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New dating indicates intermittent human occupation of the Nwya Devu Paleolithic site on the high-altitude central Tibetan Plateau during the past 45,000 years

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Science China Earth Sciences 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling zhang Shejiang WANG Linhui LI Wei HE Yingshuai JIN peiqi zhang Bing XU Chenglong DENG John WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Tibetan Cultural Relics Conservation Institute Lhasa 850000China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China School of Anthropology University of ArizonaTucson85721USA

The timing and mechanisms of the human occupation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,located nearly 4600 meters above sea level on the central Tibetan Plateau.A new microblade techno-complex was identified on a lower lake shore at this site,distinct from the previously reported blade tool *** two lithic assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optically stimulated luminescence and accelerator mass spectrometry^(14)C *** represent,respectively,the earliest known Paleolithic and microlithic sites on the interior Tibetan Plateau,indicating multiple occupation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional conditions and a paleoenvironment characterized by a comparatively warm climate facilitated these multiple occupations at Nwya *** contemporaneous occurrence of the Upper Paleolithic blade technology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indicates rapid,large-scale dispersals of humans that profoundly affected human demography on a large *** new archaeological evidence and previously reported genetic data,we conclude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic hunter-gatherers,which may have contributed to the complex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Microblade industry Early Upper Paleolithic OSLdating AMS^(14)C dating

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Ultrasound-assisted isolation:A new method to isolate stromal vascular fraction

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第1期6卷 8-15页

作者： Yiming Gao Xiaojie zhang Poh-Ching Tan Yun Xie peiqi zhang Tianyu zhang Qingfeng Li Shuangbai Zhou Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Burns and Plastic Surgery Shanghai Changzheng HospitalShanghai200003China College of Life Sciences Shanghai Normal UniversityShanghai200233China

Background:The stromal vascular fraction(SVF),a cluster of stem and progenitor cells isolated from adipose tissue,holds significant promise for application in regenerative ***,the existing methods for SVF isolation are time-consuming and ***,in this study,we explored a new method of SVF extrac-tion-ultrasound-assisted SVF isolation(USASI)-and compared the viability and characteristics of SVF isolated using different ***:SVF extraction methods using different combinations of ultrasound power,ultrasound time,collagenase dosage,and collagenase digestion time were compared with those of the control group(collagenase digestion method).The cell yield and vitality of the SVF were evaluated via cell counting and trypan blue *** cell components and immunophenotypes of freshly isolated SVF were analyzed using flow *** prolifer-ative capacity and differentiation potential of the SVF were also ***:Ultrasonication at 95 W-20 kHz for 30 s followed by digestion with 0.15%collagenase for 30 min was identified as the most suitable parameter for the USASI method in isolating SVF,as recommended based on the evaluation of various tested *** USASI method significantly reduced the collagenase dosage and shortened the digestion *** to the collagenase digestion method,the USASI method had a higher cell yield and cell viability,with no adverse effects on cell components,proliferative capacity,or multipotential differentiation ***:With reduced processing time,lower collagenase dosage,and increased cell yield without impairing the viability and characteristics of SVF,USASI holds the potential to emerge as a time-saving and cost-effective method for future clinical applications.

关键词： Stromal vascular fractions SVF isolation Mechanical force Ultrasound

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A randomized clinical trial assessing the efficacy of single and multiple intralesional collagenase injections for treating contracted scars

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第3期5卷 120-125页

作者： Shuangbai Zhou Poh-Ching Tan Cheng-An Chiang Yun Xie peiqi zhang Qingfeng Li Kai Liu Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and *** minimally invasive methods for scar contraction have shown limited applicability and *** study investigated the feasibility and efficacy of intralesional collagenase injections for scar contraction ***:Patients with contracted scars who had limited joint movement and physical disfiguration for>1 year were enrolled in this single-blind,randomized clinical trial from July 2017 to February 2018 at Shanghai Ninth People’s *** was injected into the firm-contracted scar(15 U/cm^(2))three times at 4-week intervals in the multiple treatment group and once in the single treatment group,and a placebo injection was performed in the control *** length and skin texture were documented at the 4-and 12-week *** safety of the collagenase treatment was also ***:The contracted scar was significantly elongated after both single and multiple collagenase *** results showed that,compared to a one-time treatment,repeated injections were more effective at 12 weeks,with an average improvement of 26.83(15.79%).At 12 weeks,78.9% of the patients in the multiple group and 52.9%in the single group achieved significant improvement at 12 *** severe adverse events were ***:Intralesional collagenase injection showed promising results in improving scar contraction and provides an alternative treatment for patients.

关键词： Contracted scar Collagenase Intralesional injection Functional improvement Clinical trial

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Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy

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Acta Epileptologica 2024年第1期7卷 44-52页

作者： Hua Li Yao Wang Jing Guo peiqi zhang Zheng Xu Kai Peng Xiaoli Dong Liming Zhao Department of Neurology Guangdong Sanjiu Brain HospitalGuangzhou510510China

Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in *** study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epilepsy in Chinese *** Patients with drug-resistant epilepsy were enrolled to receive treatment with modified MCTKD in Guangdong Sanjiu Brain Hospital during December 2020 and September *** modified MCTKD contained fat that provided 50–70%of the total energy,as well as proteins and carbohydrates that provided 20–30%and 20%of energy,*** fat component was composed of 20–30%medium-chain triglycerides(MCTs)and 30–40%long-chain *** efficacy and safety of the diet were assessed at 1,3 and 6 *** A total of 123 patients aged 2.5 to 65 years,were included in this *** response rates at 1,3 and 6 months were 49.6%,43.1%,and 30.9%,*** seizure freedom rates at 1,3 and 6 months were 12.2%,10.6%,and 6.5%,*** retention rates at 1,3 and 6 months were 98.4%,65.0%and 33.3%*** effects occurred in 21.14%of patients,which were predominantly gastrointestinal symptoms such as abdominal pain,diarrhea,vomiting,and constipation,and most of them resolved after dietary adjustments.A total of 82 patients(66.7%)discontinued the treatment with the reason of refusing to eat(8.1%),poor efficacy(35.0%),poor compliance(4.9%),and inability to follow-up(9.8%).Only 4 patients(3.3%)withdrew the diet due to side *** The modified MCTKD with MCTs providing 20–30%of energy has a good safety in patients with drug-resistant epilepsy,but its effectiveness needs to be *** modifications of MCTKD with an optimal energy ratio are required to achieve a better efficacy and safety.

关键词： Medium-chain triglyceride ketogenic diet Ketogenic diet Drug-resistant epilepsy Efficacy Safety

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The peopling of the hinterland of the Tibetan Plateau during the late MIS 3

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Science Bulletin 2022年第23期67卷 2411-2415,M0004页

作者： peiqi zhang Xiaoling zhang Linhui Li Wei He Dawa Yingshuai Jin Junyi Ge Nicolas Zwyns Shejiang Wang Xing Gao Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Department of Anthropology University of CaliforniaDavis CA 95616USA Tibetan Cultural Relics Conservation Institute Lhasa 850000China Nagqu Cultural Relics Bureau Nagqu 852000China University of Chinese Academy of Sciences Beijing 100049China

Reaching the Tibetan Plateau is notoriously challenging due to its high elevations and the surrounding mountain *** environmental pressures such as low temperatures and precipitations,patchy resources,and especially hypoxia,continued survival in the region requires both biological and behavioral *** is probably why for a long time the Plateau was considered among the last regions occupied by human beings.

关键词：水洞沟旧石器时代晚期青藏高原腹地亚洲北部石器技术考古遗址石叶技术尼阿

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Concentrated Growth Factor from Autologous Platelet Promotes Hair Growth in Androgenetic Alopecia

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Journal of Biomedical Science and Engineering 2019年第3期12卷 201-211页

作者： Poh-Ching Tan Yun Xie Wei Wu peiqi zhang Yiming Gao Kai Liu Shuangbai Zhou Qingfeng Li Department of Plastic & Reconstructive Surgery Shanghai Ninth People’s Hospital Shanghai Medical College of Jiao Tong University Shanghai China

Studies have shown that platelet concentrates can induce the proliferation of the dermal papilla and the vascularization of the perifollicular tissue, as well as accelerate the telogen-to-anagen transition, thereby promoting the regrowth of hair improving the appearance of hair loss. Herein, we report on the application of a new, modified form of platelet concentrates, namely, concentrated growth factors (CGFs), in 15 cases of androgenetic alopecia (AGA). 15 cases of androgenetic alopecia were treated with the use of monthly, subcutaneous injections of autologous CGF in the scalp. A total of 3 injections were administered 4 weeks apart, and the patients were followed up for 6 months. Assessments were performed before the treatments and at 4, 8, 12 and 24 weeks after the first treatment. The treatment outcomes were assessed by taking macroscopic photographs and trichoscopic photomicrographs, as well as by using the Global Aesthetic Improvement Scale (GAIS) and the patient satisfaction survey. In order to determine the safety of the treatment, the injection area was observed for signs of infection or mass evaluation. The photographs showed significant improvement in hair appearance after injections of CGF. The hair photomicrographs showed that CGF promoted the regrowth of hair in balding areas, with an increased hair density and an increased ratio of terminal to vellus hair. The GAIS suggested that CGF treatments were effective in treating AGA, and the majority of patients were satisfied with their improvement. In addition, treatments resulted in a faster rate of hair growth and a decrease in the greasy and unpleasant sensation of the hair of the patients. At the last visit, none of the 15 patients reported experiencing side-effects during the follow-up period. To conclude, the application of CGF can be an effective method in the treatment of androgenetic alopecia.

关键词： Androgenetic Alopecia Concentrated Growth Factor

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基于无线倾角传感器的活动翼面偏转测试

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浙江大学学报（工学版） 2024年第3期58卷 635-645页

作者：张沛奇刘博锋崔明琦胡铮王青浙江大学机械工程学院浙江省先进制造技术重点实验室浙江杭州310027 西安飞机工业(集团)有限责任公司陕西西安710089

为了解决传统活动翼面偏转测试中传感器安装平行度要求高、线缆长、人工操作复杂繁琐等问题,提高空间角度测量准确性和现场测试效率,在分析倾角传感器底层测量原理的基础上,综合考虑飞机测试现场系统误差,参考已有的空间角度测量模型,... 详细信息

为了解决传统活动翼面偏转测试中传感器安装平行度要求高、线缆长、人工操作复杂繁琐等问题,提高空间角度测量准确性和现场测试效率,在分析倾角传感器底层测量原理的基础上,综合考虑飞机测试现场系统误差,参考已有的空间角度测量模型,对双测量轴空间旋转模型进行推导和改进.得到适用于机翼活动翼面绕水平轴偏转情况下的空间角度测量误差模型,提出适用于活动翼面偏转测试需求的倾角传感器校准方法.以该模型和校准方法为基础设计实现基于无线倾角传感器的大型飞机活动翼面偏转测试系统.实验平台旋转角度精度测试和活动翼面现场测试的结果表明,相对于现有方法,该校准方法能够获得更大有效测量量程以满足实际工况需求,提升角度校准精度,并显著提升测试效率.

关键词：活动翼面角度测量倾角传感器校准算法偏转测试

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西夏语的副词子句

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西夏学 2018年第2期 144-169页

作者：张珮琪台湾政治大学斯拉夫语文学系

在本文中我们对于西夏语的副词子句进行综合的探讨。文中分出了六种类型:时间句、同时性句、因果句、让步句、条件句及方式句。此外,我们对每种类型的语法手段进行描写,并尝试对若干从属标记进行来源分析。分析结果显示,西夏语从属标记... 详细信息

在本文中我们对于西夏语的副词子句进行综合的探讨。文中分出了六种类型:时间句、同时性句、因果句、让步句、条件句及方式句。此外,我们对每种类型的语法手段进行描写,并尝试对若干从属标记进行来源分析。分析结果显示,西夏语从属标记可来自于格助词、趋向前缀以及名词。

关键词：西夏语副词子句从属连词格助词

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开展品管圈活动降低急救药品及物品出现问题的护理研究

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实用临床护理学电子杂志 2019年第45期4卷 3-3页

作者：张佩琦武汉市一医院急诊科

目的探讨品管圈活动对降低急救药品及物品出现问题率的效果。方法成立品管圈,确定"降低急救药品及物品出现问题率"为活动主题,应用品管圈手法对出现的问题进行原因分析,提出改进对策并实施。结果开展品管圈活动后,急救药品及物品出现问... 详细信息

目的探讨品管圈活动对降低急救药品及物品出现问题率的效果。方法成立品管圈,确定"降低急救药品及物品出现问题率"为活动主题,应用品管圈手法对出现的问题进行原因分析,提出改进对策并实施。结果开展品管圈活动后,急救药品及物品出现问题率由28.57%降低至4.76%;目标达标率为125%,进步率为83.34%。结论通过开展品管圈活动,降低了急救用品出现问题概率,保证了护理安全。

关键词：品管圈急救用品问题率

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离心式压缩机调速控制及转速冗余设置研究

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仪表技术 2022年第3期 47-50,71页

作者：张佩奇中国石油化工股份有限公司扬子石油化工分公司江苏南京210048

压缩机组是炼化行业生产过程中的重要一环,机组的调速控制能帮助机组运行在正常工况下并满足工艺要求。而机组的转速信号是检测、判断离心式压缩机运行状态、参与机组调速控制的重要信号。阐明了压缩机组的调速控制对保障机组正常稳定... 详细信息

压缩机组是炼化行业生产过程中的重要一环,机组的调速控制能帮助机组运行在正常工况下并满足工艺要求。而机组的转速信号是检测、判断离心式压缩机运行状态、参与机组调速控制的重要信号。阐明了压缩机组的调速控制对保障机组正常稳定运行的重要性,分析了机组键相和转速测量实际情况,针对压缩机转速突然为零的情况提出了相应的解决方案,对操控压缩机组正常运行具有一定的指导意义。

关键词：调速控制转速信号冗余设置离心式压缩机控制系统

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