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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

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Food Science and Human Wellness 2024年第4期13卷 1951-1961页

作者： peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China Institute of Food Biotechnology(Yangzhou) Jiangnan UniversityYangzhou 225004China

Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived mice.CCFM1025 improved the body weight and food and water intake of the mice.It also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related behaviours.CCFM1025 significantly altered the gut microbial composition and genome function.Key microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the serum.Those metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1.Collectively,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites.These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

关键词： Bifidobacterium Sleep Circadian rhythm Purine Gut microbiome

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Nested hollow architectures of nitrogen-doped carbon-decorated Fe,Co,Ni-based phosphides for boosting water and urea electrolysis

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Nano Research 2022年第3期15卷 1916-1925页

作者： Jie Zhang Shoushuang Huang Ping Ning peijun xin Zhiwen Chen Qing Wang Kajsa Uvdal Zhangjun Hu Shanghai Applied Radiation Institute School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Division of Molecular Surface Physics&Nanoscience Department of PhysicsChemistry and BiologyLinköping UniversityLinköping 58183Sweden

Tailoring the nanostructure/morphology and chemical composition is important to regulate the electronic configuration of electrocatalysts and thus enhance their performance for water and urea electrolysis.Herein,the nitrogen-doped carbon-decorated tricomponent metal phosphides of FeP4 nanotube@Ni-Co-P nanocage(NC-FNCP)with unique nested hollow architectures are fabricated by a self-sacrifice template strategy.Benefiting from the multi-component synergy,the modification of nitrogen-doped carbon,and the modulation of nested porous hollow morphology,NC-FNCP facilitates rapid electron/mass transport in water and urea electrolysis.NC-FNCP-based anode shows low potentials of 248 mV and 1.37 V(vs.reversible hydrogen electrode)to attain 10 mA/cm^(2) for oxygen evolution reaction(OER)and urea oxidation reaction(UOR),respectively.In addition,the overall urea electrolysis drives 10 mA/cm^(2) at a comparatively low voltage of 1.52 V(vs.RHE)that is 110 mV lower than that of overall water electrolysis,as well as exhibits excellent stability over 20 h.This work strategizes a multi-shell-structured electrocatalyst with multi-compositions and explores its applications in a sustainable combination of hydrogen production and sewage remediation.

关键词： tri-metal phosphides nested hollow nano-architecture oxygen evolution reaction urea oxidation reaction

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Phosphorus-doped Fe_(7)S_(8)@C nanowires for efficient electrochemical hydrogen and oxygen evolutions:Controlled synthesis and electronic modulation on active sites

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Journal of Materials Science & Technology 2021年第15期74卷 168-175页

作者： Thanh-Tung Le Xiao Liu peijun xin Qing Wang Chunyan Gao Ye Wu Yongjiang Zhangjun Hu Shoushuang Huang Zhiwen Chen School of Environmental and Chemical Engineering Shanghai UniversityShanghai200444China Department of Physics Chemistry and BiologyLinkoping UniversityLinkoping58183Sweden

Developing low-cost,efficient,and stable non-precious-metal electrocatalysts with controlled crystal structure,morphology and compositions are highly desirable for hydrogen and oxygen evolution reactions.Herein,a series of phosphorus-doped Fe_(7)S_(8)nanowires integrated within carbon(P-Fe_(7)S_(8)@C)are rationally synthesized via a one-step phosphorization of one-dimensional(1D)Fe-based organicinorganic nanowires.The as-obtained P-Fe_(7)S_(8)@C catalysts with modified electronic configurations present typical porous structure,providing plentiful active sites for rapid reaction kinetics.Density functional calculations demonstrate that the doping Fe_(7)S_(8)with P can effectively enhance the electron density of Fe_(7)S_(8)around the Fermi level and weaken the Fe-H bonding,leading to the decrease of adsorption free energy barrier on active sites.As a result,the optimal catalyst of P-Fe_(7)S_(8)-600@C exhibits a relatively low overpotential of 136 mV for hydrogen evolution reaction(HER)to reach the current density of 10 mA/cm^(2),and a significantly low overpotential of 210 mV for oxygen evolution reaction(OER)at 20 mA/cm^(2)in alkaline media.The work presented here may pave the way to design and synthesis of other prominent Fe-based catalysts for water splitting via electronic regulation.

关键词： Ron sulfide P-doping Hydrogen and oxygen evolution reaction Electrocatalysis

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Simultaneous estimation of surface soil moisture and soil properties with a dual ensemble Kalman smoother

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Science China Earth Sciences 2015年第12期58卷 2327-2339页

作者： CHU Nan HUANG ChunLin LI xin DU peijun School of Environment Science and Spatial Informatics China University of Mining and Technology Key Laboratory of Remote Sensing of Gansu Province Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Heihe Remote Sensing Experimental Research Station Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences CAS Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences

In this paper, a new state-parameter estimation approach is presented based on the dual ensemble Kalman smoother(DEn KS) and simple biosphere model(Si B2) to sequentially estimate both the soil properties and soil moisture profile by assimilating surface soil moisture observations. The Arou observation station, located in the upper reaches of the Heihe River in northwestern China, was selected to test the proposed method. Three numeric experiments were designed and performed to analyze the influence of uncertainties in model parameters, atmospheric forcing, and the model's physical mechanics on soil moisture estimates. Several assimilation schemes based on the ensemble Kalman filter(En KF), ensemble Kalman smoother(En KS), and dual En KF(DEn KF) were also compared in this study. The results demonstrate that soil moisture and soil properties can be simultaneously estimated by state-parameter estimation methods, which can provide more accurate estimation of soil moisture than traditional filter methods such as En KF and En KS. The estimation accuracy of the model parameters decreased with increasing error sources. DEn KS outperformed DEn KF in estimating soil moisture in most cases, especially where few observations were available. This study demonstrates that the DEn KS approach is a useful and practical way to improve soil moisture estimation.

关键词：卡尔曼平滑土壤水分土壤性质集合参数估计方法平滑器卡尔曼滤波模型参数

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Probiotics Administration Alleviates Cognitive Impairment and Circadian Rhythm Disturbance Induced by Sleep Deprivation

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Food Science and Human Wellness 2023年

作者： peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen National Engineering Research Center for Functional Food Jiangnan University (4Yangzhou) Institute of Food Biotechnology Jiangnan University School of Food Science and Technology Jiangnan University State Key Laboratory of Food Science and Technology Jiangnan University

Gut microbiome is indispensable for maintaining normal brain function. Specifically， gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study， neurobehavioral effects of the Bifidobacterium breve strain CCFM1025 were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test)， but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified， such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut–brain communication by acting on the striatal melatonin system， for example to increase melatonin levels， and by regulating the expression of circadian clock genes such as those encoding the adenosine A2Areceptor and period circadian regulator 1. Collectively， administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

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Hypervalent iodine-mediated gem-difluorination of vinyl halides enabled by exclusive 1,2-halo migration

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Science China Chemistry 2021年第6期64卷 999-1003页

作者： Chenglong Li Yangzhen Liao Xuemei Tan Xiaozu Liu peijun Liu Wen-xin Lv Honggen Wang Key Laboratory of Biocatalysis&Chiral Drug Synthesis of Guizhou Province Generic Drug Research Center of Guizhou ProvinceSchool of PharmacyZunyi Medical UniversityZunyi 563000China Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563000China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China

β-Difluorinated alkyl halides are of significant value in the modular synthesis of gem-difluorinated molecules.An exclusive 1,2-halo migratory gem-difluorination of vinyl halides with in situ-generated PhIF_(2)·HF is described.This protocol provides a general and practical approach towards a wide variety ofβ-difluorinated alkyl bromides.Bothα-andβ-bromoalkyl alkenes are suitable substrates,leading to two distinct types of products.The extension of this protocol to vinyl chloride and iodide are also feasible.The synthetic versatility of this method has been highlighted by the late-stage modification of complex small molecules and further transformations of theβ-difluorinated alkyl halides to valuable CF_(2)-containing compounds.

关键词： gem-difluorination vinyl halides 1,2-halo migration hypervalent iodine late-stage modification

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三黄理湿方治疗湿热浸淫型急性湿疹36例临床观察

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中医杂志 2022年第3期63卷 251-255页

作者：徐平马欣丁佩军上海中医药大学附属曙光医院上海市201203

目的观察三黄理湿方治疗湿热浸淫型急性湿疹的临床疗效及安全性。方法将72例湿热浸淫型急性湿疹患者随机分为治疗组和对照组各36例。两组患者均外用3%硼酸洗液,治疗组再给予三黄理湿方口服,每日1剂;对照组再给予西替利嗪片口服,每日10 ... 详细信息

目的观察三黄理湿方治疗湿热浸淫型急性湿疹的临床疗效及安全性。方法将72例湿热浸淫型急性湿疹患者随机分为治疗组和对照组各36例。两组患者均外用3%硼酸洗液,治疗组再给予三黄理湿方口服,每日1剂;对照组再给予西替利嗪片口服,每日10 mg,晚餐时口服,两组均治疗2周。比较两组患者治疗前后湿疹面积及严重度指数评分(EASI评分)、瘙痒时间占夜间睡眠的百分比(PIT值)、瘙痒程度视觉模拟评分(VAS评分)、中医证候评分及外周血白细胞介素-4(IL-4)水平、嗜酸性粒细胞计数(EOS)。治疗后评价临床疗效,比较两组愈显患者治疗结束1个月后的复发率,并观察不良反应。结果治疗组EASI评分、PIT值、VAS评分和中医证候评分,血清IL-4和EOS水平均明显低于治疗前(P<0.05或P<0.01)。与对照组比较,治疗组EASI评分、PIT值和中医证候评分均较治疗前下降更明显(P<0.01),EOS较治疗前下降优于对照组(P<0.05);治疗组愈显率(47.2%)优于对照组(19.4%,P<0.05);治疗组17例愈显患者中有3例出现复发,对照组7例愈显患者中有5例出现复发。两组均无明显不良反应。结论口服三黄理湿方治疗湿热浸淫型急性湿疹疗效明显,可有效减少炎症反应,改善患者中医症状。

关键词：急性湿疹三黄理湿方湿热浸淫型炎症反应

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Discovery of the ancient Ordovician oil-bearing karst cave in Liuhuanggou,North Tarim Basin,and its significance

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Science China Earth Sciences 2012年第9期55卷 1406-1426页

作者： ZHONG JianHua MAO Cui LI Yong LI Yang YUAN XiangChun NIU YongBin CHEN xin HuANG ZhiJuan SHAO ZhuFu WANG peijun LI Jia ZHANG DanFeng College of Geoscience and Technology China University of PetroleumQingdao 266580China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China Oilfield Department Sinopec GroupBeijing 100825China Institute of Exploration and Development Sinopec GroupBeijing 100083China Institute of Resources and Environment College Henan Polytechnic UniversityJiaozuo 454000China BGP Geophysical Research Institute CNPCZhuozhou 072751China Institute ofTarim Oilfield CNPCKorla 841000China Graduate University of Chinese Academy of Sciences Beijing 100049China

A typical ancient karst cave is found in the Yijianfang Formation of Ordovician at Liuhuanggou,North Tarim Basin.With an entrance of 4.8 m wide and 20 m high,the Liuhuanggou ancient karst cave extends to NW 315° and has been filled by sediments,which can be classified into three types according to their nature and origin:clastic sediments(gravels),chemical sediments(palaeotravertine),and mixed sediments.Among them,the Paleotravertine and gravels are most common.The palaeotravertine is laminated type and yellowish brown or black in color due to oil inside.When saturated with oil,the palaeotravertine is black.Under microscope,oil mainly accumulates in the cracks between calcite crystals.The filling period of the Liuhuanggou karst cave can be divided into three stages:mixed filling,chemical filling,and clastic(palaeotravertine breccia) filling.Numerous fractures are distributed on one side of the karst cave.The fractures can be as wide as 40 cm and over 40 m long.Fractures of different periods and sizes constitute a fracture network and are all filled with calcite veins.Oil can be found inside the fractures.In the chemical fillings,sulfur is also found,which can indicate the magma influence on karst caves.The existence of sulfur also confirms that the Liuhunggou karst cave was formed in ancient times rather than recently or nowadays.Different from normal sedimentary limestone,the ancient Liuhuanggou karst cave has a distinct isotope fractionation and the depletion of heavy carbon and oxygen isotope.Controlled by the northwest oriented vertical strike-slip shear fault,the karst cave is actually a dissolved vertical fault belt.

关键词：岩溶洞穴奥陶系硫磺盆地碎屑沉积物化学沉积物油气裂缝分布

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多时相遥感影像样本迁移模型与地表覆盖智能分类

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同济大学学报（自然科学版） 2022年第7期50卷 955-966页

作者：杜培军林聪陈宇王欣张伟郭山川南京大学地理与海洋科学学院江苏南京210023 自然资源部国土卫星遥感应用重点实验室江苏南京210023 中国矿业大学环境与测绘学院江苏徐州221116 成都理工大学地质灾害防治与地质环境保护国家重点实验室四川成都610059

利用时间序列遥感影像重建过去几十年的地表覆盖是实现时空多维地理场景感知与动态建模的基础,但存档历史遥感影像分类面临样本选择难、多时相影像协同解译水平低的问题。研究提出了一种基于已有土地覆盖产品与对应遥感影像中几何及属... 详细信息

利用时间序列遥感影像重建过去几十年的地表覆盖是实现时空多维地理场景感知与动态建模的基础,但存档历史遥感影像分类面临样本选择难、多时相影像协同解译水平低的问题。研究提出了一种基于已有土地覆盖产品与对应遥感影像中几何及属性特征约束的样本时空迁移方法,将迁移获得的训练样本嵌入多时相地表覆盖分类框架,获得多期地表覆盖分类结果,实现历史时期地表环境的智能感知与动态制图。太湖流域多时相分类的结果表明,无监督样本迁移方法可以充分利用先验几何约束和光谱属性,从参考地表覆盖产品中快速获得可靠的训练样本,多时相分类精度均高于89%,满足大区域多时相地表覆盖的分类需求,为地理环境演变建模提供了有效支持。

关键词：遥感影像分类地表覆盖迁移学习聚类分析变化检测

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Rice seeds identification based on back propagation neural network model

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International Journal of Agricultural and Biological Engineering 2019年第6期12卷 122-128页

作者： Xuebin Feng peijun He Huaxi Zhang Wenqing Yin Yan Qian Peng Cao Fei Hu College of Engineering Nanjing Agricultural UniversityNanjing 210031China

Rice quality directly affects the final rice yield.In order to achieve rapid,non-destructive testing of rice seeds,this paper combines the three-dimensional laser scanning technology and back propagation(BP)neural network algorithm to build a rice seeds identification platform.The information on rice seed surface is collected from four angles and processed using Geomagic Studio software.Based on the noise filtering,smoothing of the point cloud,vulnerability repair,and downsampling,the three-dimensional(3D)morphological characteristics of a rice seed surface,and the projection features of the main plane cross-section are obtained through the calculation of the features.The experiments were performed on five rice varieties,including Da Hua aromatic glutinous,Hong ShiⅠ,Tian You VIII,xin Dao X,and Yu Jing VI.The resulting input vector consisted respectively of:(1)nine 3D morphological surface features,(2)nine projection features of the main cross-section plane of rice,and(3)all of the above features.The results showed that for an input vector consisting of nine surface 3D morphological features,the recognition rate of the five rice varieties was 95%,96%,87%,93%,and 89%,respectively;for an input vector consisting of nine projection features of the main cross-section plane of rice seeds,the recognition rate was 96%,96%,90%,92%,and 89%,respectively;and lastly,for an input vector consisting of all the features,the highest recognition rate of 96%,97%,91%,94%,and 90%,respectively,was achieved.The analysis showed that rice varieties could be identified by using 3D laser scanning.Therefore,the proposed method can improve the accuracy of rice varieties identification.

关键词： rice seeds identification BP neural network three-dimensional laser scanning features point cloud

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