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Intestinal helminth infections and associated risk factors among adults in the Lao People’s Democratic Republic

Infectious Diseases of Poverty 2023年第3期12卷 99-100页

作者： Sengaloun Phonekeo Sengchanh Kounnavong Manithong Vonglokham Latsamy Siengsounthone Anousin Homsana Sascha Gummin penelope vounatsu Prawat Nittiyanant Suchin Worawichawong Wichai Aekplakorn Peter Odermatt Somphou Sayasone Lao Tropical and Public Health Institute Ministry of HealthVientianeLao People’s Democratic Republic Epidemiology and Public Health Department Swiss Tropical and Public Health InstituteAllschwilSwitzerland University of Basel BaselSwitzerland Ramathibodi Hospital Faculty of MedicineMahidol UniversityBangkokThailand Department of Pathology Ramathibodi HospitalFaculty of MedicineMahidol UniversityBangkokThailand

Background Helminthiases are highly endemic in Southeast Asia,including the Lao People’s Democratic Republic(Lao PDR).This study aimed to assess the current intestinal helminth infections and the associated risk factors among adults across the Lao *** A cross-sectional survey was conducted in 165 villages across 17 provinces and the Vientiane Capital,Lao PDR.A multi-stage sampling method was employed to select the adult study participants(≥18 years).Data collection included(1)interview of the study participants,(2)physical measurements,and(3)a fve gram of stool sample from each study participant was collected and preserved in 10%formalin solution for intestinal helminth detection using formalin-ether concentration technique(FECT).Descriptive analysis was used to describe the socio-demographic characteristics of study participants and the prevalence of intestinal helminth *** regressions were applied to test the association between intestinal helminth infection and individual risk factors.A P-value below 0.05 was considered statistically *** A total of 2800 study participants were *** average age was 46.0 years;57.8%were ***,30.9%,8.6%and 1.5%of study participants were infected with one,two,or three diferent intestinal helminth species,*** the study participants 21.6%were infected with hookworm,18.8%with Opisthorchis viverrini-like(Ov-like)infection,4.8%with Strongyloides stercoralis,2.3%with Ascaris lumbricoides,1.5%with Trichuris trichiura,and 3.3%with Taenia ***-like infection was of high prevalence in the southern(28.8%)and central(21.3%)provinces,while hookworm(26.3%),***(7.3%),***(3.1%),and Taenia spp.(4.2%)were prevalent in the northern *** analysis showed that men were more likely to be infected with hookworm[adjusted odds ratio(aOR)=1.2,P=0.019].The Lao-Tai ethnic group had a 5.2-times(P<0.001)higher chance of having Ov-like infection than the minorit

关键词： Intestinal helminth Prevalence Risk factors Investigation Regions Lao PDR

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Cultivating potential:Harnessing plant stem cells for agricultural crop improvement

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Molecular Plant 2024年第1期17卷 50-74页

作者： penelope Lindsay Kyle W.Swentowsky David Jackson Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei430070China

Meristems are stem cell-containing structures that produce all plant organs and are therefore important targets for crop *** regulators control the balance and rate of cell divisions within the *** these regulators impacts meristem architecture and,as a consequence,plant *** this review,we discuss genes involved in regulating the shoot apical meristem,inflorescence meristem,axillary meristem,root apical meristem,and vascular cambium in *** highlight several examples showing how crop breeders have manipulated developmental regulators to modify meristem growth and alter crop traits such as inflorescence size and branching *** transformation techniques are another innovation related to plant meristem research because they make crop genome engineering *** discuss recent advances on plant transformation made possible by studying genes controlling meristem ***,we conclude with discussions about how meristem research can contribute to crop improvement in the coming decades.

关键词： meristem crop improvement plant transformation plant breeding crop yield gene editing

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淋浴时听音乐可能会阻止创造性思维的流动

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中学生英语 2024年第7期 26-28页

作者： penelope Clifton 笃景行(译) 不详

可能是时候放弃播放列表了——专家表示,淋浴时听音乐不利于创造力。研究表明,在洗澡、散步或上学途中播放音乐让大脑保持忙碌,可能会影响你跳出定式思维并想出有艺术性或创造性的事情的能力。

关键词：定式思维创造性思维创造力淋浴艺术性音乐

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Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification

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World Journal of Radiology 2024年第8期16卷 294-316页

作者： Woongsoon John Choi Peggy Lee penelope C Thomas Tanya J Rath Monique A Mogensen Roberta W Dalley Pattana Wangaryattawanich Division of Neuroradiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of Radiology M&S Radiology AssociatesSan AntonioTX 78217United States Division of Oral Radiology University of Washington School of DentistrySeattleWA 98195United States Division of Neuroradiology Department of RadiologyMayo ClinicPhoenixAZ 85054United States

Jaw and maxillofacial bone lesions encompass a wide variety of both neoplastic and non-neoplastic *** lesions can arise from various tissues,including bone,cartilage,and soft tissue,each presenting distinct challenges in diagnosis and *** some pathologies exhibit characteristic imaging features that aid in diagnosis,many others are *** overlap often necessitates a multimodal imaging approach,combining techniques such as radiographs,computed tomography,and magnetic resonance imaging to achieve a diagnosis or narrow the diagnostic *** article provides a comprehensive review of the imaging approach to jaw and maxillofacial bone tumors,including updates on the 2022 World Health Organization classification of these *** relevant anatomy of the jaw and dental structures that is important for accurate imaging interpretation is discussed.

关键词： Mandible Maxilla Maxillofacial Jaw Tumor Neoplasm

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Exploring Educator Values Alignment Strategies in an Intervention Context: The Emergence of the Beacon Strategy

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ECNU Review of Education 2021年第2期4卷 327-348页

作者： penelope Kalogeropoulos James Anthony Russo Philip Clarkson Monash University Australian Catholic University

Purpose:The purpose of this paper is to explore whether the four value alignment strategies available to educators(Scaffolding,Balancing,Intervention,and Refuge)previously identified in the mathematics education literature comprehensively capture educator value alignment strategies in an in terve ntion con ***/Approach/Methods:To this end,we analyse semi-structured interview data with two teacher-leaders involved in the Getting Ready in Numeracy(G.R.I.N.)intervention program through a value alignment ***:We ascertain that a fifth strategy,the Beacon strategy,is needed to describe the range of value alignment strategies employed by educators in the *** Beacon strategy involves the educator digging in and reasserting their expectations until the student behaves in a manner that aligns with the educator's *** part it invoIves the educator being able to recognize their own values and clearly communicating these values to students.O rigin al ity/Value:This article further explores strategies that educators have at their disposal for aligning their values with those of their *** uncovering of the Beacon strategy is particularly valuable as it suggests that educators could be purposefully pursuing value alignment even when they do not appear to take any active steps to move further towards their students'sets of values.

关键词： Engagement values values alignment

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Advances in murine models of breast cancer bone disease

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 158-177页

作者： penelope D.Ottewell Michelle A.Lawson Department of Oncology and Metabolism Mellanby Centre for Bone ResearchUniversity of SheffieldSheffield S102RXUK

Bone is the most prevalent metastatic site for breast cancer affecting~70%of patients with late-stage *** for this condition currently focus on controlling disease progression and limiting tumour-induced damage to bone,thereby playing a valuable role in increasing quality of ***,limited understanding of the interplay between tumour cells and their environment during bone metastasis has impeded the development of curative *** unravel the complex genetic and phenotypic alterations that occur during this process,it would be helpful to have a model in which tumours develop spontaneously at the primary site,spread to bone,undergo a dormancy phase and then,after a fixed timeframe,become re-activated to form osteolytic/mixed lesions in the *** humans,spontaneous metastasis of primary mammary tumours to bone is rare in mice and no syngeneic models of oestrogen receptor positive disease have been *** there is no single model that authentically reproduces all of the genetic and phenotypic changes representative of human bone metastasis,this review discusses the traditional and novel mouse models that are used to study bone metastasis from breast ***,this review focuses on advances that have been made towards making these models more closely related to human disease in an attempt to help researchers select the correct model(s)for their experimental needs with the aim of improving translational efficacy between the laboratory and the clinic.

关键词： Breast cancer bone metastasis mouse models

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Increased ΤGF-β3 in primary biliary cirrhosis: An abnormality related to pathogenesis?

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World Journal of Gastroenterology 2010年第40期16卷 5057-5064页

作者： Argyro Voumvouraki Mairi Koulentaki Maria Tzardi Ourania Sfakianaki penelope Manousou George Notas Elias Kouroumalis University Hospital Department of Gastroenterology University of Crete Faculty of Medicine Liver Research Laboratory University of Crete Faculty of Medicine University Hospital Department of Pathology University of Crete Faculty of Medicine Laboratory of Experimental Endocrinology University of Crete Faculty of Medicine

AIM: To investigate the transforming growth factor-β (TGF-β) isoforms in the peripheral and hepatic venous blood of primary biliary cirrhosis (PBC) patients. METHODS: We examined TGF-β1, TGF-β2 and TGF-β3 (enzyme-linked immunosorbent assay), in 27 stage Ⅳ PBC patients (27 peripheral and 15 hepatic vein sera), 35 early (Ⅰ-Ⅱ) PBC and 60 healthy controls. As disease controls 28 hepatitis C virus (HCV) cirrhosis (28 peripheral and 17 hepatic vein serum), 44 chronic HCV hepatitis and 38 HCV-related hepatocellular carcinomas were included. We also tested liver tissue by immunohistochemistry to identify localization of TGF isoforms. RESULTS: TGF-β1 was significantly decreased in all cirrhotics (PBC Ⅲ-Ⅳ: median 13.4 ng/mL; range, 7.4-26.2, HCV cirrhosis: 11.6 ng/mL; range, 5.0-33.8), compared to controls (30.9 ng/mL; range, 20.9-37.8). TGF-β2 was increased in viral cirrhosis but not in PBC and chronic hepatitis. TGF-β3 (47.2 pg/mL; range, 27.0-79.7 in healthy controls) was increased in early and late PBC (Ⅰ-Ⅱ: 94.3 pg/mL; range, 41.5-358.6; Ⅲ-Ⅳ: 152.8 pg/mL; range, 60.4-361.2; P < 0.001) and decreased in viral cirrhosis (37.4 pg/mL; range, 13.3-84.0; P < 0.05). Hepatic vein TGF-β levels were analogous to those in peripheral blood. Immunohistochemistry identified all isoforms in portal tract lymphocytes, sinusoidal cells and cholangiocytes. TGF-β3 was additionally overexpressed in hepatocytes in PBC patients. CONCLUSION: The serum profile of TGF-β isoforms is different in cirrhotics. Increased TGF-β3 is characteristic of PBC. These findings may be related to the immunological abnormalities of PBC.

关键词： Transforming growth factor-β Primary biliary cirrhosis Liver fibrosis Cirrhosis

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Traditional Chinese Medicine Needs Clinical Trials

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新高考(英语进阶) 2017年第9期 36-37页

作者： penelope

词数:496阅读难度:★★★☆☆建议阅读时间:5分钟Traditional Chinese medicine needs to prove its worth through rigorous clinical trials,according to the head of one of China’s largest herbal remedy companies,as a contentious new law to boost the $40bn sector comes into *** Chinese medicine is estimated by analysts to account for a third of sales in China’s$117bn pharmaceutical market,the

关键词： TCM Traditional Chinese Medicine Needs Clinical Trials

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How to Drink Coffee can Reduce Sugar?

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新高考(英语进阶) 2017年第11期 34-36页

作者： penelope

词数:587阅读难度:★★★建议阅读时间:6分钟People who’d like to reduce their daily calories without restrictive dieting should consider taking their coffee with little or no sugar—and savouring(调味)the beverage might help in that regard,researchers *** are 48 calories in one tablespoon of sugar,and over the course of a day,some coffee drinkers may use their entire recommended daily allotment(分配)of added

关键词：推理判断题定语从句 How to Drink Coffee can Reduce Sugar 复合句

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A Person Preferring Black Coffee may Have Psychopathic Tendencies

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新高考(英语进阶) 2017年第10期 36-37页

作者： penelope

词数:408阅读难度:★★★☆☆建议阅读时间:5分钟If you’ve ever been on a co ee date with someone who chose black coffee over the typical indulgent(宽容的)caffeinated creation,you might want to take your latte(拿铁)and ***,you’re on a date with a psychopath.A new study from the University of Innsbruck in Austria found that people who prefer their coffee black often have psychopathic(精神病的)or sadistic(虐待狂的)*** study,

关键词： A Person Preferring Black Coffee may Have Psychopathic Tendencies

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