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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing peng yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Controlled-growth of Zn（OH）F Microbesoms in the Mild Aqueous Solution and Their Photocatalytic Activity

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Chinese Journal of Chemistry 2011年第1期29卷 191-195页

作者： peng, yin Anhui Key Laboratory of Functional Molecular Solids College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China

Zn（OH）F microbesoms have been synthesized on a large scale by a facile solution-based method using polymer as crystal growth modifier. The obtained products were characterized by X-ray powder diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, and scanning electron microscopy （SEM）. The effects of modifier polyacryla- mide （PAM）, reaction time, concentrations of NaF on the morphology and size of the product were studied. The resuits revealed that the Zn（OH）F microbesom had orthorhombic structures. Experimental conditions had all influence on the shape and size of the final products, but polymer PAM played the key role in formation of the Zn（OH）F microbesom. This novel structures exhibited good UV photocatalytic abilities,

关键词： Zn(OH)F synthesis design photocatalysis

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Light dark sector searches at low-energy high-luminosity e^＋e^- colliders

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Frontiers of physics 2016年第5期11卷 9-22页

作者： peng-Fei yin Shou-Hua Zhu Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Institute of Theoretical Physics & State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China Center for High Energy Physics Peking University Beijing 100871 China

Although the standard model （SM） is extremely successful, there are various motivations for considering the physics beyond the SM. For example, the SM includes neither dark energy nor dark matter, which has been confirmed through astrophysical observations. Examination of the dark sector, which contains new, light, weakly-coupled particles at the GeV scale or lower, is well motivated by both theory and dark-matter detection experiments. In this mini-review, we focus on one particular case in which these new particles can interact with SM particles through a kinematic mixing term be- tween U（1） gauge bosons. The magnitude of the mixing can be parameterized by a parameter e. Following a brief overview of the relevant motivations and the constraints determined from numerous experiments, we focus on the light dark sector phenomenology at low-energy high-luminosity e^＋e^- colliders. These colliders are ideal for probing the new light particles, because of their large production rates and capacity for precise resonance reconstruction. Depending on the details of a given model, the typical observed signatures may also contain multi lepton pairs, displaced vertices, and/or missing energy. Through the use of extremely large data samples from existing experiments, such as KLOE, CLEO, BABAR, Belle, and BESIII, the ε 〈 10^-4-10^-3 constraint can be obtained. Obviously, future experiments with larger datasets will provide opportunities for the discovery of new particles in the dark sector, or for stricter upper limits on ε. Once the light dark sector is confirmed, the particle physics landscape will be changed significantly.

关键词： dark photon electron-positron collider dark matter

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On the convergence and improvement of stochastic normalized gradient descent

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Science China(Information Sciences) 2021年第3期64卷 105-117页

作者： Shen-Yi ZHAO yin-peng XIE Wu-Jun LI National Key Laboratory for Novel Software Technology Department of Computer Science and TechnologyNanjing University

Non-convex models, like deep neural networks, have been widely used in machine learning applications. Training non-convex models is a difficult task owing to the saddle points of models. Recently,stochastic normalized gradient descent(SNGD), which updates the model parameter by a normalized gradient in each iteration, has attracted much attention. Existing results show that SNGD can achieve better performance on escaping saddle points than classical training methods like stochastic gradient descent(SGD).However, none of the existing studies has provided theoretical proof about the convergence of SNGD for non-convex problems. In this paper, we firstly prove the convergence of SNGD for non-convex ***, we prove that SNGD can achieve the same computation complexity as SGD. In addition, based on our convergence proof of SNGD, we find that SNGD needs to adopt a small constant learning rate for convergence guarantee. This makes SNGD do not perform well on training large non-convex models in practice. Hence, we propose a new method, called stagewise SNGD(S-SNGD), to improve the performance of SNGD. Different from SNGD in which a small constant learning rate is necessary for convergence guarantee,S-SNGD can adopt a large initial learning rate and reduce the learning rate by stage. The convergence of S-SNGD can also be theoretically proved for non-convex problems. Empirical results on deep neural networks show that S-SNGD achieves better performance than SNGD in terms of both training loss and test accuracy.

关键词： non-convex problems stochastic normalized gradient descent computation complexity

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Numerical investigation of thermocapillary migration of the drop for large Marangoni numbers

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Science China(Technological Sciences) 2007年第5期50卷 694-696页

作者： GAO peng yin ZhaoHua HU WenRui National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

An axisymmetric model is adopted to simulate the problem of unsteady drop thermocapillary motion for large Marangoni numbers. Front tracking methods are used in the investigation. It is found that the non-dimensional drop migration ve- locity will decrease with increasing Marangoni number. This agrees well with the experimental results obtained from the 4th Shen-Zhou space ship. In the meanwhile, this is also the first time for numerical simulations to verify the experimental phe- nomenon under large Marangoni numbers.

关键词： thermocapillary migration of drops, microgravity, front tracking methods

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Defect-enhanced Photocatalytic Activity of ZnO Micro/nanostructures

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Chinese Journal of Chemistry 2013年第12期31卷 1557-1563页

作者： Yu Wang Mei Yan Qinguo Chen yin peng The Key Laboratory of Functional Molecular Solids Ministry of Education Anhui Key Laboratory of MolecularBased Materials College of Chemistry and Materials Science Anhui Normal University Wuhu 241000 China

ZnO micro/nanocrystals with controlled oxygen defects are successfully prepared through annealing precursors obtained via a simple solvothermal method. The size and surface defects of the as-synthesized ZnO mi- cro/nanocrystals increase with the solvent volume ratio of water/ethanol increasing; the BET surface areas of the corresponding samples decrease during these processes; photoluminescence reveals that the type and concentration of surface defects （oxygen vacancy and interstitial oxygen） are quite different for the samples prepared via different solvent volume ratio of water/ethanol. In addition, it is found that the photocatalytic activity of the synthesized ZnO nanocrystals is mainly dependent on the concentration of surface defects. The sample with more surface defects ex- hibits higher photocatalytic activity toward the degradation of methylene blue （MB）. The possible photocatalytic mechanism is discussed in detail.

关键词： ZnO micro/nanocrystals surface defects photocatalytic activity

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Status of dark matter detection

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Frontiers of physics 2013年第6期8卷 794-827页

作者： Xiao-Jun Bi peng-Fei yin Qiang Yuan Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

The detection of dark matter has made great progresses in recent years. We give a brief review on the status and progress in dark matter detection, including the progresses in direct detection, collider detection at LHC and focus on the indirect detection. The results from PAMELA, ATIC, Fermi-LAT and relevant studies on these results are introduced. Then we give the progress on indirect detection of gamma rays from Fermi-LAT and ground based Cerenkov telescopes. Finally the detection of neutrinos and constraints on the nature of dark matter are reviewed briefly.

关键词： dark matter annihilation cosmic rays gamma rays

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A Distributed Cell Outage Compensation Mechanism Based on RS Power Adjustment in LTE Networks

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China Communications 2014年第A01期11卷 40-47页

作者： LI Wenjing YU peng yin Mengjun MENG Luoming StateKeyLaboratoryofNetworkingandSwitchingTechnology BeijingUniversityofPostsandTelecommunicationsBeijing100876China

To solve the coverage and quality problems caused by cell outage in LTE networks, this paper proposes a distributed self-organizing networks management architecture and a distributed cell outage compensation management mechanism. After detecting and analyzing the outage, a cell outage compensation algorithm based on reference signal power adjustment is proposed. The simulation results show that the proposed mechanism can mitigate the performance degradation significantly. Compared with other algorithms, the proposed scheme is more effective in compensating the coverage gap induced by cell outage

关键词： LTE cell outage compensation (COC) reference signal power PSO

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Chronic Obstructive Pulmonary Disease-Associated Mortality — China, 2014–2021

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China CDC weekly 2024年第43期6卷 1105-1110页

作者： Zifang Zhou Lijun Wang Maigeng Zhou peng yin National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:China faces a growing burden of chronic obstructive pulmonary disease(COPD).Previous mortality estimations were primarily based on the underlying cause of *** study analyzed COPD-associated death and its comorbidities using all COPD cases listed on the chain of events on death ***:A retrospective analysis of the National Mortality Surveillance System(NMSS)was conducted to estimate COPD-associated mortality from 2014 to ***-standardized mortality rates(ASMRs)were calculated stratified by sex,region,and *** regression was used to estimate the average annual percentage change(AAPC)during the study ***:From 2014 to 2021,the ASMR of COPD decreased from 91.85 to 45.90 per 100,000 *** but uneven decreases in COPD mortality were observed across gender[females:AAPC:−11.2%,95%confidence interval(CI):−11.9 to−10.4%;males:AAPC:−8.0%,95%CI:−9.2 to−6.8%],regions(eastern:AAPC:−10.7%,95%CI:−11.5 to−9.9%;central:AAPC:−9.9%,95%CI:−10.9 to−8.9%;western:AAPC:−7.7%,95%CI:−10.6 to−4.7%),and residential areas(urban:AAPC:−10.9%,95%CI:−12.3 to−9.5%;rural:AAPC:−8.3%,95%CI:−9.1 to−7.4%).Other than COPD,cardiovascular diseases and respiratory conditions were the major underlying causes of death in COPDassociated ***:COPD is a significant comorbidity of other disorders in *** COPDassociated mortality substantially decreased from 2014 to 2021,the burden remained high in underdeveloped regions.

关键词： mortality listed stratified

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Study of Viscoelastic Properties of White Carbon Black Reinforced Synthetic Polyisoprene

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Chinese Journal of Polymer Science 2016年第4期34卷 457-465页

作者： Guang-jun Cui Shi-wei Wang peng-gang yin 郭林 Key Laboratory of Bio-Inspired-Smart Interfacial Science and Technology of Ministry of Education School of Chemistry and EnvironmentBeihang UniversityBeijing 100191China

The viscoelastic properties of synthetic polyisoprenes （PI） reinforced by white carbon black （WCB） have been investigated and compared with WCB reinforced natural rubber （NR）, including cure characteristics, physio-mechanical and dynamic mechanical properties. Compared with NR, PI loaded with the same amount of WCB （PI/WCB） exhibited shorter scorch time and optimal cure time, indicating that WCB fillers are comparatively easier to conjugate with PI. The tensile strength and elongation at break decreased with WCB filling in both PI and NR vulcanizates. The hardness of the rubber vulcanizates increased with the WCB filling in the rubber matrix. PI/WCB blends exhibited smaller hardness data, lower tensile strength, as well as lower elongation at break and tensile stress. Increasing the amount of WCB in rubber matrix induced the Payne effect. However, the Payne effect is much more obvious for the PI/WCB system, and PI/WCB also displayed higher storage modulus whereas lower loss modulus and loss tangent than NR/WCB, which could all be attributed to the poor dispersibilities of WCB in the PI matrix.

关键词： Reinforcement White carbon black Synthetic polyisoprene Natural rubber Viscoelastic properties Payne effect.

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