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New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling zhang Shejiang WANG Linhui LI Wei HE Yingshuai JIN peiqi zhang Bing XU Chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

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Ultrasound-assisted isolation:A new method to isolate stromal vascular fraction

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 8-15页

作者： Yiming Gao Xiaojie zhang Poh-Ching Tan Yun Xie peiqi zhang Tianyu zhang Qingfeng Li Shuangbai Zhou Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Burns and Plastic Surgery Shanghai Changzheng HospitalShanghai200003China College of Life Sciences Shanghai Normal UniversityShanghai200233China

Background:The stromal vascular fraction(SVF),a cluster of stem and progenitor cells isolated from adipose tissue,holds significant promise for application in regenerative ***,the existing methods for SVF isolation are time-consuming and ***,in this study,we explored a new method of SVF extrac-tion-ultrasound-assisted SVF isolation(USASI)-and compared the viability and characteristics of SVF isolated using different ***:SVF extraction methods using different combinations of ultrasound power,ultrasound time,collagenase dosage,and collagenase digestion time were compared with those of the control group(collagenase digestion method).The cell yield and vitality of the SVF were evaluated via cell counting and trypan blue *** cell components and immunophenotypes of freshly isolated SVF were analyzed using flow *** prolifer-ative capacity and differentiation potential of the SVF were also ***:Ultrasonication at 95 W-20 kHz for 30 s followed by digestion with 0.15%collagenase for 30 min was identified as the most suitable parameter for the USASI method in isolating SVF,as recommended based on the evaluation of various tested *** USASI method significantly reduced the collagenase dosage and shortened the digestion *** to the collagenase digestion method,the USASI method had a higher cell yield and cell viability,with no adverse effects on cell components,proliferative capacity,or multipotential differentiation ***:With reduced processing time,lower collagenase dosage,and increased cell yield without impairing the viability and characteristics of SVF,USASI holds the potential to emerge as a time-saving and cost-effective method for future clinical applications.

关键词： Stromal vascular fractions SVF isolation Mechanical force Ultrasound

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Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy

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Acta Epileptologica 2024年第1期7卷 44-52页

作者： Hua Li Yao Wang Jing Guo peiqi zhang Zheng Xu Kai Peng Xiaoli Dong Liming Zhao Department of Neurology Guangdong Sanjiu Brain HospitalGuangzhou510510China

Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in *** study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epilepsy in Chinese *** Patients with drug-resistant epilepsy were enrolled to receive treatment with modified MCTKD in Guangdong Sanjiu Brain Hospital during December 2020 and September *** modified MCTKD contained fat that provided 50–70%of the total energy,as well as proteins and carbohydrates that provided 20–30%and 20%of energy,*** fat component was composed of 20–30%medium-chain triglycerides(MCTs)and 30–40%long-chain *** efficacy and safety of the diet were assessed at 1,3 and 6 *** A total of 123 patients aged 2.5 to 65 years,were included in this *** response rates at 1,3 and 6 months were 49.6%,43.1%,and 30.9%,*** seizure freedom rates at 1,3 and 6 months were 12.2%,10.6%,and 6.5%,*** retention rates at 1,3 and 6 months were 98.4%,65.0%and 33.3%*** effects occurred in 21.14%of patients,which were predominantly gastrointestinal symptoms such as abdominal pain,diarrhea,vomiting,and constipation,and most of them resolved after dietary adjustments.A total of 82 patients(66.7%)discontinued the treatment with the reason of refusing to eat(8.1%),poor efficacy(35.0%),poor compliance(4.9%),and inability to follow-up(9.8%).Only 4 patients(3.3%)withdrew the diet due to side *** The modified MCTKD with MCTs providing 20–30%of energy has a good safety in patients with drug-resistant epilepsy,but its effectiveness needs to be *** modifications of MCTKD with an optimal energy ratio are required to achieve a better efficacy and safety.

关键词： Medium-chain triglyceride ketogenic diet Ketogenic diet Drug-resistant epilepsy Efficacy Safety

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火龙果粉冷冻-真空微波干燥工艺优化及贮藏品质

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食品研究与开发 2024年第6期45卷 136-141,166页

作者：靳学远黄丽萍张培旗海南科技职业大学临床医药学院海南海口571126 郑州轻工业大学食品与生物工程学院河南郑州450000

为优化火龙果粉的冷冻干燥结合真空微波干燥工艺并研究其贮藏品质,以火龙果为原料,以复水比和维生素C保留率加权转化的综合评分为指标,通过单因素和响应面试验优化火龙果粉的工艺条件并分析其贮藏品质。结果表明,优化后的工艺条件为采... 详细信息

为优化火龙果粉的冷冻干燥结合真空微波干燥工艺并研究其贮藏品质,以火龙果为原料,以复水比和维生素C保留率加权转化的综合评分为指标,通过单因素和响应面试验优化火龙果粉的工艺条件并分析其贮藏品质。结果表明,优化后的工艺条件为采用冷冻干燥将火龙果干燥到水分含量35%后,再采用真空度40 Pa、微波功率1 500 W的真空微波干燥继续将其干燥至水分含量3.5%。该条件下,产品实际综合评分为85.17,与理论预测值基本吻合。联合干燥技术的产品在25℃、相对湿度65%的条件下贮藏30 d时,火龙果粉中的VC保留率为(83.36±0.65)%,感官评分65.6,VC的保留率和感官评分均较高,具有较好的贮藏品质。

关键词：火龙果粉冷冻干燥真空微波干燥工艺贮藏特性

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基于无线倾角传感器的活动翼面偏转测试

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浙江大学学报（工学版） 2024年第3期58卷 635-645页

作者：张沛奇刘博锋崔明琦胡铮王青浙江大学机械工程学院浙江省先进制造技术重点实验室浙江杭州310027 西安飞机工业(集团)有限责任公司陕西西安710089

为了解决传统活动翼面偏转测试中传感器安装平行度要求高、线缆长、人工操作复杂繁琐等问题,提高空间角度测量准确性和现场测试效率,在分析倾角传感器底层测量原理的基础上,综合考虑飞机测试现场系统误差,参考已有的空间角度测量模型,... 详细信息

为了解决传统活动翼面偏转测试中传感器安装平行度要求高、线缆长、人工操作复杂繁琐等问题,提高空间角度测量准确性和现场测试效率,在分析倾角传感器底层测量原理的基础上,综合考虑飞机测试现场系统误差,参考已有的空间角度测量模型,对双测量轴空间旋转模型进行推导和改进.得到适用于机翼活动翼面绕水平轴偏转情况下的空间角度测量误差模型,提出适用于活动翼面偏转测试需求的倾角传感器校准方法.以该模型和校准方法为基础设计实现基于无线倾角传感器的大型飞机活动翼面偏转测试系统.实验平台旋转角度精度测试和活动翼面现场测试的结果表明,相对于现有方法,该校准方法能够获得更大有效测量量程以满足实际工况需求,提升角度校准精度,并显著提升测试效率.

关键词：活动翼面角度测量倾角传感器校准算法偏转测试

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生酮饮食对PIGA基因突变所致发育性癫痫性脑病疗效分析

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癫痫杂志 2024年第1期10卷 12-20页

作者：张佩琪李花郭静王瑶彭凯广东三九脑科医院癫痫中心广州510520

目的探讨生酮饮食对PIGA基因突变相关性发育性癫痫性脑病患者的疗效。方法回顾性分析2016年3月-2020年6月广东三九脑科医院收治的发育性癫痫性脑病患者,筛选出PIGA基因突变阳性的患者,分析其临床特征及治疗效果。结果共收集6例PIGA... 详细信息

目的探讨生酮饮食对PIGA基因突变相关性发育性癫痫性脑病患者的疗效。方法回顾性分析2016年3月-2020年6月广东三九脑科医院收治的发育性癫痫性脑病患者,筛选出PIGA基因突变阳性的患者,分析其临床特征及治疗效果。结果共收集6例PIGA基因突变阳性的癫痫患者,均为男性,5例来源母亲杂合突变,1例为新发突变。6例患者均伴有不同程度的精神运动发育迟滞,多种癫痫发作类型,脑电图表现为多灶性放电,头颅磁共振成像检查提示不同程度的脑发育不全。6例患者均符合药物难治性癫痫,均建议采用生酮饮食治疗,但三例患者早期则停用。其中病例3生酮饮食第五天出现高脂血症而停用,病例5在第二天出现一过性低血糖而家属拒绝使用。病例6生酮饮食一周后家属自行停用。只有三例患者坚持长期生酮饮食,坚持2年以上。病例1和4生酮饮食治疗后疗效非常显著,达到无发作。病例2生酮饮食治疗后发作频率减少50%。病例4在生酮饮食两年后出现高脂血症,停用生酮饮食约2个月后血脂恢复正常。将生酮组患者与非生酮组患者进行对照发现,生酮组治疗后疗效明确,其中两例患者一年以上无发作,发育较前明显进步,生酮饮食治疗后两年复查脑电图示癫痫样放电较前明显减少或消失。结论 PIGA基因突变导致的发育性癫痫性脑病患者,起病年龄早,癫痫发作类型多样,伴不同程度精神运动发育迟滞,部分伴有多种畸形。多为药物难治性癫痫,大部分患者对生酮饮食治疗有效,建议尽早启动。

关键词：生酮饮食癫痫 PIGA基因发育性癫痫性脑病

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抗髓鞘少突胶质细胞糖蛋白抗体相关脑炎患者脑电图特点

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中国神经免疫学和神经病学杂志 2024年第1期31卷 20-24,33页

作者：王瑶郭静赵黎明张佩琪匡祖颖李花广东三九脑科医院神经内科 510510

目的探讨抗髓鞘少突胶质细胞糖蛋白(MOG)抗体相关脑炎患者脑电图特点。方法回顾性收集2021年6月至2022年11月广东三九脑科医院收治的MOG抗体相关脑炎患者28例,其中男19例,女9例,年龄(23.0±10.5)岁,病程中位数16 d,四分位数间距39 d。... 详细信息

目的探讨抗髓鞘少突胶质细胞糖蛋白(MOG)抗体相关脑炎患者脑电图特点。方法回顾性收集2021年6月至2022年11月广东三九脑科医院收治的MOG抗体相关脑炎患者28例,其中男19例,女9例,年龄(23.0±10.5)岁,病程中位数16 d,四分位数间距39 d。分析患者脑电图特点;根据头颅磁共振病灶分布模式,将患者分为仅皮层和/或脑膜受累组、仅深部白质和/或幕下受累组及混合受累组;根据血清MOG抗体滴度,将患者分为弱阳性组(1∶10)、中等阳性组(1∶32)和强阳性组(1∶100~1∶1000);根据有无复发将患者分为复发组和未复发组,比较各组间脑电图异常率的差异。结果正常脑电图12例(42.9%),异常脑电图16例(57.1%),其中慢波增多11例(39.3%),癫痫样放电8例(28.6%),生理节律消失3例(10.7%)。最常见的异常脑电图为慢波增多,多为局灶性。癫痫样放电多为局灶性,常分布在额区、中央区及前颞区。不同病灶分布模式组间、不同MOG抗体滴度组间以及有无复发组间脑电图异常率比较均无统计学差异(P=0.796,P=0.427,P=0.613)。结论局灶性的慢波增多以及位于额区、中央区或前颞区的局灶性放电提示MOG抗体相关脑炎的可能,脑电图在MOG抗体相关脑炎的诊治中具有重要意义。

关键词：抗髓鞘少突胶质细胞糖蛋白抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病 MOG抗体相关脑炎脑电图

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SO_(2)-Insertion induced enantioselective oxysulfonylation to access β-chiral sulfones with quaternary carbon stereocenters

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Science China Chemistry 2024年第3期67卷 908-913页

作者： Jun zhang Xuefeng Wang peiqi Wang Jiayuan Fang Shaoyu Li Jie Wu School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies Taizhou UniversityShanghai 200438China Department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

β-Chiral sulfones are structural motifs widely found in natural products and bioactive molecules, while also serving as important intermediates for the synthesis of valuable chiral scaffolds. In contrast to the rapid growth of sulfur dioxide insertion chemistry over the last decade, enantioselective catalytic variants for accessing β-chiral sulfones, especially those bearing a quaternary carbon stereocenter, remain rare. Herein, we report an enantioselective copper/bisoxazoline catalyzed oxysulfonylation of alkenes to yield isoxazolinyl-containing β-chiral sulfones bearing quaternary carbon stereocenters with moderate to excellent yields and up to 96:4 er. The advantage and irreplaceability of this sulfur dioxide insertion catalytic system have been demonstrated by achieving transformations clearly unavailable with the previously reported sulfonyl chloride system. Additionally,the recoverability of the new-developed bisoxazoline ligand L9 and its reusability without any erosion of the catalytic activity and enantioselectivity further demonstrate the usefulness of the protocol.

关键词： β-chiral sulfones sulfur dioxide insertion oxysulfonylation copper catalysis enantioselectivity

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A randomized clinical trial assessing the efficacy of single and multiple intralesional collagenase injections for treating contracted scars

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第3期5卷 120-125页

作者： Shuangbai Zhou Poh-Ching Tan Cheng-An Chiang Yun Xie peiqi zhang Qingfeng Li Kai Liu Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and *** minimally invasive methods for scar contraction have shown limited applicability and *** study investigated the feasibility and efficacy of intralesional collagenase injections for scar contraction ***:Patients with contracted scars who had limited joint movement and physical disfiguration for>1 year were enrolled in this single-blind,randomized clinical trial from July 2017 to February 2018 at Shanghai Ninth People’s *** was injected into the firm-contracted scar(15 U/cm^(2))three times at 4-week intervals in the multiple treatment group and once in the single treatment group,and a placebo injection was performed in the control *** length and skin texture were documented at the 4-and 12-week *** safety of the collagenase treatment was also ***:The contracted scar was significantly elongated after both single and multiple collagenase *** results showed that,compared to a one-time treatment,repeated injections were more effective at 12 weeks,with an average improvement of 26.83(15.79%).At 12 weeks,78.9% of the patients in the multiple group and 52.9%in the single group achieved significant improvement at 12 *** severe adverse events were ***:Intralesional collagenase injection showed promising results in improving scar contraction and provides an alternative treatment for patients.

关键词： Contracted scar Collagenase Intralesional injection Functional improvement Clinical trial

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The peopling of the hinterland of the Tibetan Plateau during the late MIS 3

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Science Bulletin 2022年第23期67卷 2411-2415,M0004页

作者： peiqi zhang Xiaoling zhang Linhui Li Wei He Dawa Yingshuai Jin Junyi Ge Nicolas Zwyns Shejiang Wang Xing Gao Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Department of Anthropology University of CaliforniaDavis CA 95616USA Tibetan Cultural Relics Conservation Institute Lhasa 850000China Nagqu Cultural Relics Bureau Nagqu 852000China University of Chinese Academy of Sciences Beijing 100049China

Reaching the Tibetan Plateau is notoriously challenging due to its high elevations and the surrounding mountain *** environmental pressures such as low temperatures and precipitations,patchy resources,and especially hypoxia,continued survival in the region requires both biological and behavioral *** is probably why for a long time the Plateau was considered among the last regions occupied by human beings.

关键词：水洞沟旧石器时代晚期青藏高原腹地亚洲北部石器技术考古遗址石叶技术尼阿

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