析了数字时代商业银行转型升级的背景和内在驱动因素,结合国内外多家不同类型商业银行在数字化转型方面的实践探索,总结出“渠道+组织”“市场+伙... 详细信息

“加快数字化发展、建设数字中国”战略是推动商业银行数字化转型的重要机遇,本文首先分析了数字时代商业银行转型升级的背景和内在驱动因素,结合国内外多家不同类型商业银行在数字化转型方面的实践探索,总结出“渠道+组织”“市场+伙伴”“人才+技术”三种数字化转型路径;同时分析了数字时代的客户体验发展趋势,并从实际出发总结了商业银行数字化转型需要加强的六大创新能力,以及基于“数字运营”“数据驱动”的线上金融生态构建和客户体验提升。商业银行应积极把握数字时代带来的发展机遇,选取符合自身实际的数字化转型路径,提升市场竞争力,扩展知识边界,提高在客户获取、数据协同、产品创新等方面的能力,以更高效、便捷的金融服务为切入点,办好人民满意金融。

关键词：数字化转型银行转型金融科技开放银行大数据数据治理数字金融数字经济

单侧并联储能变流器并网谐振机理分析及抑制方法

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高电压技术 2024年第6期50卷 2490-2501页

作者：王承祥杜海江王爽宋希琛彭浪中国农业大学信息与电气工程学院北京100083

为解决单侧并联储能变流器并网谐振问题,对谐振机理进行分析,设计抑制方法。通过研究系统待机与运行工况下的幅相参数,获取谐振特性。将谐振成因分为内因与外因,内因为并联系统输出电流随并机叠加,在并网阻抗上产生谐波压降,导致的电压... 详细信息

为解决单侧并联储能变流器并网谐振问题,对谐振机理进行分析,设计抑制方法。通过研究系统待机与运行工况下的幅相参数,获取谐振特性。将谐振成因分为内因与外因,内因为并联系统输出电流随并机叠加,在并网阻抗上产生谐波压降,导致的电压谐波放大。外因为网侧所含背景电压谐波与并联系统阻抗频率在某些频段重叠。随并机数量增加,系统谐振点频率将降低。采用设计的电压谐波补偿单元进行功率解耦及动态多比例谐振控制器进行控制解耦两种方法,实现谐振抑制。通过仿真验证了谐振成因机理及抑制方法有效性。

关键词：储能变流器谐振分析阻抗分析电压谐波补偿单元动态多比例谐振控制器

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广义控制系统的动态补偿器镇定分析

集成电路应用 2024年第3期41卷 124-125页

作者：彭浪吉林师范大学数学与计算机学院吉林136000

阐述为实现状态观测器和状态反馈的结合而设计的动态补偿器,在广义系统的动态补偿器基础上进一步得到动态补偿器。利用广义系统的能稳性和脉冲能控、能检测、能观性,推出存在广义动态补偿器使闭环广义系统为容许的充要条件。

关键词：广义控制系统动态补偿器状态观测器

Current Research and Prospect of <i>Dendrobenthamia hongkongensis</i>in China

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Natural Resources 2013年第6期4卷 435-440页

作者： Longyi Yuan peng lang Xinghua Xue College of Horticulture and Garden Yangtze University Jingzhou China

Dendrobenthamia hongkongensis is an excellent ornamental tree species, which has a wide range in germplasm resources distribution and rich varieties within species in China and has also a great development prospect of the new superior species for city landscape. So it is necessary for us to do much research for the development and utilization of this species. According to the latest existing research data of D. hongkongensis, the research achievements of D. hongkongensis in Germplasm resource distribution, bio-ecological habits, breeding and cultivation techniques and so on have been analyzed and summed up. On the other hand, its Ornamental value has been utilized in the modern landscape. At the same time, Edible and Medicinal value of D. hongkongensis has been discussed in the paper as well as Material value of D. hongkongensis. In addition, the future aspects of physiological and ecological research, domestication and breeding new varieties, resource protection and landscape application of D. hongkongensis have been proposed.

关键词： Dendrobenthamia hongkongensis Germplasm Resource Distribution Ornamental Value Breeding Color-Leaf Tree Species

缺氧对AML骨髓单个核细胞的增殖及基因组甲基化的影响

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华夏医学 2024年第1期37卷 44-49页

作者：周贵珍彭浪邹立新刘小柳长沙市第四医院血液肿瘤科长沙410006

目的研究缺氧对急性髓系白血病(AML)患者骨髓单个核细胞的增殖及基因组甲基化的影响。方法收集初诊AML患者的骨髓液,分离单个核细胞,以不同浓度的氧(氧含量分别为21%、3%和1%)处理细胞24、48、72 h,以常氧(氧含量21%)作为对照。CCK-8法... 详细信息

目的研究缺氧对急性髓系白血病(AML)患者骨髓单个核细胞的增殖及基因组甲基化的影响。方法收集初诊AML患者的骨髓液,分离单个核细胞,以不同浓度的氧(氧含量分别为21%、3%和1%)处理细胞24、48、72 h,以常氧(氧含量21%)作为对照。CCK-8法、乳酸脱氢酶检测及Hoechst 33258染色等分析缺氧对骨髓单个核细胞的增殖、代谢及凋亡的影响。采用5-羟甲基化胞嘧啶(5-hmC)和5-甲基化胞嘧啶(5-mC)检测试剂盒分析缺氧对基因组甲基化状态的影响。结果随着缺氧程度的增加,AML细胞增殖活性增强,代谢活性增加,而细胞凋亡减少,差异有统计学意义(P<0.05)。随着缺氧程度增加,细胞基因组5-hmC的含量升高,5-mC的含量降低(P<0.05)。浓度1%的O_(2)培养细胞48 h,细胞的增殖和去甲基化最强。结论缺氧促进AML患者骨髓单个核细胞的增殖与代谢,抑制细胞凋亡,促进细胞基因组去甲基化。

关键词：缺氧急性髓系白血病甲基化 5-羟甲基化胞嘧啶 5-甲基化胞嘧啶

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

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Protein & Cell 2021年第9期12卷 734-740页

作者： Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu peng lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng Institute for Interdisciplinary Information Sciences Tsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Winghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China Silexon Al Technology Co. LtdNanjing 210033China NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjing 210009China Bioinformatics Division BNRIST/Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Protein Preparation and Identification Facility Technology Center for Protein ScienceTsinghua UniversityBeijing 100084China Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Center for Global Health Nanjing Medical UniversityNanjing 210009China Convalife(Shanghai)Co. LtdShanghai 201203China Ministry of Education Key Laboratory of Protein Sciences Beijing Advaneed Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China

Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020).

关键词： respiratory acute therapeutic

Detection of Oscillations in Process Control Loops From Visual Image Space Using Deep Convolutional Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 982-995页

作者： Tao Wang Qiming Chen Xun lang Lei Xie peng Li Hongye Su the Department of Electronic Engineering the School of InformationYunnan UniversityKunming 650091China DAMO Academy Alibaba GroupHangzhou 311100China the State Key Laboratory of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China

Oscillation detection has been a hot research topic in industries due to the high incidence of oscillation loops and their negative impact on plant profitability.Although numerous automatic detection techniques have been proposed,most of them can only address part of the practical difficulties.An oscillation is heuristically defined as a visually apparent periodic variation.However,manual visual inspection is labor-intensive and prone to missed detection.Convolutional neural networks(CNNs),inspired by animal visual systems,have been raised with powerful feature extraction capabilities.In this work,an exploration of the typical CNN models for visual oscillation detection is performed.Specifically,we tested MobileNet-V1,ShuffleNet-V2,Efficient Net-B0,and GhostNet models,and found that such a visual framework is well-suited for oscillation detection.The feasibility and validity of this framework are verified utilizing extensive numerical and industrial cases.Compared with state-of-theart oscillation detectors,the suggested framework is more straightforward and more robust to noise and mean-nonstationarity.In addition,this framework generalizes well and is capable of handling features that are not present in the training data,such as multiple oscillations and outliers.

关键词： Convolutional neural networks(CNNs) deep learning image processing oscillation detection process industries

Stress Concentration Effect in Interface Between Conductor and Epoxy Resin in Coaxial Components of Power Equipment

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 412-420页

作者： Chuang Wang Kang Lei Qing Sun Hui Li Jiawei Zhang lang Zhao Zongren peng School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an Power Supply Company State Grid Shaanxi Electric Power CompanyXi’an 710032China State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

The spacer used in gas insulated switchgear(GIS)plays a vital role in its safe operation.The mismatch of mechanical properties between conductor and insulating material in spacers results in stress concentration at the interface between them.During a hydrostatic test,mechanical damages are often initiated from the interface.In this paper,the stress between aluminum conductors and epoxy resin is studied by using a simplified coaxial structure specimen.The measurement system and finite element simulation are used to explore the generation of stress and strain during curing and shrinkage.The real-time measurement of strain at the interface shows that the residual strain in the entire process is primarily generated during the cooling stage.Consequently,the temperature and stress/strain distribution at the interface during the cooling stage are further studied,and combined with experiments and simulations.The consistency between the finite element simulation and the experimental measurement results verifies the validity of the simulation method used.The results show that the maximum of the first principal stress generated during the cooling stage of the production process is concentrated on the upper and lower edges of the interface which is critical to the impact of the production quality of the spacer.

关键词： Epoxy resin GIS interface stress/strain distribution