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Inhibition of PI3K/Akt/m TOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro

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Chinese Journal of Cancer Research 2014年第5期26卷 564-572页

作者： Yunlang Cai Xiaoqiang Tan Jun Liu Yang shen Di Wu Mulan Ren peilin Huang Dandan Yu Department of Obstetrics & Gynecology Zhongda HospitalSoutheast University Medical College Southeast University

The activation of the PI3K/AKT/m TOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and m TOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/m TOR signaling pathway and inducing cell cycle arrest and apoptosis.

关键词： PI3K/AKT/m TOR cisplatin ovarian cancer

“服务-学习”模式在医德教育中的作用——探索医教协同提高医学生医德人文素质的有效模式

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中国医学伦理学 2016年第2期29卷 205-208页

作者：梁仟陈茂怀沈沛麟付艳红郁丽娜李丽萍汕头大学医学院广东汕头515041 汕头大学医学院党委广东汕头515041 汕头大学医学院学生工作部广东汕头515041

目的探索"服务-学习"模式在医教协同提高医学生医德人文素质中的作用。方法对汕头大学医学院831名在校生及302名毕业生进行定性与定量研究。结果 "服务-学习"模式为大多数医学生所接受和认可;参加"服务-学习"活动的在校生和毕业生比未... 详细信息

目的探索"服务-学习"模式在医教协同提高医学生医德人文素质中的作用。方法对汕头大学医学院831名在校生及302名毕业生进行定性与定量研究。结果 "服务-学习"模式为大多数医学生所接受和认可;参加"服务-学习"活动的在校生和毕业生比未参加者有较高的医德认知水平和较正面的行为选择倾向,且调查对象的医德认知水平和较正面的行为选择倾向与参加次数正相关。结论 "服务-学习"模式在医德教育中具有重要作用,是深入践行《关于医教协同深化临床医学人才培养改革的意见》的有效途径。

关键词：服务学习医德教育医学生人文素质

General approach for atomically dispersed precious metal catalysts toward hydrogen reaction

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Carbon Energy 2023年第7期5卷 100-111页

作者： Ruisong Li Daoxiong Wu Peng Rao peilin Deng Jing Li Junming Luo Wei Huang Qi Chen Zhenye Kang Yijun shen Xinlong Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikouChina

As a carbon-free energy carrier,hydrogen has become the pivot for future clean energy,while efficient hydrogen production and combustion still require precious metal-based ***-atom catalysts(SACs)with high atomic utilization open up a desirable perspective for the scale applications of precious metals,but the general and facile preparation of various precious metal-based SACs remains ***,a general movable printing method has been developed to synthesize various precious metal-based SACs,such as Pd,Pt,Rh,Ir,and Ru,and the features of highly dispersed single atoms with nitrogen coordination have been identified by comprehensive *** importantly,the synthesized Pt-and Ru-based SACs exhibit much higher activities than their corresponding nanoparticle counterparts for hydrogen oxidation reaction and hydrogen evolution reaction(HER).In addition,the Pd-based SAC delivers an excellent activity for photocatalytic hydrogen *** for the superior mass activity of Ru-based SACs toward HER,density functional theory calculations confirmed that the adsorption of the hydrogen atom has a significant effect on the spin state and electronic structure of the catalysts.

关键词： hydrogen evolution reaction hydrogen oxidation reaction photocatalytic hydrogen evolution reaction precious metals single-atom catalysts

Rational design ternary platinum based electrocatalysts for effective methanol oxidation reaction

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Journal of Energy Chemistry 2022年第7期31卷 230-235,I0007页

作者： Hao Tian Daoxiong Wu Jing Li Junming Luo Chunman Jia Zhongxin Liu Wei Huang Qi Chen Chong Michael Shim peilin Deng Yijun shen Xinlong Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikou 570228HainanChina

Exploring effective, durable, and affordable electrocatalysts of methanol oxidation reaction(MOR) is of vital significance for the industrial application of direct methanol fuel cells. Herein, an efficient, general,and expandable method is developed to synthesis two-dimensional(2D) ternary Pt Bi M nanoplates(NPLs), in which various M(Co, Ni, Cu, Zn, Sn) is severed as the third component to the binary Pt Bi system. The MOR performance of Pt Bi M NPLs is entirely investigated, demonstrating that both the MOR activity and durability is enhanced with the introduction of the additional composition. Pt3Bi3Zn NPLs shows much higher MOR activity and stability than that of the Pt Bi counterparts, not to mention the current advanced Pt Ru/C and Pt/C catalysts. The prominent performances are attributed to the modulated electronic structure of the surface Pt in Pt Bi NPLs by the addition of Zn, resulting in a weakened affination between Pt and the adsorbed poisoning species(mainly CO) compared with Pt Bi NPLs, verified by density functional theory(DFT) calculations. In addition, the absorbed OH can be generated on the surface of Zn atom due to its favorable water activation properties, thus the CO removal on the adjacent Pt atoms is accelerated, further leading to a high activity and anti-poisoning performance of the resulting Pt_(3)Bi_(3)Zn catalyst. This work provides new insights and robust strategy for highly efficient MOR electrocatalyst with extraordinary anti-poisoning performance and stability.

关键词： Fuel cells Ternary nanoplates Durability Methanol oxidation reaction Anti-poisoning

Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo

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Science China Chemistry 2020年第3期63卷 393-397页

作者： Jianlei shen Kun Tao peilin Gu Chen Gui Dong Wang Zhenyu Tan Lihua Wang Zhiming Wang Anjun Qin Ben Zhong Tang Shisan Bao School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Tongren Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200240China Discipline of Pathology Bosch Institute and School of Medical SciencesCharles Perkins CentreThe University of SydneyAustralia Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Synchrotron Radiation FacilityShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Department of Chemistry HKUST Jockey Club Institute for Advanced StudyInstitute of Molecular Functional MaterialsDivision of Biomedical EngineeringState Key Laboratory of Molecular NeuroscienceDivision of Life ScienceThe Hong Kong University of Science and TechnologyHong KongChina State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

Colorectal cancer(CRC)is still a major killer,mainly due to the lack of early detection biomarker with sensitivity/*** histopathology is the gold standard approach in practice,but there are still some issues(false diagnosis and long waiting period).Aggregation-induced emission(AIE)is a novel photophysical phenomenon which has been widely utilized for biological imaging in vitro,including malignant cells,showing remarkable imaging contrast and enhanced emission in high concentrated ***,it is unclear if AIE dyes can identify malignant cells specifically in vivo.A great challenge for specific labeling of malignant cells is probably ascribed to the complex compositions in tumor ***,an AIE dye-based mitochondria-targeted histological staining strategy was employed to localize cancer and the metastatic track in the fresh colorectal *** novel approach holds great potential to revolutionize the clinical diagnosis and intervention for devastating malignancy.

关键词： aggregation-induced emission histological staining colorectal cancer

One-dimensional PtFe hollow nanochains for the efficient oxygen reduction reaction

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Carbon Energy 2022年第6期4卷 1003-1010页

作者： Peng Rao Junming Luo Jing Li Wei Huang Wei Sun Qi Chen Chunman Jia Zhongxin Liu peilin Deng Yijun shen Xinlong Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikouChina

Integration of electronic and strain effects with tailored structures is significant to tuning the electrocatalytic activity and stability of the electrocatalysts for the oxygen reduction reaction(ORR).In this study,onedimensional PtFe hollow nanochains are synthesized by a facile and effective method,which exhibit a highly open and porous *** modulated electronic and strain effects of Pt atoms are verified by extensive structural characterizations,and the mass and specific activities of the prepared catalyst are roughly 7.45 and 12.44 times higher than those of the commercial Pt/C catalyst,***,the catalyst demonstrates robust performance with negligible activity decay after an accelerated durability test for 30,000 *** high activity of the catalyst is probably due to the optimized absorption affinity of Pt-O accelerating the reaction kinetics induced by the cooperation of Fe atoms as well as the unique hollow and curved *** study provides new insights into the rational design of high-performance ORR catalysts with considerable durability.

关键词： electrocatalysts hollow nanochains one-dimensional oxygen reduction reaction zinc-air battery

Engineering Ruthenium-Based Electrocatalysts for Effective Hydrogen Evolution Reaction

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Nano-Micro Letters 2021年第10期13卷 288-307页

作者： Yingjie Yang Yanhui Yu Jing Li Qingrong Chen Yanlian Du Peng Rao Ruisong Li Chunman Jia Zhenye Kang peilin Deng Yijun shen Xinlong Tian State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikou 570228People’s Republic of China

The investigation of highly effective,durable,and cost-effective electrocatalysts for the hydrogen evolution reaction(HER)is a prerequisite for the upcoming hydrogen energy *** establish a new hydrogen energy system and gradually replace the traditional fossil-based energy,electrochemical water-splitting is considered the most promising,environmentally friendly,and efficient way to produce pure *** with the commonly used platinum(Pt)-based catalysts,ruthenium(Ru)is expected to be a good alternative because of its similar hydrogen bonding energy,lower water decomposition barrier,and considerably lower *** and revealing the HER mechanisms,as well as identifying a rational design of Ru-based HER catalysts with desirable activity and stability is *** this review,the research progress on HER electrocatalysts and the relevant describing parameters for HER performance are briefly ***,four major strategies to improve the performance of Ru-based electrocatalysts,including electronic effect modulation,support engineering,structure design,and maximum utilization(single atom)are ***,the challenges,solutions and prospects are highlighted to prompt the practical applications of Rubased electrocatalysts for HER.

关键词： Hydrogen evolution reaction Ruthenium-based catalysts Performance Electrochemical water splitting

Phase transferring luminescent gold nanoclusters via single-stranded DNA

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Science China Chemistry 2022年第6期65卷 1212-1220页

作者： Yu Li Hui Lu Zhibei Qu Mingqiang Li Haoran Zheng peilin Gu Jiye Shi Jiang Li Qian Li Lihua Wang Jing Chen Chunhai Fan Jianlei shen Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai200240China Shanghai Synchrotron Radiation Facility Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai201210China Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai200127China

Atomically precise gold nanoclusters(Au NCs) are an emerging class of quantum-sized nanomaterials with discrete electronic energy levels, which has led to a range of attractive electronic and optical applications. Nevertheless, the lack of general methods to transfer Au NCs protected with hydrophobic ligands to an aqueous solution hampers their use in physiological settings. Here,we developed a single-stranded DNA-based approach that could transfer ~90% hydrophobic Au NCs into an aqueous *** experimentally and theoretically established that multivalent electrostatic and hydrophobic interactions between DNA strands and the hydrophobic ligand layer on Au NCs resulted in monodispersed DNA-coated Au NCs with high physical integrity in an aqueous solution. The fluorescence quantum yield of Au NCs was increased by ~13 fold, and surface-constrained DNA retained the specific recognition ability for biosensing. We further demonstrated the versatility of this phase-transfer approach, which thus holds great potential to advance biological and medical applications of Au NCs.

关键词： gold nanoclusters DNA monodispersed phase transfer biological application

DIELECTRIC RESPONSE OF A SEMICONDUCTING CERAMIC BASED ON BARIUM TITANATE

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Chinese Physics Letters 1987年第4期4卷 145-148页

作者： ZHANG peilin ZHONG Weilie shen Chenghang LIU Sidong Department of Physics Shandong UniversityJinan

Complex dielectric constant ε=ε′-iε″ er-iert of a semiconducting BaTiO_(3) ceramics has been measured at room temperature over the frequency range of 10kHz-500MHz・This dielec-trzc response can be approximately described by the Debye type relaxation equations^whereas the conductzvzty dominates the imaginary part at lower frequencies・From the dielectr'ic measurement3 the resisti-vity and the dz~electric constant have been evaluated for the grains and grain boundaries separately.

关键词： ceramics relaxation imaginary