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FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes

Cellular & Molecular Immunology 2023年第3期20卷 292-304页

作者： Wenjuan Yang Rukun He Hao Qu Wenwen Lian Yue Xue Tao Wang Wenlong Lin peishuo zhu Meng Xia Lihua Lai Qingqing Wang Institute of Immunology Zhejiang University School of Medicine310058 HangzhouChina Liangzhu Laboratory Zhejiang University Medical Center1369 West Wenyi Road311121 HangzhouChina Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of Medicine310009 HangzhouChina Department of Pharmacology Zhejiang University School of Medicine310058 HangzhouChina

Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal ***,the regulatory complexity of cytokine and cellular networks still needs to be ***,we show that the expression of FXYD3,a member of the FXYD domain-containing regulators of Na+/K+ATPases family,is significantly increased in the lesional skin of psoriasis patients and mice with imiquimod(IMQ)-induced ***-17A,a cytokine important for the development of psoriatic lesions,contributes to FXYD3 expression in human primary ***3 deletion in keratinocytes attenuated the psoriasis-like phenotype and inflammation in an IMQ-induced psoriasis ***,FXYD3 promotes the formation of the IL-17R-ACT1 complex by competing with IL-17R for binding to TRAF3 and then enhances IL-17A signaling in *** promotes the activation of the NF-κB and MAPK signaling pathways and leads to the expression of proinflammatory *** results clarify the mechanism by which FXYD3 serves as a mediator of IL-17A signaling in keratinocytes to form a positive regulatory loop to promote psoriasis *** FXYD3 may serve as a potential therapeutic approach in the treatment of psoriasis.

关键词： FXYD3 TRAF3 IL-17signaling Keratinocytes Psoriasis

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FXYD3 maintains intestinal immune homeostasis by regulating mucus layer formation

FXYD3 maintains intestinal immune homeostasis by regulating ...

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浙江省免疫学会第十三次学术大会

作者： Wenjuan Yang Yue Xue peishuo zhu Lihua Lai Qingqing Wang Institute of Immunology Zhejiang University School of Medicine

Background:The intestinal epithelial cells produce a complex layer of mucus which covers the intestinal epithelium and creates a physical barrier against bacterial *** colon possesses a double layer where the dense inner layer is associated with epithelium to prevent bacterial invasion,whereas the loose outer mucus layer serves as a habitat for commensal *** cells,a specialized secretory epithelial cell type,are mainly responsible for mucin production and ***2-deficient mice exhibit a disrupted intestinal mucus layer and direct contact between gut bacteria and epithelial cells,leading to increased susceptibility to ulcerative colitis and colorectal *** the roles of goblet cells and mucus have been recognized for decades,the regulatory mechanism of mucus layer formation are not fully ***:FXYD3（FXYD domain-containing transport regulator 3）,belongs to the FXYD family,and all members of this family have a conserved FXYD motif（Phe-X-TyrAsp）.It has been reported that FXYD3 was abnormally expressed in colon cancer,breast cancer and other tumors,and participated in regulating the proliferation and survival of tumor *** addition,FXYD3 is highly expressed in colon,skin,and prostate,but the role of FXYD3 in tissue inflammation has not been *** study aims to investigate the role and mechanism of FXYD3 in the regulation of mucosal immune *** and methods:FXYD3 mice on a C57 BL/6 J background were generated by Nanjing Biomedical Research Institute of Nanjing ***-Cre mice on a C57 BL/6 J background were obtained from the Model Animal Research Center of Nanjing ***3-deficient LS174 T cells was generated using the CRISPR-Cas9 *** colonic samples were obtained from Sir Run Run Shaw Hospital,Zhejiang University School of ***:Our results showed that FXYD3 is highly expressed in colonic epithelial cells,particularly in goblet *** generating

关键词： FXYD3 Goblet cells Mucus layer Inflammatory Bowel Diseases Intestinal homeostasis

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Intrinsically stretchable polymer semiconductor based electronic skin for multiple perceptions of force,temperature,and visible light

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Nano Research 2023年第1期16卷 1196-1204页

作者： Dongjuan Liu Pengcheng zhu Fukang Zhang peishuo Li Wenhao Huang Chang Li Ningning Han Shuairong Mu Hao Zhou Yanchao Mao Key Laboratory of Materials Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China

As a stretchable seamless device,electronic skin(E-skin)has drawn enormous interest due to its skin-like sensing *** the basic perception of force and temperature,multiple perception that is beyond existing functions of human skin is becoming an important direction for E-skin ***,the present E-skins for multiple perceptions mainly rely on different sensing materials and heterogeneous integration,resulting in a complex device ***,their stretchability is usually achieved by the complicated microstructure design of rigid ***,we report an intrinsically stretchable polymer semiconductor based E-skin with a simple structure for multiple perceptions of force,temperature,and visible *** E-skin is on the basis of poly(3-hexylthiophene)(P3HT)nanofibers percolated polydimethylsiloxane(PDMS)composite polymer semiconductor,which is fabricated by a facile solution *** E-skin shows reliable sensing capabilities when it is used to perceive strain,pressure,temperature,and visible *** on the E-skin,an intelligent robotic hand sensing and controlling system is further *** with conventional E-skins for multiple perceptions,this E-skin only has a simple monolayer sensing membrane without the need of combining different sensing materials,heterogeneous integration,and complicated microstructure *** a strategy of utilizing intrinsically stretchable polymer semiconductor to create simple structured E-skin for multiple perceptions will promote the development of E-skins in a broad application scenario,such as artificial robotic skins,virtual reality,intelligent gloves,and biointegrated electronics.

关键词： electronic skin stretchable polymer semiconductor multiple perception visible light artificial robotic skin

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CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production

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JOURNAL OF MOLECULAR CELL BIOLOGY 2024年第5期16卷 mjae021页

作者： Yan, peishuo Yang, Kun Xu, Mengwei zhu, Miaomiao Duan, Yudi Li, Wenwen Liu, Lulu Liang, Chenxi Li, Zhongzheng Pan, Xin Wang, Lan Yu, Guoying Henan Normal Univ Coll Life Sci Henan Ctr Outstanding Overseas Scientists Organ Fi State Key Lab Cell Differentiat & RegulatPingyuan Xinxiang 453007 Peoples R China

Idiopathic pulmonary fibrosis (IPF) is a lethal progressive fibrotic lung disease. The development of IPF involves different molecular and cellular processes, and recent studies indicate that lactate plays a significant role in promoting the progression of the disease. Nevertheless, the mechanism by which lactate metabolism is regulated and the downstream effects remain unclear. The molecular chaperone CCT6A performs multiple functions in avariety of biological processes. Our research has identified a potential association between CCT6A and serum lactate levels in IPF patients. Herein, we found that CCT6A was highly expressed in type 2 alveolar epithelial cells (AEC2s) of fibrotic lung tissues and correlated with disease severity. Lactate increases the accumulation of lipid droplets in epithelial cells. CCT6A inhibits lipid synthesis by blocking the production of lactate in AEC2s and alleviates bleomycininduced pulmonary fibrosis in mice. In addition, our results revealed that CCT6A blocks HIF-1 alpha-mediated lactate production by driving the VHL-dependent ubiquitination and degradation of HIF-1 alpha and further inhibits lipid accumulation in fibrotic lungs. In conclusion, we propose that there is a pivotal regulatory role of CCT6A in lactate metabolism in pulmonary fibrosis, and strategies aimed at targeting these key molecules could represent potential therapeutic approaches for pulmonary fibrosis.

关键词： IPF CCT6A lactate signaling metabolism HIF-1 alpha

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乘用车车道保持辅助系统开发及调试

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汽车实用技术 2022年第15期47卷 96-100页

作者：祝宝营欧阳康强颜培硕北京理工大学前沿技术研究院山东济南250300

行车过程中驾驶员的分神、粗心大意、误触碰等都可能引起车辆偏离本车道,这可能造成与相邻车道的车辆发生剐蹭,危及驾乘人员生命安全。车道保持辅助系统可保证车辆在车道中间行驶,或检测到车辆即将无意识偏离本车道时进行及时纠偏,可有... 详细信息

行车过程中驾驶员的分神、粗心大意、误触碰等都可能引起车辆偏离本车道,这可能造成与相邻车道的车辆发生剐蹭,危及驾乘人员生命安全。车道保持辅助系统可保证车辆在车道中间行驶,或检测到车辆即将无意识偏离本车道时进行及时纠偏,可有效防止剐蹭等碰撞事故的发生。文章详细介绍了乘用车车道保持辅助系统的开发流程,包括车道居中保持(LCC)和车道偏离抑制(LDP)两个功能的仿真和实车调试。调试完毕后,车道居中保持功能和车道偏离抑制功能可以正常使用,且所开发功能顺利通过了规程GB/T 39323—2020的要求。

关键词：车道保持辅助系统车道居中车道偏离抑制调试乘用车

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某大型水电站工业电视系统智能化设计

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现代信息科技 2021年第10期5卷 106-109页

作者：王清萍陆帅关培烁李冲朱斌雅砻江流域水电开发有限公司四川成都610051

借助工业电视监控系统,监控人员可以对生产现场进行实时监控,不仅能直观地监视并记录工作现场的安全生产情况,更能及时发现事故苗子,防患于未然。结合当前水电站工业电视系统的实际业务需求,文章阐述了工业电视系统设计的主要原则、系... 详细信息

借助工业电视监控系统,监控人员可以对生产现场进行实时监控,不仅能直观地监视并记录工作现场的安全生产情况,更能及时发现事故苗子,防患于未然。结合当前水电站工业电视系统的实际业务需求,文章阐述了工业电视系统设计的主要原则、系统组成以及系统将要实现的智能巡检、红外测温、安全帽识别、作业区域管控、智能联动等功能。

关键词：水电站工业电视智能化作业区域管控

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经肛穴肛门成形术治疗女婴肛门闭锁直肠前庭瘘的效果

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郑州大学学报（医学版） 2019年第4期54卷 634-637页

作者：李亚萍杨合英李延安耿培硕丁一常新捷祝永康高如月郑州大学第一附属医院小儿外科

目的:探索经肛穴肛门成形术(TAARP)治疗女婴肛门闭锁直肠前庭瘘的临床价值。方法:回顾性分析61例肛门闭锁直肠前庭瘘女婴的临床资料,年龄均小于半岁。26例接受TAARP,35例接受前矢状入路肛门成形术(ASARP)。记录术后会阴体愈合、并发症... 详细信息

目的:探索经肛穴肛门成形术(TAARP)治疗女婴肛门闭锁直肠前庭瘘的临床价值。方法:回顾性分析61例肛门闭锁直肠前庭瘘女婴的临床资料,年龄均小于半岁。26例接受TAARP,35例接受前矢状入路肛门成形术(ASARP)。记录术后会阴体愈合、并发症发生情况;术后2a根据Krickenbeck国际评分评估患儿排便功能。结果:两组手术时间差异无统计学意义(P>0.05),TAARP组术后住院时间短于ASARP组(P=0.018)。TAARP组术后会阴体均顺利恢复正常外观,ASARP组7例发生会阴体相关并发症,差异有统计学意义(P=0.017)。TAARP组术后1周发生伤口感染1例,术后半年发生黏膜脱垂1例、肛门狭窄1例,并发症总发生率11.5%(3/26);ASARP组术后发生伤口感染4例,黏膜脱垂2例,肛门狭窄2例,直肠回缩1例,并发症总发生率25.7%(9/35)。两组均发生轻度污粪便秘,TAARP组污粪、便秘发生率分别为3.8%、7.7%,ASARP组分别为8.6%、11.4%。两组并发症总发生率,污粪、便秘发生率比较,差异均无统计学意义(P>0.05)。结论:TAARP是一种安全可行的治疗女婴肛门闭锁直肠前庭瘘的方法。

关键词：肛门直肠畸形直肠前庭瘘会阴体经肛穴肛门成形术肛门闭锁

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