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试论宇宙、空间、物质、时间及其关系

西部学刊 2024年第14期 159-162页

作者：刘佩军湖北文理学院襄阳441053

人们对时间的概念会因不同学者的不同观点而显得模糊,时间属性也会因一些学术争议而无法统一。如果将还处在争议中的时间概念纳入宇宙概念,结果就会因时间概念模糊导致宇宙概念一同模糊起来。目前,人们对时间的看法是“过程”,即物质变... 详细信息

人们对时间的概念会因不同学者的不同观点而显得模糊,时间属性也会因一些学术争议而无法统一。如果将还处在争议中的时间概念纳入宇宙概念,结果就会因时间概念模糊导致宇宙概念一同模糊起来。目前,人们对时间的看法是“过程”,即物质变化过程。物质在空间内存在,在空间内演化,没有空间内的物质变化,时间就无法被确认。显然,空间与时间是隶属关系,而非并列关系。如果抛开时间,单把空间对应宇宙,宇宙“轮廓”会清晰许多,人类意识和潜意识中的宇宙概念也明了很多,在空间与宇宙同域的概念下再去讨论宇宙问题,其大小或边界就替换成整体空间的大小或边界,时间就不再是宇宙要素,讨论宇宙起源或宇宙终结也没有意义,因为空间既不存在起源,也不存在终结。看清宇宙、空间、物质、时间之间的相互关系,将拥有不一样的宇宙观。

关键词：宇宙空间物质时间

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基于近红外漫射光谱的离体血氧测量技术研究

中北大学学报（自然科学版） 2024年第3期45卷 348-356页

作者：刘培俊李为龙张睿芝高国雅桂志国尚禹中北大学信息与通信工程学院山西太原030051

基于近红外漫射光谱技术(Near-Infrared Diffuse Optical Spectroscopy,NIRS)和修正的比尔朗伯定律(Modified Beer-LambertLaw,MBLL)提出了一种适用于离体血液的新型氧含量测量方法,同时开发了血氧实时监测系统以实现体外循环血氧参数... 详细信息

基于近红外漫射光谱技术(Near-Infrared Diffuse Optical Spectroscopy,NIRS)和修正的比尔朗伯定律(Modified Beer-LambertLaw,MBLL)提出了一种适用于离体血液的新型氧含量测量方法,同时开发了血氧实时监测系统以实现体外循环血氧参数的连续监测。NIRS利用脱氧血红蛋白和氧合血红蛋白对两种波长近红外光吸收率的差异来计算组织的吸收和散射系数,朗伯-比尔定律是表征光强衰减与光子传输路径关系的数学表达式,将二者结合可估算血红蛋白的吸收系数;与传统的测量方式不同,本文所提出的透射式测量方法,通过双波长(660~904 nm)光源探头交替切换可获取多参数的光学信号,信号实时上传至采集界面(LabVIEW),经过对数化处理,并结合创新的血氧算法得到血液吸收系数、血氧饱和度与光信号的线性模型。为了验证本文研究方案的可行性,开展了液态仿体实验和离体血溶液实验,以滴入溶液墨水体积(仿体实验)和酵母溶液体积(血溶液实验)为变量,通过调控溶液浓度改变光密度变化幅度,证实二者均与光密度(DO)具有良好的线性关系(r^(2)>0.95,p<0.01)。本研究所提出的新型血氧测量方法和血氧实时监测系统适合于离体血液的血氧测量,数据准确可靠、重复稳定性好。

关键词：近红外漫射光谱技术修正的比尔朗伯定律体外循环血氧饱和度

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Estimation of interfacial damage in composites with reinforced particles based on ultrasonic data

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Journal of University of Science and Technology Beijing 2007年第3期14卷 280-285页

作者： Xiqiang liu peijun Wei Li Zhang Hang Wang Applied Science School University of Science and Technology Beijing Beijing 100083 China

The scattering of elastic waves by a spherical particle with imperfect interface and the nondestructive detection of interfacial damage were studied. First, the scattering of elastic waves by a spherical particle with imperfect interface, i.e. spring interface model, was studied. Then, multiple scattering by random distributed particles was investigated and the equations to evaluate the velocity and attenuation of effective waves defined by statistic averaging were given. Furthermore, on the basis of the established relation between the velocity and interfacial constants, a method to evaluate the interfacial damage nondestructively from the ultrasonic data was proposed. Numerical simulation was performed for the SiC-Al composites. The velocities of the effective waves were computed to show the influence of the interface constants. Using the genetic algorithm, the interfacial damage was evaluated from the synthetic experimental data with various noise levels. The numerical results showed the feasibility of the method proposed.

关键词： spring model average waves scattering genetic algorithm inverse problem

A case report of chylous ascites after cardiac surgery

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Emergency and Critical Care Medicine 2024年第1期4卷 42-45页

作者： Shuaishuai Yuan Pailing Xie Xiantao liu peijun Li The University of Hong Kong-Shenzhen Hospital Cardiovascular Medicine Center Cardiac Intensive Care Unit ShenzhenGuangdongChina.

Background:Chylous ascites(CA),an emulsion rich in triglycerides,is a rare type of ascites,especially after cardiac ***,there are few reports of the occurrence of CA after mitral valve replacement,aortic valve replacement,tricuspid valvuloplasty,and coronary artery bypass *** presentation:We report the case of a 53-year-old man who underwent surgery for a diagnosis of mitral incompetence,aortic incompetence,tricuspid incompetence,and coronary atherosclerotic heart *** days after surgery,3000 mL of milky-yellow ascites appeared in the abdominal cavity,diagnosed as CA by laboratory *** ascites gradually disappeared after being drained,and the patients *** curative was objective,but the exact cause is not ***:Although CA is rare,it may occur during the surgical intervention in cardiac surgery.

关键词： Cardiac intensive care unit Cardiac valve replacement Case report Chylous ascites Coronary artery bypass graft Department of cardiac surgery

Identification and validation of ferroptosisrelated hub genes in obstructive sleep apnea syndrome

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Identification and validation of ferroptosisrelated hub gene...

Active Ingredients and potential mechanisms of Notopterygium incisum against Obstructive Sleep Apnea Syndrome(OSAS): Network analysis and Experimental Validation

中国睡眠研究会第十五届全国学术年会

作者： peijun liu Ke Hu Enshi Tujia and Miao Autonomous Prefecture Central Hospital Renmin Hospital of Wuhan University

Background: By 2020, the prevalence of Obstructive Sleep Apnea Syndrome(OSAS) in the US has reached 26.6–43.2% in men and 8.7–27.8% in *** promotes hypertension, diabetes, and tumor growth through unknown *** intermittent hypoxia(CIH), sleep fragmentation, and increased pleural pressure are central mechanisms of OSAS *** exacerbates ferroptosis, which is closely related to *** mechanism of ferroptosis in OSAS disease progression remains ***: OSAS-related datasets(GSE135917 and GSE38792) were obtained from the *** expressed genes(DEGs) were screened using the R software and intersected with the ferroptosis database(FerrDb V2) to get ferroptosis-related DEGs(f-DEGs).GO, DO, KEGG, and GSEA enrichment were performed, a PPI network was constructed, and hub genes were *** TCGA database was used to obtain the thyroid cancer(THCA) gene expression profile, and hub genes were analyzed for differential and survival *** mechanism was investigated using GSEA and immune *** hub genes were validated with RT-qPCR, IHC, and other ***-Dawley rats were randomly separated into normoxia and CIH ***, MDA, and GSH methods were used to detect CIH-induced ferroptosis and oxidative ***: GSEA revealed a statistically significant difference in ferroptosis in OSAS(FDR < 0.05).HIF1A, ATM, HSPA5, MAPK8, MAPK14, TLR4, and CREB1 were identified as hub genes among 3144 DEGs and 74 ***1A and ATM were the only two validated genes.F-DEGs were mainly enriched in ***1A overexpression in THCA promotes its ***1A is associated with CD8 T cells and macrophages, which may affect the immunological *** result found CIH increased ROS and MDA while lowering GSH indicating that it could cause *** OSAS patients, non-invasive ventilation did not affect HIF1A and ATM ***, hydralazine, and caffeine may be important in the treatm

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Active Ingredients and potential mechanisms of Notopterygium...

Hypervalent iodine-mediated gem-difluorination of vinyl halides enabled by exclusive 1,2-halo migration

中国睡眠研究会第十五届全国学术年会

作者： peijun liu Ke Hu Department of Respiratory and Critical Care Medicine The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Department of Respiratory and Critical Care Medicine Renmin Hospital of Wuhan University

Background: Notopterygium incisum is an antiinflammatory natural medicinal *** is the primary active constituent, although the other ingredients and their mechanisms of action remain *** study aims to investigate the potential mechanisms of active ingredients for treating Obstructive Sleep Apnea Syndrome(OSAS) through network analysis and experimental validation ***: The active ingredients and target genes of Notopterygium incisum were extracted from public ***, OMIM, PharmGkb, TTD, and DrugBank databases, were searched for OSASrelated *** 3.9.0 was used to construct the drug-targetdisease network and screen for hub *** bronchial epithelial(HBE) cells were cultivated in normoxia and chronic intermittent hypoxia(CIH) medium for 24 ***-6(IL-6), tumor necrosis factor-alpha(TNF-α), and prostaglandin E2(PGE2) were quantified by EnzymeLinked Immunosorbent Assay(ELISA).Prostaglandin-endoperoxide synthase 2(PTGS2) mRNA was detected using RT-qPCR, while PTGS2 and nuclear factor-kappa B(NF-κB) proteins were identified using Western blot ***-Immunoprecipitation(CoIP) and Western blot were utilized to evaluate the ubiquitination of PTGS2 in HBE ***: Pterostilbene and notopterol were isolated from Notopterygium incisum to treat *** PTGS2 and estrogen receptor alpha(ESR1) hub genes were associated with *** pathway enrichment analysis focuses on the NF-κB, apoptosis, and HIF-1A *** response to CIH, notopterol and pterostilbene decreased IL-6, TNF-α, and PGE2 *** NF-κB pathway was activated by an increase in PTGS2 *** promotes proteasome-mediated ubiquitination of PTGS2 protein and reduced PTGS2 levels inhibit NF-κB pathway ***: Our findings have identified the active ingredients of Notopterygium incisum and hub genes that can be utilized in treating *** results provide new evidence and research insights into the role of bo

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Science China Chemistry 2021年第6期64卷 999-1003页

作者： Chenglong Li Yangzhen Liao Xuemei Tan Xiaozu liu peijun liu Wen-Xin Lv Honggen Wang Key Laboratory of Biocatalysis&Chiral Drug Synthesis of Guizhou Province Generic Drug Research Center of Guizhou ProvinceSchool of PharmacyZunyi Medical UniversityZunyi 563000China Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563000China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China

β-Difluorinated alkyl halides are of significant value in the modular synthesis of gem-difluorinated *** exclusive 1,2-halo migratory gem-difluorination of vinyl halides with in situ-generated PhIF_(2)·HF is *** protocol provides a general and practical approach towards a wide variety ofβ-difluorinated alkyl ***α-andβ-bromoalkyl alkenes are suitable substrates,leading to two distinct types of *** extension of this protocol to vinyl chloride and iodide are also *** synthetic versatility of this method has been highlighted by the late-stage modification of complex small molecules and further transformations of theβ-difluorinated alkyl halides to valuable CF_(2)-containing compounds.

关键词： gem-difluorination vinyl halides 1,2-halo migration hypervalent iodine late-stage modification

High-efficiency monolayer metallic metasurface for modulation of orbital angular momentum

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Chinese Optics Letters 2022年第12期20卷 68-72页

作者：刘佩军付亚男谢希闵长俊张聿全袁小聪 Nanophotonics Research Center Shenzhen Key Laboratory of Micro-Scale Optical Information Technology&Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

The optical vortex beam has widely been studied and used because of its unique orbital angular momentum(OAM).To generate and control OAM in compact and integrated systems,many metallic metasurface devices have been proposed,however,most of them suffer from the low ***,we propose and experimentally verify a high-efficiency monolayer metallic metasurface composed of semicircular nano-grooves distributed with detour *** metasurface can generate single or an array of OAM with spin-sensitive modulation and achieve the maximum efficiency of 60.2%in theory and 30.44%in *** work has great potential in compact OAM detection and communication systems.

关键词： optical vortex orbital angular momentum monolayer metallic metasurface

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青少年健康促进的国家战略及其政策着力点

中国学校卫生 2022年第1期43卷 10-13页

作者：刘培俊国家教育部体育卫生与艺术教育司北京100816

当今新冠肺炎疫情助推人类健康全球治理深刻变革,在健康中国和教育强国两大战略历史交汇点上,青少年健康成为中国之核心关切。全文立足中国学校卫生健康工作实际,以青少年健康为价值追求,青少年健康促进政策为研究主线,高站位地回顾了... 详细信息

当今新冠肺炎疫情助推人类健康全球治理深刻变革,在健康中国和教育强国两大战略历史交汇点上,青少年健康成为中国之核心关切。全文立足中国学校卫生健康工作实际,以青少年健康为价值追求,青少年健康促进政策为研究主线,高站位地回顾了当前青少年健康促进政策出台的时代背景,新定位地解读了政策设计过程中的全局性思维、超常规战略、突破性政策、先导性项目和前沿性技术,多方位地分析了政策着力点,与此同时,基于"健康中国2030"和"中国教育现代化2035"战略总蓝图,遵循教育部等五部门提出的政策路线图,以大健康、大教育、大卫生视角描述了当前和今后一个时期落实国家战略的行动流程图。

关键词：健康促进卫生政策青少年