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The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury

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Neural Regeneration Research 2011年第12期6卷 885-891页

作者： peiman alesheikh Huiling Tang Pengtao Li Wei Zhang Yanshu Pan Arezou Mashoufi Liyun Zhao Runjun Wang Bo Di Yangyang Yan Department of Pathology Preclinical Medical School Beijing University of Chinese Medicine Beijing 100029 China Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing 100700 China Department of Histology and Embryology Preclinical Medical School Beijing University of Chinese Medicine Beijing 100029 China

The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao （TLJN）, which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor （BDNF） and tropomyosin-related kinase B （TrkB） in a rat model of focal cerebral ischemic injury. Xue Sai Tong （XST）, comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST.

关键词： brain-derived neurotrophic factor tropomyosin-related kinase B Tongluo Jiunao injection ischemic stroke

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Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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Neural Regeneration Research 2015年第3期10卷 445-450页

作者： peiman alesheikh Arezou Mashoufi Hui-ling Tang Wei Zhang Bo Di Yang-yang Yan Peng-tao Li Yan-shu Pan Research Center of Natural Product Health North Khorasan University of Medical Science Department of Pathology Preclinical Medical SchoolBeijing University of Chinese Medicine Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

The Chinese herbal formula Tongluo fiunao, containing the active components Panax notogin- seng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control （Xuesai Tong, containing Panax notoginseng） or saline intraperitoneally to investigate the pathway involved in the action of TongIuo fiunao injection. 2,3,5-Triphenyltetrazolium chloride （TTC） staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo fiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo fiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/ tropomyosin-related kinase C pathway.

关键词： neural regeneration cerebral ischemia Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration

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Semaphorin 3A在局灶性脑缺血大鼠脑组织中的表达特征及通络救脑注射液的保护作用

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世界科学技术-中医药现代化 2010年第3期12卷 363-367页

作者：唐卉凌李澎涛张玮潘彦舒 alesheikh peiman 狄波周莉李忻杨鑫北京中医药大学基础医学院北京100029 中日友好医院临床研究所北京100029

目的:观察局灶性脑缺血损伤后大鼠脑组织中Semaphorin 3A(Sema3A)蛋白表达水平,以及通络救脑注射液对该因子表达的影响。方法:以线拴法制作大鼠大脑中动脉缺血模型(MCAO),设正常组、模型组及通络救脑注射液组,分别在造模后12h、24h、3d... 详细信息

目的:观察局灶性脑缺血损伤后大鼠脑组织中Semaphorin 3A(Sema3A)蛋白表达水平,以及通络救脑注射液对该因子表达的影响。方法:以线拴法制作大鼠大脑中动脉缺血模型(MCAO),设正常组、模型组及通络救脑注射液组,分别在造模后12h、24h、3d、7d,共4个时间点采取动物脑组织,测定脑梗死体积及脑组织中GAP43的表达水平,及Sema 3A的表达部位和蛋白表达水平。结果:通络救脑注射液能够减少脑缺血动物脑梗死体积,与模型组相比均有显著差异。结论:大鼠脑缺血损伤后Sema3A表达增加与神经元的坏死有相关性,通络救脑注射液能够降低其表达水平,对缺血损伤的脑组织发挥保护作用。

关键词：脑缺血损伤通络救脑注射液 Semaphorin 3A

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Design and modeling of high‑performance mid‑wave infrared InAsSb‑based nBn photodetector using barrier band engineering approaches

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Frontiers of Optoelectronics 2023年第1期16卷 73-83页

作者： Maryam Shaveisi peiman Aliparast Aerospace Research Institute(Ministry of Science Research and Technology)Tehran ***Iran

We report a new nBn photodetector(nBn-PD)design based on the InAlSb/AlSb/InAlSb/InAsSb material systems for midwavelength infrared(MWIR)*** this structure,delta-doped compositionally graded barrier(δ-DCGB)layers are suggested,the advantage of which is creation of a near zero valence band ofset in nBn *** design of theδ-DCGB nBn-PD device includes a 3µm absorber layer(n-InAs0.81Sb0.19),a unipolar barrier layer(AlSb),and 0.2μm contact layer(n-InAs0.81Sb0.19)as well as a 0.116µm linear grading region(InAlSb)from the contact to the barrier layer and also from the barrier to the absorber *** analysis includes various dark current contributions,such as the Shockley-Read-Hall(SRH),trap-assisted tunneling(TAT),Auger,and Radiative recombination mechanisms,to acquire more precise ***,we show that the method used in the nBn device design leads to difusion-limited dark current so that the dark current density is 2.596×10^(−8)A/cm^(2)at 150 K and a bias voltage of−0.2 *** proposed nBn detector exhibits a 50%cutof wavelength of more than 5µm,the peak current responsivity is 1.6 A/W at a wavelength of 4.5µm and a−0.2 V bias with 0.05 W/cm2 backside illumination without anti-refective *** maximum quantum efciency at 4.5µm is about 48.6%,and peak specifc detectivity(D*)is of 3.37×10^(10)cm⋅Hz1/2/***,to solve the refection concern in this nBn devices,we use a BaF_(2)anti-refection coating layer due to its high transmittance in the MWIR *** leads to an increase of almost 100%in the optical response metrics,such as the current responsivity,quantum efciency,and detectivity,compared to the optical response without an anti-refection coating layer.

关键词： Mid-wave infrared detectors III-V compound semiconductors Grading material systems nBn architecture

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Adaptive Control of a Two-Link Robot Using Batch Least-Square Identifier

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 86-93页

作者： Mostafa Bagheri Iasson Karafyllis peiman Naseradinmousavi Miroslav Krstić the Department of Mechanical and Aerospace Engineering University of California San Diego and San Diego State UniversityLa JollaCA 92037 USA the Department of Mathematics National Technical University of AthensAthina 10682Greece the Department of Mechanical Engineering San DiegoCA 92182 USA the Department of Mechanical and Aerospace Engineering University of California San DiegoLa JollaCA 92037 USA

We design a regulation-triggered adaptive controller for robot manipulators to efficiently estimate unknown parameters and to achieve asymptotic stability in the presence of coupled *** manipulators are widely used in telemanipulation systems where they are subject to model and environmental *** conventional control algorithms on such systems can cause not only poor control performance,but also expensive computational costs and catastrophic ***,system uncertainties need to be estimated through designing a computationally efficient adaptive control *** focus on robot manipulators as an example of a highly nonlinear *** a case study,a 2-DOF manipulator subject to four parametric uncertainties is ***,the dynamic equations of the manipulator are derived,and the corresponding regressor matrix is constructed for the unknown *** a general nonlinear system,a theorem is presented to guarantee the asymptotic stability of the system and the convergence of parameters'***,simulation results are discussed for a two-link manipulator,and the performance of the proposed scheme is thoroughly evaluated.

关键词： Backstepping least-square identifier robot manipulators trigger-based adaptive control

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医学临床研究 2024年第7期41卷 998-1000,1004页

作者：王红芳李培满耿鹏漯河市中医院外科河南漯河462000

【目的】探讨手术与保守治疗在高龄恶性肿瘤相关性急性肠梗阻中的应用效果及预后影响因素分析。【方法】对本院收治的96例高龄急性肠梗阻患者的临床资料进行回顾性分析,其中71例根据病情予以肠切除肠吻合术、肠造口或肠外置术治疗,25例... 详细信息

【目的】探讨手术与保守治疗在高龄恶性肿瘤相关性急性肠梗阻中的应用效果及预后影响因素分析。【方法】对本院收治的96例高龄急性肠梗阻患者的临床资料进行回顾性分析,其中71例根据病情予以肠切除肠吻合术、肠造口或肠外置术治疗,25例予以胃肠减压等保守治疗,根据治疗2个月后的预后结局分为预后良好组(79例)和预后不佳组(17例),分析患者预后的影响因素。【结果】71例手术组患者治疗成功率为94.37%(67/71),高于25例非手术组患者的48.00%(12/25)(P0.05)。预后不佳组病理分期Ⅲ期、肿瘤低分化占比及年龄均高于预后良好组(P<0.05)。Logistic多因素回归分析结果显示,年龄、病理分期、肿瘤分化程度均为患者预后的影响因素(P<0.05)。【结论】相对于非手术方案,高龄恶性肿瘤相关性急性肠梗阻患者应用手术治疗更有助于缓解肠梗阻症状,而患者年龄、病理分期和肿瘤分化程度均可对预后产生影响。

关键词：肿瘤/并发症肠梗阻/并发症肿瘤/外科学肠梗阻

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Correlation Between Magnetic Properties and Allotropic Phase Transition of Fe–Co–V Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1055-1058页

作者： Saeed Hasani Ali Shafyei Morteza Shamanian peiman Behjati Hossein Mostaan Timu Juuti Jerzy A.Szpunar Department of Materials Engineering Isfahan University of Technology Department of Materials and Metallurgical Engineering Arak University Centre for Advanced Steels Research University of Oulu Department of Mechanical Engineering University of Saskatchewan

In this study, the allotropic phase transition and its effect on the magnetic behavior of Fe Co–7 wt%V alloy were investigated. It was found that c phase is observed in the microstructure in the as-cast condition, and it diminishes after severe cold rolling（90% reduction）. After annealing at temperatures higher than 500 up to 750 ℃, the c phase is observed in the structure, again. But, this phase is disappeared by annealing at temperatures above 750 ℃ due to the formation of vanadium-rich precipitates. Thermocalc software was used in order to elucidate the influence of vanadium percent on the stability of c phase in Fe–Co alloys. Also, magnetic studies showed that the saturation induction is reduced by annealing at temperatures from 500 up to 750 ℃, which is related to the formation of residual non-magnetic γ phase.

关键词： Fe–Co–V alloy Thermocalc software Magnetic material Phase transformation Electron backscatter diffraction(EBSD)

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Structure,Texture and Magnetic Properties of Laser-Welded Ultrathin Fe-Co-V Foils

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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 338-347页

作者： Hossein Mostaan Morteza Shamanian Seyed Mahmoud Monirvaghefi peiman Behjati Jerzy A.Szpunar Morteza Amiri Mashallah Fathi Moghadam Department of Materials Engineering Isfahan University of Technology Department of Mechanical Engineering University of Saskatchewan Department of Materials Engineering Yazd University Department of Materials Science and Engineering Sharif University of Technology

This research aims to investigate the effect of pulsed Nd：YAG laser micro-welding on the microstructure,texture and magnetic properties of ultra-thin Fe-Co-7.15 wt%V magnetic *** microscopy,scanning electron microscopy and electron backscattered diffraction techniques were used to study the microstructural ***,vibrating sample magnetometry was used to characterize the magnetic *** results showed that the fractions of low Σ coincidence site lattice boundaries in the fusion zone are higher than those of the base *** welded samples experience a significant decrease in their magnetic *** was found that the formation of new fiber texture in the fusion zone and grain coarsening are the most important factors affecting the magnetic properties.

关键词： Magnetic properties Ultra-thin magnetic foils Texture analysis EBSD study Nd:YAG laser micro-welding

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Micro-Bio Stratigraphy of Asmari Formation in Mamoolan Stratigraphy Section, Sout of Khorramabad

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Open Journal of Geology 2016年第6期6卷 459-467页

作者： peiman Rajabi Department of Geology Payame Noor University Tehran Iran

In this paper, Biostratigraphy of Asmari formation to San oligo-Myocene was studied in North Mamulan, South West Lorestan Province. In this region, Shahbazan-Asmari carbonate formation is located between Kashkan formation beneath and evaporative formation of Gachsaran as old as lower Miocene in the form of disconformity above. From 180 m real thickness observed in this study, 23 genera and 15 species of benthic foraminifera were identified and studied. These foraminifera were found in four assemblage zones suggesting that this formation dates back to Oligocene (Chattian-Rupelian) and early Miocene (Aquitanian-Burdigalian). Moreover, based on microscopic studies and visual observations, nine microfacies were identified that were deposited in three zones: lagoon, dam, and shallow open marine.

关键词： Zagros Asmari Lorestan Foraminifera Depositional Environment

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Synthesis of 3D Hexagram-Like Cobalt–Manganese Sulfides Nanosheets Grown on Nickel Foam: A Bifunctional Electrocatalyst for Overall Water Splitting

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Nano-Micro Letters 2018年第1期10卷 53-62页

作者： Jingwei Li Weiming Xu Jiaxian Luo Dan Zhou Dawei Zhang Licheng Wei peiman Xu Dingsheng Yuan School of Chemistry and Materials Science Jinan University

The exploration of low-cost and efficient bifunctional electrocatalysts for oxygen evolution reaction and hydrogen evolution reaction through tuning the chemical composition is strongly required for sustainable resources. Herein, we developed a bimetallic cobalt–manganese sulfide supported on Ni foam(CMS/Ni) via a solvothermal method. It has discovered that after combining with the pure Co_9S_8 and Mn S, the morphologies of CMS/Ni have modulated. The obtained three-dimensionally hexagram-like CMS/Ni nanosheets have a significant increase in electrochemical active surface area and charge transport ability. More than that, the synergetic effect of Co and Mn has also presented in this composite. Benefiting from these, the CMS/Ni electrode shows great performance toward hydrogen evolution reaction and oxygen evolution reaction in basic medium, comparing favorably to that ofthe pure Co_9S_8/Ni and Mn S/Ni. More importantly, this versatile CMS/Ni can catalyze the water splitting in a twoelectrode system at a potential of 1.47 V, and this electrolyzer can be efficiently driven by a 1.50 V commercial dry battery.

关键词： Bifunctional electrocatalysts Oxygen evolution reaction Hydrogen evolution reaction Cobalt–manganese sulfides Water splitting

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