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Exploring the Mechanism of Action of Gastrodin in Parkinson's Disease Based on Network Pharmacology

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Medicinal Plant 2024年第4期15卷 16-19,25页

作者： Feifan LIU Shifang LUO Yan WAN Linao ZHANG Xue WU Yuhuan XIE peixin guo College of Ethnic Medicine Yunnan University of Chinese MedicineKunming 650500China College of Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China College of Basic Medicine Yunnan University of Chinese MedicineKunming 650500China

[Objectives]To explore the mechanism of action of gastrodin in the treatment of Parkinson's disease(PD)by employing network pharmacology technology,and to provide a scientific theoretical basis for the rational clinical application of gastrodin.[Methods]The target of gastrodin was identified through a search of the SwissTargetPrediction *** keyword"Parkinson Disease"was employed to identify the pertinent targets of PD in the GeneCards and OMIM *** relationship between gastrodin and PD was elucidated,and a Veen map was constructed to identify the genes that were common to both.A total of 52 common drug targets associated with PD as identified in the Wayne chart were imported into the String database(https://***/)for protein-protein interaction ***,Cytoscape 3.9.1 software was employed to construct a"drug-target"*** potential targets of gastrodin in the treatment of PD were then imported into the DAVID database,where GO analysis and KEGG enrichment results were obtained.[Results]A total of 22 core targets and 53 related pathways of gastrodin were identified as potentially beneficial for the treatment of PD.[Conclusions]Gastrodin may be a potential therapeutic agent for the treatment of PD by modulating the biological process of apoptosis,affecting the relevant pathways such as the IL-17 signaling pathway and the TNF signaling pathway,and acting on GAPDH,EGFR,CASP3,MMP9 and other targets.

关键词： Parkinson's disease Network pharmacology Gastrodin

Research Progress of Dai and Western Medicine in the Treatment of Gouty Arthritis

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Medicinal Plant 2024年第4期15卷 118-121页

This paper reviews the pathogenesis,diagnostic criteria,and treatment means of gouty arthritis from the perspectives of Western medicine and Dai medicine in order to provide a reference for clinical medication.

关键词： Gout Dai medicine Western medicine Research progress

Research Progress on Modern Biological Mechanism of Chinese Medicine in Prevention and Treatment of Gouty Nephropathy

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Medicinal Plant 2024年第4期15卷 129-132页

Chinese medicine prevention and treatment of gouty nephropathy often uses single drugs and compound formulae to regulate uric acid,which has the effect of lowering uric acid,protecting the kidneys and improving clinical *** conclusion,the mechanism of action of Chinese medicine against gouty nephropathy mainly involves oxidative stress,inflammatory response,etc.,with a view to providing new ideas and methods for the prevention and treatment of gouty nephropathy by Chinese medicine.

关键词： Chinese medicine Gouty nephropathy Mechanism of action Research progress

Advances in Research of Chinese Medicine Tianma in the Treatment of Parkinson's Disease

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Medicinal Plant 2024年第4期15卷 133-135页

In this study,a systematic review was conducted on the experimental study as well as the clinical application of Tianma(Gastrodia elata Blume),a traditional Chinese medicine,in the prevention and treatment of Parkinson's disease(PD).On this basis,a summary and outlook were made,so as to provide ideas and theoretical basis for the study,development and utilization of Tianma PD field.

关键词： Tianma(Gastrodia elata Blume) Parkinson's disease(PD) Clinical application

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外泌体在肾移植中的应用研究进展

外科研究与新技术（中英文） 2024年第3期13卷 243-248页

作者：黄宇诗郭培鑫马丽云惠佳亮南方医科大学南方医院麻醉手术中心广东广州510515 南方医科大学南方医院器官移植科广东广州510515

肾移植作为终末期肾病的首选治疗手段之一,已在全球范围内被广泛应用,然而肾移植引起的免疫排斥反应和术后并发症等预后不良问题一直存在。如何提高肾移植手术成功率及延长移植肾寿命是当前面临的一大难题。外泌体具有信息传递和物质运... 详细信息

肾移植作为终末期肾病的首选治疗手段之一,已在全球范围内被广泛应用,然而肾移植引起的免疫排斥反应和术后并发症等预后不良问题一直存在。如何提高肾移植手术成功率及延长移植肾寿命是当前面临的一大难题。外泌体具有信息传递和物质运输功能,能够参与到肾移植的全过程中,包括辅助术前诊断、干预免疫排斥反应及术后并发症等。本文分别从免疫排斥反应、免疫抑制剂毒性及其他移植后并发症3个方面,阐述外泌体在肾移植术中的重要作用及相关应用进展,以期为临床诊断和治疗提供新思路。

关键词：肾移植外泌体免疫排斥反应

基于16S rDNA技术研究“雅解沙把”抗急性酒精性肝损伤小鼠的作用机制

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世界科学技术-中医药现代化 2024年第6期26卷 1583-1592页

作者：白元美刘非凡郑丽捷万艳范嘉辰邓家浩郭沛鑫李琼超云南中医药大学民族医药学院昆明650500

目的探究“雅解沙把”对酒精诱导肝损伤小鼠的药效作用,通过16S rDNA技术研究“雅解沙把”对肠道菌群的调节作用机制。方法取健康雄性KM小鼠随机分为空白组、模型组“、雅解沙把”低剂量、中剂量、高剂量(0.39、1.17、3.51 g生药·kg^(-... 详细信息

目的探究“雅解沙把”对酒精诱导肝损伤小鼠的药效作用,通过16S rDNA技术研究“雅解沙把”对肠道菌群的调节作用机制。方法取健康雄性KM小鼠随机分为空白组、模型组“、雅解沙把”低剂量、中剂量、高剂量(0.39、1.17、3.51 g生药·kg^(-1))组和联苯双酯(2.93 mg·kg^(-1))组,每组8只。“雅解沙把”预给药1周后,一次性灌服56%酒精建立小鼠急性酒精性肝损伤模型,检测小鼠血清中AST和ALT的含量,并通过HE染色观察肝脏组织病理形态学的变化;其次,在无菌操作下提取各组大鼠粪便DNA,进行16S rDNA测序并通过Alpha多样性及门和属水平上物种组成进行差异分析。结果“雅解沙把”对肝功生化指标(ALT、AST)均有明显的改善作用,HE染色结果显示,肝损伤程度明显减轻;同时,16S rDNA测序研究表明“雅解沙把”具有增加急性酒精性小鼠肠道菌群多样性的作用;在门水平上,“雅解沙把”可显著降低变形菌门丰度,增高拟杆菌门丰度;在属水平上,“雅解沙把”显著上调拟杆菌属、拟普雷沃氏菌属丰度,下调普氏菌属和幽门螺杆菌属丰度,使肠道菌群处于动态平衡状态。结论“雅解沙把”可能通过调节肠道菌群及其代谢产物来发挥抗急性酒精性肝损伤的作用。

关键词： “雅解沙把” 16S rDNA 肠道菌群肝损伤药效

Effect and mechanism of ethanol extracts of muxiang(Radix Aucklandiae) on gastric ulcers in rats

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Journal of Traditional Chinese Medicine 2020年第1期40卷 59-66页

作者： Xu Yuannan guo peixin Wang Yulian Xia Tingting Shen Yue Zhang Qing Huang Jinhong Chen Haifeng Lei Na Xie Yuhuan School of Basic Medical Sciences Yunnan University of Chinese MedicineYunnan 650500China School of Traditional Chinese Pharmacy Yunnan University of Chinese MedicineYunnan 650500China School of Ethnic Medicine Yunnan University of Chinese MedicineYunnan 650500China International Education College Yunnan University of Chinese MedicineYunnan 650500China

OBJECTIVE:To investigate the effect of ethanol extracts of Muxiang(Radix Aucklandiae)(RA)on gastric ulcers in rats and explore the potential ***:A model was established by ethanol(0.75 m L/kg).According to body weight,rats were pretreated with RA extracts(2.5 or 5 g/kg).The rats were administered 95%ethanol orally after 1 *** effects of ethanol were evaluated by measuring the gastric secretion volume,p H,pepsin activity,and ulcer *** analysis and immunohistochemistry were also ***,the effect of the ethanol extract of RA on transiting activity of the gastrointestinal tract was observed in ***:Intragastric administration of RA extracts protected the gastric mucosa from ethanol-induced gastric ulcers,while reducing submucosal edema and preventing hemorrhagic ***,the extracts increased the production of gastric mucus,upregulated Bcl-2,and downregulated Bax ***,pretreated rats exhibited no significant change in the gastric secretion volume,gastric juice acidity,or ***,pretreatment prominently(P<0.05)enhanced propulsive movement of the gastrointestinal tract in normal mice and mice with gastrointestinal motility ***:Ethanol extracts of RA ameliorated gastric lesions in the gastric ulcer rat *** mechanisms of action were related to improvement of gastrointestinal dynamics,maintenance of mucus integrity,and inhibition of apoptosis by downregulating proapoptotic Bax protein and upregulating anti-apoptotic Bcl-2 protein.

关键词： Stomach ulcer Gastric mucosa Apoptosis Genes,Bcl-2 Gastrointestinal dynamics Muxiang(Radix Aucklandiae)

Research Progress in the Treatment of Gouty Nephropathy with Dai and Western Medicine

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Medicinal Plant 2022年第4期13卷 99-101,104页

作者： Lijie ZHENG Yuanmei BAI peixin guo Yunnan University of Chinese Medicine Kunming 650500China

If gouty nephropathy is not treated properly,repeated attacks can gradually lead to nephrotic *** may bring pain to patients and affect their quality of *** main goal of Western medicine in the treatment of gouty nephropathy is to stop acute attacks,control serum uric acid and avoid *** there are many adverse reactions to long-term *** medicine has unique efficiency in improving clinical symptoms and controlling *** it can avoid the potential risks associated with too low control of blood uric ***,this paper reviewed the research status of Dai and Western medicine in the treatment of gouty nephropathy in order to provide reference for clinical medication.

关键词： Gouty nephropathy Dai medicine Western medicine Research progress

Soft soil Treatment for Large Coal-fired Power Plant

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Electricity 1997年第4期 42-44页

作者： Zhang Jianfeng guo peixin Lu Zhiming Jin Zhixiong

This paper describes the engineeringapplication of soil improvement in manylarge coal-fired power plants designed byEast China Electric Power Design *** improvement technology is especiallysuitable for strengthening soft soil. Exceptfor increasing soil bearing capacity andcontrolling soil deformation, it can also beused to eliminate loose sand liquefactionunder seismic loading, or to strengthen slopestability. The applications introduced in thispaper include dynamic consolidation,drained consolidation, stone pile, soil-cement mixed pile, jet grouting andcompacting grouting, reinforced earth, *** kinds of soil layer to be improvedinclude typical Shanghai soft soil, loose siltand silt sand, miscellaneous fill andhydraulic filled soil. As a result of thetreatments described in this paper, nobuilding fissures caused by soil differentialsettlement had ever occurred in the powerplants engineered by ECEPDI andconstructed in 1990s.

关键词： soft soil soil improvement soil bearing capacity soil settlement