检索结果-南通市图书馆

Food Science and Human Wellness 2024年第4期13卷 1951-1961页

作者： peijun tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Institute of Food Biotechnology(Yangzhou) Jiangnan UniversityYangzhou 225004China

Gut microbiome is indispensable for maintaining normal brain ***,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive *** this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived ***1025 improved the body weight and food and water intake of the *** also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related ***1025 significantly altered the gut microbial composition and genome *** microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the *** metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator ***,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its *** findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

关键词： Bifidobacterium Sleep Circadian rhythm Purine Gut microbiome

Unveiling the Role of Acetate in Probiotic-Mediated Promotion of Intestinal Serotonin Production Using Intestinal Organoids

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： peijun tian Zheng Wang Xin Qian Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University

The neurotransmitter 5-hydroxytryptamine （5-HT）， primarily produced by intestinal enterochromaffin cells （EC）， relies on Tryptophan hydroxylase （TPH1） for synthesis. Research suggested Bifidobacterium breve CCFM1025's potential in regulating Tph1 gene expression， maintaining 5-HT levels in stressed mice， but its precise mechanisms were unclear. This study used metabolomic techniques to assess probiotic fermentation products， revealing acetate as the crucial element in Bb-CCFM1025's regulation of gut 5-HT synthesis. Further exploration correlated acetate with Tph1 transcription in intestinal organoids. Transcriptomic methods and qRT-PCR validation demonstrated how acetate facilitated 5-HT synthesis and secretion. It unveiled that acetate orchestrates signaling pathways (PI3K-AKT， PLC-pERK， and PLC-IP3-Ca2+) within EC cells， enabling 5-HT production. These findings elucidate the biochemical mechanisms behind specific probiotics' effects， aiding in the targeted selection of similar beneficial strains. This study offers theoretical support for choosing probiotics with analogous functionalities based on their physiological impacts.

关键词：

Bifidobacterium adolescentis CCFM8630 Exerts Anti-Obesity Effects by Modulating Gut Microbiota-Related Tryptophan Metabolism

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bo Zhang Linlin Wang peijun tian Xing Jin Ming Liang Zehua Chen Jianxin Zhao Hao Zhang Gang Wang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University Infinitus (China) Company Ltd. Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch

Obesity is a major focus of researchers due to its increasing prevalence and relationship with other diseases， such as cancer and cardiovascular diseases. Probiotics are active microorganisms and have been proven to alleviate obesity by modulating the microbiota. In this study， we found that oral administration of Bifidobacterium adolescentis CCFM8630 to obese mice inhibited high-fat-diet (HFD)-induced changes in body weight and adipose tissue and alleviated hepatic oxidative stress. Furthermore， B. adolescentis CCFM8630 treatment primarily affected the relative abundances of the phyla Proteobacteria and Actinobacteria， and thereby decreased the production of lipopolysaccharide (LPS) and the occurrence of LPS-related diseases. A high fiber intake increased the abundance of Lactobacillus and the concentrations of short-chain fatty acids in obese mice， but these changes were reversed by B. adolescentis CCFM8630 treatment. In addition， targeted metabolomic analysis and microbiota relationship analysis revealed that B. adolescentis CCFM8630 treatment modified the microbiota of obese mice by promoting the conversion of tryptophan (Trp) to xanthurenic acid， kynurenic acid， tryptamine， indole-3-acetic acid， and indole-3-carboxaldehyde; facilitated the expression of interleukin-17A and the aryl hydrocarbon receptor to generate interleukin-22 in the colon; and upregulated the expression of tight junction proteins， thereby strengthening intestinal barriers. In summary， our findings suggest that the intake of B. adolescentis CCFM8630 may alleviate obesity by modulating the gut microbiota and related Trp metabolism.

关键词：

Alterations in the gut microbiota and the faecal metabolomes are potentially associated with gestational diabetes mellitus through inflammatory response

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Ruili Pan Xiaopeng Xu Ying Chen Haojue Wang Linlin Wang peijun tian Xing Jin Jianxin Zhao Wei Chen Gang Wang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University The Department of Clinical Laboratory， Wuxi Xishan People's Hospital The Department of Obstetrics and Gynecology， Wuxi Xishan People's Hospital National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University

Gestational diabetes mellitus (GDM) is a disease of glucose intolerance that first occurs during pregnancy. Accumulating evidence underlined a link between gut microbiota dysbiosis and GDM， and microbial metabolites represent a unique way to explore microbiota–host interactions. However， the associations between changes in the gut microbiota and microbial metabolites and immune homeostasis in the GDM pathogenesis remain largely unclear. In this prospective study， the characteristics of gut microbiota in both first trimester (T1) and second trimester (T2 ) were investigated in 46 GDM patients and 44 matched controls. We comprehensively profiled the microbial metabolites using non-targeted metabolomics and quantitatively targeted metabolomics， measurements of inflammatory cytokines and biomarkers of intestinal barrier function， and combined with correlation analysis in T2. Gut microbiota dybiosis was observed in GDM patients in both T1 and T2， and was characterised by the enrichment of multiple potentially harmful bacteria， such as UBA1819 and Erysipelatoclostridium. Besides， alterations in the microbiota were accompanied by a disturbance in tryptophan metabolism， mainly manifested as a shift towards the production of more kynurenine and less indole derivatives. Most importantly， correlation network analysis indicated that overgrowth of potential pathogens and tryptophan metabolism disorder were associated with inflammatory imbalance and disrupted epithelial barrier in GDM patients. Theses findings provide a greater understanding of the pathogenesis and new targets for microecological interventions by mediating tryptophan metabolism in GDM.

关键词：

乳酸片球菌CCFM6432通过缓解大脑炎症改善小鼠抑郁行为

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

食品与发酵工业 2024年第19期50卷 25-32页

作者：杨红宇蒋家豪裴雨轩钱鑫田培郡王刚赵建新江南大学食品学院江苏无锡214122

乳酸片球菌(Pediococcus acidilactici)是一类高产乳酸的益生菌,该文旨在探究乳酸片球菌CCFM6432对小鼠抑郁症状的缓解作用及其作用机制。该研究通过为期4周的慢性不可预知温和刺激建立抑郁小鼠模型,并给予小鼠益生菌(乳酸片球菌CCFM643... 详细信息

乳酸片球菌(Pediococcus acidilactici)是一类高产乳酸的益生菌,该文旨在探究乳酸片球菌CCFM6432对小鼠抑郁症状的缓解作用及其作用机制。该研究通过为期4周的慢性不可预知温和刺激建立抑郁小鼠模型,并给予小鼠益生菌(乳酸片球菌CCFM6432和对照菌株FXJKS25M4)干预治疗。肠道菌群和代谢物分析结果显示,相比于模型组和对照组,CCFM6432干预后能显著调节肠道代谢物乳酸、鸟嘌呤和腺嘌呤等的含量,降低肠道致病菌的丰度,并提高了短链脂肪酸合成菌属毛螺菌科(Lachnospiraceae)的丰度,有助于恢复肠道屏障损伤,逆转血清中脂多糖(lipopolysaccharide,LPS)异常升高。此外,CCFM6432还能下调脑部TLR4/NF-kB信号通路的受体蛋白和促炎因子的异常表达,从而抑制海马中小胶质细胞的过度活化。该研究揭示了CCFM6432通过调节特定肠道代谢物来抑制肠道致病菌的生长,从而缓解神经炎症导致的抑郁症状,并为抑郁症治疗方法以及肠-脑轴信号通路探索提供新的见解。

关键词：乳酸片球菌乳酸抑郁脂多糖炎症小胶质细胞

基于Kriging代理模型的无刷双馈发电机转子优化设计

在线全文

学校读者我要写书评

暂无评论

微电机 2024年第3期57卷 47-51,64页

作者：于思洋田培均王皓张凤阁沈阳工业大学电气工程学院沈阳110870

无刷双馈发电机由于其自身没有电刷、滑环等结构特点,因此被认为是最有希望成为风力发电系统的主流发电机之一。无刷双馈发电机是依靠转子的磁场调制机理实现机电能量转换,其转子的耦合能力是影响电机性能的重要因素。因此本文提出了一... 详细信息

无刷双馈发电机由于其自身没有电刷、滑环等结构特点,因此被认为是最有希望成为风力发电系统的主流发电机之一。无刷双馈发电机是依靠转子的磁场调制机理实现机电能量转换,其转子的耦合能力是影响电机性能的重要因素。因此本文提出了一种串联笼条辅助磁障转子的新型转子结构,分析了该种转子不同结构参数对电机性能的影响,并提出一种基于Kriging代理模型的多目标差分进化算法的无刷双馈发电机转子优化设计方法。首先建立该种新型转子的参数化模型,通过Kriging代理模型建立优化变量与优化目标之间的响应关系,再利用多目标差分进化算法找到最优的变量组合,最后通过有限元仿真对电机的性能进行分析。

关键词：无刷双馈发电机笼障转子 Kriging模型多目标优化差分进化算法

填料及增塑剂对聚硫型道路灌缝胶性能的影响研究

在线全文

学校读者我要写书评

暂无评论

中国胶粘剂 2024年第4期33卷 60-68页

作者：田培军刘虓嵩陈嵩张增平杨洋夏静杰钱建行宁波东兴沥青制品有限公司浙江宁波315000 长安大学教育部特殊地区公路工程重点实验室陕西西安710064 江苏高速公路工程养护有限公司江苏淮安223000 长安大学长安都柏林国际交通学院陕西西安710018

采用轻质CaCO_(3)、重质CaCO_(3)、高岭土和纳米ZnO作为聚硫型道路灌缝胶的填料进行对比,气相SiO_(2)作为补强填料加入到灌缝胶中,并选用了两种增塑剂邻苯二甲酸二丁酯(DBP)和邻苯二甲酸丁苄酯(BBP)进行比较。研究了不同填料、增塑剂的... 详细信息

采用轻质CaCO_(3)、重质CaCO_(3)、高岭土和纳米ZnO作为聚硫型道路灌缝胶的填料进行对比,气相SiO_(2)作为补强填料加入到灌缝胶中,并选用了两种增塑剂邻苯二甲酸二丁酯(DBP)和邻苯二甲酸丁苄酯(BBP)进行比较。研究了不同填料、增塑剂的类型以及掺量对聚硫型道路灌缝胶性能的影响,同时确定了配制聚硫型灌缝胶的填料及增塑剂的最佳掺量。研究结果表明:轻质CaCO_(3)作为填料制备的聚硫型灌缝胶具有更好的力学性能,并且能够在体系中更好地分散;BBP相较于DBP更加绿色环保,不容易污染基材,因此填料和增塑剂分别选用轻质CaCO_(3)和BBP。通过对其力学性能、微观形貌、分散情况和热稳定性的研究后认为,当轻质CaCO_(3)的最佳掺量为200份、BBP的最佳掺量为80份时,所制备的聚硫型灌缝胶的综合性能较好。

关键词：聚硫型道路灌缝胶填料增塑剂道路养护

在线全文

学校读者我要写书评

暂无评论

生物基高分子改性沥青研究进展

中国胶粘剂 2024年第5期33卷 11-18,24页

作者：田培军阚士云张增平钱建行杨洋夏静杰刘浩宁波东兴沥青制品有限公司浙江宁波315000 长安大学教育部特殊地区公路工程重点实验室陕西西安710064 长安大学都柏林国际交通学院陕西西安710018

随着我国道路桥梁建设的蓬勃发展,改性沥青逐渐占领应用市场,在沥青中掺加环氧树脂、聚氨酯、酚醛树脂等高分子可获得高性能的改性沥青或沥青混合料。为了减少对不可再生资源的消耗,以便于道路工程的可持续发展,生物基原料逐渐替代石油... 详细信息

随着我国道路桥梁建设的蓬勃发展,改性沥青逐渐占领应用市场,在沥青中掺加环氧树脂、聚氨酯、酚醛树脂等高分子可获得高性能的改性沥青或沥青混合料。为了减少对不可再生资源的消耗,以便于道路工程的可持续发展,生物基原料逐渐替代石油基原料。本文针对树脂类(生物基聚氨酯、生物基酚醛树脂)改性沥青、生物基橡胶改性沥青、生物基天然弹性体改性沥青、生物基复合型改性沥青等原料和研究进展进行了梳理和汇总,并对生物基改性剂(植物油、植物酚、木质素、松香和衣康酸等)最新研究成果进行分享。提出了生物基高分子改性沥青目前存在的问题,最后对其未来发展进行了展望。

关键词：改性沥青生物基高分子改性机理

Microbiota in colorectal cancer related to liver metastasis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第1期36卷 17-24页

作者： peijun Wei Weiming Han Zitong Zhang Xue tian Chen Yang Qiaoxuan Wang Weihao Xie Ying Liu Yuanhong Gao Hui Chang Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China Guangdong Provincial Clinical Research Center for Cancer Guangzhou 510060China Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Pediatric Oncology State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

The prevalence of colorectal cancer(CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum(F. nucleatum), Escherichia coli, and Bacteroides fragilis, and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC. However,little clinical evidence exists on the specific interplay between the gut microflora and colorectal cancer liver metastasis(CRLM). Some research showed the existence of viable F. nucleatum in distant metastasis of ***, gut microbiota products, such as lipopolysaccharides, sodium butyrate, and protein cathepsin K, were also found to affect the development of CRC. This article summarizes the mechanism and research status of the interplay between gut microflora and CRLM, discusses the importance of gut microflora in the treatment of CRLM, and proposes a new approach to understanding the mechanism of CRLM and potential treatments for the microbiome. It is anticipated that the gut microbiota will be a formidable therapeutic and prophylactic tool for treating and preventing CRLM.

关键词： Gut microbiota liver metastasis colorectal cancer

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

在线全文

学校读者我要写书评

暂无评论

Engineering 2020年第4期6卷 415-423页

作者： Wanqiang Wu Qingmin Kong peijun tian Qixiao Zhai Gang Wang Xiaoming Liu Jianxin Zhao Hao Zhang Yuan Kun Lee Wei Chen a State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Wuxi 214122China International Joint Research Laboratory for Probiotics Jiangnan UniversityWuxi 214122China Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijing 100048China

It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic *** recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and *** review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota *** topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and *** research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.

关键词： Gut microbiota Gut-brain axis Neurological disorders Intervention strategies