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A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models

Chinese Chemical Letters 2024年第3期35卷 394-398页

作者： Hongyao liu Yan Yu Taixiong Xue Cailing Gan Yuting Xie Doudou Wang peilin li Zhiyong Qian Tinghong Ye Department of Gastroenterology and Hepatology Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer and Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell injury.After various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and dysfunction.There is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of fibrosis.Therefore,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced myofibroblast.In addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary fibrosis.Furthermore,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver fibrosis.Moreover,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological sections.Taken together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates.

关键词： Fibrosis H_(2)O_(2) Electrochemical sensor NOX4 Nintedanib

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In-situ Generation of Hydroxyl Layers in Coo@FeSe_(2) Catalyst for High Selectivity Seawater Electrolysis

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Chinese Journal of Chemistry 2024年第1期42卷 48-54,I0004页

作者： Suyang Feng Peng Rao Xiao Wu Ke li Anyuan Qi Yanhui Yu Jing li peilin Deng Yuliang Yuan Shaolei Wang Xinlong Tian Zhenye Kang State Key Laboratoryof Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchoolof Chemical Engineering andTechnologyHainan UniversityHaikouHainan 570228China Key Laboraory of Polyoxmetalate andReticular Material Chemtry of Ministy of Education School of Chmistry Northeast NormalUniversity ChangchunJilin 130024China National Energy Group Ledong Power Generation Co. Ltd.LedongHainan 572539China

Seawater electrolysis holds great promise for hydrogen production in the future,while the development of anodic catalysts has been severely hampered by the side-reaction,chloride evolution reaction.In this work,nano-flower-cluster structured Coo@FeSe_(2)/CF catalysts are synthesized via a scalable electrodeposition technique,and the performance is systematically studied.The oxygen evolution reaction(OER)overpotential of Co0@FeSe_(2)/CF is 267 mV at 100 mA.cm^(-2),which is significantly lower than that of the IrO_(2) catalyst(435 mV).Additionally,the catalyst shows high selectivity for OER(97.9%)and almost no loss of activity after a durability test for 1100 h.The impressive performance is attributed to the dense rod-like structure with abundant active centers after electrochemical activation and the in-situ generated CoOOH and FeOOH that improve the catalytic activity of the catalyst.The synergistic effect induced bythenon-uniform structureendows the catalyst with excellent stability.

关键词： Energy Transfer Seawat erelectrolysis Oxygen evolution reaction Electrodeposition method CoO@FeSe_(2)/CF catalyst Nano-flower-cluster structure Catalytic activity

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Plasma induced grain boundaries to boost electrochemical reduction of CO2 to formate

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Journal of Energy Chemistry 2024年第8期95卷 636-643页

作者： Guan Wang Shengtao Zhong Xiaoqian Xiong Jing li Fangyuan Wang li Huo Daoxiong Wu Xingqi Han Zhitong Wang Qi Chen Xinlong Tian peilin Deng School of Marine Science and Engineering State Key Laboratory of Marine Resource Utilization in South China Sea Hainan University

Bismuth-based catalysts are highly promising for the electrochemical carbon dioxide reduction reaction（eCO2RR） to formate product.However,achieving high activity and selectivity towards formate and ensuring long-term stability remains challenging.This work reports the oxygen plasma inducing strategy to construct the abundant grain boundaries of Bi/BiOxon ultrathin two-dimensional Bi nanosheets.The oxygen plasma-treated Bi nanosheet（OP-Bi） exhibits over 90% Faradaic efficiency（FE） for formate at a wide potential range from-0.5 to-1.1 V,and maintains a great stability catalytic performance without significant decay over 30 h in flow cell.Moreover,membrane electrode assembly（MEA） device with OPBi as catalyst sustains the robust current density of 100 mA cm-2over 50 h,maintaining a formate FE above 90%.In addition,rechargeable Zn-CO2battery presents the peak power density of1.22 mW cm-2with OP-Bi as bifunctional catalyst.The mechanism experiments demonstrate that the high-density grain boundaries of OP-Bi provide more exposed active sites,faster electron transfer capacity,and the stronger intrinsic activity of Bi atoms.In situ spectroscopy and theo retical calculations further elucidate that the unsaturated Bi coordination atoms between the grain boundaries can effectively activate CO2molecules through elongating the C-O bond,and reducing the formation energy barrier of the key intermediate（*OCOH）,thereby enhancing the catalytic performance of eCO2RR to formate product.

关键词： Bi nanosheet CO2 electroreduction Grain boundary MEA device Unsaturation Bi atoms

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TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin Zhang Xiaoxiao Fan Yang Fan Ning Hua Duguang li Shengxi Jin Yirun li Peng Chen Yongle Chen Xiaobo Cai Yi Zhang linhua Jiang Wei Yang peilin Yu Hui lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and transplantation.Despite recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still lacking.Here,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR injury.Our data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in mice.Moreover,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related pathways.Consistently,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed this.Interestingly,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR injury.Furthermore,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in vivo.Collectively,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 lipid Hepatic

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Introducing sulfur to nickel-iron selenide for high-efficiency alkaline seawater electrolysis

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Science China Chemistry 2024年第8期 2747-2754页

作者： Xuanwa Chen Yanhui Yu Xingqi Han Huan Wang Yingjie Hua Daoxiong Wu peilin Deng Juanxiu Xiao Xinlong Tian Jing li School of Marine Science and Engineering Hainan Provincial Key Lab of Fine Chemistry School of Chemistry and Chemical EngineeringHainan University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) College of Chemistry Nankai University Key Laboratory of Electrochemical Energy Storage and Energy Conversion of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University

Seawater electrolysis is an effective way to obtain hydrogen（H2） in a sustainable manner. However, the lack of electrocatalysts with high activity, stability, and selectivity for oxygen evolution reaction（OER） severely hinders the development of seawater electrolysis technology. Herein, sulfur-doped nickel-iron selenide nanosheets（S-NiFeSe2） were prepared by an ion-exchange strategy and served as highly active OER electrocatalyst for alkaline seawater electrolysis. The overpotential is 367 m V, and it can run stably for over 50 h at 100 m A cm-2. Excitingly, the S-NiFeSe2||Pt/C pair exhibits cell voltage of 1.54 V at 10 m A cm-2under alkaline seawater conditions, which can run smoothly for 100 h without decay, and the efficiency of electricity-tohydrogen（ETH） energy conversion reaches more than 80%. Such electrode, with abundant accessible reactive sites and good corrosion resistance, is a good candidate for seawater electrolysis. Moreover, density functional theory calculations reveal that the surface sulfur atoms can activate the adjacent Ni sites and decrease the free energy changes of the associated intermediates at the adjacent Ni sites for OER, and the step of*OH →*O is the potential rate-limiting step. In this work, the true reactive site in nickel-iron selenides is the Ni sites, but not the Fe sites as commonly believed.

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新中国血吸虫病防治史研究的回顾与省思

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医学与社会 2024年第1期37卷 30-35页

作者：李沛霖南京医科大学马克思主义学院南京医科大学医学史研究中心江苏南京211166

血吸虫病是严重危害人类健康、影响社会经济发展的传染性疾病。新中国成立以来,血吸虫病防治史研究取得重要进展及突破。通过梳理血吸虫病防治史研究的学术源流,从血吸虫病防治研究代表作筑牢理论基础、党和政府层面研究凸显宏观视野、... 详细信息

血吸虫病是严重危害人类健康、影响社会经济发展的传染性疾病。新中国成立以来,血吸虫病防治史研究取得重要进展及突破。通过梳理血吸虫病防治史研究的学术源流,从血吸虫病防治研究代表作筑牢理论基础、党和政府层面研究凸显宏观视野、区域和地方层面研究专注微观视域、省思研究的成效与展望等4个维度,总结该领域的学术成果与不足之处。通过回顾与省思,认为当前新中国血防史研究成果斐然,但仍存在研究内容与立论观点同质化、区域研究不均衡、跨学科合作不足等有待加强之处。伴随着“新史料”“新视角”“新方法”“新观点”出现,本领域会有新的突破与拓展,助推新中国医疗卫生史研究的学术发展。

关键词：传染病防治血吸虫病医学史

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China＇s Path to Overcoming the Double Middle-income Traps

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China & World Economy 2017年第6期25卷 28-44页

作者： peilin li Institute of Sociology Chinese Academy of Social Sciences China

China is at a crucial stage of overcoming the middle-income trap, with the factors that drive economic growth having undergone significant changes, and domestic consumption playing a more important role in economic growth. It is necessary, at this point, to promote mass consumption by expanding the middle-income group. The present paper puts forward the concept of the “double middle-income traps.” This refers to the situation in which an economy's per capita output stagnates and the size of the middle-income group is unable to expand for an extended period of time. These two factors are closely related. Based on data from the Chinese Social Survey conducted by the Institute of Sociology at the Chinese Academy of Social Sciences, the present paper analyzes the scale and development of middle-income groups, and the relationship among middle-income groups, the middle-class and middle-class identity. The marginal consumption propensities of middle-income groups are also considered. The findings of the paper indicate that the expansion of the middle-income group plays an important role in promoting mass consumption, maintaining continuous and stable economic growth, and overcoming the double middle-income traps.

关键词：中国社会科学院收入陷阱边际消费倾向经济增长路径调查数据社会学

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考虑不同制氢方法的高速公路加氢站布局规划

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电力自动化设备 2024年第4期44卷 9-17页

作者：王书征单婷婷赵洋李沛林蒋宇南京工程学院电力工程学院江苏南京211167

针对高速公路加氢设施不完善的问题,提出一种基于改进自适应遗传算法的高速公路加氢站布局方法。根据高速公路特性及电子收费记录,建立高速公路网络和加氢判断模型。基于多层次-模糊综合评价方法,从经济性、环保性以及安全性角度,提供... 详细信息

针对高速公路加氢设施不完善的问题,提出一种基于改进自适应遗传算法的高速公路加氢站布局方法。根据高速公路特性及电子收费记录,建立高速公路网络和加氢判断模型。基于多层次-模糊综合评价方法,从经济性、环保性以及安全性角度,提供适合高速公路加氢站的制氢方法和制氢地点的组合。再结合分布式光伏的投入,以经济效益最优为目标,构建高速公路站外和站内制氢2组目标函数,利用改进自适应遗传算法分别进行优化布局和容量配置。以沈海高速(浙江段)作为研究对象进行分析,提供了不同制氢方法下加氢站布局方案及相关设施的容量配置,算例结果与模糊综合评价结果相互验证了模型的有效性。

关键词：氢燃料电池汽车加氢站规划高速公路模糊综合评价自适应遗传算法

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陆海统筹视域下海洋与陆地环境民事公益诉讼协同研究

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中国环境管理 2024年第2期16卷 129-135页

作者：李佩霖邵丞玉中国政法大学证据科学研究院北京100088 国家“2011计划”司法文明协同创新中心北京100088 中国人民大学法学院北京100872

海洋环境民事公益诉讼与环境民事公益诉讼系特殊与一般的关系,海洋环境问题较强的涉外属性决定了海洋环境民事公益诉讼在适格主体、管辖法院等方面存在特殊的规定,此种特殊规定不宜废除。但海洋环境民事公益诉讼与环境民事公益诉讼双轨... 详细信息

海洋环境民事公益诉讼与环境民事公益诉讼系特殊与一般的关系,海洋环境问题较强的涉外属性决定了海洋环境民事公益诉讼在适格主体、管辖法院等方面存在特殊的规定,此种特殊规定不宜废除。但海洋环境民事公益诉讼与环境民事公益诉讼双轨并行的关系造成了海陆交叉污染案件存在适格主体、管辖等争议,且存在两诉协同上的挑战。导致这一问题的根本原因在于,海洋环境民事公益诉讼的受案范围限制在地理概念上的海域,这割裂了同一污染行为下陆地与海洋的联系。陆海统筹理念要求打通陆地与海洋之间的联系,以陆海一体化保护海洋生态环境。在这一理念的指导下,可对海洋环境民事公益诉讼受案范围进行陆海一体化调整,以克服陆地与海洋环境民事公益诉讼双轨并行造成的协同问题。具体而言,在海陆交叉污染案件中可以损害发生地为判断标准,当损害发生地在海洋时,则以海统陆,属海洋环境民事公益诉讼受案范围;当损害发生地在陆地时,则以陆统海,属环境民事公益诉讼受案范围。

关键词：陆海统筹海洋环境民事公益诉讼环境民事公益诉讼海洋主权陆源污染

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Mechanical properties and microstructure analysis of refilling friction stir welding on 2219 aluminum alloy

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Acta Metallurgica Sinica(English Letters) 2012年第3期25卷 225-234页

作者： peilin li Zhongfeng XU Chun YU Hao LU Junshan YAO Guoyu CHEN School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Key Laboratory of Materials Laser Processing and Modificatkon Shanghai 200240 China Shanghai Aerospace Equipments Manufacture Shanghai 200240 China

The 2219 aluminum alloy under refilling friction stir welding （RF-FSW） was investi- gated. The micrographs showed that the bead could be divided into six zones, and the grain size and shape were greatly different in these zones. According to the mi- crostructure analysis, the weld nugget zone and the shoulder stirring zone consisted of equiaxed grains, while the grains in the heat affected zone were seriously coars- ened. It was obvious that bending deformation occurred in the thermo-mechanically affected zone. According to the microhardness analysis, the lowest hardness of the weld was at the thermo-mechanically affected zone, and the microhardness increased with the retraction of the stir-pin. The tensile strength and elongation of the bead were 70% and 80% of the base metal, respectively. The tensile strength was slightly different for the stable stage and the retraction stage, while the elongation decreased in the retraction stage. The mechanical different retraction speed were analyzed, with increasing retraction speed. properties and microstrueture responded to and it showed that the elongation decreased

关键词： Aluminium alloy Friction stir welding Microstructure Mechan- icM property

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