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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3176-3241页

作者： pelin Lu Dongxue Ruan Meiqi Huang Mi Tian Kangshun Zhu Ziqi Gan Zecong Xiao Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630PR China Department of Minimally Invasive Interventional Radiology and Laboratory of Interventional RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260PR China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120PR China Department of Stomatology Chengdu Second People's HospitalChengdu 610021PR China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055PR China

The applications of hydrogels have expanded significantly due to their versatile,highly tunable properties and breakthroughs in biomaterial *** this review,we cover the major achievements and the potential of hydrogels in therapeutic applications,focusing primarily on two areas:emerging cell-based therapies and promising non-cell therapeutic *** the context of cell therapy,we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms,provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy,as well as list specific examples of their applications in different disease *** then explore the potential of hydrogels in drug delivery,physical intervention therapies,and other non-cell therapeutic areas(e.g.,bioadhesives,artificial tissues,and biosensors),emphasizing their utility beyond mere delivery ***,we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions,particularly in terms of integration with advanced biomanufacturing *** review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and noncell therapies,tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： directions overcome breakthrough

Inflammatory responses in esophageal mucosa before and after laparoscopic antireflux surgery

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 871-881页

作者： pelin Ergun Sezgi Kipcak Nur Selvi Gunel Eser Yildirim Sozmen Serhat Bor Department of Otolaryngology Medical College of WisconsinMilwaukeeWI 53226United States Division of Gastroenterology Ege UniversityFaculty of MedicineEge Reflux GroupIzmir 35100Turkiye Department of Medical Biology Ege UniversityFaculty of MedicineIzmir 35100Turkiye Department of Medical Biochemistry Ege UniversityFaculty of MedicineIzmir 35100Turkiye

BACKGROUND Currently,the primary treatment for gastroesophageal reflux is acid suppression with proton pump inhibitors,but they are not a cure,and some patients don’t respond well or refuse long-term ***,alternative therapies are needed to understand the disease and develop better *** anti-reflux surgery(LARS)can resolve symptoms of these patients and plays a significant role in evaluating esophageal healing after preventing harmful *** LARS improves typical gastroesophageal reflux symptoms in most patients,main-ly by reducing the exposure time to gastric contents in the ***-ration of the inflammatory response and a recovery response in the esophageal epithelium is expected following the cessation of the noxious *** To explore the role of inflammatory biomolecules in LARS and assess the time required for esophageal epithelial *** Of 22 patients with LARS(pre-and post/5.8±3.8 months after LARS)and 25 healthy controls(HCs)were *** subjects underwent 24-h multichannel intraluminal impedance-pH monitoring and upper gastrointestinal endoscopy,during which esophageal biopsy samples were collected using endoscopic *** molecules in esophageal biopsies were investigated by reverse transcription-polymerase chain reaction and multiplex-enzyme-linked immunosorbent *** Post-LARS samples showed significant increases in proinflammatory cytokines[interleukin(IL)-1β,interferon-γ,C-X-C chemokine ligand 2(CXCL2)],anti-inflammatory cytokines[CC chemokine ligand(CCL)11,CCL13,CCL17,CCL26,CCL1,CCL7,CCL8,CCL24,IL-4,IL-10],and homeostatic cytokines(CCL27,CCL20,CCL19,CCL23,C-CL25,CXCL12,migration inhibitory factor)compared to both HCs and pre-LARS ***17 and CCL21 levels were higher in pre-LARS than in HCs(P<0.05).The mRNA expression levels of AKT1,fibroblast growth factor 2,HRAS,and mitogen-activated protein kinase 4 were significantly decreased post-LARS vs pre-LARS.

关键词： Anti-reflux surgery Gastroesophageal reflux disease Cytokine Inflammatory response Esophagus

Effects of Tungsten and Boron Contents on Crystallization Temperature and Microhardness of Tungsten Based Metallic Glasses

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 733-738页

作者： pelin ztürk Aytekin Hitit Department of Materials Science and Engineering AfyonKocatepe University

Effects of tungsten and boron contents on the thermal properties and microhardness of W-Fe-B metallic glass system were studied. Thin foils, with thicknesses of 20 and 100 ktm, of the alloys were produced by piston and anvil method in an arc furnace. The structures of the foils were investigated by X-ray diffraction. Thermal stabilities of the alloys were examined by using differential scanning calorimetry. 20-μm- thick foils of all the alloys were determined to be fully amorphous, but crystalline phases were detected in the 100-μm-thick foils. It was found that crystallization temperatures of the alloys are between 1060 and 1177 K. Tungsten and boron content increases improve the crystallization temperature and microhardness of the alloys significantly, but deteriorate the glass forming ability of the alloys. It was also observed that for constant Fe content, increasing tungsten content to the level higher than that of boron content does not result in any further improvement in crystallization temperature, but improves glass forming ability significantly. The alloy containing highest total amount of tungsten and boron, W35Fe35B3o, has the highest crystallization temperature, 1177 K, and microhardness, 1634 HV.

关键词： Metallic glass Refractory metal Crystallization temperature Hardness

Numerical investigation of seismic performance of high modulus columns under earthquake loading

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 811-822页

作者： Selcuk Demir pelin Ozener Abant Izzet Baysal University Bolu 14030 Turkey Yildiz Technical University Istanbul 34210 Turkey

This paper presents the result of two-dimensional fi nite element modeling studies in order to investigate the seismic behavior of high modulus columns in liquefi able soil. Particular attention was paid to the shear stress reduction mechanism of the high modulus columns and the shear strain distribution between soil and columns during earthquake motion. Numerical analyses were performed using a nonlinear elasto-plastic model in Plaxis 2016. The reliability of the numerical simulations was verifi ed through the results of a centrifuge test model designed to investigate the contribution of high modulus columns in liquefaction mitigation. The capability of numerical simulations was assessed primarily through comparison of predicted acceleration-time histories, pore water pressures, and displacements with the measured counterparts. The results of the numerical analysis showed that the presence of the columns did not reduce seismic shear stresses in the soil when compared to the unimproved soil condition and pure shear behavior between soil and column did not develop as expected in the current design methodology.

关键词： liquefaction high modulus column soil improvement UBC3D-PLM

An Ordinal Multi-Dimensional Classification(OMDC)for Predictive Maintenance

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Computer Systems Science & Engineering 2023年第2期44卷 1499-1516页

作者： pelin Yildirim Taser Izmir Bakircay University Department of Computer EngineeringIzmir35665Turkey

Predictive Maintenance is a type of condition-based maintenance that assesses the equipment's states and estimates its failure probability and when maintenance should be *** machine learning techniques have been frequently implemented in this area,the existing studies disregard to the nat-ural order between the target attribute values of the historical sensor ***,these methods cause losing the inherent order of the data that positively affects the prediction *** deal with this problem,a novel approach,named Ordinal Multi-dimensional Classiﬁcation(OMDC),is proposed for estimating the conditions of a hydraulic system's four components by taking into the natural order of class *** demonstrate the prediction ability of the proposed approach,eleven different multi-dimensional classiﬁcation algorithms(traditional Binary Relevance(BR),Classiﬁer Chain(CC),Bayesian Classiﬁer Chain(BCC),Monte Carlo Classiﬁer Chain(MCC),Probabilistic Classiﬁer Chain(PCC),Clas-siﬁer Dependency Network(CDN),Classiﬁer Trellis(CT),Classiﬁer Dependency Trellis(CDT),Label Powerset(LP),Pruned Sets(PS),and Random k-Labelsets(RAKEL))were implemented using the Ordinal Class Classiﬁer(OCC)***,seven different classiﬁcation algorithms(Multilayer Perceptron(MLP),Support Vector Machine(SVM),k-Nearest Neighbour(kNN),Decision Tree(C4.5),Bagging,Random Forest(RF),and Adaptive Boosting(AdaBoost))were chosen as base learners for the OCC *** experimental results present that the proposed OMDC approach using binary relevance multi-dimensional classiﬁcation methods predicts the conditions of a hydraulic system's multiple components with high ***,it is clearly seen from the results that the OMDC models that utilize ensemble-based classiﬁcation algorithms give more reliable prediction performances with an average Hamming score of 0.853 than the others that use traditional algorithms as base learners.

关键词： Machine learning multi-dimensional classiﬁcation ordinal classiﬁcation predictive maintenance

Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey

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环境科学与工程前沿(英文) 2023年第8期17卷 95-105页

作者： pelin Koyuncuoğlu Gülbin Erden Environmental Engineering Department Engineering FacultyPamukkale UniversityKınıklıCampusDenizli 20160Turkey

Plastic particles smaller than 5 mm are *** are among the significant pollutants that recently attracted *** quantities of microplastics enter the sewage system daily and reach wastewater treatment plants(WWTPs).As a result,WWTPs are potential microplastic ***,they create a pathway for microplastics to reach aquatic environments with treated wastewater *** on microplastic characterization in WWTPs have gained momentum in *** study investigates the abundance,size,shape,color,polymer type,and removal efficiencies of microplastics in a municipal wastewater treatment plant(WWTP)in Denizli/*** results showed that the dominant microplastic shape in wastewater samples was fibers(41.78%–60.77%)in the 100–500μm(58.57%–80.07%)size *** of the microplastics were transparent-white(32.86%–58.93%).The dominant polymer types were polyethylene(54.05%)and polyethylene vinyl acetate(37.84%)in raw ***,the microplastic removal efficiencies of the Denizli Central WWTP as a whole and for individual treatment units were *** the microplastic pollution removal efficiency of the Denizli Central WWTP was over 95%,the microplastic concentration discharged daily into the receiving environment was considerably high(1.28×1010 MP/d).Thus,Denizli Central WWTP effluents result in a high volume of emissions in terms of microplastic pollution with a significant daily discharge to theÇürüksu Stream.

关键词： Microplastics Wastewater treatment plant Removal efficiency Daily discharge

Estimation of residual shear strength ratios of liquefied soil deposits from shear wave velocity

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Earthquake Engineering and Engineering Vibration 2012年第4期11卷 461-484页

作者： pelinzener Yildiz Technical University Davutpasa CampusDepartment of Civil Engineering

For sites susceptible to liquefaction induced lateral spreading during a probable earthquake, geotechnical engineers often need to know the undrained residual shear strength of the liquefied soil deposit to estimate lateral spreading displacements, and the forces acting on the piles from the liquefied soils in order to perform post liquefaction stability analyses. The most commonly used methods to estimate the undrained residual shear strength （Su~） of liquefied sand deposits are based on the correlations determined from liquefaction induced flow failures with SPT and CPT data. In this study, 44 lateral spread case histories are analyzed and a new relationship based on only lateral spread case histories is recommended, which estimates the residual shear strength ratio of the liquefiable soil layer from normalized shear wave velocity. The new proposed method is also utilized to estimate the residual lateral displacement of an example bridge problem in an area susceptible to lateral spreading in order to provide insight into how the proposed relationship can be used in geotechnical engineering practice.

关键词： liquefaction lateral spread undrained residual shear strength undrained residual shear strength ratio shearwave velocity

Piezoelectric d_(15) shear response-based torsion actuation mechanism:an experimental benchmark and its 3D finite element simulation

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International Journal of Smart and Nano Materials 2010年第3期1卷 224-235页

作者： pelin Berik Ayech Benjeddou Institute of Technical Mechanics Johannes Kepler University of LinzLinzAustria Institut Supérieur de Mécanique de Paris(Supméca) ParisFrance

An experimental benchmark is proposed for piezoelectric,direct-torsion actuation using mono-morph piezoceramic d_(15)shear *** is reached by designing and assembling an adaptive plate having two identical composite faces sandwiching a core made of connected six oppositely polarized(OP)piezoceramic d15 shear patches along the *** electronic speckle pattern interferometry system was used to measure the static tip deflection of the adaptive sandwich composite plate that was mounted in a cantilever configuration and actuated in torsion by progressively applied voltages on the piezoceramic shear core electroded major ***,the effective rate of twist was post-processed and proposed as an evaluation criterion for smart composites under piezoelectric torsion *** verification of the experimental results,the proposed experimental benchmark was simulated using three-dimensional piezoelectric finite elements(FE)within ABAQUS®commercial *** comparison of the obtained experimental and simulation results showed reasonable agreement,but the slight nonlinear experimental response was not confirmed by the linear FE *** experimentally proved torsion actuation mechanism,produced by OP piezoceramic d15 shear patches,can be applied actively to prevent torsion in many applications,such as in wind turbines,helicopter blades,robot arms,flexible space structures,etc.

关键词： torsion actuation shear-mode piezoceramic benchmark experiment simulation

Static experimentations of the piezoceramic d_(15)-shear actuation mechanism for sandwich structures with opposite or same poled patches-assembled core and composite faces

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International Journal of Smart and Nano Materials 2011年第4期2卷 230-244页

作者： pelin Berik Ayech Benjeddou Institute of Technical Mechanics Johannes Kepler University of LinzLinzAustria Institut Supérieur de Mécanique de Paris(Supméca) ParisFrance

Static d_(15)-shear actuated smart composites consisting of glass fiber/epoxy layers sandwiching piezoceramic shear patches-assembled cores were investigated experimentally and *** piezoceramic cores were formed by connecting two or three patches with the same or opposite polarization *** each cantilevered benchmark the shear-induced transverse tip deflection,under increasing actuation voltage,ranging from 61.5 V to 198 V,was measured by an electronic speckle pattern interferometer *** performance of the shear actuated smart composites was characterized by their shear-induced transverse deflection per length per *** was found that this performance is much better at high voltages for which the response becomes *** verification of the experimental results the proposed benchmarks were simulated within ABAQUS®commercial code using three-dimensional piezoelectric finite *** comparison of the obtained experimental and simulation results show a nonlinear dependence of the transverse deflection for voltages higher than around 92 V.

关键词： piezoceramic d_(15)-shear static actuation smart composite