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Alteration of the airway microbiota is associated with the progression of post-CoVID-19 chronic cough in adults: a prospective study

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Journal of Genetics and Genomics 2024年第10期51卷 1111-1120页

作者： peiying Huang Zhaowei yang Chen Zhan Xiaojun Xiao Zexuan Lian Liman Fang Shuxin Zhong Jiahan Xu Mo Xian Naijian Li Xinru Wang Jing Li Ruchong Chen State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Allergy and Clinical ImmunologyGuangdong Provincial Key Laboratory of Allergy&Clinical ImmunologyGuangzhou Institute of Respiratory HealthTheFirst Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 510182China State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen UniversityShenzhenGuangdong 518055China

Cough is one of the most common symptoms observed in patients presenting with COVID-19,persisting for an extended duration following SARS-CoV-2 *** aim to describe the distribution of airway microbiota and explore its role in patients with post-CovID-19 chronic cough.A total of 57 patients experiencing persistent cough after infection were recruited during the Omicron wave of SARS-CoV-2 in *** microbiota profiling is assessed in nasopharyngeal swab,nasal lavage,and induced sputum samples at 4 and 8 weeks after SARS-CoV-2 *** findings reveal that bacterial families Staph-ylococcaceae,Corynebacteriaceae,and Enterobacteriaceae are the most prevalent in the upper airway,while Streptococcaceae,Lachnospiraceae,and Prevotellaceae emerge as the most prevalent bacterial families in the lower *** increase in the abundance of Staphylococcus in nasopharyngeal swab samples and of Streptococcus in induced sputum samples is observed after one ***,the abundance of Staphylococcus identified in nasopharyngeal swab samples at the baseline period emerges as an insightful predictor for improvement in cough *** conclusion,dynamic alterations in the airway microbial composition may contribute to the post-coviD-19 chronic cough progression,while the compositional signatures of nasopharyngeal microbiota could reflect the improvement of this disease.

关键词： Airway microbiota COVID-19 Airway dysbiosis Chronic cough Staphylococcus

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Distribution and Source of Main Contaminants in Surface Sediments of Tidal Flats in the Northern Shandong Province

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Journal of Ocean University of China 2014年第5期13卷 842-850页

作者： LIU Zhijie LI peiying ZHANG Xiaolong LI Ping XU Yuanqin College of Environmental Science and Engineering Ocean University of China National Marine Data and Information Service First Institute of Oceanography State Oceanic Administration Environmental College Yantai University

Twenty-nine samples of surface sediments from tidal flats in the Northern Shandong Province were collected for grain size, heavy metal(Hg, Cu, Pb, Zn, Cd, and Cr), and oil pollution analyses. The geoaccumulation index(Igeo) and factor analysis were introduced to evaluate sediment quality and source of contaminants. The mean concentrations of Hg, Cu, Pb, Zn, Cd, Cr, and oil in the surface sediments in the study area are 0.033, 17.756, 19.121, 55.700, 0.291, 59.563, and 14.213 μg g-1, respectively. The heavy metal contamination in the old delta lobe is slightly higher than that in the abandoned delta lobe; however, the opposite was observed for oil pollution. The Igeo results revealed that the overall quality of the surface sediments in the study area is in good condition. The heavy metal pollution levels show a descending order: Cd> Hg> Cr> Cu> Zn> Pb, Cd being the main pollutant. The contamination level for in the study area is relatively lower than those for China's other tidal flats. Heavy metals are mainly derived from natural sources of rock weathering and erosion, partly influenced by industrial and agricultural discharge. However, oil pollution is mainly from runoff input, motorized fishing boat sewage, and oil exploitation.

关键词： tidal flat sediments heavy metals quality evaluation factor analysis source of contaminants Northern Shandong Province

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Multi-wave mixing Autler-Townes splitting in the five-level atomic system

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Science China(Physics,Mechanics & Astronomy) 2011年第9期54卷 1600-1607页

作者： WU ZhenKun LI peiying ZHANG Zhaoyang SANG SuLing WANG RuiMin ZHANG YanPeng Key Laboratory for Physical Electronics Devices of the Ministry of Education & Shaanxi Key Lab of lnformation Photonic Technique and School of Science Xi'an Jiaotong University Xi'an 710049 China

We have demonstrated the Autler-Townes (AT) splitting of the four-wave mixing (FWM) process and the six-wave mixing (SWM) process in an elec tromag netically induced transparency (EIT) window in five-level atomic vapor of 87 Rb. Moreover we discuss interactions of multi-dressed states. The experimental results agree well with the theoretical analysis.

关键词： four.wave mixing six-wave mixing multi-dressed states Autler-Townes splitting

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A PSO Based Multi-Domain Virtual Network Embedding Approach

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China Communications 2019年第4期16卷 105-119页

作者： Yongjing Ni Guoyan Huang Sheng Wu Chenxi Li peiying Zhang Haipeng Yao College of Information Science and Engineering Yanshan University College of Information Science and Engineering Hebei University of Science and Technology The Key Laboratory for Computer Virtual Technology and System Integration of Hebei Province Yanshan University School of Information and Communication Engineering Beijing University of Posts and Telecommunications College of Computer & Communication Engineering China University of Petroleum (East China)

This paper proposed a multi-domain virtual network embedding algorithm based on multi-controller SDN architecture. The local controller first selects candidate substrate nodes for each virtual node in the domain. Then the global controller abstracts substrate network topology based on the candidate nodes and boundary nodes of each domain, and applies Particle Swarm Optimization Algorithm on it to divide virtual network requests. Each local controller then embeds the virtual nodes of the divided single-domain virtual network requests in the domain, and cooperates with other local controllers to embed the inter-domain virtual links. Simulation experimental results show that the proposed algorithm has good performance in reducing embedding cost with good stability and scalability.

关键词： multi-domain virtual network embedding candidate node particle swarm optimization algorithm virtual network request division

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航空货物安保声明研究

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综合运输 2023年第2期45卷 113-119页

作者：杨培颖杨曼邱斌耿硕赵振武中国民用航空局信息中心北京100710 中国民航大学安全科学与工程学院天津300300

为了缓解机场终端安检压力,确保航空货运安保供应链中相关实体对货物安保状态负责以及实现货物安保信息的有效传递,我国有必要借助货物安保声明(CSD)。通过研究国际组织、部分国家或地区CSD的签发实体、签发内容以及CSD在航空货运安保... 详细信息

为了缓解机场终端安检压力,确保航空货运安保供应链中相关实体对货物安保状态负责以及实现货物安保信息的有效传递,我国有必要借助货物安保声明(CSD)。通过研究国际组织、部分国家或地区CSD的签发实体、签发内容以及CSD在航空货运安保供应链中的传输流程,进而对我国内地CSD的实施进行系统分析,得出我国内地航空货运已达到建立CSD实施试点的条件。根据分析结果,对我国内地CSD的实施提出如下建议:规范CSD实施要求、建立CSD签发授权制度、落实前端主体责任以及建设代理人信用管理机制。

关键词：航空货运安保供应链货物安保声明已知托运人管制代理人

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An Efficient Synthesis of(+)-Subersic Acid

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Chinese Journal of Chemistry 2015年第6期33卷 679-682页

作者： Jing Wang Peiqiang Wang Jue Li peiying Wu Jiangmeng Ren Bubing Zeng Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(−)-Sclareol in 7 *** key step of this route relied on the cross coupling of the diterpene with the arene fragment using t... 详细信息

关键词： (+)-subersic acid (−)-Sclareol cross coupling Heck reaction

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Akkermansia muciniphila and Bifidobacterium bifidum Prevent NAFLD by Regulating FXR Expression and Gut Microbiota

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 763-776页

作者： Fulin Nian Longyun Wu Qiaoyun Xia peiying Tian Chunmei Ding Xiaolan Lu Department of Gastroenterology Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghaiChina

Background and aims:Non-alcoholic fatty liver disease(NAFLD)is closely associated with gut microbiota and has become the most common chronic liver disease worldwide,but the relationship between specific strains and NAFLD has not been fully *** aimed to investigate whether Akkermansia muciniphila and Bifidobacterium bifidum could prevent NAFLD,the effects of their action alone or in combination,possible mechanisms,and modulation of the gut ***:Mice were fed with high-fat diets(HFD)for 20 weeks,in which experimental groups were pretreated with quadruple antibiotics and then given the corresponding bacterial solution or *** expression of the glycolipid metabolism indicators,liver,and intestinal farnesol X receptors(FXR),and intestinal mucosal tight junction proteins were *** also analyzed the alterations of inflammatory and immune status and the gut microbiota of ***:Both strains were able to attenuate mass gain(p<0.001),insulin resistance(p<0.001),and liver lipid deposition(p<0.001).They also reduced the levels of the pro-inflammatory factors(p<0.05)and the proportion of Th17(p<0.001),while elevating the proportion of Treg(p<0.01).Both strains activated hepatic FXR while suppressing intestinal FXR(p<0.05),and elevating tight junction protein expression(p<0.05).We also perceived changes in the gut microbiota and found both strains were able to synergize beneficial microbiota to ***:Administration of *** or *** alone or in combination was protective against HFD-induced NAFLD formation and could be used as alternative treatment strategy for NAFLD after further exploration.

关键词： Non-alcoholic fatty liver disease Farnesoid X receptor Probiotics Akkermansia muciniphila Bifidobacterium bifidum

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Global ITS diversity in the Sporothrix schenckii complex

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Fungal Diversity 2014年第3期66卷 153-165页

作者： Xun Zhou Anderson M.Rodrigues peiying Feng G.S.de Hoog Department of Dermatology Affiliated Hospital of Chongqing Medical UniversityChongqingChina Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre PO Box 851673508 AD UtrechtThe Netherlands Department of Microbiology Immunology and Parasitology-DMIPCellular Biology DivisionFederal University of São Paulo-UNIFESPSão PauloBrazil Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Peking University Health Science Center Research Center for Medical MycologyBeijingChina

Molecular phylogeny has revealed that sporotrichosis is caused by several Sporothrix species which differ in clinical *** complex is embedded within Ophiostoma,a genus mainly comprising fungi that live in association with bark beetles,but differs by a high virulence towards humans and other *** different ecology is corroborated by phylogenetic *** aim of the present study was to determine the validity of the rDNA internal transcribed spacer(ITS)region as a marker for diagnostics of species in the clinical group,using betatubulin sequences to calibrate species *** topology of the two gene trees was concordant,and all clinically relevant Sporothrix species could easily be recognized by means of the ITS *** increased geographic sampling did not affected delimitation success in the clinical clade of the *** complex.

关键词： Sporothrix schenckii Sporotrichosis Taxonomy Phylogeny ITS Barcoding

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The difference analysis of physical-mechanical properties of sediments in the central South Yellow Sea and Zhe-Min coastal area in China

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Acta Oceanologica Sinica 2017年第7期36卷 77-85页

作者： XU Yuanqin LI Ping LI peiying DU Jun LIU Lejun GAO Wei LIU Jie Key Laboratory of Marine Sedimentology and Environmental Geology The First Institute of OceanographyState Oceanic AdministrationQingdao 266061China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China Research Center for Islands and Coastal Zones The First Institute of OceanographyState Oceanic AdministrationQingdao 266061China Marine Engineering Environment and Geomatic Center The First Institute of OceanographyState Oceanic AdministrationQingdao 266061China

The difference analysis of physical-mechanical properties of muddy sediments is made in the central South Yellow Sea and the Zhe-Min（Zhejiang Province to Fujian Province of China） coastal area. The results show that sediments in the two regions are both dominated by mud. There are perfect negative power function correlations between the water content and the density, the compression coefficient and the compression modulus; a good positive power function correlation between the liquid limit and the plastic limit, a perfect positive linear correlation between the water content and the void ratio, and a perfect polynomial function correlation between the miniature vane shear strength and the pocket penetration resistance. In general, compared with sediments in the Zhe-Min coastal area, sediments in the central South Yellow Sea possess high water content, high void ratio,low density, high plasticity, high compressibility, low shear strength. The causes of the differences between physical-mechanical properties of sediments are analyzed from the topographic features, material sources,hydrodynamic conditions, deposition rate, and material composition. Compared with the Zhe-Min coastal area,the central South Yellow Sea is far from the Mainland and low-lying; has poor hydrodynamic condition; the materials diffused to the area are less and dominated by fine clay, have the high content of smectite and organic matters. These factors lead to sediments of the central South Yellow Sea has the higher water content, the higher plasticity, the lower density, and the lower strength than sediments in the Zhe-Min coastal area.

关键词： sediment Zhe-Min coastal area central South Yellow Sea physical-mechanical properties difference analysis

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Pharmacotherapy for the core symptoms of autism spectrum disorder

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JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B 2024年第11期25卷 956-971页

作者： Tan, peiying Shen, Xiaolin Zeng, Lizhang Weng, Xuchu Geng, Hongyan South China Normal Univ Key Lab Brain Cognit & Educ Sci Minist Educ Guangzhou 510631 Peoples R China South China Normal Univ Inst Brain Res & Rehabil Guangzhou 510631 Peoples R China South China Normal Univ Guangdong Key Lab Mental Hlth & Cognit Sci Guangzhou 510631 Peoples R China

Autism spectrum disorder (ASD) is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors. The etiology of ASD remains largely unexplored, resulting in a diverse array of described clinical manifestations and varying degrees of severity. Currently, there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD. Childhood and adolescence are crucial stages for making significant achievements in ASD treatment, necessitating the development of drugs specifically for these periods. Based on the drug targets and mechanisms of action, it can be found that atypical psychotropic medications, anti-inflammatory and antioxidant medications, hormonal medications, ion channel medications, and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents. In addition, comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development. While further evaluation of the effectiveness and safety of these medications is needed, they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.

关键词： Autism spectrum disorder (ASD) Core symptom Pharmacotherapy Repetitive behaviors Social dysfunction

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