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Discoidin domain receptor 1 as a potent therapeutic target in solid tumors

hLife 2024年第9期2卷 454-466页

作者： Shaheen Bibi Weihong Zeng peiyi zheng Seyed Majid Mousavi Mehmandousti Tengchuan Jin Department of Obstetrics and Gynecology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineCenter for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of ChinaAnhuiChina Laboratory of Structural Immunology The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaAnhuiChina Institute of Health and Medicine Hefei Comprehensive National Science CenterAnhuiChina Biomedical Sciences and Health Laboratory of Anhui Province University of Science&Technology of ChinaAnhuiChina Clinical Research Hospital of Chinese Academy of Sciences(Hefei) University of Science and Technology of ChinaAnhuiChina

Despite signiﬁcant discoveries in basic cancer research and improvements in treatment options and clinical outcomes,cancer remains a major public health concern ***,the main focus of cancer research is the signaling pathways that are crucial for cell survival,cell proliferation,and cell *** aberrant expression of proteins involved in these signaling pathways often leads to abnormal cell growth,cell metastasis,and invasion of healthy *** such protein is discoidin domain receptor 1(DDR1)which belongs to the family of receptor tyrosine kinases(RTKs)and is activated upon collagen binding,as a result,downstream signaling pathways are stimulated which are responsible for cell survival,cell growth,adhesion,extracellular matrix remodeling,and cell ***1 is found to have abnormally elevated expression in various solid tumors,implying a critical role in cancer ***-tional cancer treatment involves the use of cytotoxic drugs,chemotherapy,radiotherapy,and surgery,which do not pro-vide long-term survival and often result in cancer *** small-molecule kinase inhibitors have been synthesized against RTKs including DDR1 and have been highly efﬁcacious in tumor *** recently,targeting the DDR1 extracellular domain(ECD)has garnered much attention from researchers,as inhibiting the DDR1-collagen binding has been attributed to maximizing the likelihood of the combined cytotoxic effect of both immune cells and tar-geted *** review focuses on the structure,function,activation,and signaling partners of DDR1,its role in different solid tumors,andﬁnally discusses about designing more DDR1 non-kinase inhibitors as promising therapeutic strategies against DDR1-driven tumors.

关键词： discoidin domain receptor 1(DDR1) signaling pathway solid tumors non-kinase inhibitors

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A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3584-3591页

作者： Xinghai Zhang Huajun Zhang Tingting Li Shaohong Chen Feiyang Luo Junhui Zhou peiyi zheng Shuyi Song Yan Wu Tengchuan Jin Ni Tang Aishun Jin Chengyong Yang Guofeng Cheng Rui Gong Sandra Chiu Ailong Huang CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430o71 HubeiChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqing 400010China Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology Chongqing Medical UniversityChongqing 400010China University of Chinese Academy of Sciences 100049 BeijingChina Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026 AnhuiChina Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing 400010China Mindao Haoyue Co LtdSQ0042 Lanyuan HallNo.61 Daxuecheng Middle RoadChongqing 400042China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still rapidly spreading *** drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 ***,the emergence of SARS-CoV-2 variants of concern(VOCs),such as Delta(B.1.617.2)and the recently emerged Omicron(B.1.1.529),has seriously challenged the application of current ***,there is still a pressing need for identification of new broad-spectrum ***,we further characterized a human antibody(58G6),which we previously isolated from a patient,with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations(ICso)of 1.69 ng/ml and 54.31 ng/ml,respectively.58G6 shows prophylactic and therapeutic effcacy in hamsters challenged with the Delta and Omicron variants through nasal ***,a very low dosage(2 mg/kg daily)of 58G6 efficiently prevented Omicron variant replication in the *** advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous *** general,58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging *** the best of our knowledge,58G6 is one of the most potent neutralizing antibodies against Omicron,with a broader spectrum than those approved for clinical use.58G6 could be developed as a nebulized therapy,which would be more cost effective and user friendly and enhance the clinical outcome comparedto thatobtainedwithdirect nasaldelivery.

关键词： nasal dosage prevention

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A dry-electrode enabled ECG-on-Chip with arrhythmia-aware data transmission

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Science China(Information Sciences) 2025年第2期68卷 338-353页

作者： Xinzi XU Yanxing SUO Yang ZHAO peiyi ZHOU Xiao HAN Qiao CAI Min WANG Jiajun YUAN Liebin ZHAO Yongfu LI Guoxing WANG Yong LIAN Department of Micro-Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Pediatric AI Clinical Application and Research Center Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP)Child Health Advocacy InstituteShanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong University Shanghai Engineering Research Center of Intelligence Pediatrics (SERCIP) Xin Hua Hospital Affiliate to Shanghai Jiao Tong University School of Medicine

Early detection and treatment of cardiovascular diseases(CVDs) can be significantly enhanced through the use of flexible wearable electrocardiogram(ECG) sensors, potentially reducing CVD-related mortality. This paper introduces an ECG-on-Chip(EoC) solution tailored for flexible ECG sensors, incorporating novel features to address common challenges in wearable ECG technology. The EoC integrates a chopper-stabilized capacitively-coupled instrumentation amplifier(CS-CCIA),ensuring a high common-mode rejection ratio(CMRR) and low noise performance. Performance is further boosted via a positive feedback loop(PFL) and a programmable gain amplifier(PGA) with shared on-chip calibration logic, which enhances input impedance and minimizes gain variability to ensure consistent algorithm performance. Additionally, a secondary chopping technique is employed to further reduce noise, achieving an input-referred noise level of 454 nVrms. The embedded algorithm within the EoC is designed to extract clinically meaningful features, facilitating robust real-time arrhythmia analysis. Fabricated using a 0.18 μm CMOS process, the EoC consumes 14.9 μW with a supply voltage of 1.2 V. The algorithm's efficacy has been validated over 0.4 million heartbeats, demonstrating a sensitivity of over 99.7% for R-peak detection and 98.3% for arrhythmia analysis. To demonstrate practical application, the EoC has been integrated with a commercial Bluetooth low energy(BLE)transceiver, forming a wireless arrhythmia monitoring sensor equipped with dry electrodes. This system consumes 292.04 μW in arrhythmia-aware transmission mode, supporting 13 days of operation with a 30 mAh thin-film battery.

关键词： ECG flexible dry electrodes analog front-end abnormality detection ASIC wireless transmission

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Tailor-made high elasticity and low-hysteresis hydrogels based on asymmetric H-bonding crosslinking for wearable applications

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Science China Chemistry 2025年第03期 1117-1125页

作者： Xiaofang Shi Nan Shi Miaomiao Dang Chengyu Ji Yingjie Li peiyi Wu Zhiguo Hu Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical MaterialsSchool of Chemistry and Chemical EngineeringHenan Normal University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and Biotechnology & Center for Advanced Low-dimension MaterialsDonghua University

The conventional method of fabricating hydrogels constantly confronts the conflict between elasticity and toughness,limiting their repetitive *** the desired elasticity through a simple and low-cost approach is a significant challenge for hydrogels,particularly through rational molecular ***,low-hysteresis and high-toughness hydrogels are developed from the design of a new feature monomer,N-acryloylethylsemicarbazide(NACE).Based on a concept of “asymmetric Hbonding design”,the unique double and triple H-bonding of NACE can result in a novel asymmetric crosslinking polymer with alternating strong and weak H-bonding *** NACE is copolymerized with acrylamide(AM) to regulate the mechanical properties of hydrogel via H-bonding *** P(NACE-AM) ionic hydrogels are obtained simply and rapidly via one-step photopolymerization without a chemical cross-linking *** P(NACE-AM) hydrogels combine superb mechanical elasticity and toughness,and excellent ionic conductivity,showing great potential as durable ionic conductive devices for wearable utilization.

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Correlation between grain size,mechanical properties and deformed microstructure of Fe-20Mn-6Al-0.6C-0.15Si low-density steel

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Journal of Iron and Steel Research International 2025年第1期32卷 282-292页

作者： Qi Zhang Guang-hui Chen zheng-liang Xue zheng-kun Chen Guang Xu State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Red Eagle Novel Refractory Materials Research Institute Zhejiang Red Eagle Group Co.Ltd.Huzhou313000ZhejiangChina

The effects of austenite grain size on the deformed microstructure and mechanical properties of an Fe-20Mn-6Al-0.6C-0.15Si(wt.%)low-density steel were *** microstructure of the experimental steel after solution treatment was single austenitic *** austenite grain size increased with solution temperature and time.A model was established to show the relationship between temperature,time and austenite grain size for the experimental *** addition,as the solution temperature increased,the strength decreased,while the elongation first increased and then *** decrease in elongation after solution treatment at 1100℃ for 90 min is contributed to the over-coarse austenite ***,after solution treatment at 900℃ for 90 min,the strength-elongation product reached the highest value of 44.4 GPa%.As the austenite grain size increased,the intensity of//tensile direction fiber *** was accompanied by a decrease in dislocation density,resulting in a lower fraction of low-angle grain boundaries and a lower work hardening ***,the austenite grain size has a critical influence on the mechanical properties of the low-density *** grains lead to a lower yield strength due to the Hall-Petch effect and a lower tensile strength because of lower dislocation strengthening.

关键词： Austenitic low-density steel Solution treatment Grain size Mechanical property Deformed microstructure

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An efficient conversion model between acceleration and pseudo-acceleration response spectra considering effects of magnitude,distance,and site class

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 15-30页

作者： Liu zheng Zhao Yan-Gang Zhang Haizhong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China Faculty of Agriculture Yamagata University1-23Wakaba-machiTsuruoka-shiYamagata 997-8555Japan

Both acceleration and pseudo-acceleration response spectra play important roles in structural seismic ***,only one of them is generally provided in most seismic ***,many studies have attempted to develop conversion models between the acceleration response spectrum(SA)and the pseudo-acceleration response spectrum(PSA).Our previous studies found that the relationship between SA and PSA is affected by magnitude,distance,and site ***,we developed an SA/PSA model incorporating these ***,this model is suitable for cases with small and moderate magnitudes and its accuracy is not good enough for cases with large *** paper aims to develop an efficient SA/PSA model by considering influences of magnitude,distance,and site class,which can be applied to cases not only with small or moderate magnitudes but also with large *** this purpose,regression analyses were conducted using 16,660 horizontal seismic records with a wider range of *** magnitude of these seismic records varies from 4 to 9 and the distances vary from 10 to 200 *** ground motions were recorded at 338 stations covering four site *** comparing them with existing models,it was found that the proposed model shows better accuracy for cases with any magnitudes,distances,and site classes considered in this study.

关键词： acceleration response spectrum pseudo-acceleration response spectrum magnitude distance site class

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新冠病毒中和单克隆抗体及纳米抗体研究进展

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生物工程学报 2022年第9期38卷 3173-3193页

作者：陈玉磊林锦锦郑培义曹敏杰金腾川集美大学海洋食品与生物工程学院福建厦门361021 中国科学技术大学基础医学院安徽合肥230027

由严重急性呼吸系统综合征冠状病毒2型(severe acute respiratory syndrome coronavirus-2,SARS-CoV-2)引起的疾病被命名为新型冠状病毒肺炎(coronavirus disease 2019,COVID-19),是一种具有强传染性、高易感性、长潜伏期的传染病。病毒刺突蛋白受体结合结构域(receptor binding domain,RBD)和细胞血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)之间的相互作用使得SARS-CoV-2顺利进入细胞。本文对SARS-CoV-2与ACE2的相关作用机制进行了简单概述,对目前针对SARS-CoV-2中和单克隆抗体、纳米抗体的最新研究进展进行了总结,探讨了新冠肺炎的发展过程和抗体药物的研究方向,以期为包括新冠肺炎在内的新发、突发传染病中和抗体药物的研发提供参考。

关键词：新冠病毒新型冠状病毒肺炎受体结合结构域单克隆抗体纳米抗体

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Luminescence: a new perspective for investigating perovskite precursors

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Science China Materials 2025年第1期68卷 312-313页

作者： Haofeng zheng Shaocong Hou School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Wuhan University Shenzhen Research Institute Shenzhen 518057China

In the past two decades, perovskite materials have made significant progress in optoelectronic semiconductors, emerging as formidable candidates for the next generation of commercial solar cells, light-emitting diodes (LEDs), and *** the fundamental solution chemistry and photophysics in solution-processed perovskite devices is crucial for comprehending to achieve highly efficient optoelectronic devices.

关键词： optoelectronic diodes perovskite

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针灸疗法对合并睡眠障碍的早期脑卒中患者运动功能的影响

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中国康复理论与实践 2000年第2期6卷 72-75页

作者：阮经文郑沛仪中山医科大学附属第一医院针灸科广州510080

选择 70例生命体征稳定、合并睡眠障碍的脑卒中早期患者 ,按日期分成实验组 ( E组 )、对照组( C1组、C2 组 ) ,观察三组病例在其它康复治疗都相同的情况下 ,针对睡眠障碍 :( 1)应用针灸配合贴压耳穴的办法改善患者睡眠质量 ( E组 ) ,( ... 详细信息

选择 70例生命体征稳定、合并睡眠障碍的脑卒中早期患者 ,按日期分成实验组 ( E组 )、对照组( C1组、C2 组 ) ,观察三组病例在其它康复治疗都相同的情况下 ,针对睡眠障碍 :( 1)应用针灸配合贴压耳穴的办法改善患者睡眠质量 ( E组 ) ,( 2 )口服安定 ( C1组 ) ,( 3)无任何干预 ( C2 组 )。经 8周治疗后 ,发现 ( 1)凡能提高睡眠质量的 E组、C1组的肢体运动功能康复速度快 ,其简式 Fugl- Meyer积分与 C2 组相比 ,P<0 .0 1,( 2 ) E组总睡眠时间与 C1组相比 ,P<0 .0 5,说明针灸疗法的远期安眠作用优于安定 ,提示针灸疗法是治疗脑卒中后遗症及合并症的重要手段之一。

关键词：针灸疗法脑卒中睡眠障碍运动功能

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A Comprehensive Survey of Few-shot Information Networks

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Machine Intelligence Research 2025年第1期22卷 60-78页

作者： Xinxin zheng Feihu Che Jianhua Tao School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Institute of Automation Chinese Academy of SciencesBeijing100190China Department of Automation Tsinghua UniversityBeijing100084China

Information networks store rich information in the nodes and edges,which benefit many downstream tasks,such as recommender systems and knowledge graph *** networks contain homogeneous information,heterogeneous information and knowledge graphs.A significant number of surveys focus on one of the three parts and summarize the research works,but few surveys conclude and compare the three kinds of information *** addition,in real scenarios,lots of information networks lack sufficient labeled data,so the combination of meta-learning and information networks can bring in extended *** paper concentrates on few-shot information networks and systematically presents recent works to help analyze and follow related works.

关键词： Few-shot learning meta-learning homogeneous information networks heterogeneous information networks knowledge graphs

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