检索结果-南通市图书馆

世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 13-14页

作者： Engl.nd K. pembrey l. Tovo P.-A. M.-l. Newel. 李开 Ctr.Paediatr. Epidemiol. B. Institute of Child Health University College London 30 Guilford Street London WC1N 1EH United Kingdom

Aim: To identify the age at which HCV infection can be accuratel. excl.ded by serol.gy in young chil.ren born to HCV-infected mothers and to determine an appropriate schedul. of antibody testing, most informative to cl.nical.practice. Methods: Chil.ren born to HCV-infected mothers were fol.owed in centres of the European Paediatric HCV Network. Turnbul. survival.anal.sis techniques were used to estimate the age at which HCV-uninfected chil.ren wil. l.se maternal.y acquired HCVantibodies. Factors associated with age at antibody l.ss were assessed in l.gistic regression. Resul.s: In 1104 chil.ren fol.owed from birth and l.ter confirmed to be HCV uninfected, an estimated 57% wil. have l.st passivel. acquired HCVantibodies before 6 mo of age and an estimated 95% by 12 mo. Maternal.HCV viraemia antenatal.y was associated with l.ter, and maternal.HIV-HCV coinfection with earl.er l.ss of antibody. Actual.antibody testing of uninfected chil.ren at 12 mo identified 82% of those tested to be anti-HCV negative. Concl.sions: Serol.gical.confirmation of HCV uninfection remains necessary given the uncertainty in the specificity of virol.gical.tests. These resul.s suggest that, in most chil.ren, HCV infection can be rul.d out with serol.gical.testing at an earl.er age than previousl. thought, and that nearl. al. chil.ren born to HCV-infected mothers wil. have l.st passivel. acquired maternal.antibodies by 1 y of age. Antibody l.ss was significantl. l.ter among chil.ren born to HCV viraemic mothers. The earl.er l.ss of HCV antibodies in chil.ren born to HIV coinfected mothers may be due to HIV treatment.

关键词： HCV感染血清学抗体检测阴性反应病毒血症逻辑回归病原学检测迟后分析技术特异性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

丙型肝炎母婴传播何时发生

引用

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 18-18页

作者： Mok J. pembrey l. Tovo P.- A. Newel. M.- l. 朱新菊 Ctr. Paediatr. Epidemiol./Biostat. Institute of Child Health University College London 30 Guilford Street London WC1N 1EH United Kingdom Prof.

Objective: To investigate when hepatitis C virus (HCV) infection from mother to chil. occurs, and eval.ate possibl. associafed factors. Design: Prospective c ohort study. Patients: Fifty four HCV infected chil.ren tested within three days of birth and their mothers. Main outcome measures: HCV RNA pol.merase chain rea ction (PCR) resul.s. Resul.s: Seventeen of the chil.ren (31% , 95% confidence interval.19% to 46% )- were positive in the first 3 days of l.fe and coul. be assumed to have acquired infection in utero. Testing PCR positive was not ass ociated with sex (53% v 49% boys; p = 0.77) or mode of del.very (29% el.ct ive caesarean section in both groups; p = 0.98). Chil.ren with evidence of intra uterine infection were significantl. more l.kel. to be of l.wer birthweight and infected with genotype 1 (58% v 12% , p = 0.01). Al.hough a higher proportion of infants born to HCV/HIV co- infected women were PCR positive in the first 3 days of l.fe, this difference did not reach statistical.significance; excl.ding infants born to co- infected women did not affect the resul.s. Thirty seven of the chil.ren (68% ) were negative in the first 3 days of l.fe, 27 of whom were positive when tested again at 3 months, and nine were first PCR positive after 3 months (one chil. had no further tests). Concl.sions: These resul.s suggest th at at l.ast one third and up to a hal. of infected chil.ren acquired infection i n utero. Al.hough postpartum transmission cannot be excl.ded, these data suggest that it is rare. The rol. of HCV genotypes in the timing and mechanism of infec tion shoul. be expl.red further.

关键词：母婴传播丙型肝炎宫内感染婴儿出生体重定群研究丙肝病毒出生后多聚酶链反应病毒感染混合感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

围生期获得的丙型肝炎感染不会影响儿童生后前5年的生长发育

引用

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 30-30页

作者： Engl.nd K. pembrey l. Tovo P.-A. Newel. M.-l. 王一飞 Centre f or Paediatric Epidemiol.gy and Biostatistics Institute of Child Health Univers ity College London 30 Guilford St LondonWC1N 1EH United Kingdom Prof.

Objectives: To identify the effect of vertical.hepatitis C virus (HCV) infecti on or exposure on growth in chil.hood. Study design: Chil.ren (n = 1203) born to HCV-infected mothers were fol.owed up from birth prospectivel. in centers of t he European Paediatric Hepatitis C virus Network. Z-scores compared height-and weight-for-age in HCV-infected and -uninfected chil.ren, adjusting for othe r factors using l.near regression. We al.o quantified the effect of maternal.chr onic infection with HCV on chil.hood growth. Resul.s: There was no significant e ffect of vertical.HCV infection on growth (height P = .223, weight P = .095) nor a significant effect of maternal.chronic infection with HCV (height P = .733, w eight P = .274). Prematurity and maternal.injecting drug use were associated wit h a significant reduction in height (P l. HCV -exposed chil.ren. Concl.sions: This popul.tion of HCV exposed infants has high er rates of maternal.injecting drug use and prematurity than standard popul.tion s and so there are impl.cations for growth of these chil.ren, but this is not a direct resul. of HCV infection or exposure to chronic maternal.HCV infection.

关键词：丙型肝炎感染生长发育围生期年龄别体重年龄别身高儿童身高丙型肝炎病毒注射吸毒垂直感染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：