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基于SEER数据库的胰腺胶样癌生存预测模型的构建与验证

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南京医科大学学报（自然科学版） 2024年第7期44卷 909-914,940页

作者：李晨晨陈重发尹凌帝彭云鹏苗毅南京医科大学附属明基医院胰腺中心江苏南京210019 南京医科大学胰腺研究所江苏南京210029 南京医科大学第一附属医院胰腺中心江苏南京210029

目的:明确影响胰腺胶样癌(colloid carcinoma,cc)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510... 详细信息

目的:明确影响胰腺胶样癌(colloid carcinoma,cc)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510例患者,将其分为训练集和验证集,并根据训练集的临床变量构建预后模型,以预测cc患者在1、3、5年的癌症特异性生存率的概率值,而后用验证集验证训练集筛选出的变量及校准预测模型。结果:利用SEER数据库筛选cc患者预后的影响因素,包括肿瘤分级、检出淋巴结数量、是否手术、T分期、是否转移,并根据以上影响因素构建了临床预后模型。受试者特征曲线及曲线下面积值表明本预测模型具有较高的准确性。校正曲线显示模型预测的生存率与实际生存率相近。结论:本研究构建出cc患者的临床预后模型,并利用此模型对患者的生存预后进行了有效评估,填补了这种罕见肿瘤预后研究的空白,为临床医生评估cc患者预后提供了一项有力依据。

关键词：胰腺导管腺癌胶样癌 SEER数据库预后模型

Surface for methane combustion:O(^3P)+CH4→OH+CH3

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Chinese Physics B 2020年第7期29卷 286-294页

作者： Ya peng Zhong-An Jiang Ju-Shi Chen School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Kinetic investigations including quasi-classical trajectory and canonical unified statistical theory method calculations are carried out on a potential energy surface for the hydrogen-abstraction reaction from methane by atom O(^3P).The surface is constructed using a modified Shepard interpolation *** ab initio calculations are performed at the ccSD(T)*** account of the contribution of inner core electrons to electronic correlation interaction in ab initio electronic structure calculations,modified optimized aug-cc-pCVQZ basis sets are applied to the all-electrons *** this potential energy surface,the triplet oxygen atom attacks methane in a near-collinear H-CH3 direction to form a saddle point with barrier height of 13.55 kcal/mol,which plays a key role in the kinetics of the title *** the temperature range of 298-2500 K,our calculated thermal rate constants for the O(^3P)+CH4→OH+CH3 reaction show good agreement with relevant experimental *** work provides detailed mechanism of this gas-phase reaction and a theoretical guidance for methane combustion.

关键词： methane combustion potential energy surface transition state kinetic ab initio electronic structure calculation

Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation through NF-κB and AKT Signaling Pathway

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Chinese Journal of Integrative Medicine 2022年第5期28卷 419-424页

作者： XU Ben peng Yi-ji ZHU Wei-jie Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing(100034)China

Objective:To investigate the effect of curcumin on viability of clear cell renal cell carcinoma(cc Rcc)and analyze its possible ***:In cell lines of A498 and 786-O,the effects of curcumin(1.25,2.5,5 and 10μmol/L)on the viability of cc Rcc were analyzed at 24,48 and 72 h by MTT *** protein expression levels of ADAMTS18 gene,p65,phosphorylation p65(pp65),AKT,phosphorylation AKT(p AKT)and matrix metallopeptidase 2(MMP-2)before and after curcumin(10μmol/L)treatment were examined by Western ***-time PCR and methylation specific PCR(MSP)were applied to analyze the expression and methylation level of ADAMTS18 gene before and after curcumin treatment(10μmol/L).Results:Curcumin significantly inhibited the viability of A498 and 786-O cell lines in a dose-and time-dependent manner(Pccompanied by down-regulation of nuclear factorκB(NF-κk B)related protein(p65 and pp65),AKT related protein(AKT and p AKT),and NF-κB/AKT common related protein *** ADAMTS18 gene overexpressed,the expression levels of p65,AKT and MMP2 were downregulated,of which were conversely up-regulated in silenced ADAMTS18(sh-ADAMTS18).The expression of pp65,p AKT and MMP2 in sh-ADAMTS18 was down-regulated after being treated with PDTC(NF-κB inhibitor)and LY294002(AKT inhibitor).Conclusion:Curcumin could inhibit the viability of cc Rcc by down-regulating ADAMTS18 gene methylation though NF-κB and AKT signaling pathway.

关键词： curcumin clear cell renal cell carcinoma ADAMTS18 gene methylation signaling pathway

Effect of long-term continuous cropping of strawberry on soil bacterial community structure and diversity

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Journal of Integrative Agriculture 2018年第11期17卷 2570-2582页

作者： LI Wei-hua LIU Qi-zhi CHEN peng College of Plant Protection China Agricultural University

Long-term monoculture leads to continuous cropping （cc） problems, which complicate agricultural production, both locally and abroad. This study contrasted the different bacterial community compositions, physicochemical properties and enzyme activities of strawberry soil subjected to cc, cc rhizosphere （ccR）, non-cc （Ncc） and non-cc rhizosphere （NccR） treatments. The soil physicochemical properties and enzyme activities were significantly reduced after long-term cc. In addition, five variation trends were observed for the 11 major bacterial genera in the soil. Sphingomonas was the only stable group among all treatments. The proportions of Novosphingobium, Rhodoplanes, Povalibacter, Cellvibrio and Stenotrophobacterdecreased after cc. The relative abundances of Pelagibius, Thioprofundum and AIIokutzneria increased only in the cc treatment. Nitrospira were more abundant in rhizosphere soil than in non-rhizosphere soil. The relative abundance of Bacillus increased after cc. Redundancy analysis revealed that Bacillus, Pelagibius and AIIokutzneria had significant negative correlations with the soil physicochemical properties and enzyme activities. Therefore, these genera may be the key bacteria influenced by the physicochemical properties and enzyme activities altered by replanting. These results indicate that long-term cc of strawberry leads to less favourable rhizosphere soil conditions, which can be understood as a stress-induced response of the bacterial community diversity. Further research is needed to determine how the quality of soil is reduced by the shift in the diversity of the soil bacterial community.

关键词： rhizosphere soil high-throughput sequencing biogeochemical cycle bacterial diversity

Ultralow-voltage hydrogen production and simultaneous Rhodamine B beneficiation in neutral wastewater

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Journal of Energy Chemistry 2023年第6期81卷 574-582,I0013页

作者： Xiang peng Song Xie Shijian Xiong Rong Li peng Wang Xuming Zhang Zhitian Liu Liangsheng Hu Biao Gao Peter Kelly Paul K.Chu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205HubeiChina Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloon 999077Hong KongChina State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063GuangdongChina Surface Engineering Group Manchester Metropolitan UniversityManchester M15GDUK

Electrocatalytic water splitting for hydrogen production is hampered by the sluggish oxygen evolution reaction(OER)and large power consumption and replacing the OER with thermodynamically favourable reactions can improve the energy conversion *** iron corrodes easily and even self-corrodes to form magnetic iron oxide species and generate corrosion currents,a novel strategy to integrate the hydrogen evolution reaction(HER)with waste Fe upgrading reaction(FUR)is proposed and demonstrated for energy-efficient hydrogen production in neutral *** heterostructured MoSe_(2)/MoO_(2) grown on carbon cloth(MSM/cc)shows superior HER performance to that of commercial Pt/C at high current *** replacing conventional OER with FUR,the potential required to afford the anodic current density of 10 m A cm^(-2)decreases by 95%.The HER/FUR overall reaction shows an ultralow voltage of 0.68 V for 10 m A cm^(-2)with a power equivalent of 2.69 k Wh per m^(3)H_(2).Additionally,the Fe species formed at the anode extract the Rhodamine B(Rh B)pollutant by flocculation and also produce nanosized magnetic powder and beneficiated Rh B for value-adding *** work demonstrates both energy-saving hydrogen production and pollutant recycling without carbon emission by a single system and reveals a new direction to integrate hydrogen production with environmental recovery to achieve carbon neutrality.

关键词： Energy-saving hydrogen production Hydrogen evolution reaction Neutral water splitting MoSe_(2)/MoO_(2)heterostructure Environmental recovery

谷物膳食纤维和酚类物质结合对肠道健康影响的研究进展

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保鲜与加工 2024年第9期24卷 147-156页

作者：胡文凯王艳丽彭镰心时小东郑婷闵钟熳沈阳师范大学粮食学院辽宁沈阳110034 成都大学农业农村部杂粮加工重点实验室四川成都610106 大连赛姆生物工程技术有限公司辽宁大连116000

谷物是膳食纤维和酚类物质的良好来源,二者多以结合态形式存在,发挥调节肠道菌群及增强健康体质的作用。介绍了谷物膳食纤维和酚类物质的组分、结构及相互结合作用机制,阐述了膳食纤维与酚类物质在体内的吸收代谢途径,以及二者对肠道菌... 详细信息

谷物是膳食纤维和酚类物质的良好来源,二者多以结合态形式存在,发挥调节肠道菌群及增强健康体质的作用。介绍了谷物膳食纤维和酚类物质的组分、结构及相互结合作用机制,阐述了膳食纤维与酚类物质在体内的吸收代谢途径,以及二者对肠道菌群、短链脂肪酸和酚酸的协同调节作用,为肠道健康领域功能性产品的开发和应用提供科学依据。

关键词：谷物膳食纤维酚类物质结合肠道菌群

滋肾清热利湿化瘀方治疗多囊卵巢综合征的网络药理学作用机制及实验研究

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中国药理学通报 2024年第4期40卷 764-775页

作者：金晶李佩双丁志玲彭佳华刘淑娟梁瑞宁江西中医药大学研究生院江西南昌330004 江西中医药大学附属医院江西南昌330006 江西中医药大学中医妇产科学研究所江西南昌330006 江西中医药大学附属生殖医院江西南昌330001 江西中医药大学第二附属医院江西南昌330006

目的采用网络药理学探讨滋肾清热利湿化瘀方(Zishen Qingre Lishi Huayu Prescription,ZQLHP)治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)的作用机制,并进行实验验证。方法基于网络药理学预测滋肾方的核心成分、靶基因和主要通... 详细信息

目的采用网络药理学探讨滋肾清热利湿化瘀方(Zishen Qingre Lishi Huayu Prescription,ZQLHP)治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)的作用机制,并进行实验验证。方法基于网络药理学预测滋肾方的核心成分、靶基因和主要通路,对其中PCOS相关成分、靶基因、通路进行筛选;采用来曲唑(letrozole,LET)诱导PCOS小鼠模型,观察滋肾方对PCOS小鼠的作用,并对网络药理学结果进行机制验证。结果网络药理学结果表明,滋肾方456个成分中含有361个相关靶点,PCOS相关靶点1397个,交集靶点125个;获得槲皮素、豆甾醇、β-谷甾醇等主要活性成分与丝裂原活化蛋白激酶3(mitogen-activated protein kinase 3,MAPK3)、蛋白激酶1(AKT serine/threonine kinase 1,AKT1)和信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)等核心靶点;GO分析得到BP 663条目,cc 64条目,MF 119条目,其中富集基因数量较多的条目为negative regulation of apoptotic process,plasma membrane,protein binding;KEGG分析显示潜在作用靶点主要富集在癌症信号通路、PI3K-AKT和TNF等信号通路;PPI网络分析结果显示,MAPK3、AKT1和STAT3可能是滋肾方治疗PCOS的关键靶点。动物实验结果表明,与模型组比较,滋肾方组的小鼠的体重降低(P<0.05),且能有效改善PCOS模型小鼠的组织病理学表现,囊性卵泡数量降低(P<0.05),黄体数量增加(P<0.01)。降低卵巢组织中IL-10水平(P<0.01),升高IL-6、TNF-α水平(P<0.05,P<0.01)。Western blot和免疫组织化学(immunohistochemistry,IHC)结果显示,PCOS小鼠卵巢组织p-AKT蛋白表达量下降(P<0.05,P<0.01),p-p38MAPK和p-STAT3蛋白表达较正常组升高(P<0.05,P<0.01),而经滋肾方治疗后p-AKT蛋白表达上升(P<0.05),p-p38MAPK和p-STAT3蛋白表达明显下降(P<0.05,P<0.01)。结论滋肾方可能通过调控AKT/p38MAPK/STAT3信号改善来曲唑诱导的PCOS小鼠的炎性损伤。

关键词：滋肾清热利湿化瘀方多囊卵巢综合征网络药理学机制 AKT p38MAPK STAT3

Controlling continuum wavepacket interference by two-color laser field in over-the-barrier ionization regime

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Frontiers of physics 2016年第1期11卷 105-110页

作者： Sheng-peng Zhou Yu-Jun Yang Da-Jun Ding Institute of Atomic and Molecular Physics Jilin University Changchun 130012 China

Continuum wavepacket interference is investigated by numerically solving the time-dependent SchrSdinger equation for the interaction of hydrogen atoms with laser fields. The obtained wavepacket evolution indicates that, in the over-the-barrier ionization regime （1016 W/cm2）, the continuum-continuum （cc） interference of ionizing electrons becomes the main process in high- order harmonics generation （HHG）, compared with continuum-bound （CB） transition, as reported by Kohler et al. [Phys. Rev. Lett. 105（20）, 203902 （2010）]. We propose a two-color laser field scheme for controlling the quantum trajectories of ionizing electrons and for extending the cc harmonic energy. As a result, a high energy platform occurs in the HHG spectrum, which entirely originates from the cc harmonics, with a cutoff adjustable by the relative phase of the two-color fields. This provides further understanding of the dynamic feature of atoms and molecules in super intense laser fields and provides an opportunity to image the atomic or molecular potential.

关键词： continuum continuum interference high-order harmonic generation over-the-barrierionization

Degradation of sulfadiazine antibiotics by water falling film dielectric barrier discharge

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Chinese Chemical Letters 2014年第1期25卷 187-192页

作者： Shao-peng Rong Ya-Bing Sun Ze-Hua Zhao State Key Laboratory of Pollution Control & Resources Reuse School of the EnvironmentNanjing University

A new water falling film dielectric barrier discharge was applied to the degradation of sulfadiazine in the aqueous solution. The various parameters that affect the degradation of sulfadiazine and the proposed evolutionary process were investigated. The results indicated that the inner concentrations of 10 mg/L sulfadiazine can be all removed within 30 min. The optimum pH value was 9.10 and both strong acidic and alkaline solution conditions were not suitable for the degradation. The degradation of sulfadiazine can be enhanced by the addition of hydrogen radical scavengers, but be inhibited by adding hydroxyl radical scavengers. The water falling film dielectric barrier discharge was rather ineffective in mineralization, because of the intermediates were recalcitrant to be degraded. The existence of Fe2＋ and ccI4 in the liquid phase can promote the degradation and mineralization of sulfadiazine. It was found that the degradation of SDZ was enhanced by cc14 was mainly because of the increase of＇OH due to the reaction of cc14 with ＊H that reduce the chances of their recombination with ＂OH. Based on the 8 intermediate products identified by LC-MS, the proposed evolution of the degradation process was investigated.

关键词： Sulfadiazine Water falling film dielectric barrier discharge Degradation efficiency LC-MS Degradation pathway