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Prognostic impact of hypernatremia for septic shock patients in the intensive care unit

World Journal of Clinical Cases 2025年第7期13卷 28-38页

作者： Mai-Qing Shi Jun Chen Fu-Hai Ji Hao Zhou ke peng Jun Wang Chun-Lei Fan Xu Wang Yang Wang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of General Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Intensive Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains *** To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic *** In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were *** were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with ***,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of ***,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the *** is highly recommended that hypernatremia be

关键词： Hypernatremia Hypernatremia acquired in the intensive care unit Septic shock Persistent inflammation Immunosuppression Catabolism syndrome Chronic critical illness Prognosis

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Modelling and analysis of initial icing roughness with fixed-grid enthalpy method based on DPM-VOF algorithm

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Chinese Journal of Aeronautics 2022年第7期35卷 168-178页

作者： Jie LIU peng ke Department of Civil Helicopter Research and Development China Helicopter Research and Development InstituteTianjin 300000China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China

Ice particles could form under the continuous impingement of incoming supercooled droplets in icing conditions,which will change the surface roughness to enhance the further heat and mass transfer during icing process.A fixed-grid porous enthalpy method based on the improved Discrete Phase Model(DPM)and Volume of Fluid(VOF)integrated algorithm is developed to solve the multiphase heat transfer problem to give more detailed demonstration of the formation of initial ice *** algorithms to determine the criterion of transformation from DPM to VOF and the allocation of source items during transformation are improved to the general DPM-VOF *** verification cases,namely two glycerine-solution droplets impact and single droplet freeze,are conducted to verify the accuracy and reliability of the enthalpy-DPMVOF method,where the simulation results match well with experiment *** roughness on a NACA0012 airfoil is precisely captured and the effects on convective heat transfer characteristics are preliminarily *** results illustrate that the enthalpy-DPM-VOF method could successfully capture the characteristics of motion and the phase change process of droplet,as well as balance the calculation accuracy and efficiency.

关键词： Discrete phase model Fixed-grid porous enthalpy method Ice roughness Icing modelling Integrated algorithm Multiphase heat transfer Volume of fluid

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How ploughing and frictional melting regulate ice-skating friction

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Friction 2023年第11期11卷 2036-2058页

作者： Feng DU peng ke Ping HONG School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Beijing Sports University Beijing 100084China

The slipperiness of ice is well known while,for ice skating,its mechanism still needs further investigation,where the complex interactions including the thermal conduction of the skate–meltwater–ice system,the ploughing and the frictional melting of ice to the friction force are still *** study presents a theoretical framework and a simplified analytical solution to unveil the friction mechanism when a curved skate sliding on *** theory is validated by experiments and the effects of these various factors,including the sliding velocity,the ice temperature,the supporting weight,and the geometry of the skate blade to the friction are revealed in *** study finds that the contribution of friction force from the ploughing deformation through skate indentation and that from the fluid friction through the shear motion of the meltwater layer is comparable with each other,which thus clarifies how the ploughing deformation of the ice substrate together with its frictional melting regulates the friction during skating.

关键词： ice friction skating ploughing frictional melting coefficient of friction

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Modeling and Verification of an Astronaut Handling Large-mass Payload

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Chinese Journal of Mechanical Engineering 2010年第4期23卷 517-523页

作者： YANG Aiping YANG Chunxin ke peng School of Aeronautics Science and Engineering Beihang University Beijing 100191 China School of Transportation Science andEngineering Beihang University Beijing 100191 China

The experiments on astronaut motions are difficult to conduct due to the limitation and high cost of constructing or simulating the microgravity environment of space. Therefore, the method of computer simulation on astronaut extravehicular activity is broadly promoted. However, validations and verifications for these simulations stated in related literatures are incomplete such as comparing with the limits of human body movements or reconstructing a three-dimensional movement for some parts of EVA video. Novel modeling and verification methods for the task of an astronaut handling targe-mass payload during EVA were revealed. A simplified model of an astronaut was constructed, and the astronaut motion was conceived as a planar movement of a multi-body system which includes seven segments with six revolute joints in the human body sagittal plane. The inverse kinematics method was used to calculate joint angles, joint velocities, and joint accelerations in time domain. The solution of joint torques using the inverse recursive dynamics was achieved. Furthermore, a virtual model with the ADAMSTM software was developed and implemented to verify the results by adding the kinematical data calculated to joints in order to achieve the trace of the center of mass of the hand. Additionally, the joints kinematics and kinetics data with time in the virtual model were obtained and compared with the corresponding calculated data. This result indicates that the modeling methods proposed can be employed as a solid algorithm to conduct the simulation of astronaut＇s tasks in EVA, and verification using the virtual model can be easily operated and has a good accuracy. This study provides an effective and economical way of modeling and simulation for extravehicular missions.

关键词： extravehicular activity inverse kinematics inverse recursive dynamics ADAIVISTM virtual model

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Prediction of Seasonal Tropical Cyclone Activity in the NUIST-CFS1.0 Forecast System

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Advances in Atmospheric Sciences 2023年第7期40卷 1309-1325页

作者： ke peng Jing-Jia LUO Yan LIU key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Institute for Climate and Application Research(ICAR)Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences and Key Laboratory of Mesoscale Severe Weather/Ministry of EducationNanjing UniversityNanjing 210023China

Prediction skill for the seasonal tropical cyclone(TC)activity in the Northern Hemisphere is investigated using the coupled climate forecast system(version 1.0)of Nanjing University of Information Science and Technology(NUISTCFS1.0).This assessment is based on the seven-month(May to November)hindcasts consisting of nine ensemble members during 1982–*** predictions are compared with the Japanese 55-year Reanalysis and observed tropical storms in the Northern *** results show that the overall distributions of the TC genesis and track densities in model hindcasts agree well with the observations,although the seasonal mean TC frequency and accumulated cyclone energy(ACE)are underestimated in all basins due to the low resolution(T106)of the atmospheric component in the ***-CFS1.0 closely predicts the interannual variations of TC frequency and ACE in the North Atlantic(NA)and eastern North Pacific(ENP),which have a good relationship with indexes based on the sea surface *** the western North Pacific(WNP),NUIST-CFS1.0 can closely capture ACE,which is significantly correlated with the El Ni?o–Southern Oscillation(ENSO),while it has difficulty forecasting the interannual variation of TC frequency in this *** the WNP is further divided into eastern and western subregions,the model displays improved TC activity forecasting ***,it is found that biases in predicted TC genesis locations lead to inaccurately represented TC–environment relationships,which may affect the capability of the model in reproducing the interannual variations of TC activity.

关键词： seasonal tropical cyclone activity interannual variation global ocean-atmosphere coupled forecast system

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Localization of Oscillation Source in DC Distribution Network Based on Power Spectral Density

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 156-167页

作者： Zida Zhao ke peng Richang Xian Xinhui Zhang Shandong University of Technology ZiboChina

Direct current(DC)bus voltage stability is essential for the stable and reliable operation of a DC *** an oscillation source can be quickly and accurately localized,the oscillation can be adequately *** propose a method based on the power spectral density for identifying the voltage oscillation ***,a DC distribution network model combined with the component connection method is developed,and the network is separated into multiple power *** with a conventional method,the proposed method does not require determining the model parameters of the entire power grid,which is typically ***,combined with a novel judgment index,the oscillation source can be identified more intuitively and clearly to enhance the applicability to real power *** performance of the proposed method has been evaluated using the MATLAB/Simulink software and PLECS RT Box experimental *** simulation and experimental results verify that the proposed method can accurately identify oscillation sources in a DC distribution network.

关键词： Direct current(DC)distribution network oscillation source component connection method power spectral density

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Identification of a novel caspase cleavage motif AEAD

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Virologica Sinica 2024年第5期39卷 755-766页

作者： Yujie Fang Zhou Gong Miaomiao You ke peng State key Laboratory of Virology Center for Antiviral ResearchCenter for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430207China University of Chinese Academy of Sciences Beijing100049China State key Laboratory of Magnetic Resonance and Atomic Molecular Physics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430071China Provincial key Laboratory of Jiangxia Wuhan430207China

Infections of many viruses induce caspase activation to regulate multiple cellular pathways,including programmed cell death,immune signaling and *** of caspase cleavage sites and substrates are important for understanding the regulation mechanisms of caspase ***,we identified and analyzed a novel caspase cleavage motif AEAD,and confirmed its caspase dependent cleavage activity in natural substrate,such as nitric oxide-associated protein 1(NOA1).Fusing the enhanced green fluorescent protein(EGFP)with the mitochondrial marker protein Tom20 through the AEAD motif peptide localized EGFP to the *** the activation of caspase triggered by Sendai virus(SeV)or herpes simplex virus type 1(HSV-1)infection,EGFP diffusely localized to the cell due to the caspase-mediated cleavage,thus allowing visual detection of the virusinduced caspase *** AEAD peptide-derived inhibitor Z-AEAD-FMK were developed,which significantly inhibited the activities of caspases-1,-3,-6,-7,-8 and-9,exhibiting a broad caspase inhibition *** inhibitor further prevented caspases-mediated cleavage of downstream substrates,including BID,PARP1,LMNA,pro-IL-1β,pro-IL-18,GSDMD and GSDME,protecting cells from virus-induced apoptotic and pyroptotic cell ***,our findings provide a new perspective for the identification of novel caspase cleavage motifs and the development of new caspase inhibitors and anti-inflammatory drugs.

关键词： Caspase AEAD motif Inhibitor Virus Cell death

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Coordinated Control of Multi-Agent Systems with a Varying-Velocity Leader and Input Saturation

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Communications in Theoretical Physics 2009年第9期52卷 449-456页

作者： peng ke SU Hou-Sheng YANG Yu-Pu Department of Automation Shanghai Jiao Tong University Shanghai 200240 China

In this paper,we investigate a leader-following tracking problem for multi-agent systems with *** propose a distributed bounded protocol for each follower to track a leader whose states may not be *** theoretically prove that each agent can follow the leader with estimable track ***,somenumerical simulations are presented to illustrate our theoretical results.

关键词： consensus coordinated control multi-agent system networked system input saturation switching topology

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Study on the breakup lengths of free round liquid jets

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航空动力学报 2007年第8期22卷 1258-1263页

作者： ZHU Ying WAN Yun-xia HUANG Yong peng Xin-ke School of Jet Propulsion Beijing University of Aeronautics and Astronautics Beijing 100083 China

An experi ment was conducted to measure the breakup lengths of water jets with a high-speed video camera for Weber numbers from0 to about 1.1×*** initial jet diameters are changed from0.3 mmto 1. 0 *** results indicate that at lowjet velocity the breakup lengths of the jets are increased linearly from 0 to a maxi *** the Weber number about 20 the breakup length of the jet reaches its maxi mum value for different initial jet *** based onthe dispersion equationis conducted to study the relationship between the growth rate of the jet surface wave and the maxi mumbreakup *** computations showthat the maxi mumgrowth rate for the axisymmetric surface wave has a turning point at Weber number about 20,and that agrees well with the experi ments.

关键词：高速照相机表面波循环液体喷射分散雾化生长率

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Adaptive Integrated Guidance and Autopilot for Hypersonic Glider 36

Adaptive Integrated Guidance and Autopilot for Hypersonic Gl...

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第36届中国控制会议

作者： Liang Wang Weihua Zhang ke peng School of Aerospace Science and Technology National University of Defense Technology

ISBN: (纸本)9781538629185

This paper proposes a novel method for the integrated guidance and control（IGC） of glider in dive and pull-up *** main objective is robust and adaptive tracking for flight path angle（FPA）.Firstly,the integrated guidance and autopilot nonlinear model is built based on the IGC with a second order rudder *** the back-stepping Xi adaptive control is implemented to deal with the aerodynamics coefficient uncertainties,control surface uncertainties and unmatched time-varying disturbances in IGC *** the autopilot,a back-stepping sliding mode control is designed to track the control input of IGC,and a nonlinear differentiator is used to avoid direct differential of the control *** a series of 6-DOF numerical simulations,it’s shown that the proposed scheme successfully cancels out the uncertainties and disturbances in tracking two kinds of FPA *** contribution of this paper lies in the application and determination of nonlinear integrated design of guidance and control system for hypersonic glide.

关键词： hypersonic glide IGC back-stepping sliding mode control L1 adaptive control

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