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Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival

Cancer Biology & Medicine 2023年第6期20卷 438-451页

作者： Meizhi Du Yu wang Jillian Vallis Matin Shariati Patrick S.Parfrey John R.Mclaughlin peizhong peter wang Yun Zhu Department of Epidemiology and Biostatistics School of Public HealthTianjin Medical UniversityTianjin 300070China Division of Community Health and Humanities Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Clinical Epidemiology Unit Faculty of MedicineMemorial University of NewfoundlandSt.John's A1B 3V6Canada Dalla Lana School of Public Health University of TorontoToronto M5T 3M7Canada Beatrice Hunter Cancer Institute Halifax B3H 4R2Canada Centre for New Immigrant Wellbeing Markham L3R 9V1Canada

Objective:Leptin(LEP)is an obesity-associated adipokine associated with tumor cell *** examined the relevance of genetic variants of LEP and leptin receptor(LEPR)to colorectal cancer(CRC)survival by using data from the Newfoundland Familial Colorectal Cancer ***:A total of 532 patients newly diagnosed with CRC between 1997 and 2003 were followed up until April *** on their demographics and lifestyles were collected via *** of blood samples was performed with the Illumina Human Omni-Quad Bead *** Cox models were used to assess the relationships of 35 tag single-nucleotide polymorphisms(SNPs)in LEP and LEPR with overall survival(OS),disease-free survival(DFS),and CRC-specific ***:At the gene level,LEP was associated with DFS(P=0.017),and LEPR was associated with both DFS(P=0.021)and CRCspecific survival(P=0.013)in patients with *** single-SNP analysis,LEP rs11763517,LEPR rs9436301,and LEPR rs7602 were associated with DFS after adjustment for multiple *** LEPR haplotypes G-C-T(rs7534511-rs9436301-rs1887285)and A-A-G(rs7602-rs970467-rs9436748)were associated with prolonged OS among patients with CRC overall(G-C-T:HR,0.63;95%CI,0.43–0.93;A-A-G:HR,0.59;95%CI,0.38–0.91)and those diagnosed with colon cancer(G-C-T:HR,0.54;95%CI,0.34–0.86;A-A-G:HR,0.49;95%CI,0.29–0.83).Similar results were observed for ***,significant interactions were found among LEPR rs7602(A vs.G),LEPR rs1171278(T vs.C),red meat intake,and BMI status:the associations between these variants and prolonged DFS were limited to patients with below-median red meat consumption and body mass index(BMI)<25 kg/***:Polymorphic variations in the LEP and LEPR genes were associated with survival of patients after CRC *** LEP/LEPR-CRC survival association was modified by participants’red meat intake and BMI.

关键词： colorectal cancer intake

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妊娠期高血压疾病患者母子两代均应尽早开始心血管疾病防控

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中国循环杂志 2016年第3期31卷 214-217页

作者：李玉明杨宁 peizhong peter wang 武警后勤学院附属医院武警部队心血管病研究所天津市300162 Division of Community Health and Humanities Faculty of Medicine Memorial University of Newfoundland

心血管疾病(CVD)是导致女性死亡的首要原因。女性CVD发病率在绝经期后增加更为明显,临床症状不典型,预后差。女性CVD的早期防控研究迄今未受到应有重视。患有妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)的女性,其CVD风... 详细信息

心血管疾病(CVD)是导致女性死亡的首要原因。女性CVD发病率在绝经期后增加更为明显,临床症状不典型,预后差。女性CVD的早期防控研究迄今未受到应有重视。患有妊娠期高血压疾病(hypertensive disorders in pregnancy,HDP)的女性,其CVD风险起源于妊娠期。HDP与CVD享有共同的病理生理机制,在防控上要进行一体化的临床监测和干预。对于有子痫前期(pre-eclampsia,PE)高危因素者在妊娠期即应开始CVD一级预防;对于PE患者,在分娩后即应开始CVD的二级预防。对于有PE宫内暴露的子代,也应尽早开始CVD的一级预防。CVD的防控重点在控制危险因素及增强人体的自组织功能。

关键词：评论高血压,妊娠性先兆子痫

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Intra-operative frozen section diagnosis of breast lesions:a retrospective analysis of 13 243 Chinese patients

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Chinese Medical Journal 2007年第8期120卷 630-635页

作者： NIU Yun FU Xi-lin YU Yong peizhong peter wang CAO Xu-chen Breast Cancer Pathological Department and Research Laboratory Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Epidemical and Bio-statistic Department Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Breast Cancer Surgical Department Breast Cancer Research Key laboratory of National Education Ministry Tianjin Cancer Institute Tianjin Medical University Tianjin 300060 China Division of Community Health Faculty of Medicine Memorial University of Newfoundland St. John＇s NL Canada

Background Although cytological methods for breast oncology have been used in recent decades, intra-operative frozen section has been playing a vital role in making therapeutic decisions. We analyzed a large series of frozen section diagnoses for Chinese cases of breast lesion within the last 15 years. The experience was expected to increase the diagnostic accuracy of cases with breast lesions. Methods The data from consecutive 13243 cases of breast lesions diagnosed with intra-operative frozen sections between 1988 to 2002 were compared with paraffin sections in a case by case manner. The causes of false negative and positive diagnoses as well as delayed diagnoses were analyzed. Results One hundred and seventeen cases （0.9%） were falsely diagnosed, with one false positive case and 116 false negative cases. The diagnosis of 47 cases （0.4%） was delayed. The proportion of several lesions had the features of the patients＇ ages. Six types （false invasion, peri-papUloma, adenoma of nipple duct, florid adenosis, sclerosing adenosis, and granulose cell tumor） of lesions may lead to false positive, and four types （morphological changes responding chemotherapy, well differentiated papillary carcinoma, invasive Iobular carcinoma, and tubular carcinoma） to a false negative. Gross and microscopic findings may be inconsistent in two types of lesions （radial scar and florid adenosis） microscopic and clinical findings in three types （ganulomatous mastitis mammary, duct ectasia, and fat necrosis）, and three types （abundant fat or sclerous tissues; borderline lesions and changes of post-chemotherapy） were likely wrongly classified. Conclusions Intra-operative frozen section can accurately identify breast lesions in many instances, leading to fewer errors on account of more diaanostic experience and understandina of diaanostic limitations.

关键词： breast neoplasm frozen section differential diagnosis

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女性心血管病防控：以妊娠期高血压疾病为视窗的回望与前瞻

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中华高血压杂志 2015年第11期23卷 1018-1021页

作者：李玉明蔡伟牛建民周欣 peizhong peter wang 中国人民武装警察部队后勤学院附属医院心脏中心/武警部队心血管病研究所天津市心血管重塑与靶器官损伤重点实验室天津300160 广东省妇幼保健院/广东省妇产医院产科 Division of Community Health and Humanities Faculty of MedicineMemorial University of Newfoundland

在全球范围内,心血管病是导致女性死亡的第一位原因。2015年发表的美国心脏病与脑卒中统计年鉴显示全美女性死亡者中1/3死因为心血管病（每年死于心血管病的女性总数超过40万）,比死于癌症、慢性呼吸道疾病、老年性痴呆和交通意外的总... 详细信息

在全球范围内,心血管病是导致女性死亡的第一位原因。2015年发表的美国心脏病与脑卒中统计年鉴显示全美女性死亡者中1/3死因为心血管病（每年死于心血管病的女性总数超过40万）,比死于癌症、慢性呼吸道疾病、老年性痴呆和交通意外的总和还要高,是死于乳腺癌女性总数的10倍。

关键词：心血管病慢性呼吸道疾病子痫前期交通意外降压药物心脏病学绒毛膜滋养细胞氧化应激靶器官损伤

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加拿大华人移民健康状况及生活工作满意度

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中国公共卫生 2007年第12期23卷 1497-1498页

作者：吴秀云丁晓良 peizhong peter wang 潍坊医学院卫生管理学院潍坊261042 加拿大普通话华人联合会加拿大纽芬兰纪念大学医学院社区卫生系

目的了解加拿大华人移民对生活、工作及健康状况的认知与评价,包括健康状况自我评价、工作及生活满意度、不满意的原因等。方法以问卷调查为主,辅以电话调查和网络通讯调查。按年龄分层抽取调查对象。结果移民健康状况自我评价不高,主... 详细信息

目的了解加拿大华人移民对生活、工作及健康状况的认知与评价,包括健康状况自我评价、工作及生活满意度、不满意的原因等。方法以问卷调查为主,辅以电话调查和网络通讯调查。按年龄分层抽取调查对象。结果移民健康状况自我评价不高,主要困难和不满意之处是难以找到合适工作(45.0%),生活缺乏乐趣(33.2%),看病时与医务人员交流有语言障碍(26.0%),交朋友困难(23.5%)。结论调查结果反映了加拿大华人移民对工作、生活的感知、认识与看法,反映了华人移民生活与工作的需要。对于社会各界及政府了解加拿大华人移民的生活与工作状况,完善移民相关政策具有参考价值。

关键词：华人移民健康状况满意度

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A product version of the Hilton-Milner-Frankl theorem

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Science China Mathematics 2024年第2期67卷 455-474页

作者： peter Frankl Jian wang Alfréd Rényi Institute of Mathematics Hungarian Academy of SciencesBudapest H-1053Hungary Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

Two families F and G of k-subsets of {1, 2,..., n} are called non-trivial cross t-intersecting if|F ∩ G|≥t for all F ∈ F, G ∈ G and | ∩ {F : F ∈ F}| < t, | ∩ {G : G ∈ G}| < t. In the present paper,we determine the maximum product of the sizes of two non-trivial cross t-intersecting families of k-subsets of{1, 2,..., n} for n≥4(t + 2)2k2, k≥5, which is a product version of the Hilton-Milner-Frankl theorem.

关键词： extremal set theory cross t-intersecting family product version non-trivial

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Comparisons and optimization of two absorption chiller types by considering heat transfer area,exergy and economy as single-objective functions

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Clean Energy 2024年第1期8卷 55-65页

作者： Yida Qiu Jingkun wang Jing Han Yuzhu Chen Jun wang peter D.Lund Management School University of LiverpoolLiverpool L693BXUK Power China Huadong Engineering Corporation Limited No.201 Gaojiao RoadHangzhou 311122China Key Laboratory of Solar Energy Science and Technology in Jiangsu Province Southeast UniversityNo 2 Si Pai LouNanjing210096China School of Science Aalto UniversityPO Box 15100FI-00076Aalto(Espoo)Finland

Absorption cooling technology is an environmentally friendly method to generate continuous chilled water making use of multiple thermal sources,such as waste heat and renewable thermal *** this study,two absorption chillers(nominal capacity of 400 kW)with series and parallel connections are *** research the ideal configuration of chillers after thermodynamic analysis,the structures of the chillers are optimized using the particle swarm optimization algorithm by considering the heat transfer area(HTA),exergy efficiency and total annual cost as single-objective *** impact of temperature differences between external and internal flows,heat exchanger efficiencies and the solution allocation ratio is *** optimized HTA,coefficient of perform-ance,exergy efficiency and total annual cost are 149.0 m^(2),1.56,29.44%and$229119 for the series-connected chiller,and 146.7 m^(2),1.59,31.45%and$234562 for the parallel-connected type,*** the lowest HTA condition,compared with the reference simulation results,the energy and exergy performances are improved,while the annual total cost is *** annual total cost is highest when maximizing the exergy efficiency,which is attributed to the increase in the *** operating cost accounts for 27.42%(series type)and 26.54%(parallel type)when the annual cost is the lowest.

关键词： absorption chiller series/parallel-connected temperature difference parameters solution allocation ratio

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Full-spectrum Bi@SrTiO_(3) for bi-directional promotion effects on photocatalytic redox reaction:Insight into intermediates and mechanism

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Journal of Rare Earths 2024年第5期42卷 917-929,I0004页

作者： Bin Liu Nanhao Zhou Jun Liu Xinglei wang peter K.J.Robertson Xiaoyuan Chen Chao Chen Jianmin Luo Chuanyi wang School of Chemistry and Civil Engineering Shaoguan UniversityShaoguan512005China Chengdu Customs Technology Center Chengdu610041China Key Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining835000China School of Chemistry and Chemical Engineering Queen's University BelfastStranmillis RoadBelfastBT95AGUnited Kingdom Guangzhou Institute of Industrial Intelligence(GIII) Guangzhou511400China

The development of full-spectrum photocatalysts active in the near-infrared(NIR)region has gained increasing attention for deleterious pollutant *** integration of plasmonic metals with semico nductors is an effective way to widen the light re sponse range of photocatalysts due to the strong light absorption and fast plasmonic energy transfer of the localized surface plasmon resonance(LSPR).In this work,the full-spectrum responsive Bi@SrTiO_(3) was prepared via facile solvothermal chemical *** optimal Bi@SrTiO_(3) achieves exceptional photocatalytic Cr(VI)reduction efficiency and tetracycline degradation,realizing bi-directional promotion effects on redox *** to density functional theory(DFT)simulations,the extraordinary photocatalytic performance is attributed to the tunable builtin electric field(IEF)of the Ohmic *** favorable adaptability in real water and high stability of BSTO-25 were proved by experime ntal *** the po ssible photocatalytic mechanism was proposed based on theoretical calculation and experimental ***,the non-toxicity of the BSTO-25 was evaluated by *** cultivation,which further proves the feasibility of treating wastewater with *** work provides a new perspective on constructing full-spectrum-driven photocatalysts for applications dealing with environmental remediation.

关键词： Full-spectrum photocatalysts Localized surface plasmon resonance Ohmic contact Cr(Ⅵ)reduction Antibiotic degradation Rare earths

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Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 308-325页

作者： Adilson Fonseca Teixeira Yanhong wang Josephine Iaria peter ten Dijke Hong-Jian Zhu Department of Surgery(The Royal Melbourne Hospital) The University of MelbourneParkvilleVICAustralia Huagene Institute Kecheng Science and Technology ParkPukou DistrictNanjingJiangsuChina Department of Cell and Chemical Biology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands

Metastasis is the leading cause of cancer-related *** growth factor beta(TGF-β)signaling drives metastasis and is strongly enhanced during cancer ***,the use of on-target TGF-βsignaling inhibitors in the treatment of cancer patients remains unsuccessful,highlighting a gap in the understanding of TGF-βbiology that limits the establishment of efficient anti-metastatic ***,we show that TGF-βsignaling hyperactivation in breast cancer cells is required for metastasis and relies on increased small extracellular vesicle(sEV)*** sEV’s unique role,TGF-βsignaling levels induced by sEVs exceed the activity of matching concentrations of soluble ligand TGF-β.Further,genetic disruption of sEV secretion in highlymetastatic breast cancer cells impairs cancer cell aggressiveness by reducing TGF-βsignaling to nearly-normal ***,TGF-βsignaling activity in non-invasive breast cancer cells is inherently low,but can be amplified by sEVs,enabling invasion and metastasis of poorly-metastatic breast cancer *** the translational potential of inhibiting sEV trafficking in advanced breast cancers,treatment with dimethyl amiloride(DMA)decreases sEV secretion,TGF-βsignaling activity,and breast cancer progression in *** both the sEV trafficking and TGF-βsignaling by combining DMA and SB431542 at suboptimal doses potentiated this effect,normalizing the TGF-βsignaling in primary tumors to potently reduce circulating tumor cells,metastasis,and tumor ***,this study establishes sEVs as critical elements in TGF-βbiology,demonstrating the feasibility of inhibiting sEV trafficking as a new therapeutic approach to impair metastasis by normalizing TGF-βsignaling levels in breast cancer cells.

关键词： metastasis doses invasion

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Sparse identification-assisted exploration of the atomic-scale deformation mechanism in multiphase CoCrFeNi high-entropy alloys

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Science China(Technological Sciences) 2024年第4期67卷 1124-1132页

作者： XIAO Lu GUO XiaoXiang SUN YuTong wang Gang LONG WeiMin LIAW peter K. REN JingLi School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Institute of Materials Shanghai UniversityShanghai 200444China SKL of Advanced Brazing Metals&Technology Zhengzhou Research Institute of Mechanical EngineeringZhengzhou 450001China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

This study investigated the atomic-scale deformation mechanism of multiphase CoCrFeNi high-entropy alloys(HEAs)at liquid helium,liquid nitrogen,and room temperatures.A million-atom multiphase HEA was prepared using molecular dynamics simulation involving melt and quench *** HEA exhibited high-density dislocations and some twins,consistent with experimental *** analysis revealed an inconsistent evolution of the microstructure under tensile *** particular,the elastic and initial plastic stages exhibited an increase in the disordered structure at the expense of the face-centered cubic and hexagonal close-packed structures,followed by a subsequent transformation involving multiple structural ***,through sparse identification,a model depicting microstructural evolution during tension was extracted for the CoCrFeNi HEA at three typical temperatures and three tensile *** model highlighted the importance of the body-centered cubic structure in the evolutionary process.

关键词： high-entropy alloy data-driven method microstructure evolution multiphase structure molecular dynamics simulation

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